Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (29 [6])

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Volume 29, Issue 6; June 1, 2009

In Memoriam
Editorials
History of Discovery
Integrative Physiology/Experimental Medicine
Cell Biology/Signaling
Clinical and Population Studies

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

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	In Memoriam
	Akira Takeshita, MD, PhD: 1940–2009 Hiroaki Shimokawa and Donald Heistad Arterioscler Thromb Vasc Biol. 2009;29:787-788, doi:10.1161/ATVBAHA.109.190041 Extract \| Full Text \| PDF
	Editorials
	Some Things Just Have to Be Done In Vivo: GPIHBP1, Caloric Delivery, and the Generation of Remnant Lipoproteins Kevin Jon Williams Arterioscler Thromb Vasc Biol. 2009;29:792-795, doi:10.1161/ATVBAHA.109.187823 Abstract \| Full Text \| PDF
	History of Discovery
	Vascular Endothelial Growth Factor Napoleone Ferrara Arterioscler Thromb Vasc Biol. 2009;29:789-791; published online before print January 22 2009, doi:10.1161/ATVBAHA.108.179663 Abstract \| Full Text \| PDF
	Integrative Physiology/Experimental Medicine
	Therapeutic Neovascularization by Nanotechnology-Mediated Cell-Selective Delivery of Pitavastatin Into the Vascular Endothelium Mitsuki Kubo, Kensuke Egashira, Takahiro Inoue, Jun-ichiro Koga, Shinichiro Oda, Ling Chen, Kaku Nakano, Tetsuya Matoba, Yoshiaki Kawashima, Kaori Hara, Hiroyuki Tsujimoto, Katsuo Sueishi, Ryuji Tominaga, and Kenji Sunagawa Arterioscler Thromb Vasc Biol. 2009;29:796-801; published online before print March 26 2009, doi:10.1161/ATVBAHA.108.182584 Abstract \| Full Text \| PDF \| Data Supplement We tested the hypothesis that selective nanoparticle (NP)-mediated delivery of pitavastatin to endothelial cells can be an integrative approach to enhance therapeutic neovascularization. We used a murine model of hindlimb ischemia and showed that polymeric NP-mediated delivery of pitavastatin is useful for increasing therapeutic neovascularization.
	Amplification of Coronary Arteriogenic Capacity of Multipotent Stromal Cells by Epidermal Growth Factor Souad Belmadani, Khalid Matrougui, Chris Kolz, Yuh Fen Pung, Desiree Palen, Darwin J. Prockop, and William M. Chilian Arterioscler Thromb Vasc Biol. 2009;29:802-808; published online before print April 2 2009, doi:10.1161/ATVBAHA.109.186189 Abstract \| Full Text \| PDF \| Data Supplement
	CREB-Mediated IL-6 Expression Is Required for 15(S)-Hydroxyeicosatetraenoic Acid–Induced Vascular Smooth Muscle Cell Migration Koteswara R. Chava, Manjula Karpurapu, Dong Wang, Manjula Bhanoori, Venkatesh Kundumani-Sridharan, Qiuhua Zhang, Toshihiro Ichiki, Wayne C. Glasgow, and Gadiparthi N. Rao Arterioscler Thromb Vasc Biol. 2009;29:809-815; published online before print April 2 2009, doi:10.1161/ATVBAHA.109.185777 Abstract \| Full Text \| PDF \| Data Supplement
	Late Outgrowth Endothelial Cells Derived From Wharton Jelly in Human Umbilical Cord Reduce Neointimal Formation After Vascular Injury: Involvement of Pigment Epithelium-Derived Factor Shu-Huei Wang, Shing-Jong Lin, Yung-Hsiang Chen, Fen-Yen Lin, Jin-Chung Shih, Chau-Chung Wu, Hua-Lin Wu, and Yuh-Lien Chen Arterioscler Thromb Vasc Biol. 2009;29:816-822; published online before print April 2 2009, doi:10.1161/ATVBAHA.109.184739 Abstract \| Full Text \| PDF \| Data Supplement We described a streamlined method for the isolation and expansion of WJC-OECs. Transplantation of these cells establishes endothelial integrity in injured vessels, thereby inhibiting neointimal hyperplasia. In addition, it shows that these effects are closely associated with PEDF.
	Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse Phyllis Chew, Derek Y.C. Yuen, Philip Koh, Nada Stefanovic, Mark A. Febbraio, Ismail Kola, Mark E. Cooper, and Judy B. de Haan Arterioscler Thromb Vasc Biol. 2009;29:823-830; published online before print March 26 2009, doi:10.1161/ATVBAHA.109.186619 Abstract \| Full Text \| PDF \| Data Supplement Ebselen-gavage of diabetic apoE-/- mice led to site-specific lesional reductions within most regions of the aorta but not within the aortic sinus. Where reductions occurred, ebselen also lowered oxidative stress and proatherogenic RAGE and VEGF. Based on our results, ebselen may be effective as an antiatherogenic therapy in diabetic macrovascular disease.
	Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice: Role of Lipoxidation via Receptor-Mediated Mechanisms Carla Iacobini, Stefano Menini, Carlo Ricci, Angela Scipioni, Viola Sansoni, Samantha Cordone, Maurizio Taurino, Matteo Serino, Giuseppe Marano, Massimo Federici, Flavia Pricci, and Giuseppe Pugliese Arterioscler Thromb Vasc Biol. 2009;29:831-836; published online before print April 9 2009, doi:10.1161/ATVBAHA.109.186791 Abstract \| Full Text \| PDF \| Data Supplement To assess the role of galectin-3 as a receptor for modified lipoproteins, mice lacking galectin-3 were fed an atherogenic diet. These animals showed accelerated atherosclerosis, with increased extent and particularly complexity of lesions and a distinct inflammatory phenotype, thus suggesting a protective scavenging and antiinflammatory role for galectin-3 in atherogenesis.
	Overexpression of Human 15(S)-Lipoxygenase-1 in RAW Macrophages Leads to Increased Cholesterol Mobilization and Reverse Cholesterol Transport Ginny L. Weibel, Michelle R. Joshi, Eric T. Alexander, Peijuan Zhu, Ian A. Blair, and George H. Rothblat Arterioscler Thromb Vasc Biol. 2009;29:837-842; published online before print March 26 2009, doi:10.1161/ATVBAHA.109.186163 Abstract \| Full Text \| PDF \| Data Supplement
	Apolipoprotein A-I and Its Role in Lymphocyte Cholesterol Homeostasis and Autoimmunity Ashley J. Wilhelm, Manal Zabalawi, Jason M. Grayson, Ashley E. Weant, Amy S. Major, John Owen, Manish Bharadwaj, Rosemary Walzem, Lawrence Chan, Kazuhiro Oka, Michael J. Thomas, and Mary G. Sorci-Thomas Arterioscler Thromb Vasc Biol. 2009;29:843-849; published online before print March 12 2009, doi:10.1161/ATVBAHA.108.183442 Abstract \| Full Text \| PDF \| Data Supplement Diet-fed DKO mice exhibit accumulation of cholesterol in skin draining LNs. This accumulation was associated with an expansion and activation of T and B lymphocytes and increased concentrations of circulating autoantibodies. Diet-fed DKO mice also showed increased aortic atherosclerosis compared to SKO mice despite having lower levels of plasma cholesterol. These results suggest that apoA-I is important in regulating specific inflammatory pathways as they relate to the development of atherosclerosis.
	Sphingomyelin Synthase 2 Is One of the Determinants for Plasma and Liver Sphingomyelin Levels in Mice Jing Liu, Hongqi Zhang, Zhiqiang Li, Tiruneh K. Hailemariam, Mahua Chakraborty, Kailiu Jiang, Daniel Qiu, Hai H. Bui, David A. Peake, Ming-Shang Kuo, Raj Wadgaonkar, Guoqing Cao, and Xian-Cheng Jiang Arterioscler Thromb Vasc Biol. 2009;29:850-856; published online before print March 12 2009, doi:10.1161/ATVBAHA.109.185223 Abstract \| Full Text \| PDF \| Data Supplement
