Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (28 [7])

About This Cover

Volume 28, Issue 7; July 1, 2008

Editorials
Brief Reviews
Integrative Physiology/Experimental Medicine
Cell Biology and Signaling
Clinical and Population Studies
Corrections

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

To see an article, click its "Full Text" or "PDF" link. To review many abstracts, check the boxes to the left of the titles you want, and click the "Get All Checked Abstract(s)" button. To see one abstract at a time, click its "Abstract" link.

button_lock_image article is free immediately upon publication

	Editorials
	Are the Mechanisms for NO-Dependent Vascular Remodeling Different From Vasorelaxation In Vivo? Michael Schleicher and William C. Sessa Arterioscler Thromb Vasc Biol. 2008;28:1207-1208, doi:10.1161/ATVBAHA.108.167403 Extract \| Full Text \| PDF
	CD36 Goes Native Maria Febbraio Arterioscler Thromb Vasc Biol. 2008;28:1209-1210, doi:10.1161/ATVBAHA.108.169342 Extract \| Full Text \| PDF
	Adipose Tissue Lymphocytes and Macrophages in Obesity and Insulin Resistance: Makers or Markers, and Which Comes First? A. Bouloumié, L. Casteilla, and M. Lafontan Arterioscler Thromb Vasc Biol. 2008;28:1211-1213, doi:10.1161/ATVBAHA.108.168229 Extract \| Full Text \| PDF
	A Central Resource for Platelet Proteomics Gerard Cagney and James McRedmond Arterioscler Thromb Vasc Biol. 2008;28:1214-1215, doi:10.1161/ATVBAHA.108.167452 Extract \| Full Text \| PDF
	Double Tribble: Two TRIB3 Variants, Insulin, Akt, and eNOS Ingrid Fleming Arterioscler Thromb Vasc Biol. 2008;28:1216-1218, doi:10.1161/ATVBAHA.108.169250 Extract \| Full Text \| PDF
	A Novel Role for Adiponectin in the Regulation of Inflammation Noriyuki Ouchi and Kenneth Walsh Arterioscler Thromb Vasc Biol. 2008;28:1219-1221, doi:10.1161/ATVBAHA.108.165068 Extract \| Full Text \| PDF
	The Time for Cardiovascular Inflammation Reduction Trials Has Arrived: How Low to Go for hsCRP? Paul M Ridker Arterioscler Thromb Vasc Biol. 2008;28:1222-1224, doi:10.1161/ATVBAHA.108.168989 Extract \| Full Text \| PDF
	Brief Reviews
	Overproduction of Very Low–Density Lipoproteins Is the Hallmark of the Dyslipidemia in the Metabolic Syndrome Martin Adiels, Sven-Olof Olofsson, Marja-Riitta Taskinen, and Jan Borén Arterioscler Thromb Vasc Biol. 2008;28:1225-1236, doi:10.1161/ATVBAHA.107.160192 Abstract \| Full Text \| PDF Diabetic dyslipidemia is a cluster of potentially atherogenic lipid and lipoprotein abnormalities that are metabolically interrelated. Recent evidence suggests that a fundamental defect is an overproduction of large very low-density lipoprotein (VLDL) particles. Here, we review the pathophysiology of VLDL biosynthesis and metabolism in the metabolic syndrome.
	Integrative Physiology/Experimental Medicine
	Temporally Expressed PDGF and FGF-2 Regulate Embryonic Coronary Artery Formation and Growth Robert J. Tomanek, Heidi K. Hansen, and Lance P. Christensen Arterioscler Thromb Vasc Biol. 2008;28:1237-1243; published online before print April 17 2008, doi:10.1161/ATVBAHA.108.166454 Abstract \| Full Text \| PDF
	Role of Smooth Muscle cGMP/cGKI Signaling in Murine Vascular Restenosis Robert Lukowski, Pascal Weinmeister, Dominik Bernhard, Susanne Feil, Michael Gotthardt, Joachim Herz, Steffen Massberg, Alma Zernecke, Christian Weber, Franz Hofmann, and Robert Feil Arterioscler Thromb Vasc Biol. 2008;28:1244-1250; published online before print April 17 2008, doi:10.1161/ATVBAHA.108.166405 Abstract \| Full Text \| PDF \| Data Supplement
