Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (29 [3])

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Volume 29, Issue 3; March 1, 2009

Go Red for Women
Venous Thromboembolism: Mechanisms, Treatment, and Public Awareness
Editorials
Integrative Physiology/Experimental Medicine
Cell Biology/Signaling
Clinical and Population Studies

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

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	Go Red for Women
	Cardiovascular Disease in Women Nigel Mackman and Susan Smyth Arterioscler Thromb Vasc Biol. 2009;29:277-278; published online before print February 16 2009, doi:10.1161/ATVBAHA.108.183673 Extract \| Full Text \| PDF
	Status of Women in Cardiovascular Clinical Trials Esther S.H. Kim and Venu Menon Arterioscler Thromb Vasc Biol. 2009;29:279-283; published online before print February 16 2009, doi:10.1161/ATVBAHA.108.179796 Extract \| Full Text \| PDF
	Thrombosis and Antithrombotic Therapy in Women Alison L. Bailey, Dawn C. Scantlebury, and Susan S. Smyth Arterioscler Thromb Vasc Biol. 2009;29:284-288; published online before print February 16 2009, doi:10.1161/ATVBAHA.108.179788 Abstract \| Full Text \| PDF
	Estrogen and Mechanisms of Vascular Protection Dongqi Xing, Susan Nozell, Yiu-Fai Chen, Fadi Hage, and Suzanne Oparil Arterioscler Thromb Vasc Biol. 2009;29:289-295; published online before print February 16 2009, doi:10.1161/ATVBAHA.108.182279 Abstract \| Full Text \| PDF
	Venous Thromboembolism: Mechanisms, Treatment, and Public Awareness
	Venous Thromboembolism: Risk Factors, Biomarkers, and Treatment Alisa S. Wolberg and Nigel Mackman Arterioscler Thromb Vasc Biol. 2009;29:296-297, doi:10.1161/ATVBAHA.109.184580 Extract \| Full Text \| PDF
	Venous Thromboembolism: Risk Factors for Recurrence Tienan Zhu, Isabelle Martinez, and Joseph Emmerich Arterioscler Thromb Vasc Biol. 2009;29:298-310, doi:10.1161/ATVBAHA.108.182428 Abstract \| Full Text \| PDF
	Metabolic Syndrome Is Associated With Venous Thromboembolism in the Korean Population Moon Ju Jang, Won-il Choi, Soo-Mee Bang, Taeseung Lee, Yeo-Kyeoung Kim, Walter Ageno, and Doyeun Oh Arterioscler Thromb Vasc Biol. 2009;29:311-315, doi:10.1161/ATVBAHA.109.184085 Abstract \| Full Text \| PDF
	New Insights Into Cancer-Associated Thrombosis Tarek Sousou and Alok A. Khorana Arterioscler Thromb Vasc Biol. 2009;29:316-320, doi:10.1161/ATVBAHA.108.182196 Abstract \| Full Text \| PDF
	Venous Thrombosis in the Antiphospholipid Syndrome Mary Katherine Farmer-Boatwright and Robert A.S. Roubey Arterioscler Thromb Vasc Biol. 2009;29:321-325, doi:10.1161/ATVBAHA.108.182204 Abstract \| Full Text \| PDF
	Venous Thromboembolism in Pregnancy Andra H. James Arterioscler Thromb Vasc Biol. 2009;29:326-331, doi:10.1161/ATVBAHA.109.184127 Abstract \| Full Text \| PDF
	Biomarkers and Venous Thromboembolism Ingrid Pabinger and Cihan Ay Arterioscler Thromb Vasc Biol. 2009;29:332-336, doi:10.1161/ATVBAHA.108.182188 Abstract \| Full Text \| PDF
	Editorials
	Oxidized Phospholipid Inhibition of LPS-Signaling: A Good Side to the Bad Guys? Clett Erridge Arterioscler Thromb Vasc Biol. 2009;29:337-338, doi:10.1161/ATVBAHA.108.181909 Extract \| Full Text \| PDF
	ADAGIO-Lipids Gives Promises but Faces the Setbacks Marja-Riitta Taskinen Arterioscler Thromb Vasc Biol. 2009;29:339-340, doi:10.1161/ATVBAHA.108.183178 Extract \| Full Text \| PDF
	Integrative Physiology/Experimental Medicine