	Human Placental Ectonucleoside Triphosphate Diphosphohydrolase Gene Transfer via Gelatin-Coated Stents Prevents In-Stent Thrombosis Yasuhiro Takemoto, Hiroyuki Kawata, Tsunenari Soeda, Keiichi Imagawa, Satoshi Somekawa, Yukiji Takeda, Shiro Uemura, Masanori Matsumoto, Yoshihiro Fujimura, Jun-ichiro Jo, Yu Kimura, Yasuhiko Tabata, and Yoshihiko Saito Arterioscler Thromb Vasc Biol. 2009;29:857-862; published online before print March 26 2009, doi:10.1161/ATVBAHA.109.186429 Abstract \| Full Text \| PDF \| Data Supplement In the present study, we generated a new type of gene-eluting stent for the purpose of preventing in-stent thrombosis. Our results suggested that human placental E-NTPDase gene transfer via cationic gelatin-coated stents inhibited platelet aggregation by providing the enhanced E-NTPDase expression and preserved local NTPDase activity, thereby preventing in-stent thrombosis.
	Inferior Vena Cava Ligation Rapidly Induces Tissue Factor Expression and Venous Thrombosis in Rats Ji Zhou, Linda May, Peng Liao, Peter L. Gross, and Jeffrey I. Weitz Arterioscler Thromb Vasc Biol. 2009;29:863-869; published online before print March 5 2009, doi:10.1161/ATVBAHA.109.185678 Abstract \| Full Text \| PDF Vena cava ligation in rats results in rapid formation of venous thrombi. Most thrombi develop at sites of endothelial denudation. Tissue factor expression by endothelial cells and leukocytes may also trigger thrombosis. Tissue factor colocalizes with protein disulfide isomerase, suggesting that tissue factor decryption may play a role in venous thrombosis.
	Cell Biology/Signaling
	Proteomic Analysis of Defined HDL Subpopulations Reveals Particle-Specific Protein Clusters: Relevance to Antioxidative Function W. Sean Davidson, R.A. Gangani D. Silva, Sandrine Chantepie, William R. Lagor, M. John Chapman, and Anatol Kontush Arterioscler Thromb Vasc Biol. 2009;29:870-876; published online before print March 26 2009, doi:10.1161/ATVBAHA.109.186031 Abstract \| Full Text \| PDF \| Data Supplement Proteomic analyses have revealed that physicochemically-defined particle subpopulations of normolipidemic human HDL are distinguished by distinct protein abundance patterns. Enrichment of apolipoprotein L-I and paraoxonases 1 and 3 in dense HDL3 correlated with the capacity to attenuate LDL oxidation, suggesting that distinct particle-specific protein clusters may profoundly impact HDL function.
	Role of 3β-Hydroxysteroid- ${Delta}$ 24 Reductase in Mediating Antiinflammatory Effects of High-Density Lipoproteins in Endothelial Cells K.C.Y. McGrath, X.H. Li, R. Puranik, E.C. Liong, J.T.M. Tan, V.M. Dy, B.A. DiBartolo, P.J. Barter, K.A. Rye, and A.K. Heather Arterioscler Thromb Vasc Biol. 2009;29:877-882; published online before print March 26 2009, doi:10.1161/ATVBAHA.109.184663 Abstract \| Full Text \| PDF \| Data Supplement This study investigates the ability of high-density lipoproteins (HDLs) to upregulate genes with the potential to protect against inflammation in endothelial cells. The results suggest that the effects of rHDLs are mediated through an upregulation of 3β-hydroxysteroid-{Delta}24 reductase (DHCR24) that functioned as a negative regulator of nuclear factor-kappa B.
	Rab8 Regulates ABCA1 Cell Surface Expression and Facilitates Cholesterol Efflux in Primary Human Macrophages Matts D. Linder, Mikko I. Mäyränpää, Johan Peränen, Taija E. Pietilä, Vilja M. Pietiäinen, Riikka-Liisa Uronen, Vesa M. Olkkonen, Petri T. Kovanen, and Elina Ikonen Arterioscler Thromb Vasc Biol. 2009;29:883-888; published online before print March 19 2009, doi:10.1161/ATVBAHA.108.179481 Abstract \| Full Text \| PDF \| Data Supplement
