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Arteriosclerosis, Thrombosis, and Vascular Biology
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Volume 29, Issue 1; January 1, 2009
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Key:  VB = Vascular Biology  AL = Atherosclerosis/Lipoproteins  TH = Thrombosis
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EditorialsBack

TH gif  Arteriosclerosis, Thrombosis, and Vascular Biology, 2009

Mark Taubman
Arterioscler Thromb Vasc Biol. 2009;29:1-2, doi:10.1161/ATVBAHA.108.181123
Extract | Full Text | PDF Free Article  

AL gif  Carotid Plaque Stabilization and Progression After Stroke or TIA

Renu Virmani, Aloke V. Finn, and Frank D. Kolodgie
Arterioscler Thromb Vasc Biol. 2009;29:3-6, doi:10.1161/ATVBAHA.108.177659
Extract | Full Text | PDF Free Article  

AL gif  Cannabinoid CB1 Receptor Antagonists for Atherosclerosis and Cardiometabolic Disorders: New Hopes, Old Concerns?

Pál Pacher
Arterioscler Thromb Vasc Biol. 2009;29:7-9, doi:10.1161/ATVBAHA.108.178129
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TH gif  Vascular Remodeling in Diabetes: Don’t Leave Without Your STAT5

Anna Zampetaki and Qingbo Xu
Arterioscler Thromb Vasc Biol. 2009;29:10-11, doi:10.1161/ATVBAHA.108.178137
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Integrative Physiology/Experimental MedicineBack

AL gif  Rimonabant, a Selective Cannabinoid CB1 Receptor Antagonist, Inhibits Atherosclerosis in LDL Receptor–Deficient Mice

Frédérique Dol-Gleizes, Réjane Paumelle, Virgile Visentin, Anne-Marie Marés, Perrine Desitter, Nathalie Hennuyer, Andries Gilde, Bart Staels, Paul Schaeffer, and Françoise Bono
Arterioscler Thromb Vasc Biol. 2009;29:12-18; published online before print October 9 2008, doi:10.1161/ATVBAHA.108.168757
Abstract | Full Text | PDF | Data Supplement
Rimonabant (30 mg/kg/d in the diet) significantly reduced atherosclerotic lesion size in the aortic sinus of Western diet-fed LDLR-deficient mice without affecting serum cholesterol levels, whereas higher doses strongly decreased serum cholesterol and atherosclerosis. Rimonabant also reduced thioglycollate-induced recruitment of macrophages in vivo. These results show that rimonabant has antiatherosclerotic effects in LDLR-/- mice partly related to an antiinflammatory effect.  

AL gif  Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice

Jennifer J. Manning-Tobin, Kathryn J. Moore, Tracie A. Seimon, Susan A. Bell, Maia Sharuk, Jacqueline I. Alvarez-Leite, Menno P.J. de Winther, Ira Tabas, and Mason W. Freeman
Arterioscler Thromb Vasc Biol. 2009;29:19-26; published online before print October 23 2008, doi:10.1161/ATVBAHA.108.176644
Abstract | Full Text | PDF | Data Supplement  

AL gif  Endothelial Nitric Oxide Deficiency Reduces MMP-13–Mediated Cleavage of ICAM-1 in Vascular Endothelium: A Role in Atherosclerosis

Carlos Tarín, Monica Gomez, Enrique Calvo, Juan Antonio López, and Carlos Zaragoza
Arterioscler Thromb Vasc Biol. 2009;29:27-32; published online before print November 6 2008, doi:10.1161/ATVBAHA.108.169623
Abstract | Full Text | PDF | Data Supplement  

AL gif  Transient Increase in Plasma Oxidized LDL During the Progression of Atherosclerosis in Apolipoprotein E Knockout Mice

Rina Kato, Chihiro Mori, Keiko Kitazato, Satoru Arata, Takashi Obama, Masahiro Mori, Katsuhiko Takahashi, Toshihiro Aiuchi, Tatsuya Takano, and Hiroyuki Itabe
Arterioscler Thromb Vasc Biol. 2009;29:33-39; published online before print November 6 2008, doi:10.1161/ATVBAHA.108.164723
Abstract | Full Text | PDF | Data Supplement
We successfully measured murine circulating OxLDL using sandwich ELISA. ApoE knockout mice showed a significant rise in the plasma OxLDL level at 20 weeks of age, whereas the atherosclerotic lesions were still small. This suggests an increase in the oxidative stress and the appearance of OxLDL before the progression of atherosclerotic lesions.  