	Despite Antiatherogenic Metabolic Characteristics, SCD1-Deficient Mice Have Increased Inflammation and Atherosclerosis Marcia L.E. MacDonald, Miranda van Eck, Reeni B. Hildebrand, Brian W.C. Wong, Nagat Bissada, Piers Ruddle, Anatol Kontush, Hala Hussein, Mahmoud A. Pouladi, M. John Chapman, Catherine Fievet, Theo J.C. van Berkel, Bart Staels, Bruce M. McManus, and Michael R. Hayden Arterioscler Thromb Vasc Biol. 2009;29:341-347; published online before print December 18 2008, doi:10.1161/ATVBAHA.108.181099 Abstract \| Full Text \| PDF \| Data Supplement Absence of stearoyl-CoA desaturase-1 (SCD1) unexpectedly increases atherosclerosis lesion area at the aortic root in low-density lipoprotein receptor-deficient mice. This is associated with numerous signs of inflammation, including increases in plasma interleukin-6 and soluble intercellular adhesion molecule-1 and proinflammatory changes in HDL particles.
	Genetic Regulation of Atherosclerotic Plaque Size and Morphology in the Innominate Artery of Hyperlipidemic Mice Brian J. Bennett, Susanna S. Wang, Xuping Wang, Xiaohui Wu, and Aldons J. Lusis Arterioscler Thromb Vasc Biol. 2009;29:348-355; published online before print January 2 2009, doi:10.1161/ATVBAHA.108.176685 Abstract \| Full Text \| PDF \| Data Supplement We sought to determine the genetic factors contributing to atherosclerotic plaque size and cellular composition in the innominate artery. We identified one novel locus on Chromosome 2 for innominate artery lesion size. Multiple aspects of innominate lesion composition are genetically determined, but in a manner independent of the aortic sinus.
	Cell Biology/Signaling
	Multi-Hit Inhibition of Circulating and Cell-Associated Components of the Toll-Like Receptor 4 Pathway by Oxidized Phospholipids Elena von Schlieffen, Olga V. Oskolkova, Gernot Schabbauer, Florian Gruber, Stephan Blüml, Melinda Genest, Alexandra Kadl, Claudia Marsik, Sylvia Knapp, Jesse Chow, Norbert Leitinger, Bernd R. Binder, and Valery N. Bochkov Arterioscler Thromb Vasc Biol. 2009;29:356-362; published online before print December 26 2008, doi:10.1161/ATVBAHA.108.173799 Abstract \| Full Text \| PDF \| Data Supplement In this work, open questions concerning the regulation of TLR4 by oxidized phospholipids (OxPLs) were addressed. The data demonstrate that OxPLs simultaneously inhibit several steps in LPS recognition and activation of TLR4 signaling.
	Platelet Activation by Low Concentrations of Intact Oxidized LDL Particles Involves the PAF Receptor Rui Chen, Xi Chen, Robert G. Salomon, and Thomas M. McIntyre Arterioscler Thromb Vasc Biol. 2009;29:363-371; published online before print December 26 2008, doi:10.1161/ATVBAHA.108.178731 Abstract \| Full Text \| PDF \| Data Supplement Oxidized LDL contains truncated phospholipids that depolarize mitochondria of nucleated cells, and mitochondrial depolarization aids platelet activation. Indeed, very low amounts of intact oxLDL particles activated platelets. However, the PAF receptor unexpectedly recognized medium length oxidized alkyl phospholipids, and oxidized LDL stimulates platelets via the PAF receptor, not mitochondrial damage.
	Downregulation of Platelet Responsiveness Upon Contact With LDL by the Protein-Tyrosine Phosphatases SHP-1 and SHP-2 Suzanne J.A. Korporaal, C. Arnold Koekman, Sandra Verhoef, Dianne E. van der Wal, Martineke Bezemer, Miranda Van Eck, and Jan-Willem N. Akkerman Arterioscler Thromb Vasc Biol. 2009;29:372-379; published online before print December 18 2008, doi:10.1161/ATVBAHA.108.173278 Abstract \| Full Text \| PDF \| Data Supplement
	Statins Control Oxidized LDL-Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells Philippe Dje N'Guessan, Fabian Riediger, Kremena Vardarova, Stefanie Scharf, Julia Eitel, Bastian Opitz, Hortense Slevogt, Wilko Weichert, Andreas C. Hocke, Bernd Schmeck, Norbert Suttorp, and Stefan Hippenstiel Arterioscler Thromb Vasc Biol. 2009;29:380-386; published online before print January 2 2009, doi:10.1161/ATVBAHA.108.178319 Abstract \| Full Text \| PDF \| Data Supplement