	Androgen Increases AT1a Receptor Expression in Abdominal Aortas to Promote Angiotensin II–Induced AAAs in Apolipoprotein E–Deficient Mice Tracy Henriques, Xuan Zhang, Frederique B. Yiannikouris, Alan Daugherty, and Lisa A. Cassis Arterioscler Thromb Vasc Biol. 2008;28:1251-1256; published online before print May 1 2008, doi:10.1161/ATVBAHA.107.160382 Abstract \| Full Text \| PDF \| Data Supplement Castration decreases AT1aR mRNA abundance in abdominal aortas from male and female apoE-/- mice, whereas DHT administration increased AT1aR mRNA abundance. DHT administration increased AAA incidence in castrated males and promoted AAAs in female mice. These results demonstrate that androgen increases AT1aR abundance in abdominal aortas to promote AAA formation.
	Alpha2-Antiplasmin Is a Critical Regulator of Angiotensin II–Mediated Vascular Remodeling YongZhong Hou, Kiyotaka Okada, Chikako Okamoto, Shigeru Ueshima, and Osamu Matsuo Arterioscler Thromb Vasc Biol. 2008;28:1257-1262; published online before print April 24 2008, doi:10.1161/ATVBAHA.108.165688 Abstract \| Full Text \| PDF \| Data Supplement {alpha}2-AP is the major circulating inhibitor of plasmin. Here we reported that {alpha}2-AP-/- suppressed Ang II and L-NAME-induced perivascular fibrosis by decreased collagen I expression. {alpha}2-AP-/- decreased Ang II-induced vascular remodeling by inhibiting p53/p21 pathway, suggesting that {alpha}2-AP is proposed to be a potential therapeutic target for vascular remodeling.
	SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells Ryohei Miyazaki, Toshihiro Ichiki, Toru Hashimoto, Keita Inanaga, Ikuyo Imayama, Junichi Sadoshima, and Kenji Sunagawa Arterioscler Thromb Vasc Biol. 2008;28:1263-1269; published online before print April 17 2008, doi:10.1161/ATVBAHA.108.166991 Abstract \| Full Text \| PDF \| Data Supplement Sirtuin1 (SIRT1) belongs to class III histone/protein deacetylases and are associated with longevity. Resveratrol significantly suppressed AT1R expression at the transcriptional level through SIRT1 activation both in vivo and in vitro. The downregulation of renin-angiotensin system may contribute to the longevity and antiatherogenic effect of resveratrol.
	Overexpression of ACE2 Enhances Plaque Stability in a Rabbit Model of Atherosclerosis Bo Dong, Cheng Zhang, Jing Bo Feng, Yu Xia Zhao, Shu Ying Li, Ya Pei Yang, Qiu Li Dong, Bi Ping Deng, Li Zhu, Qing Tao Yu, Chun Xi Liu, Bin Liu, Chun Ming Pan, Huai Dong Song, Ming Xiang Zhang, and Yun Zhang Arterioscler Thromb Vasc Biol. 2008;28:1270-1276; published online before print April 10 2008, doi:10.1161/ATVBAHA.108.164715 Abstract \| Full Text \| PDF \| Data Supplement To investigate whether ACE2 overexpression may enhance plaque stability, plaques were induced in 114 rabbits treated with local infusion of AdACE2, AdEGFP, or Ad.ACE2+A779. Local ACE2 overexpression resulted in stable plaque compositions, higher plaque stability scores, decreased angiotensin II levels, and increased angiotensin 1 to 7 levels in plaque tissues.