AL gif  Overexpression of Apolipoprotein F Reduces HDL Cholesterol Levels In Vivo

William R. Lagor, Robert J. Brown, Sue-Anne Toh, John S. Millar, Ilia V. Fuki, Margarita de la Llera-Moya, Tiffany Yuen, George Rothblat, Jeffrey T. Billheimer, and Daniel J. Rader
Arterioscler Thromb Vasc Biol. 2009;29:40-46; published online before print November 13 2008, doi:10.1161/ATVBAHA.108.177105
Abstract | Full Text | PDF | Data Supplement
Adeno-associated viral vectors were used to overexpress human or mouse ApoF in mice. ApoF overexpression reduced HDL cholesterol levels, and improved clearance of HDL cholesteryl ester from the plasma. The data suggests ApoF is an important gene affecting HDL metabolism.  

TH gif  Genetic Modifier Loci Linked to Intima Formation Induced by Low Flow in the Mouse Carotid

Vyacheslav A. Korshunov and Bradford C. Berk
Arterioscler Thromb Vasc Biol. 2009;29:47-53; published online before print October 23 2008, doi:10.1161/ATVBAHA.108.178111
Abstract | Full Text | PDF | Data Supplement
Genetic analysis of intima formation in response to low blood flow was studied in a backcross between 2 inbred mouse strains. For the first time we identified 3 quantitative trait loci that contribute to intima thickening in the mouse carotid.  

TH gif  Interaction Between P450 Eicosanoids and Nitric Oxide in the Control of Arterial Tone in Mice

Hantz C. Hercule, Wolf-Hagen Schunck, Volkmar Gross, Jasmin Seringer, Fung Ping Leung, Steven M. Weldon, Andrey Ch. da Costa Goncalves, Yu Huang, Friedrich C. Luft, and Maik Gollasch
Arterioscler Thromb Vasc Biol. 2009;29:54-60; published online before print October 16 2008, doi:10.1161/ATVBAHA.108.171298
Abstract | Full Text | PDF | Data Supplement  

TH gif  Implantation of Adipose-Derived Regenerative Cells Enhances Ischemia-Induced Angiogenesis

Kazuhisa Kondo, Satoshi Shintani, Rei Shibata, Hisashi Murakami, Ryuichiro Murakami, Masayasu Imaizumi, Yasuo Kitagawa, and Toyoaki Murohara
Arterioscler Thromb Vasc Biol. 2009;29:61-66; published online before print October 30 2008, doi:10.1161/ATVBAHA.108.166496
Abstract | Full Text | PDF | Data Supplement  

 

Cell Biology/SignalingBack

TH gif  Overexpression of Adiponectin Receptors Potentiates the Antiinflammatory Action of Subeffective Dose of Globular Adiponectin in Vascular Endothelial Cells

Peng Zhang, Ying Wang, Yanbo Fan, Zhihui Tang, and Nanping Wang
Arterioscler Thromb Vasc Biol. 2009;29:67-74; published online before print November 6 2008, doi:10.1161/ATVBAHA.108.178061
Abstract | Full Text | PDF | Data Supplement
Hypoadiponectinemia is associated with increased cardiovascular risk. We demonstrate that overexpression of adiponectin receptors potentiates the suppressive action of low-dose globular adiponectin on intercellular adhesion molecule-1 in vitro and in vivo and the involvement of PPAR-{alpha}, indicating adiponectin receptors as potential therapeutic applications for cardiovascular complications associated with metabolic syndrome.  