	Protective Role of SIRT1 in Diabetic Vascular Dysfunction Masayuki Orimo, Tohru Minamino, Hideyuki Miyauchi, Kaoru Tateno, Sho Okada, Junji Moriya, and Issei Komuro Arterioscler Thromb Vasc Biol. 2009;29:889-894; published online before print March 12 2009, doi:10.1161/ATVBAHA.109.185694 Abstract \| Full Text \| PDF \| Data Supplement The pathological role of SIRT1 is not yet fully understood. Hyperglycemia decreases SIRT1 expression and thus accelerates endothelial senescence. Activation of SIRT1 prevents the hyperglycemia-induced endothelial senescence and thereby protects against vascular dysfunction in mice with diabetes. These results suggest a protective role of SIRT1 in the pathogenesis of diabetic vasculopathy.
	Glucose 6-Phosphate Dehydrogenase Is Regulated Through c-Src–Mediated Tyrosine Phosphorylation in Endothelial Cells Shi Pan, Cameron J. World, Christopher J. Kovacs, and Bradford C. Berk Arterioscler Thromb Vasc Biol. 2009;29:895-901; published online before print April 9 2009, doi:10.1161/ATVBAHA.109.184812 Abstract \| Full Text \| PDF The molecular mechanisms for regulating glucose 6-phosphate dehydrogenase (G6PD) in endothelial cells (ECs) were studied. G6PD was regulated by Src-mediated tyrosine phosphorylation, which modulated VEGF responses including Akt activation and EC migration.
	Sphingosine-1-Phosphate: A Novel Nonhypoxic Activator of Hypoxia-Inducible Factor-1 in Vascular Cells Maude D. Michaud, Geneviève A. Robitaille, Jean-Philippe Gratton, and Darren E. Richard Arterioscler Thromb Vasc Biol. 2009;29:902-908; published online before print May 7 2009, doi:10.1161/ATVBAHA.109.185280 Abstract \| Full Text \| PDF \| Data Supplement \| Data Supplement This study demonstrates that sphingosine-1-phosphate (S1P) is a potent activator of hypoxia-inducible factor-1 (HIF-1) in vascular cells. Increases in cellular levels of HIF-1 is involved in S1P-mediated gene induction under normal oxygen conditions. We conclude that S1P is a novel nonhypoxic activator of HIF-1.
	FHL-2 Suppresses VEGF-Induced Phosphatidylinositol 3-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1 Hiroki Hayashi, Hironori Nakagami, Yoichi Takami, Hiroshi Koriyama, Masaki Mori, Katsuto Tamai, Jianxin Sun, Kaori Nagao, Ryuichi Morishita, and Yasufumi Kaneda Arterioscler Thromb Vasc Biol. 2009;29:909-914; published online before print March 26 2009, doi:10.1161/ATVBAHA.108.178541 Abstract \| Full Text \| PDF \| Data Supplement In the functional screening of a novel antiangiognic factor, the prime candidate gene was "four-and-a-half LIM only protein-2" (FHL-2). Overexpression of FHL-2 in ECs inhibited VEGF-induced SK1 activation, phosphatidylinositol 3-kinase/Akt activation, cell migration, and vascular network in Xenopus embryos. FHL-2 may directly suppress the SK1-S1P pathway in ECs.
	Role of the Low-Affinity Leukotriene B₄ Receptor BLT2 in VEGF-Induced Angiogenesis Geun-Young Kim, Jin-Wook Lee, Sung-Hoon Cho, Ji-Min Seo, and Jae-Hong Kim Arterioscler Thromb Vasc Biol. 2009;29:915-920; published online before print March 12 2009, doi:10.1161/ATVBAHA.109.185793 Abstract \| Full Text \| PDF \| Data Supplement We showed that BLT2 expression in endothelium is highly induced by VEGF, and this induced BLT2 plays a critical role in mediating VEGF-induced angiogenesis. In addition, VEGF-induced angiogenesis in vivo is strictly dependent on BLT2. These data suggest the upregulation of BLT2 may be an important mechanism for VEGF-induced angiogenesis.