	Acute Elevation of Plasma PLTP Activity Strongly Increases Pre-existing Atherosclerosis Matthijs Moerland, Hannelore Samyn, Teus van Gent, Rien van Haperen, Geesje Dallinga-Thie, Frank Grosveld, Arie van Tol, and Rini de Crom Arterioscler Thromb Vasc Biol. 2008;28:1277-1282; published online before print April 17 2008, doi:10.1161/ATVBAHA.108.165084 Abstract \| Full Text \| PDF \| Data Supplement In LDL receptor knockout mice with conditional expression of human PLTP plasma VLDL levels are strongly increased, whereas VLDL secretion is not affected. This is explained by a PLTP-dependent inhibition of VLDL catabolism. After PLTP induction, preexisting atherosclerotic lesions grow larger, even on a chow diet. In addition, the lesions show a less stable phenotype.
	CD44 Expressed on Both Bone Marrow–Derived and Non–Bone Marrow–Derived Cells Promotes Atherogenesis in ApoE-Deficient Mice Liang Zhao, Eric Lee, Alicia M. Zukas, Melissa K. Middleton, Michelle Kinder, Pinak S. Acharya, Jason A. Hall, Daniel J. Rader, and Ellen Puré Arterioscler Thromb Vasc Biol. 2008;28:1283-1289; published online before print April 17 2008, doi:10.1161/ATVBAHA.108.165753 Abstract \| Full Text \| PDF \| Data Supplement
	Mouse CD36 Has Opposite Effects on LDL and Oxidized LDL Metabolism In Vivo Vilayphone Luangrath, Mathieu R. Brodeur, David Rhainds, and Louise Brissette Arterioscler Thromb Vasc Biol. 2008;28:1290-1295; published online before print April 24 2008, doi:10.1161/ATVBAHA.107.161653 Abstract \| Full Text \| PDF \| Data Supplement
	Cholesterol Absorption From the Intestine Is a Major Determinant of Reverse Cholesterol Transport From Peripheral Tissue Macrophages Ephraim Sehayek and Stanley L. Hazen Arterioscler Thromb Vasc Biol. 2008;28:1296-1297; published online before print April 17 2008, doi:10.1161/ATVBAHA.108.165803 Abstract \| Full Text \| PDF \| Data Supplement
	Coexpression of CLA-1 and Human PDZK1 in Murine Liver Modulates HDL Cholesterol Metabolism Hidenori Komori, Hidenori Arai, Terumi Kashima, Thierry Huby, Toru Kita, and Yukihiko Ueda Arterioscler Thromb Vasc Biol. 2008;28:1298-1303; published online before print April 10 2008, doi:10.1161/ATVBAHA.108.165845 Abstract \| Full Text \| PDF \| Data Supplement Transgenic expression of human PDZK1 increased hepatic CLA-1 expression in murine liver. Enhanced hepatic CLA-1 expression increased the clearance of HDL particles containing human apoA-I. Thus CLA-1 and human PDZK1 have a potential to modulate HDL cholesterol metabolism in human.
	T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance Ulrich Kintscher, Martin Hartge, Katharina Hess, Anna Foryst-Ludwig, Markus Clemenz, Martin Wabitsch, Pamela Fischer-Posovszky, Thomas F.E. Barth, Duska Dragun, Thomas Skurk, Hans Hauner, Matthias Blüher, Thomas Unger, Anna-Maria Wolf, Uwe Knippschild, Vinzenz Hombach, and Nikolaus Marx Arterioscler Thromb Vasc Biol. 2008;28:1304-1310; published online before print April 17 2008, doi:10.1161/ATVBAHA.108.165100 Abstract \| Full Text \| PDF \| Data Supplement In a mouse model of insulin resistance (IR), high-fat diet induced IR after 5 weeks, which was associated with a marked proinflammatory T-lymphocyte infiltration in visceral adipose tissue, whereas macrophage recruitment was delayed after 10 weeks of diet, suggesting a dissociation of macrophage invasion into adipose tissue and IR initiation.
