ATVB In Focus Series

ATVB In Focus reviews will highlight selected areas of vascular biology, atherosclerosis, and thrombosis that are undergoing rapid or conceptual change. Each focused area will be featured in a series of brief reviews coordinated by a distinguished Series Editor. The brief reviews in each series will be published periodically to provide the Series Editors with flexibility to address emerging topics.
Steven R. Lentz, MD, PhD
Arterioscler. Thromb. Vasc. Biol., Jul 2002; 22: 1064

Abdominal Aortic Aneurysms: Pathophysiological Mechanisms and Clinical Implications
Edited by Robert R. Thompson, MD

Diabetic Vascular Disease: Pathophysiological Mechanisms in the Diabetic Milieu and Therapeutic Implications
Edited by Richard A. Cohen, MD

Endothelium: Signaling, Oxidative Stress, and Gene Expression
Edited by Frank M Faraci, PhD

Extracellular Mediators in Atherosclerosis and Thrombosis
Edited by Marschall S. Runge, MD, PhD

Immunity and Atherosclerosis
Edited by Göran K. Hansson

Lipoproteins, Inflammation, and Atherosclerosis
Edited by James Scott

Nitric Oxide Redux
Edited by Joseph Loscalzo

Noninvasive Assessment of Atherosclerosis: from Structure to Function
Edited by William G. Haynes, MBChB, MD

Novel Approaches to the Treatment of Dyslipidemia
Edited by Daniel J. Rader

Novel Mediators and Mechanisms in Angiogenesis and Vasculogenesis
Edited by Stefanie Dimmeler

Nutrition and Atherosclerosis
Edited by Margo Denke

Platelet Activation and the Formation of the Platelet Plug
Edited by Lawrence F. Brass

Redox Mechanisms in Blood Vessels
Edited by Kathy K. Griendling

Regulation of Coagulation
Edited by Yale Nemerson

Role of ABCA1 in Cellular Cholesterol Efflux and Reverse Cholesterol Transport
Edited by Alan R. Tall, MD

Smooth Muscle Cells
Edited by Guilio Gabbiani, MD, PhD

Abdominal Aortic Aneurysms: Pathophysiological Mechanisms and Clinical Implications

Robert W. Thompson
ATVB In Focus: Abdominal Aortic Aneurysms: Pathophysiological Mechanisms and Clinical Implications

Janet T. Powell and Anthony R. Brady
Detection, Management, and Prospects for the Medical Treatment of Small Abdominal Aortic Aneurysms

Alan Daugherty and Lisa A. Cassis
Mouse Models of Abdominal Aortic Aneurysms

Gerard Pasterkamp, Zorina S. Galis, and Dominique P.V. de Kleijn
Expansive Arterial Remodeling: Location, Location, Location

David A. Vorp and Jonathan P. Vande Geest
Biomechanical Determinants of Abdominal Aortic Aneurysm Rupture

Koichi Shimizu, Richard N. Mitchell, and Peter Libby
Inflammation and Cellular Immune Responses in Abdominal Aortic Aneurysms

Diabetic Vascular Disease: Pathophysiological Mechanisms in the Diabetic Milieu and Therapeutic Implications

Richard A. Cohen
ATVB In Focus: Diabetic Vascular Disease: Pathophysiological Mechanisms in the Diabetic Milieu and Therapeutic Implications

Yoshifumi Naka, Loredana G. Bucciarelli, Thoralf Wendt, Larisse K. Lee, Ling Ling Rong, Ravichandran Ramasamy, Shi Fang Yan, Ann Marie Schmidt
RAGE Axis: Animal Models and Novel Insights Into the Vascular Complications of Diabetes

Rama Natarajan; Jerry L. Nadler
Lipid Inflammatory Mediators in Diabetic Vascular Disease

Christian Rask-Madsen and George L. King
Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance

Florian Blaschke, Yasunori Takata, Evren Caglayan, Ronald E. Law, and Willa A. Hsueh
Obesity, Peroxisome Proliferator-Activated Receptor, and Atherosclerosis in Type 2 Diabetes

Endothelium: Signaling, Oxidative Stress, and Gene Expression

Frank M. Faraci
ATVB In Focus: Endothelium: Signaling, Oxidative Stress, and Gene Expression

Sebastian Wolfrum, Kristin S. Jensen, and James K. Liao
Endothelium-Dependent Effects of Statins

Philippe G. Frank, Scott E. Woodman, David S. Park, and Michael P. Lisanti
Caveolin, Caveolae, and Endothelial Cell Function

Zvonimir S. Katusic, Noel M. Caplice, and Karl A. Nath
Nitric Oxide Synthase Gene Transfer as a Tool to Study Biology of Endothelial Cells

Frank M. Faraci and Sean P. Didion
Vascular Protection: Superoxide Dismutase Isoforms in the Vessel Wall

Michel Félétou and Paul M. Vanhoutte
Endothelium-Derived Hyperpolarizing Factor: Where Are We Now?