	Role of Src Tyrosine Kinase in the Atherogenic Effects of the 12/15-Lipoxygenase Pathway in Vascular Smooth Muscle Cells Marpadga A. Reddy, Saurabh Sahar, Louisa M. Villeneuve, Linda Lanting, and Rama Natarajan Arterioscler Thromb Vasc Biol. 2009;29:387-393; published online before print December 18 2008, doi:10.1161/ATVBAHA.108.179150 Abstract \| Full Text \| PDF \| Data Supplement
	Fibrinogen- ${gamma}$ C-Terminal Fragments Induce Endothelial Barrier Dysfunction and Microvascular Leak via Integrin-Mediated and RhoA-Dependent Mechanism Mingzhang Guo, Dayle Daines, Jing Tang, Qiang Shen, Rachel M. Perrin, Yoshikazu Takada, Sarah Y. Yuan, and Mack H. Wu Arterioscler Thromb Vasc Biol. 2009;29:394-400; published online before print January 2 2009, doi:10.1161/ATVBAHA.108.180950 Abstract \| Full Text \| PDF \| Data Supplement The effect of fibrinogen-{gamma} C-terminal fragment ({gamma}C) on microvascular endothelial permeability was assessed by measuring albumin flux and hydraulic conductivity in mesenteric microvessels and transcellular electric resistance in endothelial monolayers. The results suggest that {gamma}C induces an integrin-mediated RhoA-dependent endothelial response leading to microvascular leakage.
	Angiopoietin-2 Exocytosis Is Stimulated by Sphingosine-1-Phosphate in Human Blood and Lymphatic Endothelial Cells Cholsoon Jang, Young Jun Koh, Nam Kyu Lim, Hyun Jung Kang, Duk Hoon Kim, Sung Kwang Park, Gyun Min Lee, Choon Ju Jeon, and Gou Young Koh Arterioscler Thromb Vasc Biol. 2009;29:401-407; published online before print December 26 2008, doi:10.1161/ATVBAHA.108.172676 Abstract \| Full Text \| PDF \| Data Supplement The underlying mechanism of Ang2 exocytosis from human endothelial cells was examined by stimulation with S1P. S1P triggers rapid Ang2 exocytosis, which is mainly mediated by EDG1/phospholipase C/intracellular calcium mobilization. The rapid secretion of Ang2 by exocytosis from endothelial cells is a possible mechanism for S1P-induced angiogenesis and inflammation.
	Insulin-Like Growth Factor-1 Receptor Expression Masks the Antiinflammatory and Glucose Uptake Capacity of Insulin in Vascular Smooth Muscle Cells Niels Engberding, Alejandra San Martín, Abel Martin-Garrido, Mitsuhisa Koga, Lily Pounkova, Erin Lyons, Bernard Lassègue, and Kathy K. Griendling Arterioscler Thromb Vasc Biol. 2009;29:408-415; published online before print January 2 2009, doi:10.1161/ATVBAHA.108.181727 Abstract \| Full Text \| PDF \| Data Supplement Insulin-like growth factor-1 receptor (IGF1R) expression is inversely related to insulin sensitivity in VSMCs. While IGF1R downregulation allows the formation of insulin holoreceptors and leads to enhanced cellular insulin sensitivity, it also unveils antiinflammatory properties of insulin.
	Clinical and Population Studies
	Effect of Rimonabant on the High-Triglyceride/ Low–HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat: The ADAGIO-Lipids Trial Jean-Pierre Després, Robert Ross, Gabor Boka, Natalie Alméras, Isabelle Lemieux for the ADAGIO-Lipids Investigators Arterioscler Thromb Vasc Biol. 2009;29:416-423; published online before print December 26 2008, doi:10.1161/ATVBAHA.108.176362 Abstract \| Full Text \| PDF \| Data Supplement
	Prognostic Utility of ApoB/AI, Total Cholesterol/HDL, Non-HDL Cholesterol, or hs-CRP as Predictors of Clinical Risk in Patients Receiving Statin Therapy After Acute Coronary Syndromes: Results From PROVE IT–TIMI 22 Kausik K. Ray, Christopher P. Cannon, Richard Cairns, David A. Morrow, Paul M Ridker, and Eugene Braunwald Arterioscler Thromb Vasc Biol. 2009;29:424-430; published online before print January 2 2009, doi:10.1161/ATVBAHA.108.181735 Abstract \| Full Text \| PDF \| Data Supplement In this analysis from PROVE IT-TIMI 22, on-treatment apoB/AI, TC/HDL, and non-HDL-C offered similar prognostic information to LDL-C. However, the addition of hs-CRP to lipids significantly improved risk prediction.

