Table.

CpGs Associated With Cholesterol Efflux Capacity or HDL Inflammatory Index

CpGGeneModel 1Model 2Variability (%)Total variability (%)
Coeff (SE)P ValueCoeff (SE)P Value
Epigenome-wide approach
 Cholesterol efflux capacity
  cg04837231PER3−0.201 (0.046)1.38×10−05−0.271 (0.049)4.04×10−082.435.38
  cg01964852HOXA3−0.184 (0.033)2.86×10−08−0.223 (0.041)5.04×10−083.84
  cg22812457PEX5−0.241 (0.043)1.82×10−08−0.219 (0.053)3.02×10−051.11
 HDL inflammatory index
  cg25671376GABRR10.229 (0.043)7.42×10−080.228 (0.042)7.62×10−080.830.83
Gene candidate approach
 Cholesterol efflux capacity
  cg08876518CMIP−0.130 (0.032)3.94×10−05−0.173 (0.036)1.82×10−063.033.70
  cg03212183CMIP−0.124 (0.033)1.53×10−04−0.165 (0.038)1.40×10−052.51
  • Model 1 adjusted for sex, age, smoking, estimated cell count, surrogate variables, and HDL-cholesterol levels. Model 2 adjusted for sex, age, smoking, estimated cell count, and surrogate variables. Coeff (SE): coefficient and SE of the standardized M value. CpGs indicates cytosine–phosphate–guanine; and HDL, high-density lipoprotein.