Extracellular Mediators in Atherosclerosis and Thrombosis

Marschall S. Runge
ATVB In Focus: Extracellular Mediators in Atherosclerosis and Thrombosis

Allan R. Brasier, Adrian Recinos, III, and Mohsen S. Eledrisi
Vascular Inflammation and the Renin-Angiotensin System

Martin Moser and Cam Patterson
Thrombin and Vascular Development: A Sticky Subject

Christopher D. Major, Rosemary J. Santulli, Claudia K. Derian, and Patricia Andrade-Gordon
Extracellular Mediators in Atherosclerosis and Thrombosis: Lessons From Thrombin Receptor Knockout Mice

Yong-Jun Yin, Zaidoun Salah, Sorina Grisaru-Granovsky, Irit Cohen, Sharona Cohen Even-Ram, Myriam Maoz, Beatrice Uziely, Tamar Peretz, and Rachel Bar-Shavit
Human Protease-Activated Receptor 1 Expression in Malignant Epithelia: A Role in Invasiveness

G.A. Stouffer and S.S. Smyth
Effects of Thrombin on Interactions Between β₃-Integrins and Extracellular Matrix in Platelets and Vascular Cells

Martha K. Cathcart
Regulation of Superoxide Anion Production by NADPH Oxidase in Monocytes/Macrophages: Contributions to Atherosclerosis

Immunity and Atherosclerosis

Göran Hansson
ATVB In Focus: Immunity and Atherosclerosis

Jan Nilsson; Göran K. Hansson; Prediman K. Shah
Immunomodulation of Atherosclerosis Implications for Vaccine Development


Johan Frostegård
Atherosclerosis in Patients With Autoimmune Disorders

Lipoproteins, Inflammation, and Atherosclerosis

James Scott
ATVB In Focus: Lipoproteins, Inflammation, and Atherosclerosis

Len A. Pennacchio and Edward M. Rubin
Apolipoprotein A5, a Newly Identified Gene That Affects Plasma Triglyceride Levels in Humans and Mice

Paul Cullen, Roberta Baetta, Stefano Bellosta, Franco Bernini, Giulia Chinetti, Andrea Cignarella, Arnold von Eckardstein, Andrew Exley, Martin Goddard, Marten Hofker, Eva Hurt-Camejo, Edwin Kanters, Petri Kovanen, Stefan Lorkowski, William McPheat, Markku Pentikäinen, Jürgen Rauterberg, Andrew Ritchie, Bart Staels, Benedikt Weitkamp, Menno de Winther, for the MAFAPS Consortium
Rupture of the Atherosclerotic Plaque: Does a Good Animal Model Exist?

Hooman Allayee, Anatole Ghazalpour, and Aldons J. Lusis
Using Mice to Dissect Genetic Factors in Atherosclerosis

Laura Calabresi, Monica Gomaraschi, and Guido Franceschini
Endothelial Protection by High-Density Lipoproteins: From Bench to Bedside

Bernardo L. Trigatti, Monty Krieger, and Attilio Rigotti
Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis

Mercedes Ricote, Annabel F. Valledor, and Christopher K. Glass
Decoding Transcriptional Programs Regulated by PPARs and LXRs in the Macrophage: Effects on Lipid Homeostasis, Inflammation, and Atherosclerosis

Nitric Oxide Redux

Joseph Loscalzo
ATVB In Focus: Nitric Oxide Redux

Daniel B. Kim-Shapiro, Alan N. Schechter, and Mark T. Gladwin
Unraveling the Reactions of Nitric Oxide, Nitrite, and Hemoglobin in Physiology and Therapeutics

Diane E. Handy and Joseph Loscalzo
Nitric Oxide and Posttranslational Modification of the Vascular Proteome: S-Nitrosation of Reactive Thiols