	Detection of Neovessels in Atherosclerotic Plaques of Rabbits Using Dynamic Contrast Enhanced MRI and 18F-FDG PET Claudia Calcagno, Jean-Christophe Cornily, Fabien Hyafil, James H.F. Rudd, Karen C. Briley-Saebo, Venkatesh Mani, Gregg Goldschlager, Josef Machac, Valentin Fuster, and Zahi A. Fayad Arterioscler Thromb Vasc Biol. 2008;28:1311-1317; published online before print May 8 2008, doi:10.1161/ATVBAHA.108.166173 Abstract \| Full Text \| PDF Neovessels are hallmarks of high-risk inflamed atherosclerotic plaques. In this study we used DCE-MRI and 18F-FDG PET to detect inflammation in atherosclerosis expressed as plaque neovessels count evaluated by histology. We found a positive correlation between neovessels count, DCE-MRI parameters, and 18F-FDG uptake. We propose that these noninvasive modalities could be used in the future to evaluate plaque-associated risk in the clinics.
	Recombinant Activated Protein C Attenuates Endothelial Injury and Inhibits Procoagulant Microparticles Release in Baboon Heatstroke Abderrezak Bouchama, Corinne Kunzelmann, Mohammed Dehbi, Aaron Kwaasi, Abdelmoneim Eldali, Fatiha Zobairi, Jean-Marie Freyssinet, and Dominique de Prost Arterioscler Thromb Vasc Biol. 2008;28:1318-1325; published online before print May 1 2008, doi:10.1161/ATVBAHA.107.161737 Abstract \| Full Text \| PDF \| Data Supplement
	Cell Biology and Signaling
	Platelet Protein Interactions: Map, Signaling Components, and Phosphorylation Groundstate Marcus Dittrich, Ingvild Birschmann, Silke Mietner, Albert Sickmann, Ulrich Walter, and Thomas Dandekar Arterioscler Thromb Vasc Biol. 2008;28:1326-1331; published online before print May 1 2008, doi:10.1161/ATVBAHA.107.161000 Abstract \| Full Text \| PDF \| Data Supplement
	Intracellular Localization of Cthrc1 Characterizes Differentiated Smooth Muscle Renée J. LeClair, Qiaozeng Wang, Meredith A. Benson, Igor Prudovsky, and Volkhard Lindner Arterioscler Thromb Vasc Biol. 2008;28:1332-1338; published online before print May 8 2008, doi:10.1161/ATVBAHA.108.166579 Abstract \| Full Text \| PDF \| Data Supplement
	KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells Joost O. Fledderus, Reinier A. Boon, Oscar L. Volger, Hanna Hurttila, Seppo Ylä-Herttuala, Hans Pannekoek, Anna-Liisa Levonen, and Anton J.G. Horrevoets Arterioscler Thromb Vasc Biol. 2008;28:1339-1346; published online before print May 8 2008, doi:10.1161/ATVBAHA.108.165811 Abstract \| Full Text \| PDF \| Data Supplement The role of KLF2 in shear-induced Nrf2-dependent gene expression in HUVECs was studied. Nrf2-mediated antioxidant transcription was increased by KLF2 through enhanced Nrf2 nuclear localization and activation which resulted in an enhanced protection against oxidative stress. We report that KLF2 and Nrf2 give a major contribution to the antioxidant and antiinflammatory endothelial response to flow.
	Nox4 and Nox2 NADPH Oxidases Mediate Distinct Cellular Redox Signaling Responses to Agonist Stimulation Narayana Anilkumar, Roberta Weber, Min Zhang, Alison Brewer, and Ajay M. Shah Arterioscler Thromb Vasc Biol. 2008;28:1347-1354; published online before print May 8 2008, doi:10.1161/ATVBAHA.108.164277 Abstract \| Full Text \| PDF \| Data Supplement We compared the effects of Nox2 versus Nox4 overexpression in HEK293 cells. These isoforms had distinctive intracellular localization and exhibited isoform-specific ROS production and signaling responses to angiotensin II, TNF{alpha}, or insulin. Nox2 and Nox4 may modulate distinct agonist-stimulated signaling pathways.
