Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (28 [6])

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Volume 28, Issue 6; June 1, 2008

Editorials
Brief Reviews
Integrative Physiology/Experimental Medicine
Corrections
Cell Biology and Signaling
Clinical and Population Studies
Abstracts of the Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2008

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	Editorials
	The Homocysteine Paradox Roman N. Rodionov and Steven R. Lentz Arterioscler Thromb Vasc Biol. 2008;28:1031-1033, doi:10.1161/ATVBAHA.108.164830 Full Text \| PDF
	"Priming" Endothelial Progenitor Cells: A New Strategy to Improve Cell Based Therapeutics Geoffrey C. Gurtner and Edwin Chang Arterioscler Thromb Vasc Biol. 2008;28:1034-1035, doi:10.1161/ATVBAHA.108.163246 Full Text \| PDF
	Preventing Stenosis by Local Inhibition of K_Ca3.1: A Finger on the Phenotypic Switch Karen M. Lounsbury Arterioscler Thromb Vasc Biol. 2008;28:1036-1038, doi:10.1161/ATVBAHA.108.164988 Full Text \| PDF
	Brief Reviews
	Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk Jean-Pierre Després, Isabelle Lemieux, Jean Bergeron, Philippe Pibarot, Patrick Mathieu, Eric Larose, Josep Rodés-Cabau, Olivier F. Bertrand, and Paul Poirier Arterioscler Thromb Vasc Biol. 2008;28:1039-1049; published online before print March 20 2008, doi:10.1161/ATVBAHA.107.159228 Abstract \| Full Text \| PDF
	Regulation of Macrophage Functions by PPAR- ${alpha}$ , PPAR- ${gamma}$ , and LXRs in Mice and Men Elena Rigamonti, Giulia Chinetti-Gbaguidi, and Bart Staels Arterioscler Thromb Vasc Biol. 2008;28:1050-1059; published online before print March 6 2008, doi:10.1161/ATVBAHA.107.158998 Abstract \| Full Text \| PDF
	Regulation of Endogenous Apolipoprotein E Secretion by Macrophages Maaike Kockx, Wendy Jessup, and Leonard Kritharides Arterioscler Thromb Vasc Biol. 2008;28:1060-1067; published online before print April 3 2008, doi:10.1161/ATVBAHA.108.164350 Abstract \| Full Text \| PDF
	Integrative Physiology/Experimental Medicine
	Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus Naoto Sasaki, Tomoya Yamashita, Tomofumi Takaya, Masakazu Shinohara, Rio Shiraki, Masafumi Takeda, Noriaki Emoto, Akiko Fukatsu, Toshio Hayashi, Kazuhisa Ikemoto, Takahide Nomura, Mitsuhiro Yokoyama, Ken-ichi Hirata, and Seinosuke Kawashima Arterioscler Thromb Vasc Biol. 2008;28:1068-1076; published online before print April 10 2008, doi:10.1161/ATVBAHA.107.160754 Abstract \| Full Text \| PDF \| Data Supplement In streptozotocin-induced diabetic mice, diabetes accelerated vascular remodeling in association with augmented superoxide production from the uncoupled eNOS. Exogenous tetrahydrobiopterin inhibited the augmentation of remodeling process by restoring eNOS coupling. These findings may provide a new crew to therapeutic strategy for diabetic vascular complication.
	CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model Hironobu Matsumae, Yoshinori Yoshida, Koh Ono, Kiyonori Togi, Katsumi Inoue, Yutaka Furukawa, Yasuhiro Nakashima, Yoji Kojima, Masakiyo Nobuyoshi, Toru Kita, and Makoto Tanaka Arterioscler Thromb Vasc Biol. 2008;28:1077-1083; published online before print April 3 2008, doi:10.1161/ATVBAHA.108.162362 Abstract \| Full Text \| PDF \| Data Supplement
	Local Delivery of the K_Ca3.1 Blocker, TRAM-34, Prevents Acute Angioplasty-Induced Coronary Smooth Muscle Phenotypic Modulation and Limits Stenosis D.L. Tharp, B.R. Wamhoff, H. Wulff, G. Raman, A. Cheong, and D.K. Bowles Arterioscler Thromb Vasc Biol. 2008;28:1084-1089; published online before print February 28 2008, doi:10.1161/ATVBAHA.107.155796 Abstract \| Full Text \| PDF The objective of the present study was to determine the role of KCa3.1 in the regulation of coronary smooth muscle cell (SMC) phenotypic modulation in a swine model of postangioplasty restenosis. Blockade of KCa3.1 by delivery of TRAM-34 via balloon catheter prevented SMC phenotypic modulation and limited subsequent restenosis.