AL gif  Role of Junctional Adhesion Molecule-Like Protein in Mediating Monocyte Transendothelial Migration

Ya-Lan Guo, Rui Bai, Celia X-J Chen, Dan-Qing Liu, Yuan Liu, Chen-Yu Zhang, and Ke Zen
Arterioscler Thromb Vasc Biol. 2009;29:75-83; published online before print October 23 2008, doi:10.1161/ATVBAHA.108.177717
Abstract | Full Text | PDF | Data Supplement  

AL gif  Endothelial Lipase Promotes Apolipoprotein AI-Mediated Cholesterol Efflux in THP-1 Macrophages

Guosong Qiu and John S. Hill
Arterioscler Thromb Vasc Biol. 2009;29:84-91; published online before print November 6 2008, doi:10.1161/ATVBAHA.108.176487
Abstract | Full Text | PDF | Data Supplement  

AL gif  Oxidized LDL-Mediated Macrophage Survival Involves Elongation Factor-2 Kinase

Johnny H. Chen, Maziar Riazy, Ewan M. Smith, Christopher G. Proud, Urs P. Steinbrecher, and Vincent Duronio
Arterioscler Thromb Vasc Biol. 2009;29:92-98; published online before print November 6 2008, doi:10.1161/ATVBAHA.108.174599
Abstract | Full Text | PDF | Data Supplement  

TH gif  PIAS1 Mediates TGFβ-Induced SM {alpha}-Actin Gene Expression Through Inhibition of KLF4 Function-Expression by Protein Sumoylation

Keiko Kawai-Kowase, Takayuki Ohshima, Hiroki Matsui, Toru Tanaka, Takehisa Shimizu, Tatsuya Iso, Masashi Arai, Gary K. Owens, and Masahiko Kurabayashi
Arterioscler Thromb Vasc Biol. 2009;29:99-106; published online before print October 16 2008, doi:10.1161/ATVBAHA.108.172700
Abstract | Full Text | PDF | Data Supplement
We provide evidence showing that PIAS1 and ubc9, an E2-ligase for sumoylation, contributed to TGFβ-induced activation of SM {alpha}-actin gene expression through a TGFβ control element which binds KLF4. We also demonstrate that PIAS1 interacted with KLF4, promoted degradation of KLF4 by protein sumoylation, and thereby inhibited KLF4-dependent repression of SM {alpha}-actin promoter activity.  

AL gif  Farp2 and Stk25 Are Candidate Genes for the HDL Cholesterol Locus on Mouse Chromosome 1

Zhiguang Su, Allison Cox, Yuan Shen, Ioannis M. Stylianou, and Beverly Paigen
Arterioscler Thromb Vasc Biol. 2009;29:107-113; published online before print November 6 2008, doi:10.1161/ATVBAHA.108.178384
Abstract | Full Text | PDF | Data Supplement  

TH gif  Formation of STAT5/PPAR{gamma} Transcriptional Complex Modulates Angiogenic Cell Bioavailability in Diabetes

Patrizia Dentelli, Antonella Trombetta, Gabriele Togliatto, Annarita Zeoli, Arturo Rosso, Barbara Uberti, Francesca Orso, Daniela Taverna, Luigi Pegoraro, and Maria Felice Brizzi
Arterioscler Thromb Vasc Biol. 2009;29:114-120; published online before print October 16 2008, doi:10.1161/ATVBAHA.108.172247
Abstract | Full Text | PDF | Data Supplement
We investigated the role of STAT5 and PPAR{gamma} in regulating CAC expansion in normal and diabetic settings. We provide evidences that STAT5 controls PPAR{gamma} expression and the formation of a STAT5/PPAR{gamma} transcriptional complex, which is a permissive event for normal and diabetic CAC expansion.  

TH gif  Microarray-Based Characterization of a Colony Assay Used to Investigate Endothelial Progenitor Cells and Relevance to Endothelial Function in Humans

Aditi Desai, Alexander Glaser, Delong Liu, Nalini Raghavachari, Arnon Blum, Gloria Zalos, Margaret Lippincott, J. Philip McCoy, Peter J. Munson, Michael A. Solomon, Robert L. Danner, and Richard O. Cannon, III
Arterioscler Thromb Vasc Biol. 2009;29:121-127, doi:10.1161/ATVBAHA.108.174573
Abstract | Full Text | PDF
Sedentary subjects underwent endothelial testing and blood sampling at baseline and after 3 months of exercise training. Microarray and flow cytometry-based characterization of colonies from an assay proposed to quantify endothelial progenitor cells was consistent with T lymphocytes, but not endothelial cells. After exercise training, subjects improved endothelial function (P=0.0043) and colony number (P=0.0210), but T lymphocyte phenotype persisted.  

