Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (28 [12])

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Volume 28, Issue 12; December 1, 2008

Editorials
Brief Reviews
Integrative Physiology/Experimental Medicine
Cell Biology/Signaling
Clinical and Population Studies
Author Index
Letters to the Editor

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

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	Editorials
	"FRNKly, Smooth Muscle, I Don’t Give a CArG!": A Novel Mechanism for Smooth Muscle Cell Differentiation Julia A. Lemmon and Brian R. Wamhoff Arterioscler Thromb Vasc Biol. 2008;28:2091-2093, doi:10.1161/ATVBAHA.108.176875 Extract \| Full Text \| PDF
	Ninein Leads the Way in Vessel Sprouting Victoria L. Bautch Arterioscler Thromb Vasc Biol. 2008;28:2094-2095, doi:10.1161/ATVBAHA.108.176180 Extract \| Full Text \| PDF
	Macrophage Glucocorticoid Receptors Join the Intercellular Dialogue in Atherosclerotic Lesion Calcification Robert Terkeltaub Arterioscler Thromb Vasc Biol. 2008;28:2096-2098, doi:10.1161/ATVBAHA.108.176461 Extract \| Full Text \| PDF
	Affirmative Action of Osteopontin on Endothelial Progenitors Daniel G.M. Molin, Nynke M.S van den Akker, and Mark J. Post Arterioscler Thromb Vasc Biol. 2008;28:2099-2100, doi:10.1161/ATVBAHA.108.176446 Extract \| Full Text \| PDF
	Brief Reviews
	The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis Cornelia Hahn and Martin A. Schwartz Arterioscler Thromb Vasc Biol. 2008;28:2101-2107; published online before print September 11 2008, doi:10.1161/ATVBAHA.108.165951 Abstract \| Full Text \| PDF
	Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability Andrew C. Newby Arterioscler Thromb Vasc Biol. 2008;28:2108-2114; published online before print September 4 2008, doi:10.1161/ATVBAHA.108.173898 Abstract \| Full Text \| PDF \| Data Supplement Overproduction of matrix metalloproteinases from macrophages plays a role in plaque rupture and myocardial infarction. Freshly recruited monocytes use a PG-dependent pathway to coordinately upregulate a highly destructive spectrum of MMPs. Resident macrophages rely on a series of pathways, including activation of nuclear factor {kappa}B, to achieve graded upregulation of MMPs.
	Integrative Physiology/Experimental Medicine
	FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury Rebecca L. Sayers, Liisa J. Sundberg-Smith, Mauricio Rojas, Haruko Hayasaka, J. Thomas Parsons, Christopher P. Mack, and Joan M. Taylor Arterioscler Thromb Vasc Biol. 2008;28:2115-2122; published online before print September 11 2008, doi:10.1161/ATVBAHA.108.175455 Abstract \| Full Text \| PDF \| Data Supplement A specific focal adhesion kinase inhibitor termed FRNK is selectively expressed in medial smooth muscle cells in postnatal large arterioles. We found that ectopic expression of FRNK promotes smooth muscle maturation, whereas vessels from FRNK-/- mice exhibit attenuated smooth muscle marker gene expression during postnatal growth and after vascular injury.
	Ninein Is Expressed in the Cytoplasm of Angiogenic Tip-Cells and Regulates Tubular Morphogenesis of Endothelial Cells Taro Matsumoto, Petter Schiller, Lothar C. Dieterich, Fuad Bahram, Yuji Iribe, Ulf Hellman, Charlotte Wikner, Gordon Chan, Lena Claesson-Welsh, and Anna Dimberg Arterioscler Thromb Vasc Biol. 2008;28:2123-2130; published online before print September 4 2008, doi:10.1161/ATVBAHA.108.169128 Abstract \| Full Text \| PDF Proteins orchestrating morphological changes accompanying formation of the vascular tube constitute new targets for antiangiogenic therapy. In this study, we identify the microtubule-anchoring protein ninein as an important new regulator of tubular morphogenesis of endothelial cells. This is the first report of a functional role of ninein in angiogenesis.