	The SWI/SNF Chromatin Remodeling Complex Regulates Myocardin-Induced Smooth Muscle–Specific Gene Expression Jiliang Zhou, Min Zhang, Hong Fang, Omar El-Mounayri, Jennifer M. Rodenberg, Anthony N. Imbalzano, and B. Paul Herring Arterioscler Thromb Vasc Biol. 2009;29:921-928; published online before print April 2 2009, doi:10.1161/ATVBAHA.109.187229 Abstract \| Full Text \| PDF \| Data Supplement We demonstrate that Brg1 and Brm bind directly to myocardin. Brg1 and Brm are required for expression of SRF-dependent smooth muscle-specific genes. Either Brg1 or Brm is required for the myogenic activity of myocardin.
	Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage Judith Haendeler, Stefan Dröse, Nicole Büchner, Sascha Jakob, Joachim Altschmied, Christine Goy, Ioakim Spyridopoulos, Andreas M. Zeiher, Ulrich Brandt, and Stefanie Dimmeler Arterioscler Thromb Vasc Biol. 2009;29:929-935; published online before print March 5 2009, doi:10.1161/ATVBAHA.109.185546 Abstract \| Full Text \| PDF \| Data Supplement TERT is localized in the mitochondrial matrix and binds to mitochondrial DNA. TERT increases respiratory chain activity and protects mitochondria from damage. Lung fibroblasts from TERT-/- mice show increased sensitivity toward UVB radiation, and mitochondria isolated from hearts of TERT-/- mice demonstrates reduced respiratory chain activity. Mitochondrially targeted TERT is most effective in protecting from apoptosis induction. Thus, mitochondrial TERT exerts a novel protective function by protecting mitochondria from damage in vitro and in vivo.
	Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix Cindy Ying Yin Yip, Jan-Hung Chen, Ruogang Zhao, and Craig A. Simmons Arterioscler Thromb Vasc Biol. 2009;29:936-942; published online before print March 19 2009, doi:10.1161/ATVBAHA.108.182394 Abstract \| Full Text \| PDF \| Data Supplement Calcification by valve interstitial cells and their differentiation to pathological phenotypes are regulated by the stiffness of the extracellular matrix in vitro. More compliant substrates promote osteogenic differentiation and bone formation, whereas stiffer substrates promote myofibroblast differentiation and calcification associated with apoptotic cells.
	Clinical and Population Studies
	HDL-Cholesterol, Blood Pressure, and Asymmetric Dimethylarginine Are Significantly Associated With Arterial Wall Thickness in Children Julian G. Ayer, Jason A. Harmer, Shirley Nakhla, Wei Xuan, Martin K.C. Ng, Olli T. Raitakari, Guy B. Marks, and David S. Celermajer Arterioscler Thromb Vasc Biol. 2009;29:943-949; published online before print April 9 2009, doi:10.1161/ATVBAHA.109.184184 Abstract \| Full Text \| PDF \| HTML Page - index.htslp The extent to which traditional and novel risk factors for atherosclerosis influence carotid intima media thickness (CIMT) in prepubertal children was evaluated in 405 community-based 8-year-old boys and girls. Systolic blood pressure, HDL-cholesterol, and asymmetrical dimethylarginine were independently associated with CIMT. CIMT was also significantly greater in children with a positive parental history of premature coronary heart disease.
	Relationships of HDL Cholesterol, ApoA-I, and ApoA-II With Homocysteine and Creatinine in Patients With Type 2 Diabetes Treated With Fenofibrate Marja-Riitta Taskinen, David R. Sullivan, Christian Ehnholm, Malcolm Whiting, Diana Zannino, R. John Simes, Anthony C. Keech, Philip J. Barter for the FIELD study investigators Arterioscler Thromb Vasc Biol. 2009;29:950-955; published online before print March 26 2009, doi:10.1161/ATVBAHA.108.178228 Abstract \| Full Text \| PDF \| Data Supplement
	Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase Anne P. Beigneux, Remco Franssen, André Bensadoun, Peter Gin, Kristan Melford, Jorge Peter, Rosemary L. Walzem, Michael M. Weinstein, Brandon S.J. Davies, Jan A. Kuivenhoven, John J.P. Kastelein, Loren G. Fong, Geesje M. Dallinga-Thie, and Stephen G. Young Arterioscler Thromb Vasc Biol. 2009;29:956-962; published online before print March 19 2009, doi:10.1161/ATVBAHA.109.186577 Abstract \| Full Text \| PDF \| Data Supplement A homozygous missense mutation in GPIHBP1 (Q115P) was identified in a 33-year-old male with lifelong chylomicronemia. The mutant GPIHBP1 lacked the ability to bind lipoprotein lipase or chylomicrons, suggesting that the Q115P mutation is functionally important and underlies the patient's chylomicronemia.
	Rosuvastatin Increases Extracellular Adenosine Formation in Humans In Vivo: A New Perspective on Cardiovascular Protection Patrick Meijer, Wim J.G. Oyen, Douwe Dekker, Petra H.H. van den Broek, Constatijn W. Wouters, Otto C. Boerman, Gert Jan Scheffer, Paul Smits, and Gerard A. Rongen Arterioscler Thromb Vasc Biol. 2009;29:963-968; published online before print April 9 2009, doi:10.1161/ATVBAHA.108.179622 Abstract \| Full Text \| PDF \| Data Supplement In healthy volunteers, oral treatment with rosuvastatin significantly augmented dipyridamole-induced vasodilation and prevented annexin A5 targeting to the ischemically exercised forearm. Both actions were inhibited by the adenosine receptor antagonist caffeine. These results provide for the first time pharmacological evidence that rosuvastatin augments extracellular formation of adenosine in humans in vivo.
	Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids Sander Kersten, Laeticia Lichtenstein, Emma Steenbergen, Karin Mudde, Henk F.J. Hendriks, Matthijs K. Hesselink, Patrick Schrauwen, and Michael Müller Arterioscler Thromb Vasc Biol. 2009;29:969-974; published online before print April 2 2009, doi:10.1161/ATVBAHA.108.182147 Abstract \| Full Text \| PDF \| Data Supplement ANGPTL4 raises plasma triglycerides by inhibiting their clearance. Very little is known about ANGPTL4 in human. We developed an ELISA to quantitatively measure plasma ANGPTL4 in numerous human interventions. We show that plasma ANGPTL4 levels are increased by fasting, caloric restriction, and exercise, probably via elevated plasma FFAs.
	Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor- ${kappa}$ B Ligand and Risk for Coronary Events: A Nested Case–Control Approach in the Prospective EPIC-Norfolk Population Study 1993–2003 Anne G. Semb, Thor Ueland, Pål Aukrust, Nicholas J. Wareham, Robert Luben, Lars Gullestad, John J.P. Kastelein, Kay-Tee Khaw, and S. Matthijs Boekholdt Arterioscler Thromb Vasc Biol. 2009;29:975-980; published online before print March 26 2009, doi:10.1161/ATVBAHA.109.184101 Abstract \| Full Text \| PDF \| Data Supplement In the EPIC-Norfolk study, of 951 healthy individuals, matched with 1705 healthy controls (followed 6.7 years), those within the highest osteoprotegerin quartile had significant higher risk for future coronary events, independent of established cardiovascular risk factors. In contrast, receptor activator of nuclear factor-{kappa}B ligand was not associated with coronary events.