	TRIB3 R84 Variant Is Associated With Impaired Insulin-Mediated Nitric Oxide Production in Human Endothelial Cells Francesco Andreozzi, Gloria Formoso, Sabrina Prudente, Marta Letizia Hribal, Assunta Pandolfi, Emanuele Bellacchio, Sara Di Silvestre, Vincenzo Trischitta, Agostino Consoli, and Giorgio Sesti Arterioscler Thromb Vasc Biol. 2008;28:1355-1360; published online before print April 24 2008, doi:10.1161/ATVBAHA.108.162883 Abstract \| Full Text \| PDF \| Data Supplement The TRIB3 R84 variant has been associated with early age at myocardial infarction. We here report that insulin-mediated Akt activation and NO synthesis are markedly impaired in human endothelial cells carrying the variant. This finding provides a plausible biological background for the deleterious role of TRIB3 R84 on genetic susceptibility to coronary artery disease.
	Urokinase Plasminogen Activator Upregulates Paraoxonase 2 Expression in Macrophages Via an NADPH Oxidase-Dependent Mechanism Bianca Fuhrman, Jasmin Khateeb, Maayan Shiner, Orna Nitzan, Rachel Karry, Nina Volkova, and Michael Aviram Arterioscler Thromb Vasc Biol. 2008;28:1361-1367; published online before print April 24 2008, doi:10.1161/ATVBAHA.108.166041 Abstract \| Full Text \| PDF \| Data Supplement Our results demonstrate that uPA upregulates macrophage PON2 expression, secondary to NADPH oxidase activation. Macrophage PON2 upregulation may provide a compensatory protective mechanism against uPA-induced NADPH oxidase-dependent stimulation of macrophage oxidative stress during atherogenesis.
	Adiponectin Decreases C-Reactive Protein Synthesis and Secretion From Endothelial Cells: Evidence for an Adipose Tissue-Vascular Loop Sridevi Devaraj, Natalie Torok, Mohan R. Dasu, David Samols, and Ishwarlal Jialal Arterioscler Thromb Vasc Biol. 2008;28:1368-1374; published online before print May 1 2008, doi:10.1161/ATVBAHA.108.163303 Abstract \| Full Text \| PDF \| Data Supplement We tested whether adiponectin reduces CRP synthesis and secretion in HAECs under normoglycemic (5.5 mmol/L glucose) and hyperglycemic conditions (15 mmol/L glucose). Adiponectin reduced CRP mRNA and protein under hyperglycemic conditions via upregulation of AMP kinase and downregulation of NFeB. Similar findings were observed in rat primary hepatocytes.
	Complete Downmodulation of P-Selectin Glycoprotein Ligand in Monocytes Undergoing Apoptosis Jan-Julius Stampfuss, Petra Censarek, Jens W. Fischer, Gernot Kaber, Bernhard H. Rauch, Kerstin Freidel, Ute Fischer, Klaus Schulze-Osthoff, Tilo Grosser, Maria Grandoch, Karsten Schrör, and Artur-Aron Weber Arterioscler Thromb Vasc Biol. 2008;28:1375-1378; published online before print May 1 2008, doi:10.1161/ATVBAHA.108.166629 Abstract \| Full Text \| PDF \| Data Supplement We have studied P-selectin glycoprotein ligand (PSGL-1) expression and function in apoptotic monocytic cells. PSGL-1 expression was virtually abolished by proteolytic ectodomain shedding resulting in a complete loss of platelet-leukocyte and leukocyte-endothelial cell interactions. Downmodulation of PGSL-1 may prevent ectopic cell clearance and may act as a molecular switch to reduce thrombogenicity.