	Estrogen-Stimulated Endothelial Repair Requires Osteopontin Laetitia Lam Shang Leen, Cédric Filipe, Audrey Billon, Barbara Garmy-Susini, Sandra Jalvy, Fanny Robbesyn, Danièle Daret, Cécile Allières, Susan R. Rittling, Nikos Werner, Georg Nickenig, Urban Deutsch, Cécile Duplàa, Pascale Dufourcq, Françoise Lenfant, Claude Desgranges, Jean-François Arnal, and Alain-Pierre Gadeau Arterioscler Thromb Vasc Biol. 2008;28:2131-2136; published online before print September 4 2008, doi:10.1161/ATVBAHA.108.167965 Abstract \| Full Text \| PDF \| Data Supplement Estradiol (E2) is known to accelerate endothelial repair and thus prevent intimal thickening and in-stent restenosis after angioplasty. However, the mechanisms are poorly understood.
	Bone Morphogenetic Proteins 2 and 4 Are Selectively Expressed by Late Outgrowth Endothelial Progenitor Cells and Promote Neoangiogenesis David M. Smadja, Ivan Bièche, Jean-Sébastien Silvestre, Stéphane Germain, Adeline Cornet, Ingrid Laurendeau, Jean-Paul Duong-Van-Huyen, Joseph Emmerich, Michel Vidaud, Martine Aiach, and Pascale Gaussem Arterioscler Thromb Vasc Biol. 2008;28:2137-2143; published online before print September 25 2008, doi:10.1161/ATVBAHA.108.168815 Abstract \| Full Text \| PDF \| Data Supplement We report that bone morphogenetic proteins 2 and 4 (BMP2/4) are selectively expressed by ECFCs but not by CFU-Hill. The BMP pathway is involved in ECFC commitment and angiogenic potential. Newly formed vessels observed after BM-MNC injection in patients with critical leg ischemia were strongly positive for BMP2/4.
	Myocyte Specific Overexpression of Myoglobin Impairs Angiogenesis After Hind-Limb Ischemia Surovi Hazarika, Michael Angelo, Yongjun Li, Amy J. Aldrich, Shelley I. Odronic, Zhen Yan, Jonathan S. Stamler, and Brian H. Annex Arterioscler Thromb Vasc Biol. 2008;28:2144-2150; published online before print September 25 2008, doi:10.1161/ATVBAHA.108.170951 Abstract \| Full Text \| PDF \| Data Supplement We hypothesized that myocyte specific overexpression of myoglobin (Mb) would attenuate ischemia-induced angiogenesis, despite normal endothelium. Mb overexpressing transgenic and wild-type mice underwent unilateral femoral artery ligation/excision. Increased Mb expression attenuates angiogenesis after hind-limb ischemia by binding NO and reducing its bioavailability, even in the setting of normal endothelium.
	Contribution of Bone Marrow–Derived Cells Associated With Brain Angiogenesis Is Primarily Through CD69⁺ Qi Hao, Jianrong Liu, Rajita Pappu, Hua Su, Radoslaw Rola, Rodney A. Gabriel, Chanhung Z. Lee, William L. Young, and Guo-Yuan Yang Arterioscler Thromb Vasc Biol. 2008;28:2151-2157; published online before print September 18 2008, doi:10.1161/ATVBAHA.108.176297 Abstract \| Full Text \| PDF \| Data Supplement
	Critical Role of Macrophages in Glucocorticoid Driven Vascular Calcification in a Mouse-Model of Atherosclerosis Michael R. Preusch, Marcello Rattazzi, Claudia Albrecht, Uta Merle, Jan Tuckermann, Günther Schütz, Erwin Blessing, Giacomo Zoppellaro, Paolo Pauletto, Robert Krempien, Michael E. Rosenfeld, Hugo A. Katus, and Florian Bea Arterioscler Thromb Vasc Biol. 2008;28:2158-2164; published online before print September 11 2008, doi:10.1161/ATVBAHA.108.174128 Abstract \| Full Text \| PDF \| Data Supplement Inflammation and glucocorticoids participate in vascular calcification. The deletion of the glucocorticoid receptor in macrophages attenuated vascular calcification in mice. Bovine smooth muscle cells revealed increased calcium deposition after treatment with conditioned medium from glucocorticoid-treated macrophages. This study demonstrates that macrophages play an important role in glucocorticoid-dependent vascular calcification.