	A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice Vincent Braunersreuther, Sabine Steffens, Claire Arnaud, Graziano Pelli, Fabienne Burger, Amanda Proudfoot, and François Mach Arterioscler Thromb Vasc Biol. 2008;28:1090-1096; published online before print April 3 2008, doi:10.1161/ATVBAHA.108.165423 Abstract \| Full Text \| PDF \| Data Supplement
	Increased ADAM17 mRNA Expression and Activity Is Associated With Atherosclerosis Resistance in LDL-Receptor Deficient Mice Lesca M. Holdt, Joachim Thiery, Jan L. Breslow, and Daniel Teupser Arterioscler Thromb Vasc Biol. 2008;28:1097-1103; published online before print March 20 2008, doi:10.1161/ATVBAHA.108.165654 Abstract \| Full Text \| PDF \| Data Supplement In previous work, we have identified an atherosclerosis susceptibility quantitative trait locus (QTL) on mouse chromosome 12 in an F2-intercross of LDL receptor-deficient FVB and C57BL/6 mice. Using expression QTL mapping and functional assays, we identified the metalloproteinase ADAM17 as a candidate gene of atherosclerosis susceptibility at this locus.
	Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice Michael Altenburg, Jose Arbones-Mainar, Lance Johnson, Jennifer Wilder, and Nobuyo Maeda Arterioscler Thromb Vasc Biol. 2008;28:1104-1110; published online before print March 27 2008, doi:10.1161/ATVBAHA.108.164863 Abstract \| Full Text \| PDF \| Data Supplement Increased LDLR expression enhances sequestration of apoE4 and VLDL on the hepatocyte surface but delays the internalization of VLDL. In contrast, apoE2, having low LDLR affinity, freely associates with VLDL in circulation and assists internalization when LDLR expression is high. This mechanism may contribute to the lipoprotein profiles associated with apoE isoforms.
	Thrombocytopenia and Platelet Abnormalities in High-Density Lipoprotein Receptor–Deficient Mice Vandana S. Dole, Jana Matuskova, Eliza Vasile, Ayce Yesilaltay, Wolfgang Bergmeier, Michael Bernimoulin, Denisa D. Wagner, and Monty Krieger Arterioscler Thromb Vasc Biol. 2008;28:1111-1116; published online before print April 24 2008, doi:10.1161/ATVBAHA.108.162347 Abstract \| Full Text \| PDF \| Data Supplement The high UC:TC ratio associated with SR-BI deficiency in mice is correlated with platelet abnormalities, including high cholesterol content, abnormal morphologies, high clearance rates, thrombocytopenia, and a minor defect in in vitro aggregation (blunted response to ADP).
	Ultrasonic Microbubble Destruction Stimulates Therapeutic Arteriogenesis Via the CD18-Dependent Recruitment of Bone Marrow–Derived Cells John C. Chappell, Ji Song, Alexander L. Klibanov, and Richard J. Price Arterioscler Thromb Vasc Biol. 2008;28:1117-1122; published online before print April 10 2008, doi:10.1161/ATVBAHA.108.165589 Abstract \| Full Text \| PDF \| Data Supplement Ultrasonic microbubble destruction represents a potential tool in therapeutic strategies, particularly in the targeted stimulation of neovascularization. In the current study, we demonstrate the ability of ultrasound-microbubble interactions to enhance arteriogenesis and perfusion in ischemic tissues through recruitment of marrow-derived cells via CD18. These observations support the development of ultrasound microbubble-based therapies.
	Cytochrome P450 2C9-Induced Angiogenesis Is Dependent on EphB4 Anke C. Webler, Rüdiger Popp, Thomas Korff, U. Ruth Michaelis, Carmen Urbich, Rudi Busse, and Ingrid Fleming Arterioscler Thromb Vasc Biol. 2008;28:1123-1129; published online before print March 13 2008, doi:10.1161/ATVBAHA.107.161190 Abstract \| Full Text \| PDF \| Data Supplement
