n=5220 | Total Incident CAD (n=159) | Nonfatal Incident CAD (n=134) | Fatal Incident CAD (n=25) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|

Unadjusted Model | P Value | Adjusted Model | P Value | Unadjusted Model | P Value | Adjusted Model | P Value | Unadjusted Model | P Value | Adjusted Model | P Value | |

Positive vs negative | 1.39 (0.97–1.99) | 0.073 | 1.36 (0.94–1.97) | 0.105 | 1.58 (1.08–2.31) | 0.018 | 1.53 (1.03–2.26) | 0.034 | 0.54 (0.16–1.80) | 0.313 | 0.56 (0.17–1.91) | 0.356 |

1 SD change in log-transformed anti-ApoA-1 IgG levels | 1.11 (0.96–1.28) | 0.159 | 1.09 (0.94–1.27) | 0.232 | 1.15 (0.99–1.34) | 0.072 | 1.14 (0.97–1.33) | 0.109 | 0.88 (0.61–1.29) | 0.520 | 0.87 (0.60–1.27) | 0.474 |

Anti-ApoA-1 IgG levels* | ||||||||||||

Negative (OD<0.64) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | ||||||

First tertile (0.64<OD≤0.77) | 1.18 (0.64–2.19) | 0.597 | 1.39 (0.74–2.59) | 0.879 | 1.32 (0.69–2.53) | 0.406 | 1.50 (0.78–2.89) | 0.227 | 0.60 (0.08–4.43) | 0.613 | 0.75 (0.96–5.92) | 0.788 |

Second tertile (0.77<OD≤0.98) | 1.16 (0.63–2.16) | 0.633 | 0.95 (0.48–1.88) | 0.879 | 1.17 (0.59–2.33) | 0.646 | 0.89 (0.41–1.93) | 0.767 | 1.02 (0.24–4.37) | 0.974 | 1.13 (0.26–4.90) | 0.872 |

Third tertile (OD>0.98) | 1.79 (1.09–2.95) | 0.021 | 1.70 (1.03–2.81) | 0.038 | 2.21 (1.34–3.67) | 0.002 | 2.14 (1.29–3.56) | 0.003 | No subjects | No subjects | ||

P value for linear trend | 0.047 | 0.160 | 0.012 | 0.021 |

Results are expressed as adjusted hazard ratios and (95% confidence interval) for subjects positive (OD>0.64) vs negative (OD<0.64) for anti-apoA-1 IgG. Statistical analysis by Cox proportional hazards regression adjusted for age, sex, systolic blood pressure, diabetes mellitus, smoking, HDL and LDL cholesterol, baseline CAD, statin, β-blocker treatment, and eGFR. Anti-apoA-1 IgG indicates anti-apolipoprotein A-1 autoantibodies; CAD, coronary artery disease; eGFR, estimated glomerular filtration rate; HDL, high density lipoprotein; LDL, low density lipoprotein; OD, optical density; and SD, standard deviation.

* Subjects with positive Anti-ApoA-1 (n=1040) were divided in tertiles (n=347) of increasing titers: first tertile (0.64<OD<0.77), second tertile (0.77<OD<0.98), and third tertile (OD>0.98).