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Arteriosclerosis, Thrombosis, and Vascular Biology
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Volume 29, Issue 7; July 1, 2009
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Key:  VB = Vascular Biology  AL = Atherosclerosis/Lipoproteins  TH = Thrombosis
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Brief ReviewsBack

Cardiovascular Molecular Imaging

Zahi A. Fayad
Arterioscler Thromb Vasc Biol. 2009;29:981-982, doi:10.1161/ATVBAHA.109.191809
Extract | Full Text | PDF Free Article  

Robin P. Choudhury and Edward A. Fisher
Arterioscler Thromb Vasc Biol. 2009;29:983-991; published online before print February 12 2009, doi:10.1161/ATVBAHA.108.165498
Abstract | Full Text | PDF  

David P. Cormode, Torjus Skajaa, Zahi A. Fayad, and Willem J.M. Mulder
Arterioscler Thromb Vasc Biol. 2009;29:992-1000; published online before print December 4 2008, doi:10.1161/ATVBAHA.108.165506
Abstract | Full Text | PDF
Nanoparticles are a crucial part of the next generation of contrast agents for medical imaging. Herein we discuss the different aspects of nanoparticle probe design and highlight some of the most advanced examples.  

Tjun Y. Tang, Karin H. Muller, Martin J. Graves, Zhi Y. Li, Stewart R. Walsh, Victoria Young, Umar Sadat, Simon P.S. Howarth, and J.H. Gillard
Arterioscler Thromb Vasc Biol. 2009;29:1001-1008; published online before print February 19 2009, doi:10.1161/ATVBAHA.108.165514
Abstract | Full Text | PDF  

James H.F. Rudd, Fabien Hyafil, and Zahi A. Fayad
Arterioscler Thromb Vasc Biol. 2009;29:1009-1016; published online before print March 20 2009, doi:10.1161/ATVBAHA.108.165563
Abstract | Full Text | PDF  

Farouc A. Jaffer, Peter Libby, and Ralph Weissleder
Arterioscler Thromb Vasc Biol. 2009;29:1017-1024; published online before print April 9 2009, doi:10.1161/ATVBAHA.108.165530
Abstract | Full Text | PDF | Data Supplement  

Dara L. Kraitchman and Jeff W.M. Bulte
Arterioscler Thromb Vasc Biol. 2009;29:1025-1030; published online before print April 9 2009, doi:10.1161/ATVBAHA.108.165571
Abstract | Full Text | PDF | Data Supplement
Cellular transplantation offers a means to stimulate cardiovascular repair. Cell labeling with contrast agents or transfection with reporter genes have enabled serial dynamic imaging of cell survival, fate, and engraftment. In this review article, we explore some of the state-of-the art methods for stem, progenitor, and beta cell tracking.  

Eduard M. Laufer, Mark H.M. Winkens, Jagat Narula, and Leonard Hofstra
Arterioscler Thromb Vasc Biol. 2009;29:1031-1038; published online before print May 21 2009, doi:10.1161/ATVBAHA.108.165522
Abstract | Full Text | PDF  

 

Integrative Physiology/Experimental MedicineBack

TH gif   Disruption of SEMA4D Ameliorates Platelet Hypersensitivity in Dyslipidemia and Confers Protection Against the Development of Atherosclerosis

Li Zhu, Timothy J. Stalker, Karen P. Fong, Hong Jiang, Anh Tran, Irene Crichton, Eric K. Lee, Keith B. Neeves, Sean F. Maloney, Hitoshi Kikutani, Atsushi Kumanogoh, Ellen Pure, Scott L. Diamond, and Lawrence F. Brass
Arterioscler Thromb Vasc Biol. 2009;29:1039-1045; published online before print April 23 2009, doi:10.1161/ATVBAHA.109.185405
Abstract | Full Text | PDF | Data Supplement
We previously demonstrated that semaphorin-4D modulates platelet function. Here, we examined the role of Sema4D in platelet function and atherogenesis in dyslipidemia. Deletion of Sema4D ameliorated atherosclerotic plaque formation and platelet hyperreactivity in dyslipidemic mice. These findings suggest that sema4D and its receptors provide a new target mechanism for preventing the development of atherothrombotic disease.  