	Microvascular Injury, Thrombosis, Inflammation, and Apoptosis in the Pathogenesis of Heatstroke: A Study in Baboon Model George T. Roberts, Hazem Ghebeh, Muhammad A. Chishti, Falah Al-Mohanna, Rafaat El-Sayed, Futwan Al-Mohanna, and Abderrezak Bouchama Arterioscler Thromb Vasc Biol. 2008;28:1130-1136; published online before print April 3 2008, doi:10.1161/ATVBAHA.107.158709 Abstract \| Full Text \| PDF \| Data Supplement Severe heatstroke is a leading cause of morbidity and mortality during heat waves. The pathogenesis of tissue injury and death in heatstroke is not well understood. Using a heatstroke baboon model, we showed that microvascular injury, thrombosis, inflammation, and apoptosis may play an important pathogenic role.
	Corrections
	Correction Arterioscler Thromb Vasc Biol. 2008;28:e150, doi:10.1161/ATVBAHA.107.654321 Full Text \| PDF
	Cell Biology and Signaling
	Upregulation of Aldose Reductase During Foam Cell Formation as Possible Link Among Diabetes, Hyperlipidemia, and Atherosclerosis Christian A. Gleissner, John M. Sanders, Jerry Nadler, and Klaus Ley Arterioscler Thromb Vasc Biol. 2008;28:1137-1143; published online before print May 1 2008, doi:10.1161/ATVBAHA.107.158295 Abstract \| Full Text \| PDF \| Data Supplement Aldose reductase (AR) is the rate-limiting enzyme of the polyol pathway, which is linked to microvascular complications in diabetes. Upregulation of AR gene expression and activity in macrophages during foam cell formation resulted in increased oxidative stress. AR expression in macrophages in human atherosclerotic lesions supports its role in atherogenesis.
	Epoxycholesterol Impairs Cholesteryl Ester Hydrolysis in Macrophage Foam Cells, Resulting in Decreased Cholesterol Efflux Mireille Ouimet, Ming-Dong Wang, Natalie Cadotte, Kenneth Ho, and Yves L. Marcel Arterioscler Thromb Vasc Biol. 2008;28:1144-1150; published online before print March 27 2008, doi:10.1161/ATVBAHA.107.157115 Abstract \| Full Text \| PDF \| Data Supplement We report that in cholesterol-loaded macrophages, epoxycholesterol decreases ABCA1- and ABCG1-mediated cholesterol efflux, despite increasing the expression of both transporters. We show that epoxycholesterol impairs cholesteryl ester hydrolysis activity in macrophage foam cells, thus reducing the availability of cholesterol for efflux to apoA-I and HDL.
	Aliskiren-Binding Increases the Half Life of Renin and Prorenin in Rat Aortic Vascular Smooth Muscle Cells Wendy W. Batenburg, René J.A. de Bruin, Jeanette M.G. van Gool, Dominik N. Müller, Michael Bader, Geneviève Nguyen, and A. H. Jan Danser Arterioscler Thromb Vasc Biol. 2008;28:1151-1157; published online before print April 3 2008, doi:10.1161/ATVBAHA.108.164210 Abstract \| Full Text \| PDF Renin inhibition with aliskiren causes a large rise in renin, potentially leading to angiotensin generation or stimulation of the (pro)renin receptor ((P)RR). This study shows that the renin rise relates to the detection of prorenin as renin and to a decrease in (pro)renin clearance. Aliskiren does not affect (pro)renin-(P)RR binding.
	Clinical and Population Studies
	Homocysteine or Renal Impairment: Which Is the Real Cardiovascular Risk Factor? Kathleen Potter, Graeme J. Hankey, Daniel J. Green, John W. Eikelboom, and Leonard F. Arnolda Arterioscler Thromb Vasc Biol. 2008;28:1158-1164; published online before print March 20 2008, doi:10.1161/ATVBAHA.108.162743 Abstract \| Full Text \| PDF We tested the effect of adjusting for renal function on the relationship between plasma homocysteine concentrations (tHcy) and carotid intima medial thickness (CIMT) and flow-mediated dilation (FMD) with regression analysis of randomized data from 173 stroke patients. Adjusting for renal function eliminated the association between tHcy and CIMT and FMD.
	Leukocyte Telomere Length and Carotid Artery Intimal Medial Thickness: The Framingham Heart Study Christopher J. O’Donnell, Serkalem Demissie, Masayuki Kimura, Daniel Levy, Jeffery P. Gardner, Charles White, Ralph B. D’Agostino, Philip A. Wolf, Joseph Polak, L. Adrienne Cupples, and Abraham Aviv Arterioscler Thromb Vasc Biol. 2008;28:1165-1171; published online before print April 3 2008, doi:10.1161/ATVBAHA.107.154849 Abstract \| Full Text \| PDF