	Clones of Interstitial Cells From Bovine Aortic Valve Exhibit Different Calcifying Potential When Exposed to Endotoxin and Phosphate Marcello Rattazzi, Laura Iop, Elisabetta Faggin, Elisa Bertacco, Giacomo Zoppellaro, Ilenia Baesso, Massimo Puato, Gianluca Torregrossa, Gian Paolo Fadini, Carlo Agostini, Gino Gerosa, Saverio Sartore, and Paolo Pauletto Arterioscler Thromb Vasc Biol. 2008;28:2165-2172; published online before print October 2 2008, doi:10.1161/ATVBAHA.108.174342 Abstract \| Full Text \| PDF \| Data Supplement In response to endotoxin and elevated phosphate levels a specific subtype of interstitial valve cells, harboring a fibroblast-like phenotype, acquires a unique procalcific profile, promoting collagen-matrix calcification.
	In Vivo and In Vitro Inhibition of Monocyte Adhesion to Endothelial Cells and Endothelial Adhesion Molecules by Eicosapentaenoic Acid Hideto Yamada, Masayuki Yoshida, Yasutaka Nakano, Takayoshi Suganami, Noriko Satoh, Tomoya Mita, Kosuke Azuma, Michiko Itoh, Yukio Yamamoto, Yasutomi Kamei, Minoru Horie, Hirotaka Watada, and Yoshihiro Ogawa Arterioscler Thromb Vasc Biol. 2008;28:2173-2179; published online before print October 23 2008, doi:10.1161/ATVBAHA.108.171736 Abstract \| Full Text \| PDF \| Data Supplement This study provides evidence that EPA inhibits monocyte adhesion to endothelial cells in parallel with the suppression of endothelial adhesion molecules and nuclear translocation of NF-{kappa}B p65 in vivo and in vitro, thereby facilitating the better understanding of the molecular mechanism underlying the antiatherogenic effect of EPA.
	Athsq1 Is an Atherosclerosis Modifier Locus With Dramatic Effects on Lesion Area and Prominent Accumulation of Versican Sara Bretschger Seidelmann, Chaoling Kuo, Nick Pleskac, Jennifer Molina, Scott Sayers, Rong Li, Jing Zhou, Pamela Johnson, Kathleen Braun, Christina Chan, Daniel Teupser, Jan L. Breslow, Thomas N. Wight, Alan R. Tall, and Carrie L. Welch Arterioscler Thromb Vasc Biol. 2008;28:2180-2186; published online before print September 25 2008, doi:10.1161/ATVBAHA.108.176800 Abstract \| Full Text \| PDF \| Data Supplement
	Molecular Mechanisms of Atherosclerosis in Metabolic Syndrome: Role of Reduced IRS2-Dependent Signaling Herminia González-Navarro, Ángela Vinué, Marian Vila-Caballer, Ana Fortuño, Oscar Beloqui, Guillermo Zalba, Deborah Burks, Javier Díez, and Vicente Andrés Arterioscler Thromb Vasc Biol. 2008;28:2187-2194; published online before print September 18 2008, doi:10.1161/ATVBAHA.108.175299 Abstract \| Full Text \| PDF \| Data Supplement Here we investigated the role of IRS2-dependent signaling in MetS states by analyzing leukocytes from MetS patients, apoE-null mice with partial inactivation of Irs2, and cultured cells. Our results suggest that MCP1 upregulation resulting from reduced IRS2 expression and accompanying defects in AKT2 and Ras/ERK1/2 signaling may contribute to MetS-induced atherosclerosis.
	Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice Yukinori Tamura, Masayuki Sugimoto, Toshinori Murayama, Yukihiko Ueda, Hiroshi Kanamori, Koh Ono, Hiroyuki Ariyasu, Takashi Akamizu, Toru Kita, Masayuki Yokode, and Hidenori Arai Arterioscler Thromb Vasc Biol. 2008;28:2195-2201; published online before print September 25 2008, doi:10.1161/ATVBAHA.108.168633 Abstract \| Full Text \| PDF \| Data Supplement To examine the role of CCR2 in the development of obesity and type 2 diabetes, we studied the effect of inhibition of CCR2 by propagermanium treatment in db/db mice. Propagermanium improved obesity-related metabolic disorders, implicating that inhibition of CCR2 improves obesity and type 2 diabetes by interfering adipose tissue inflammation.
	Deficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice Min Yang, Jiusong Sun, Tinghu Zhang, Jian Liu, Jie Zhang, Michael A. Shi, Froogh Darakhshan, Michèle Guerre-Millo, Karine Clement, Bruce D. Gelb, Gregory Dolgnov, and Guo-Ping Shi Arterioscler Thromb Vasc Biol. 2008;28:2202-2208; published online before print September 25 2008, doi:10.1161/ATVBAHA.108.172320 Abstract \| Full Text \| PDF \| Data Supplement
	Hypercholesterolemia Enhances 15-Lipoxygenase–Mediated Vasorelaxation and Acetylcholine-Induced Hypotension Nitin T. Aggarwal, Sandra L. Pfister, and William B. Campbell Arterioscler Thromb Vasc Biol. 2008;28:2209-2215; published online before print October 2 2008, doi:10.1161/ATVBAHA.108.177113 Abstract \| Full Text \| PDF \| Data Supplement
	Notch3 Is a Major Regulator of Vascular Tone in Cerebral and Tail Resistance Arteries E.J. Belin de Chantemèle, K. Retailleau, F. Pinaud, E. Vessières, A. Bocquet, A.L. Guihot, B. Lemaire, V. Domenga, C. Baufreton, L. Loufrani, A. Joutel, and D. Henrion Arterioscler Thromb Vasc Biol. 2008;28:2216-2224; published online before print September 25 2008, doi:10.1161/ATVBAHA.108.171751 Abstract \| Full Text \| PDF \| Data Supplement Notch3 regulates arterial differentiation and postnatal maturation of smooth muscle cells. By using arteries from Notch3 knockout mice we found that Notch3 plays an important role in the control of resistance arteries mechano-transduction, by modulating the RhoA/Rho kinase pathway, which is involved in pressure-induced (myogenic) tone.
	Differential Role of von Willebrand Factor and P-Selectin on Microvascular Thrombosis in Endotoxemia Kavita N. Patel, Said H. Soubra, Ricardo V. Bellera, Jing-Fei Dong, Colleen A. McMullen, Alan R. Burns, and Rolando E. Rumbaut Arterioscler Thromb Vasc Biol. 2008;28:2225-2230; published online before print September 18 2008, doi:10.1161/ATVBAHA.108.175679 Abstract \| Full Text \| PDF Alhtough endotoxin is known to promote microvascular thrombosis, the mechanisms involved remain incompletely understood. Using an in vivo photochemical injury model of thrombosis in mouse cremaster microvessels, this study demonstrates that vWF, but not P-selectin, mediates microvascular thrombosis and its enhancement by endotoxin.
	Amiodarone Inhibits Arterial Thrombus Formation and Tissue Factor Translation A. Breitenstein, S.F. Stämpfli, G.G. Camici, A. Akhmedov, H.R. Ha, F. Follath, A. Bogdanova, T.F. Lüscher, and F.C. Tanner Arterioscler Thromb Vasc Biol. 2008;28:2231-2238; published online before print October 30 2008, doi:10.1161/ATVBAHA.108.171272 Abstract \| Full Text \| PDF \| Data Supplement
	Cell Biology/Signaling
	C-Reactive Protein Isoforms Differ in Their Effects on Thrombus Growth Blanca Molins, Esther Peña, Gemma Vilahur, Carlos Mendieta, Mark Slevin, and Lina Badimon Arterioscler Thromb Vasc Biol. 2008;28:2239-2246; published online before print September 11 2008, doi:10.1161/ATVBAHA.108.174359 Abstract \| Full Text \| PDF \| Data Supplement In this work, confocal microscopy analysis of thrombus growth under arterial flow showed that the monomeric isoform of C-reactive protein induces a prothrombotic effect. mCRP significantly enhanced platelet deposition and thrombus growth when incubated with blood and when immobilized on collagen, whereas natCRP was unable to produce such an effect.