Noninvasive Assessment of Atherosclerosis: From Structure to Function

William G. Haynes
ATVB In Focus: Noninvasive Assessment of Atherosclerosis–From Structure to Function

Robin P. Choudhury, Valentin Fuster, Juan J. Badimon, Edward A. Fisher, and Zahi A. Fayad
MRI and Characterization of Atherosclerotic Plaque: Emerging Applications and Molecular Imaging

Piero O. Bonetti, Lilach O. Lerman, and Amir Lerman
Endothelial Dysfunction: A Marker of Atherosclerotic Risk

James J. Oliver and David J. Webb
Noninvasive Assessment of Arterial Stiffness and Risk of Atherosclerotic Events

Mohammad Madjid, Alireza Zarrabi, Silvio Litovsky, James T. Willerson, and Ward Casscells
Finding Vulnerable Atherosclerotic Plaques: Is It Worth the Effort?

Jason D. Morrow
Quantification of Isoprostanes as Indices of Oxidant Stress and the Risk of Atherosclerosis in Humans

David Feinbloom and Kenneth A. Bauer
Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events

James J. Oliver, David J. Webb, and David E. Newby
Stimulated Tissue Plasminogen Activator Release as a Marker of Endothelial Function in Humans

Novel Approaches to the Treatment of Dyslipidemia

Daniel J. Rader
ATVB In Focus: Novel Approaches to the Treatment of Dyslipidemia

Hubert C. Chen and Robert V. Farese, Jr
Inhibition of Triglyceride Synthesis as a Treatment Strategy for Obesity: Lessons From DGAT1-Deficient Mice

Andrew Zalewski and Colin Macphee
Role of Lipoprotein-Associated Phospholipase A₂ in Atherosclerosis: Biology, Epidemiology, and Possible Therapeutic Target

Lawrence L. Rudel, Richard G. Lee, and Paolo Parini
ACAT2 Is a Target for Treatment of Coronary Heart Disease Associated With Hypercholesterolemia

Mohamad Navab, G.M. Anantharamaiah, Srinivasa T. Reddy, Susan Hama, Greg Hough, Victor R. Grijalva, Nicholas Yu, Benjamin J. Ansell, Geeta Datta, David W. Garber, and Alan M. Fogelman
Apolipoprotein A-I Mimetic Peptides

Thierry Claudel, Bart Staels, and Folkert Kuipers
The Farnesoid X Receptor: A Molecular Link Between Bile Acid and Lipid and Glucose Metabolism

Anke H.E.M. Klerkx, Karim El Harchaoui, Wim A. van der Steeg, S. Matthijs Boekholdt, Erik S.G. Stroes, John J.P. Kastelein, and Jan Albert Kuivenhoven
Cholesteryl Ester Transfer Protein (CETP) Inhibition Beyond Raising High-Density Lipoprotein Cholesterol Levels: Pathways by Which Modulation of CETP Activity May Alter Atherogenesis

Novel Mediators and Mechanisms in Angiogenesis and Vasculogenesis

Stefanie Dimmeler
ATVB in Focus: Novel Mediators and Mechanisms in Angiogenesis and Vasculogenesis

J.E. Ferguson, III, Rusty W. Kelley, and Cam Patterson
Mechanisms of Endothelial Differentiation in Embryonic Vasculogenesis

Nikos Werner and Georg Nickenig
Influence of Cardiovascular Risk Factors on Endothelial Progenitor Cells: Limitations for Therapy?

Victor W.M. van Hinsbergh, Marten A. Engelse, and Paul H.A. Quax
Pericellular Proteases in Angiogenesis and Vasculogenesis

Masataka Sata
Role of Circulating Vascular Progenitors in Angiogenesis, Vascular Healing, and Pulmonary Hypertension: Lessons From Animal Models

Nutrition and Atherosclerosis

Elvira Isganaitis and Robert H. Lustig
Fast Food, Central Nervous System Insulin Resistance, and Obesity

James A. Levine, Mark W. Vander Weg, James O. Hill, and Robert C. Klesges
Non-Exercise Activity Thermogenesis: The Crouching Tiger Hidden Dragon of Societal Weight Gain

Arpita Basu, Sridevi Devaraj, and Ishwarlal Jialal
Dietary Factors That Promote or Retard Inflammation

Platelet Activation and the Formation of the Platelet Plug

Lawrence F. Brass
ATVB In Focus: Platelet Signal Transduction and Interactions With Vascular Cells