	Cardiovascular Events With Increased Lipoprotein-Associated Phospholipase A₂ and Low High-Density Lipoprotein-Cholesterol: The Veterans Affairs HDL Intervention Trial Sander J. Robins, Dorothea Collins, Jeanenne J. Nelson, Hanna E. Bloomfield, and Bela F. Asztalos Arterioscler Thromb Vasc Biol. 2008;28:1172-1178; published online before print March 20 2008, doi:10.1161/ATVBAHA.107.160739 Abstract \| Full Text \| PDF The phospholipase, Lp-PLA2 is known to be associated with LDL and an increase in cardiovascular events. We show in the VA-HIT population with both low HDL-C and low LDL-C that Lp-PLA2 was significantly increased, independently associated with increased cardiovascular events, and reduced by gemfibrozil therapy.
	Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004 Michal L. Melamed, Paul Muntner, Erin D. Michos, Jaime Uribarri, Collin Weber, Jyotirmay Sharma, and Paolo Raggi Arterioscler Thromb Vasc Biol. 2008;28:1179-1185; published online before print April 16 2008, doi:10.1161/ATVBAHA.108.165886 Abstract \| Full Text \| PDF Vitamin D is an inhibitor of the renin-angiotensin system and has antiinflammatory and anticoagulant properties. Among 4839 NHANES 2001 to 2004 participants, low 25(OH)D levels were associated with a higher prevalence of PAD, after multivariate adjustment. To confirm this association, longitudinal cohort and mechanistic studies are needed.
	Uric Acid Levels Are Associated With All-Cause and Cardiovascular Disease Mortality Independent of Systemic Inflammation in Men From the General Population: The MONICA/KORA Cohort Study Christa Meisinger, Wolfgang Koenig, Jens Baumert, and Angela Döring Arterioscler Thromb Vasc Biol. 2008;28:1186-1192; published online before print March 20 2008, doi:10.1161/ATVBAHA.107.160184 Abstract \| Full Text \| PDF Uric acid levels are associated with CVD mortality and all-cause mortality in middle-aged men from the general population independent of conventional cardiovascular risk factors, C-reactive protein, and diuretic intake. Thus, the measurement of UA may turn out as a useful tool for improved individual cardiovascular risk assessment, in addition to conventional risk factors.
	Association of Stearoyl-CoA Desaturase 1 Activity With Familial Combined Hyperlipidemia Rebecca Mar-Heyming, Makoto Miyazaki, Daphna Weissglas-Volkov, Nicholas A. Kolaitis, Narimaan Sadaat, Christopher Plaisier, Päivi Pajukanta, Rita M. Cantor, Tjerk W.A. de Bruin, James M. Ntambi, and Aldons J. Lusis Arterioscler Thromb Vasc Biol. 2008;28:1193-1199; published online before print March 13 2008, doi:10.1161/ATVBAHA.107.160150 Abstract \| Full Text \| PDF We used the fatty acid desaturation index to investigate the relationship of SCD1 to FCHL. The fatty acid desaturation index was elevated in FCHL individuals (P<0.0001). Specific haplotypes of HNF4{alpha} (P=0.002) were modestly associated with the desaturation index.
	Cholesterol Synthesis Inhibition Elicits an Integrated Molecular Response in Human Livers Including Decreased ACAT2 Paolo Parini, Ulf Gustafsson, Matt A. Davis, Lilian Larsson, Curt Einarsson, Martha Wilson, Mats Rudling, Hiroshi Tomoda, Satoshi Omura, Staffan Sahlin, Bo Angelin, Lawrence L. Rudel, and Mats Eriksson Arterioscler Thromb Vasc Biol. 2008;28:1200-1206; published online before print March 13 2008, doi:10.1161/ATVBAHA.107.157172 Abstract \| Full Text \| PDF \| Data Supplement Thirty-seven normocholesterolemic gallstone patients randomized to placebo, 20 mg/d fluvastatin, or 80 mg/d atorvastatin for 4 weeks were studied. Cholesterol synthesis in liver was reduced by 42% and 70% in the 2 groups receiving statins. Associated decreases in VLDL cholesterol of 20% and 55%, respectively, were shown. The activity, protein, and mRNA for hepatic ACAT2 were decreased in response to statins as was apoE mRNA.
	Abstracts of the Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2008
	2008 ATVB Oral Presentations Arterioscler Thromb Vasc Biol. 2008;28:e32-e149, doi:10.1161/01.ATV.0000319737.80976.26 PDF