AL gif  Inactivation of the Adenosine A2A Receptor Protects Apolipoprotein E–Deficient Mice From Atherosclerosis

Huan Wang, Weiyu Zhang, Chuhong Zhu, Christoph Bucher, Bruce R. Blazar, Chunxiang Zhang, Jiang-Fan Chen, Joel Linden, Chaodong Wu, and Yuqing Huo
Arterioscler Thromb Vasc Biol. 2009;29:1046-1052; published online before print April 30 2009, doi:10.1161/ATVBAHA.109.188839
Abstract | Full Text | PDF | Data Supplement
Knockout of A2AR in apolipoprotein E-deficient mice led to an increase in body weight and levels of blood cholesterol and proinflammatory cytokines. However, unexpectedly, A2AR deficiency in mice or bone marrow-derived cells dramatically inhibits atherosclerosis. Increased apoptosis of foam cells is the underlying mechanism for decreased atherosclerosis.  

AL gif  Core2 1-6-N-Glucosaminyltransferase-I Deficiency Protects Injured Arteries From Neointima Formation in ApoE-Deficient Mice

Huan Wang, Weiyu Zhang, Rong Tang, Robert P. Hebbel, M. Anna Kowalska, Chunxiang Zhang, Jamey D. Marth, Minoru Fukuda, Chuhong Zhu, and Yuqing Huo
Arterioscler Thromb Vasc Biol. 2009;29:1053-1059; published online before print April 16 2009, doi:10.1161/ATVBAHA.109.187716
Abstract | Full Text | PDF | Data Supplement
C2GlcNAcT-I deficiency suppresses injury-induced arterial neointima formation, and this effect is attributable to decreased leukocyte recruitment to injured vascular walls and increased endothelial regeneration.  

TH gif  Insulin Increases Reendothelialization and Inhibits Cell Migration and Neointimal Growth After Arterial Injury

Danna M. Breen, Kalam K. Chan, Jiwanjeet K. Dhaliwall, Michael R. Ward, Nael Al Koudsi, Loretta Lam, Melissa De Souza, Husam Ghanim, Paresh Dandona, Duncan J. Stewart, Michelle P. Bendeck, and Adria Giacca
Arterioscler Thromb Vasc Biol. 2009;29:1060-1066; published online before print April 9 2009, doi:10.1161/ATVBAHA.109.185447
Abstract | Full Text | PDF | Data Supplement
Insulin has both growth-promoting and vasculoprotective effects in vitro, however the predominant effect in vivo is unclear. After arterial injury in rats insulin decreased neointimal growth and cell migration, and increased SMC differentiation markers, reendothelialization, and the number of circulating progenitor cells. Thus, insulin has a predominant vasculoprotective effect in vivo.  

TH gif  PECAM-1 Is Necessary for Flow-Induced Vascular Remodeling

Zhongming Chen and Ellie Tzima
Arterioscler Thromb Vasc Biol. 2009;29:1067-1073; published online before print April 23 2009, doi:10.1161/ATVBAHA.109.186692
Abstract | Full Text | PDF | Data Supplement  

TH gif  Fibronectin Is an Important Regulator of Flow-Induced Vascular Remodeling

Hou-Yu Chiang, Vyacheslav A. Korshunov, Andrew Serour, Feng Shi, and Jane Sottile
Arterioscler Thromb Vasc Biol. 2009;29:1074-1079; published online before print April 30 2009, doi:10.1161/ATVBAHA.108.181081
Abstract | Full Text | PDF | Data Supplement  

TH gif  Reduced Collagen Biosynthesis Is the Hallmark of Cerebral Aneurysm: Contribution of Interleukin-1β and Nuclear Factor-{kappa}B

Tomohiro Aoki, Hiroharu Kataoka, Ryota Ishibashi, Kazuhiko Nozaki, Ryuuichi Morishita, and Nobuo Hashimoto
Arterioscler Thromb Vasc Biol. 2009;29:1080-1086; published online before print April 9 2009, doi:10.1161/ATVBAHA.108.180760
Abstract | Full Text | PDF | Data Supplement
Expression of procollagen type I, III, and lysyl oxidase (LOX) was reduced in cerebral aneurysms (CAs) through induced expression of interleukin-1β and the activation of nuclear factor-{kappa}B. Inhibition of LOX led to enhanced CA progression. These data suggested that reduced collagen biosynthesis may contribute to CA progression.  

