Table 2. Relations of Serum Ca, Pi, and [Ca×Pi] to Total Mortality

Total Mortality
Model AModel B
Ca, Pi, and [Ca×Pi] were investigated as continuous variables (per SD) and in tertiles (with the lowest group being the reference level) in separate models except when indicated. Data are Cox proportional hazard ratios (95% CI) and P values. Model A adjusts for age, albumin, and eGFRCG. Model B adjusts for age, albumin, eGFRCG, diabetes, use of antihypertensive medication, systolic and diastolic blood pressures, total cholesterol, triglycerides, body mass index, and smoking.
Per SD of Ca1.12 (1.04–1.19); P=0.0011.08 (1.01–1.16); P=0.02
By Ca tertiles
    1 (2.05–2.32 mmol/L)11
    2 (2.32–2.40 mmol/L)1.05 (0.90–1.22); P=0.511.02 (0.87–1.18); P=0.84
    3 (2.40–2.70 mmol/L)1.38 (1.17–1.63); P<0.00011.25 (1.06–1.48); P=0.009
Per SD of Pi1.07 (1.02–1.12); P=0.0061.06 (1.01–1.12); P=0.03
By Pi tertiles
    1 (0.2–0.8 mmol/L)11
    2 (0.8–0.9 mmol/L)1.13 (0.96–1.33); P=0.131.13 (0.96–1.33); P=0.14
    3 (0.9–4.9 mmol/L)1.25 (1.08–1.44); P=0.0031.16 (1.00–1.35); P=0.05
Per SD of [Ca×Pi]1.08 (1.03–1.13); P=0.0011.07 (1.01–1.12); P=0.01
By [Ca x Pi] tertiles
    1 (0.5–1.9 mmol2/L2)11
    2 (1.9–2.2 mmol2/L2)1.11 (0.95–1.30); P=0.201.11 (0.94–1.30); P=0.21
    3 (2.2–11.9 mmol2/L2)1.31 (1.12–1.52); P=0.0011.22 (1.04–1.43); P=0.01
Models including both Ca and Pi
    Per SD of Ca1.12 (1.05–1.19); P=0.0011.08 (1.01–1.16); P=0.02
    Per SD of Pi1.07 (1.02–1.12); P=0.0051.06 (1.01–1.12); P=0.03
Models including Ca, Pi, and [Ca×Pi]
    Per SD of [Ca×Pi]0.67 (0.15–2.87); P=0.590.69 (0.16–2.97); P=0.61
Subsample of 1777 men with eGFRCG >90 mL/min/1.73m2
    Per SD of Ca1.11 (1.03–1.19); P=0.0041.08 (1.01–1.16); P=0.03
    Per SD of Pi1.07 (1.02–1.13); P=0.0081.06 (1.00–1.12) (P=0.05)
    Per SD of [Ca×Pi]1.08 (1.03–1.13); P=0.0021.07 (1.01–1.12); P=0.02
Subsample of 2155 men with Pi <1.45 mmol/L and Ca <2.6 mmol/L
    Per SD of Ca1.11 (1.04–1.19); P=0.0021.08 (1.01–1.16); P=0.03
    Per SD of Pi1.11 (1.02–1.21); P=0.011.08 (0.99–1.18); P=0.07
    Per SD of [Ca×Pi]1.14 (1.05–1.23); P=0.0021.10 (1.01–1.20); P=0.03