	Cellular Procoagulant Activity Dictates Clot Structure and Stability as a Function of Distance From the Cell Surface Robert A. Campbell, Katherine A. Overmyer, C. Robert Bagnell, and Alisa S. Wolberg Arterioscler Thromb Vasc Biol. 2008;28:2247-2254; published online before print October 30 2008, doi:10.1161/ATVBAHA.108.176008 Abstract \| Full Text \| PDF \| Data Supplement Thrombin generation on the cell surface produced clots with a denser fiber network that was resistant to fibrinolysis in regions proximal versus distal to the cell surface. Our results suggest thrombin generation on the cell modulates the structure and function of the clot in three dimensions.
	Inhibition of Tumor Necrosis Factor ${alpha}$ –Stimulated Monocyte Adhesion to Human Aortic Endothelial Cells by AMP-Activated Protein Kinase Marie-Ann Ewart, Christine F. Kohlhaas, and Ian P. Salt Arterioscler Thromb Vasc Biol. 2008;28:2255-2257; published online before print September 18 2008, doi:10.1161/ATVBAHA.108.175919 Abstract \| Full Text \| PDF \| Data Supplement We investigated the functional effects of AMPK activation in cultured human endothelial cells. Stimulation of AMPK inhibited TNF{alpha}-stimulated monocyte adhesion by two distinct mechanisms: a rapid NO-dependent mechanism associated with a reduction in chemokine release and a late NO-independent mechanism whereby adhesion molecule expression is suppressed.
	Impaired Notch4 Activity Elicits Endothelial Cell Activation and Apoptosis: Implication for Transplant Arteriosclerosis T. Quillard, S. Coupel, F. Coulon, J. Fitau, M. Chatelais, M.C. Cuturi, E. Chiffoleau, and B. Charreau Arterioscler Thromb Vasc Biol. 2008;28:2258-2265; published online before print September 18 2008, doi:10.1161/ATVBAHA.108.174995 Abstract \| Full Text \| PDF \| Data Supplement Notch pathway controls key functions in vascular cells. Here we report that Notch2, -3, and -4 transcripts are downregulated in transplant arteriosclerosis. Consistently, inflammatory cytokines decrease Notch4 expression and Notch activity in endothelial cells. Notch4 or Hes1 knockdown promotes endothelial activation and apoptosis, both events that contribute to transplant arteriosclerosis pathogenesis.
	High-Density Lipoproteins Affect Endothelial BMP-Signaling by Modulating Expression of the Activin-Like Kinase Receptor 1 and 2 Yucheng Yao, Esther S. Shao, Medet Jumabay, Ani Shahbazian, Sheng Ji, and Kristina I. Boström Arterioscler Thromb Vasc Biol. 2008;28:2266-2274; published online before print October 23 2008, doi:10.1161/ATVBAHA.108.176958 Abstract \| Full Text \| PDF \| Data Supplement High-density proteins (HDL) affect signaling by bone morphogenetic proteins (BMP), inflammatory mediators in endothelial cells. HDL promotes expression of the activin-like kinase receptor (ALK)2, a BMP-receptor, which stimulates ALK1 expression and allows for increased expression of VEGF and matrix Gla protein, thereby promoting vascular health.
	Advanced Glycation End-Product of Low Density Lipoprotein Activates the Toll-Like 4 Receptor Pathway Implications for Diabetic Atherosclerosis Conrad P. Hodgkinson, Ross C. Laxton, Kunal Patel, and Shu Ye Arterioscler Thromb Vasc Biol. 2008;28:2275-2281; published online before print September 25 2008, doi:10.1161/ATVBAHA.108.175992 Abstract \| Full Text \| PDF \| Data Supplement There is substantial evidence indicating that glycated LDL promotes atherosclerosis. However, the underlying mechanism remains unclear. Our study shows that glycated LDL activates Toll-like receptor 4, inducing proinflammatory cytokine production. This finding is of importance for understanding why diabetics are at increased risk of developing atherosclerosis.