TH gif   Activated Protein C Protects Against Myocardial Ischemia/ Reperfusion Injury via Inhibition of Apoptosis and Inflammation

Sarah T.B.G. Loubele, C. Arnold Spek, Peter Leenders, René van Oerle, Hella L. Aberson, Karly Hamulyák, Gary Ferrell, Charles T. Esmon, Henri M.H. Spronk, and Hugo ten Cate
Arterioscler Thromb Vasc Biol. 2009;29:1087-1092; published online before print April 16 2009, doi:10.1161/ATVBAHA.109.188656
Abstract | Full Text | PDF | Data Supplement
Activated protein C (APC) is studied for its cytoprotective properties in several human and animal studies. APC largely inhibited early myocardial I/R injury after varying reperfusion times. Furthermore, a strong antiapoptotic and antiinflammatory effect of APC was observed and revealed a critical role for PAR-1 in this process.  

TH gif  Preconditioning by Mitochondrial Reactive Oxygen Species Improves the Proangiogenic Potential of Adipose-Derived Cells-Based Therapy

Audrey Carrière, Téni G. Ebrahimian, Stéphanie Dehez, Nathalie Augé, Carine Joffre, Mireille André, Samuel Arnal, Micheline Duriez, Corinne Barreau, Emmanuelle Arnaud, Yvette Fernandez, Valérie Planat-Benard, Bernard Lévy, Luc Pénicaud, Jean-Sébastien Silvestre, and Louis Casteilla
Arterioscler Thromb Vasc Biol. 2009;29:1093-1099; published online before print May 7 2009, doi:10.1161/ATVBAHA.109.188318
Abstract | Full Text | PDF | Data Supplement
Adipose-derived stroma cells possess a great potential to promote neovascularization in ischemic hindlimb. We demonstrated herein that in vitro preconditioning by moderate and transient mitochondrial ROS generation strongly enhanced adipose-derived cells proangiogenic properties in vivo, this being associated with an increase in angiogenic factors release and protection against oxidative stress-induced apoptosis.  

 

Cell Biology/SignalingBack

TH gif  Induction and Isolation of Vascular Cells From Human Induced Pluripotent Stem Cells—Brief Report

Daisuke Taura, Masakatsu Sone, Koichiro Homma, Naofumi Oyamada, Kazutoshi Takahashi, Naohisa Tamura, Shinya Yamanaka, and Kazuwa Nakao
Arterioscler Thromb Vasc Biol. 2009;29:1100-1103; published online before print May 7 2009, doi:10.1161/ATVBAHA.108.182162
Abstract | Full Text | PDF | Data Supplement
We induced vascular endothelial and mural cells from human iPS cells and demonstrated that the properties of human iPS cell differentiation are nearly identical to those of hES cells.  

AL gif  Notch Signaling Induces Osteogenic Differentiation and Mineralization of Vascular Smooth Muscle Cells: Role of Msx2 Gene Induction via Notch-RBP-Jk Signaling

Takehisa Shimizu, Toru Tanaka, Tatsuya Iso, Hiroshi Doi, Hiroko Sato, Keiko Kawai-Kowase, Masashi Arai, and Masahiko Kurabayashi
Arterioscler Thromb Vasc Biol. 2009;29:1104-1111; published online before print April 30 2009, doi:10.1161/ATVBAHA.109.187856
Abstract | Full Text | PDF | Data Supplement
Notch signaling induced osteogenic differentiation and matrix mineralization of HASMCs in vitro, in a manner dependent on the Msx2 gene, a master regulator of osteogenesis. Notch1, Jagged1, and Msx2 were expressed in human fibrocalcific/atherosclerotic plaques, suggesting that Notch-Msx2 signaling plays a important role in vascular calcification.  

TH gif  Sonic Hedgehog Induces Notch Target Gene Expression in Vascular Smooth Muscle Cells via VEGF-A

David Morrow, John P. Cullen, Weimin Liu, Shaunta Guha, Catherine Sweeney, Yvonne A. Birney, Nora Collins, Dermot Walls, Eileen M. Redmond, and Paul A. Cahill
Arterioscler Thromb Vasc Biol. 2009;29:1112-1118; published online before print April 30 2009, doi:10.1161/ATVBAHA.109.186890
Abstract | Full Text | PDF | Data Supplement
Notch, VEGF-A, and Hedgehogs (Hh) have been implicated in vascular morphogenesis and modeling of the embryonic vasculature. The current study demonstrated that Hh components specifically coordinate Notch signaling through VEGF-A activation in vascular SMCs in vitro and further that these component pathways are recapitulated within intimal cells after injury in vivo.  