	Clinical and Population Studies
	Prognostic Value of Leukocyte Telomere Length in Patients With Stable Coronary Artery Disease: Data From the Heart and Soul Study Ramin Farzaneh-Far, Richard M. Cawthon, Beeya Na, Warren S. Browner, Nelson B. Schiller, and Mary A. Whooley Arterioscler Thromb Vasc Biol. 2008;28:1379-1384; published online before print May 8 2008, doi:10.1161/ATVBAHA.108.167049 Abstract \| Full Text \| PDF
	High-Sensitivity C-Reactive Protein and Coronary Heart Disease in a General Population of Japanese: The Hisayama Study Hisatomi Arima, Michiaki Kubo, Koji Yonemoto, Yasufumi Doi, Toshiharu Ninomiya, Yumihiro Tanizaki, Jun Hata, Kiyoshi Matsumura, Mitsuo Iida, and Yutaka Kiyohara Arterioscler Thromb Vasc Biol. 2008;28:1385-1391; published online before print April 10 2008, doi:10.1161/ATVBAHA.107.157164 Abstract \| Full Text \| PDF hs-CRP levels were clearly associated with future coronary events in a general population of Japanese. In Japanese populations, the hs-CRP cut-off point for high-risk of future development of CHD is likely to be >1.0 mg/L, which is much lower than that for Western populations.
	Distension of the Carotid Artery and Risk of Coronary Events: The Three-City Study Nathalie Leone, Pierre Ducimetière, Jerôme Gariépy, Dominique Courbon, Christophe Tzourio, Jean-François Dartigues, Karen Ritchie, Annick Alpérovitch, Philippe Amouyel, Michel E. Safar, and Mahmoud Zureik Arterioscler Thromb Vasc Biol. 2008;28:1392-1397; published online before print April 17 2008, doi:10.1161/ATVBAHA.108.164582 Abstract \| Full Text \| PDF \| Data Supplement Relationship between B-mode ultrasound measurements of carotid wall mechanics and coronary events was investigated in a large scale population-based cohort study in the elderly. We showed that carotid distension, the stroke change in lumen diameter, was positively and independently predictive of coronary heart disease.
	Do Psychological Factors Affect Inflammation and Incident Coronary Heart Disease: The Whitehall II Study Hermann Nabi, Archana Singh-Manoux, Martin Shipley, David Gimeno, Michael G. Marmot, and Mika Kivimaki Arterioscler Thromb Vasc Biol. 2008;28:1398-1406; published online before print April 24 2008, doi:10.1161/ATVBAHA.108.167239 Abstract \| Full Text \| PDF
	Polymorphisms of the IL1-Receptor Antagonist Gene (IL1RN) Are Associated With Multiple Markers of Systemic Inflammation Alexander P. Reiner, Mark M. Wurfel, Leslie A. Lange, Christopher S. Carlson, Alex S. Nord, Cara L. Carty, Mark J. Rieder, Cindy Desmarais, Nancy S. Jenny, Carlos Iribarren, Jeremy D. Walston, O. Dale Williams, Deborah A. Nickerson, and Gail P. Jarvik Arterioscler Thromb Vasc Biol. 2008;28:1407-1412; published online before print May 1 2008, doi:10.1161/ATVBAHA.108.167437 Abstract \| Full Text \| PDF \| Data Supplement Using data from 3 large studies comprising younger and older adults, we demonstrate that common variants of the IL-1RA gene (IL1RN) are associated with circulating levels of multiple markers of systemic inflammation. The IL1RN polymorphisms were also associated with cellular IL-1RA production ex vivo in response to an inflammatory stimulus.
	Corrections
	Correction Arterioscler Thromb Vasc Biol. 2008;28:e151, doi:10.1161/ATVBAHA.108.133333 Extract \| Full Text \| PDF