Han-Mou Tsai
Platelet Activation and the Formation of the Platelet Plug: Deficiency of ADAMTS13 Causes Thrombotic Thrombocytopenic Purpura

Martin J. Quinn, Tatiana V. Byzova, Jun Qin, Eric J. Topol, and Edward F. Plow
Integrin αIIbß3 and Its Antagonism

Peter J. Newman and Debra K. Newman
Signal Transduction Pathways Mediated by PECAM-1: New Roles for an Old Molecule in Platelet and Vascular Cell Biology

Robert Flaumenhaft
Molecular Basis of Platelet Granule Secretion

Redox Mechanisms in Blood Vessels

Kathy K. Griendling
ATVB In Focus: Redox Mechanisms in Blood Vessels

Cornelius F.H. Mueller, Karine Laude, J. Scott McNally, and David G. Harrison
Redox Mechanisms in Blood Vessels

David D. Gutterman, Hiroto Miura, and Yanping Liu
Redox Modulation of Vascular Tone: Focus of Potassium Channel Mechanisms of Dilation

Stephen J. Nicholls and Stanley L. Hazen
Myeloperoxidase and Cardiovascular Disease

Jane A. Leopold and Joseph Loscalzo
Oxidative Enzymopathies and Vascular Disease

Thomas Münzel, Andreas Daiber, Volker Ullrich, Alexander Mülsch
Vascular Consequences of Endothelial Nitric Oxide Synthase Uncoupling for the Activity and Expression of the Soluble Guanylyl Cyclase and the cGMP-Dependent Protein Kinase

Regulation of Coagulation

Jolyon Jesty and Edward Beltrami
Positive Feedbacks of Coagulation: Their Role in Threshold Regulation

Dougald M. Monroe and Maureane Hoffman
What Does It Take to Make the Perfect Clot?

Ronald R. Bach
Tissue Factor Encryption

Role of ABCA1 in Cellular Cholesterol Efflux and Reverse Cholesterol Transport

Alan R. Tall
ATVB In Focus: Role of ABCA1 in Cellular Cholesterol Efflux and Reverse Cholesterol Transport

Patricia G. Yancey, Anna E. Bortnick, Ginny Kellner-Weibel, Margarita de la Llera-Moya, Michael C. Phillips, and George H. Rothblat
Importance of Different Pathways of Cellular Cholesterol Efflux

John F. Oram
HDL Apolipoproteins and ABCA1: Partners in the Removal of Excess Cellular Cholesterol

Charles Joyce, Lita Freeman, H. Bryan Brewer, Jr, and Silvia Santamarina-Fojo
Study of ABCA1 Function in Transgenic Mice

Robert J. Aiello, Dominique Brees, and Omar L. Francone
ABCA1-Deficient Mice: Insights Into the Role of Monocyte Lipid Efflux in HDL Formation and Inflammation

Erik G. Lund, John G. Menke, and Carl P. Sparrow
Liver X Receptor Agonists as Potential Therapeutic Agents for Dyslipidemia and Atherosclerosis

Nan Wang and Alan R. Tall
Regulation and Mechanisms of ATP-Binding Cassette Transporter A1-Mediated Cellular Cholesterol Efflux

Roshni R. Singaraja, Liam R. Brunham, Henk Visscher, John J.P. Kastelein, and Michael R. Hayden
Efflux and Atherosclerosis: The Clinical and Biochemical Impact of Variations in the ABCA1 Gene

Smooth Muscle Cells

Giulio Gabbiani and Göran K. Hansson
ATVB In Focus: Smooth Muscle Cells

Jan-Luuk Hillebrands, Flip A. Klatter, and Jan Rozing
Origin of Vascular Smooth Muscle Cells and the Role of Circulating Stem Cells in Transplant Arteriosclerosis

Tatsuya Iso, Yasuo Hamamori, and Larry Kedes
Notch Signaling in Vascular Development

Meena S. Kumar and Gary K. Owens
Combinatorial Control of Smooth Muscle–Specific Gene Expression

Hiroyuki Hao, Giulio Gabbiani, and Marie-Luce Bochaton-Piallat
Arterial Smooth Muscle Cell Heterogeneity: Implications for Atherosclerosis and Restenosis Development

Mikko O. Hiltunen and Seppo Ylä-Herttuala
DNA Methylation, Smooth Muscle Cells, and Atherogenesis