TH gif  Rab GTPase Regulation of VEGFR2 Trafficking and Signaling in Endothelial Cells

Helen M. Jopling, Adam F. Odell, Nigel M. Hooper, Ian C. Zachary, John H. Walker, and Sreenivasan Ponnambalam
Arterioscler Thromb Vasc Biol. 2009;29:1119-1124; published online before print April 16 2009, doi:10.1161/ATVBAHA.109.186239
Abstract | Full Text | PDF | Data Supplement  

AL gif  Stimulation of Cell Surface F1-ATPase Activity by Apolipoprotein A-I Inhibits Endothelial Cell Apoptosis and Promotes Proliferation

Claudia Radojkovic, Annelise Genoux, Véronique Pons, Guillaume Combes, Hugo de Jonge, Eric Champagne, Corinne Rolland, Bertrand Perret, Xavier Collet, François Tercé, and Laurent O. Martinez
Arterioscler Thromb Vasc Biol. 2009;29:1125-1130; published online before print April 16 2009, doi:10.1161/ATVBAHA.109.187997
Abstract | Full Text | PDF | Data Supplement
This work proposes a new role for the cell surface F1-ATPase/apoA-I tandem in endothelial cell protection. F1-ATPase activation by apoA-I or inhibition by its inhibitor IF1-H49K drives endothelial cells toward proliferation or apoptosis, respectively. Therefore, F1-ATPase pathway contributes to endothelial cell survival responses to apoA-I, possibly through extracellular production of ADP.  

TH gif  COX-2 Limits Prostanoid Production in Activated HUVECs and Is a Source of PGH2 for Transcellular Metabolism to PGE2 by Tumor Cells

M. Dolores Salvado, Arántzazu Alfranca, Amelia Escolano, Jesper Z. Haeggström, and Juan Miguel Redondo
Arterioscler Thromb Vasc Biol. 2009;29:1131-1137; published online before print May 7 2009, doi:10.1161/ATVBAHA.109.188540
Abstract | Full Text | PDF | Data Supplement
Upregulated prostanoid production by activated endothelial cells is limited by COX-2, which is functionally coupled to endothelial PGIS and TXAS. Endothelial COX-2 regulates the release of untransformed PGH2, which can either undergo nonenzymatic rearrangement or be enzymatically converted into PGE2 through a transcellular mechanism by tumor-cell mPGES-1.  

TH gif   Augmentation of Megakaryocyte Expression of Fc{gamma}RIIa by Interferon {gamma}

David J. Schneider and Heidi S. Taatjes-Sommer
Arterioscler Thromb Vasc Biol. 2009;29:1138-1143; published online before print April 16 2009, doi:10.1161/ATVBAHA.109.187567
Abstract | Full Text | PDF
To identify factors that alter expression of Fc{gamma}RIIa by megakaryocytes, we exposed human erythroleukemia (HEL) cells and CD34 stem cells to selected cytokines and growth factors. Interferon {gamma} increased protein and mRNA expression of Fc{gamma}RIIa by HEL cells and protein expression in CD34 stem cells exhibiting megakaryocyte characteristics.  

 

Clinical and Population StudiesBack

TH gif  Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons: The Health, Aging, and Body Composition (Health ABC) Study

Javed Butler, Andreas Kalogeropoulos, Vasiliki Georgiopoulou, Nathalie de Rekeneire, Nicolas Rodondi, Andrew L. Smith, Udo Hoffmann, Alka Kanaya, Anne B. Newman, Stephen B. Kritchevsky, Ramachandran S. Vasan, Peter W.F. Wilson, Tamara B. Harris for the Health ABC Study
Arterioscler Thromb Vasc Biol. 2009;29:1144-1149; published online before print April 16 2009, doi:10.1161/ATVBAHA.109.186783
Abstract | Full Text | PDF | Data Supplement
In 2902 older persons, baseline serum resistin concentrations (20.3{+/-}10.0 ng/mL) were strongly associated with risk for new onset heart failure. This association persisted after controlling for baseline characteristics, clinical predictors of incident heart failure, markers of inflammation and insulin resistance, and adiposity measures (HR, 1.15 per 10.0 ng/mL in adjusted model; 95%CI, 1.05 to 1.27; P=0.003).  

 

2009 ATVB AbstractsBack

Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2009


Arterioscler Thromb Vasc Biol. 2009;29:e9-e130, doi:10.1161/ATV.0B013E3181AB66E7
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