Table 2.

Baseline Characteristics of the Study Population According to Heme Oxygenase-1 Genotype

SS/SMMMMLLLPany differencePtrendPLL vs other
n (%)35 (4.3)665 (81.9)101 (12.4)11 (1.4)
VNTR range (shorter allele)12–2223–3123–3132–37
VNTR range (longer allele)12–3123–3132–4436–38
Baseline characteristics
 Age, y59.8±11.062.9±11.162.6±11.165.3±9.80.3680.3610.451
 Male sex, n (%)18 (51.4)337 (50.7)41 (40.6)5 (45.5)0.2930.1160.813
 Body mass index, kg/m225.2 (23.4, 27.7)25.3 (23.1, 27.8)25.7 (23.3, 27.8)24.5 (22.8, 26.1)0.6940.9960.350
 Current smoking, n (%)8 (22.9)131 (20.2)16 (16.0)1 (9.1)0.7430.3460.458
 Diabetes mellitus, n (%)2 (5.7)74 (11.1)10 (9.9)1 (9.1)0.8500.9700.748
 Systolic BP, mm Hg147.9±21.3147.9±20.7150.9±21.3147.1±15.40.6500.6760.650
 Diastolic BP, mm Hg87.2±10.186.9±9.188.2±9.787.0±5.30.7330.5080.927
 Total cholesterol, mg/dL221.7±39.6229.6±42.9235.5±42.4231.6±33.40.5120.1870.948
 HDL cholesterol, mg/dL59.9±17.558.8±16.158.1±16.456.4±15.40.7340.2670.567
 Ferritin, ng/mL65 (32, 169)88 (36, 170)64 (28, 126)46 (25, 161)0.204*0.194*0.399*
 hs-CRP, mg/L1.9 (0.9, 3.4)1.6 (0.8, 3.2)2.0 (1.1, 3.4)1.8 (1.4, 2.3)0.098*0.429*0.679*
  • Values are given as n (%), mean±SD, or median (interquartile range); Ptrend is for linear trend; P values are adjusted for age and sex, except those for age and sex, which are only adjusted for the other; S, <23 tandem repeats; M, 23–31 tandem repeats; L, ≥32 tandem repeats.

  • BP indicates blood pressure; HDL, high-density lipoprotein; hs-CRP, high-sensitivity C-reactive protein; and VNTR, variable number tandem repeat.

  • * Variables were log-transformed for significance testing.