Spotlight

TOC Spotlight File

Volume 28, Issue 6; June 1, 2008

Editorials

The Homocysteine Paradox

"Priming" Endothelial Progenitor Cells: A New Strategy to Improve Cell Based Therapeutics

Preventing Stenosis by Local Inhibition of KCa3.1: A Finger on the Phenotypic Switch

Brief Reviews

Abdominal Obesity and the Metabolic Syndrome: Contribution to Global Cardiometabolic Risk

Regulation of Macrophage Functions by PPAR-, PPAR-, and LXRs in Mice and Men

Regulation of Endogenous Apolipoprotein E Secretion by Macrophages

Integrative Physiology/Experimental Medicine

Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus

CCN1 Knockdown Suppresses Neointimal Hyperplasia in a Rat Artery Balloon Injury Model

Local Delivery of the KCa3.1 Blocker, TRAM-34, Prevents Acute Angioplasty-Induced Coronary Smooth Muscle Phenotypic Modulation and Limits Stenosis

A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice

Increased ADAM17 mRNA Expression and Activity Is Associated With Atherosclerosis Resistance in LDL-Receptor Deficient Mice

Human LDL Receptor Enhances Sequestration of ApoE4 and VLDL Remnants on the Surface of Hepatocytes but Not Their Internalization in Mice

Thrombocytopenia and Platelet Abnormalities in High-Density Lipoprotein Receptor–Deficient Mice

Ultrasonic Microbubble Destruction Stimulates Therapeutic Arteriogenesis Via the CD18-Dependent Recruitment of Bone Marrow–Derived Cells

Cytochrome P450 2C9-Induced Angiogenesis Is Dependent on EphB4

Microvascular Injury, Thrombosis, Inflammation, and Apoptosis in the Pathogenesis of Heatstroke: A Study in Baboon Model

Corrections

Correction

Cell Biology and Signaling

Upregulation of Aldose Reductase During Foam Cell Formation as Possible Link Among Diabetes, Hyperlipidemia, and Atherosclerosis

Epoxycholesterol Impairs Cholesteryl Ester Hydrolysis in Macrophage Foam Cells, Resulting in Decreased Cholesterol Efflux

Aliskiren-Binding Increases the Half Life of Renin and Prorenin in Rat Aortic Vascular Smooth Muscle Cells

Clinical and Population Studies

Homocysteine or Renal Impairment: Which Is the Real Cardiovascular Risk Factor?

Leukocyte Telomere Length and Carotid Artery Intimal Medial Thickness: The Framingham Heart Study

Cardiovascular Events With Increased Lipoprotein-Associated Phospholipase A2 and Low High-Density Lipoprotein-Cholesterol: The Veterans Affairs HDL Intervention Trial

Serum 25-Hydroxyvitamin D Levels and the Prevalence of Peripheral Arterial Disease: Results from NHANES 2001 to 2004

Uric Acid Levels Are Associated With All-Cause and Cardiovascular Disease Mortality Independent of Systemic Inflammation in Men From the General Population: The MONICA/KORA Cohort Study

Association of Stearoyl-CoA Desaturase 1 Activity With Familial Combined Hyperlipidemia

Cholesterol Synthesis Inhibition Elicits an Integrated Molecular Response in Human Livers Including Decreased ACAT2

Abstracts of the Arteriosclerosis, Thrombosis, and Vascular Biology Annual Conference 2008

2008 ATVB Oral Presentations

Spotlight

Preventing Stenosis by Local Inhibition of K_Ca3.1: A Finger on the Phenotypic Switch

Regulation of Macrophage Functions by PPAR- ${alpha}$ , PPAR- ${gamma}$ , and LXRs in Mice and Men

Local Delivery of the K_Ca3.1 Blocker, TRAM-34, Prevents Acute Angioplasty-Induced Coronary Smooth Muscle Phenotypic Modulation and Limits Stenosis

Cardiovascular Events With Increased Lipoprotein-Associated Phospholipase A₂ and Low High-Density Lipoprotein-Cholesterol: The Veterans Affairs HDL Intervention Trial