Spotlight

TOC Spotlight File

Volume 28, Issue 7; July 1, 2008

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

Editorials

Are the Mechanisms for NO-Dependent Vascular Remodeling Different From Vasorelaxation In Vivo?

CD36 Goes Native

Adipose Tissue Lymphocytes and Macrophages in Obesity and Insulin Resistance: Makers or Markers, and Which Comes First?

A Central Resource for Platelet Proteomics

Double Tribble: Two TRIB3 Variants, Insulin, Akt, and eNOS

A Novel Role for Adiponectin in the Regulation of Inflammation

The Time for Cardiovascular Inflammation Reduction Trials Has Arrived: How Low to Go for hsCRP?

Brief Reviews

Overproduction of Very Low–Density Lipoproteins Is the Hallmark of the Dyslipidemia in the Metabolic Syndrome

Integrative Physiology/Experimental Medicine

Temporally Expressed PDGF and FGF-2 Regulate Embryonic Coronary Artery Formation and Growth

Role of Smooth Muscle cGMP/cGKI Signaling in Murine Vascular Restenosis

Androgen Increases AT1a Receptor Expression in Abdominal Aortas to Promote Angiotensin II–Induced AAAs in Apolipoprotein E–Deficient Mice

Alpha2-Antiplasmin Is a Critical Regulator of Angiotensin II–Mediated Vascular Remodeling

SIRT1, a Longevity Gene, Downregulates Angiotensin II Type 1 Receptor Expression in Vascular Smooth Muscle Cells

Overexpression of ACE2 Enhances Plaque Stability in a Rabbit Model of Atherosclerosis

Acute Elevation of Plasma PLTP Activity Strongly Increases Pre-existing Atherosclerosis

CD44 Expressed on Both Bone Marrow–Derived and Non–Bone Marrow–Derived Cells Promotes Atherogenesis in ApoE-Deficient Mice

Mouse CD36 Has Opposite Effects on LDL and Oxidized LDL Metabolism In Vivo

Cholesterol Absorption From the Intestine Is a Major Determinant of Reverse Cholesterol Transport From Peripheral Tissue Macrophages

Coexpression of CLA-1 and Human PDZK1 in Murine Liver Modulates HDL Cholesterol Metabolism

T-lymphocyte Infiltration in Visceral Adipose Tissue: A Primary Event in Adipose Tissue Inflammation and the Development of Obesity-Mediated Insulin Resistance

Detection of Neovessels in Atherosclerotic Plaques of Rabbits Using Dynamic Contrast Enhanced MRI and 18F-FDG PET

Recombinant Activated Protein C Attenuates Endothelial Injury and Inhibits Procoagulant Microparticles Release in Baboon Heatstroke

Cell Biology and Signaling

Platelet Protein Interactions: Map, Signaling Components, and Phosphorylation Groundstate

Intracellular Localization of Cthrc1 Characterizes Differentiated Smooth Muscle

KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

Nox4 and Nox2 NADPH Oxidases Mediate Distinct Cellular Redox Signaling Responses to Agonist Stimulation

TRIB3 R84 Variant Is Associated With Impaired Insulin-Mediated Nitric Oxide Production in Human Endothelial Cells

Urokinase Plasminogen Activator Upregulates Paraoxonase 2 Expression in Macrophages Via an NADPH Oxidase-Dependent Mechanism

Adiponectin Decreases C-Reactive Protein Synthesis and Secretion From Endothelial Cells: Evidence for an Adipose Tissue-Vascular Loop

Complete Downmodulation of P-Selectin Glycoprotein Ligand in Monocytes Undergoing Apoptosis

Clinical and Population Studies

Prognostic Value of Leukocyte Telomere Length in Patients With Stable Coronary Artery Disease: Data From the Heart and Soul Study

High-Sensitivity C-Reactive Protein and Coronary Heart Disease in a General Population of Japanese: The Hisayama Study

Distension of the Carotid Artery and Risk of Coronary Events: The Three-City Study

Do Psychological Factors Affect Inflammation and Incident Coronary Heart Disease: The Whitehall II Study

Polymorphisms of the IL1-Receptor Antagonist Gene (IL1RN) Are Associated With Multiple Markers of Systemic Inflammation

Corrections

Correction

Spotlight