Spotlight

TOC Spotlight File

Volume 29, Issue 6; June 1, 2009

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

In Memoriam

Akira Takeshita, MD, PhD: 1940–2009

Editorials

Some Things Just Have to Be Done In Vivo: GPIHBP1, Caloric Delivery, and the Generation of Remnant Lipoproteins

History of Discovery

Vascular Endothelial Growth Factor

Integrative Physiology/Experimental Medicine

Therapeutic Neovascularization by Nanotechnology-Mediated Cell-Selective Delivery of Pitavastatin Into the Vascular Endothelium

Amplification of Coronary Arteriogenic Capacity of Multipotent Stromal Cells by Epidermal Growth Factor

CREB-Mediated IL-6 Expression Is Required for 15(S)-Hydroxyeicosatetraenoic Acid–Induced Vascular Smooth Muscle Cell Migration

Late Outgrowth Endothelial Cells Derived From Wharton Jelly in Human Umbilical Cord Reduce Neointimal Formation After Vascular Injury: Involvement of Pigment Epithelium-Derived Factor

Site-Specific Antiatherogenic Effect of the Antioxidant Ebselen in the Diabetic Apolipoprotein E–Deficient Mouse

Accelerated Lipid-Induced Atherogenesis in Galectin-3-Deficient Mice: Role of Lipoxidation via Receptor-Mediated Mechanisms

Overexpression of Human 15(S)-Lipoxygenase-1 in RAW Macrophages Leads to Increased Cholesterol Mobilization and Reverse Cholesterol Transport

Apolipoprotein A-I and Its Role in Lymphocyte Cholesterol Homeostasis and Autoimmunity

Sphingomyelin Synthase 2 Is One of the Determinants for Plasma and Liver Sphingomyelin Levels in Mice

Human Placental Ectonucleoside Triphosphate Diphosphohydrolase Gene Transfer via Gelatin-Coated Stents Prevents In-Stent Thrombosis

Inferior Vena Cava Ligation Rapidly Induces Tissue Factor Expression and Venous Thrombosis in Rats

Cell Biology/Signaling

Proteomic Analysis of Defined HDL Subpopulations Reveals Particle-Specific Protein Clusters: Relevance to Antioxidative Function

Role of 3β-Hydroxysteroid-24 Reductase in Mediating Antiinflammatory Effects of High-Density Lipoproteins in Endothelial Cells

Rab8 Regulates ABCA1 Cell Surface Expression and Facilitates Cholesterol Efflux in Primary Human Macrophages

Protective Role of SIRT1 in Diabetic Vascular Dysfunction

Glucose 6-Phosphate Dehydrogenase Is Regulated Through c-Src–Mediated Tyrosine Phosphorylation in Endothelial Cells

Sphingosine-1-Phosphate: A Novel Nonhypoxic Activator of Hypoxia-Inducible Factor-1 in Vascular Cells

FHL-2 Suppresses VEGF-Induced Phosphatidylinositol 3-Kinase/Akt Activation via Interaction With Sphingosine Kinase-1

Role of the Low-Affinity Leukotriene B4 Receptor BLT2 in VEGF-Induced Angiogenesis

The SWI/SNF Chromatin Remodeling Complex Regulates Myocardin-Induced Smooth Muscle–Specific Gene Expression

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

Calcification by Valve Interstitial Cells Is Regulated by the Stiffness of the Extracellular Matrix

Clinical and Population Studies

HDL-Cholesterol, Blood Pressure, and Asymmetric Dimethylarginine Are Significantly Associated With Arterial Wall Thickness in Children

Relationships of HDL Cholesterol, ApoA-I, and ApoA-II With Homocysteine and Creatinine in Patients With Type 2 Diabetes Treated With Fenofibrate

Chylomicronemia With a Mutant GPIHBP1 (Q115P) That Cannot Bind Lipoprotein Lipase

Rosuvastatin Increases Extracellular Adenosine Formation in Humans In Vivo: A New Perspective on Cardiovascular Protection

Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids

Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor-B Ligand and Risk for Coronary Events: A Nested Case–Control Approach in the Prospective EPIC-Norfolk Population Study 1993–2003

Spotlight

Role of 3β-Hydroxysteroid- ${Delta}$ 24 Reductase in Mediating Antiinflammatory Effects of High-Density Lipoproteins in Endothelial Cells

Role of the Low-Affinity Leukotriene B₄ Receptor BLT2 in VEGF-Induced Angiogenesis

Osteoprotegerin and Soluble Receptor Activator of Nuclear Factor- ${kappa}$ B Ligand and Risk for Coronary Events: A Nested Case–Control Approach in the Prospective EPIC-Norfolk Population Study 1993–2003