 

Clinical and Population StudiesBack

AL gif  Carotid Atherosclerotic Plaques Stabilize After Stroke: Insights Into the Natural Process of Atherosclerotic Plaque Stabilization

W. Peeters, W.E. Hellings, D.P.V. de Kleijn, J.P.P.M. de Vries, F.L. Moll, A. Vink, and G. Pasterkamp
Arterioscler Thromb Vasc Biol. 2009;29:128-133; published online before print October 17 2008, doi:10.1161/ATVBAHA.108.173658
Abstract | Full Text | PDF | Data Supplement
The composition of 804 atherosclerotic plaques from patients who underwent carotid endarterectomy has been related to the time, elapsed between the latest cerebrovascular ischemic event and surgical excision. After stroke as well after TIA, the inflammatory status of the plaque decreased independent from potential confounders at histological and protein level.  

TH gif  Potential Role for Plasma Placental Growth Factor in Predicting Coronary Heart Disease Risk in Women

Aedín Cassidy, Stephanie E. Chiuve, JoAnn E. Manson, Kathyrn M. Rexrode, Cynthia J. Girman, and Eric B. Rimm
Arterioscler Thromb Vasc Biol. 2009;29:134-139; published online before print October 16 2008, doi:10.1161/ATVBAHA.108.171066
Abstract | Full Text | PDF  

AL gif  Potent and Selective PPAR-{alpha} Agonist LY518674 Upregulates Both ApoA-I Production and Catabolism in Human Subjects With the Metabolic Syndrome

John S. Millar, Danielle Duffy, Ramprasad Gadi, LeAnne T. Bloedon, Richard L. Dunbar, Megan L. Wolfe, Rajesh Movva, Ashish Shah, Ilia V. Fuki, Mary McCoy, Cynthia J. Harris, Ming-Dauh Wang, Daniel C. Howey, and Daniel J. Rader
Arterioscler Thromb Vasc Biol. 2009;29:140-146; published online before print November 6 2008, doi:10.1161/ATVBAHA.108.171223
Abstract | Full Text | PDF | Data Supplement
We studied apoA-I and apoA-II metabolism after treatment with a potent and specific PPAR-{alpha} agonist, LY518674, or placebo for 8 weeks. LY518674 increased apoA-I and apoA-II production and fractional catabolic rates leaving HDL-C levels unchanged. LY518674 significantly increases apoA-I production and clearance despite no change in HDL.  

AL gif  Galanin Preproprotein Is Associated With Elevated Plasma Triglycerides

Christopher L. Plaisier, Mira Kyttälä, Daphna Weissglas-Volkov, Janet S. Sinsheimer, Adriana Huertas-Vazquez, Laura Riba, Salvador Ramírez-Jiménez, Tjerk W.A. de Bruin, Teresa Tusié-Luna, Bradley E. Aouizerat, Clive R. Pullinger, Mary J. Malloy, John P. Kane, Ivette Cruz-Bautista, Miguel F. Herrera, Carlos Aguilar-Salinas, Johanna Kuusisto, Markku Laakso, Marja-Riitta Taskinen, Carla J.H. van der Kallen, and Päivi Pajukanta
Arterioscler Thromb Vasc Biol. 2009;29:147-152; published online before print November 6 2008, doi:10.1161/ATVBAHA.108.178533
Abstract | Full Text | PDF | Data Supplement  

 

Acknowledgment of ReviewersBack

Acknowledgment of Reviewers


Arterioscler Thromb Vasc Biol. 2009;29:e1-e8, doi:10.1161/01.atv.0000342750.79214.2c
Extract | Full Text | PDF Free Article  

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