Spotlight

TOC Spotlight File

Volume 29, Issue 3; March 1, 2009

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

Go Red for Women

Cardiovascular Disease in Women

Status of Women in Cardiovascular Clinical Trials

Thrombosis and Antithrombotic Therapy in Women

Estrogen and Mechanisms of Vascular Protection

Venous Thromboembolism: Mechanisms, Treatment, and Public Awareness

Venous Thromboembolism: Risk Factors, Biomarkers, and Treatment

Venous Thromboembolism: Risk Factors for Recurrence

Metabolic Syndrome Is Associated With Venous Thromboembolism in the Korean Population

New Insights Into Cancer-Associated Thrombosis

Venous Thrombosis in the Antiphospholipid Syndrome

Venous Thromboembolism in Pregnancy

Biomarkers and Venous Thromboembolism

Editorials

Oxidized Phospholipid Inhibition of LPS-Signaling: A Good Side to the Bad Guys?

ADAGIO-Lipids Gives Promises but Faces the Setbacks

Integrative Physiology/Experimental Medicine

Despite Antiatherogenic Metabolic Characteristics, SCD1-Deficient Mice Have Increased Inflammation and Atherosclerosis

Genetic Regulation of Atherosclerotic Plaque Size and Morphology in the Innominate Artery of Hyperlipidemic Mice

Cell Biology/Signaling

Multi-Hit Inhibition of Circulating and Cell-Associated Components of the Toll-Like Receptor 4 Pathway by Oxidized Phospholipids

Platelet Activation by Low Concentrations of Intact Oxidized LDL Particles Involves the PAF Receptor

Downregulation of Platelet Responsiveness Upon Contact With LDL by the Protein-Tyrosine Phosphatases SHP-1 and SHP-2

Statins Control Oxidized LDL-Mediated Histone Modifications and Gene Expression in Cultured Human Endothelial Cells

Role of Src Tyrosine Kinase in the Atherogenic Effects of the 12/15-Lipoxygenase Pathway in Vascular Smooth Muscle Cells

Fibrinogen- C-Terminal Fragments Induce Endothelial Barrier Dysfunction and Microvascular Leak via Integrin-Mediated and RhoA-Dependent Mechanism

Angiopoietin-2 Exocytosis Is Stimulated by Sphingosine-1-Phosphate in Human Blood and Lymphatic Endothelial Cells

Insulin-Like Growth Factor-1 Receptor Expression Masks the Antiinflammatory and Glucose Uptake Capacity of Insulin in Vascular Smooth Muscle Cells

Clinical and Population Studies

Effect of Rimonabant on the High-Triglyceride/ Low–HDL-Cholesterol Dyslipidemia, Intraabdominal Adiposity, and Liver Fat: The ADAGIO-Lipids Trial

Prognostic Utility of ApoB/AI, Total Cholesterol/HDL, Non-HDL Cholesterol, or hs-CRP as Predictors of Clinical Risk in Patients Receiving Statin Therapy After Acute Coronary Syndromes: Results From PROVE IT–TIMI 22

Spotlight

Fibrinogen- ${gamma}$ C-Terminal Fragments Induce Endothelial Barrier Dysfunction and Microvascular Leak via Integrin-Mediated and RhoA-Dependent Mechanism