Table 3. Relations of Serum Ca, Pi, and [Ca×Pi] to Cardiovascular Mortality

Cardiovascular Mortality
Model AModel B
Ca, Pi, and [Ca×Pi] were investigated as continuous variables (per SD) in separate models. Data are Cox proportional hazard ratios (95% CI) and P values. Model A adjusts for age, albumin, and eGFRCG. Model B adjusts for age, albumin, eGFRCG, diabetes, use of antihypertensive medication, systolic and diastolic blood pressures, total cholesterol, triglycerides, body mass index, and smoking.
Per SD of Ca1.11 (1.01–1.22); P=0.041.08 (0.98–1.19); P=0.14
By Ca tertiles
    1 (2.05–2.32 mmol/L)11
    2 (2.32–2.40 mmol/L)1.01 (0.81–1.26); P=0.910.98 (0.79–1.23); P=0.89
    3 (2.40–2.70 mmol/L)1.33 (1.04–1.70); P=0.021.20 (0.94–1.54); P=0.15
Per SD of Pi1.07 (1.00–1.15); P=0.051.10 (1.02–1.18); P=0.01
By Pi tertiles
    1 (0.2–0.8 mmol/L)11
    2 (0.8–0.9 mmol/L)1.06 (0.83–1.36); P=0.621.10 (0.86–1.41); P=0.45
    3 (0.9–4.9 mmol/L)1.29 (1.05–1.59); P=0.021.31 (1.06–1.63); P=0.01
Per SD of [Ca×Pi]1.08 (1.01–1.15); P=0.031.10 (1.03–1.19); P=0.008
By [Ca×Pi] tertiles
    1 (0.5–1.9 mmol2/L2)11
    2 (1.9–2.2 mmol2/L2)1.07 (0.84–1.35); P=0.601.12 (0.88–1.42); P=0.35
    3 (2.2–11.9 mmol2/L2)1.36 (1.09–1.70); P=0.0071.39 (1.10–1.76); P=0.005
Models including both Ca and Pi
    Per SD of Ca1.11 (1.01–1.22); P=0.041.08 (0.98–1.20); P=0.13
    Per SD of Pi1.07 (1.00–1.15); P=0.051.10 (1.02–1.18); P=0.01
Models including Ca, Pi, and [Ca×Pi]
    Per SD of [Ca×Pi]0.37 (0.05–2.88); P=0.350.43 (0.06–3.00); P=0.39
Subsample of 1777 men with eGFRCG >90 mL/min/1.73m2
    Per SD of Ca1.11 (1.00–1.24); P=0.051.10 (0.98–1.22); P=0.10
    Per SD of Pi1.08 (1.01–1.16); P=0.031.11 (1.03–1.19); P=0.007
    Per SD of [Ca×Pi]1.09 (1.02–1.17); P=0.021.11 (1.03–1.20); P=0.004
Subsample of 2155 men with Pi <1.45 mmol/L and Ca <2.6 mmol/L
    Per SD of Ca1.11 (1.00–1.23); P=0.041.08 (0.97–1.20); P=0.15
    Per SD of Pi1.10 (0.97–1.24); P=0.141.13 (1.00–1.28); P=0.06
    Per SD of [Ca×Pi]1.12 (0.99–1.26); P=0.061.14 (1.01–1.30); P=0.03