	Involvement of Protein Kinase D in Phosphorylation and Increase of DNA Binding of Activator Protein 2 ${alpha}$ to Downregulate ATP-Binding Cassette Transporter A1 Noriyuki Iwamoto, Sumiko Abe-Dohmae, Rui Lu, and Shinji Yokoyama Arterioscler Thromb Vasc Biol. 2008;28:2282-2287; published online before print October 9 2008, doi:10.1161/ATVBAHA.108.174714 Abstract \| Full Text \| PDF \| Data Supplement PKD phosphorylates AP2{alpha} to negatively regulate expression of ABCA1 gene to increase HDL biogenesis. The major functional phosphorylation of AP2{alpha} was identified at Ser258 by PKD, in the AP2{alpha} basic domain highly conserved among species and all 5 subtypes of AP2.
	Liver X Receptor Activation Induces the Uptake of Cholesteryl Esters From High Density Lipoproteins in Primary Human Macrophages Stephanie Bultel, Lionel Helin, Veronique Clavey, Giulia Chinetti-Gbaguidi, Elena Rigamonti, Morvane Colin, Jean-Charles Fruchart, Bart Staels, and Sophie Lestavel Arterioscler Thromb Vasc Biol. 2008;28:2288-2295; published online before print September 18 2008, doi:10.1161/ATVBAHA.108.175042 Abstract \| Full Text \| PDF \| Data Supplement Our aim was to study whether, beside their known role in promoting cholesterol efflux from macrophages, the nuclear receptors LXR could also regulate cholesterol uptake from lipoproteins. In human macrophages, LXR activation strongly increases HDL-cholesteryl ester uptake by enhancing apoE and LPL secretion. These LXR effects require proteoglycans, raft integrity, and are correlated with caveolin-1 upregulation.
	Clinical and Population Studies
	Parental Smoking and Vascular Damage in Young Adult Offspring: Is Early Life Exposure Critical?: The Atherosclerosis Risk in Young Adults Study Caroline C. Geerts, Michiel L. Bots, Diederick E. Grobbee, and Cuno S.P.M. Uiterwaal Arterioscler Thromb Vasc Biol. 2008;28:2296-2302, doi:10.1161/ATVBAHA.108.173229 Abstract \| Full Text \| PDF In this study the association between tobacco smoke exposure and vascular damage in young adult offspring was investigated. Offspring of mothers who smoked in pregnancy had significantly thicker CIMT than offspring of mothers who did not smoke in pregnancy, indicating that permanent vascular damage attributable to tobacco smoke exposure might be initiated in gestation.
	Intramuscular Administration of AAV1-Lipoprotein Lipase^S447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients Erik S. Stroes, Melchior C. Nierman, Janneke J. Meulenberg, Remco Franssen, Jaap Twisk, C. Pieter Henny, Mario M. Maas, Aeilko H. Zwinderman, Colin Ross, Eleonora Aronica, Katherine A. High, Marcel M. Levi, Michael R. Hayden, John J. Kastelein, and Jan Albert Kuivenhoven Arterioscler Thromb Vasc Biol. 2008;28:2303-2304; published online before print September 18 2008, doi:10.1161/ATVBAHA.108.175620 Extract \| Full Text \| PDF \| Data Supplement
	Expansion of T-Cell Receptor ${zeta}$ ^dim Effector T Cells in Acute Coronary Syndromes Enrico Ammirati, Anna-Chiara Vermi, Domenico Cianflone, Michela Banfi, Chiara Foglieni, Cosmo Godino, Flavio Airoldi, Luca A. Ferri, Claire L. Gorman, Angelo A. Manfredi, Attilio Maseri, Andrew P. Cope, and Claudia Monaco Arterioscler Thromb Vasc Biol. 2008;28:2305-2311; published online before print September 11 2008, doi:10.1161/ATVBAHA.108.174144 Abstract \| Full Text \| PDF \| Data Supplement Reduction of TCR{zeta}-chain expression defines antigen-experienced effector T cells (TCR{zeta}dim T-cells) described in inflammatory and infectious diseases. We found increased numbers of TCR{zeta}Dim T cells in patients with acute coronary syndromes compared to stable angina and controls, with enhanced transendothelial migratory ability, which may be implicated in the pathogenesis of coronary instability.
	Pioglitazone Inhibits the Expression of Inflammatory Cytokines From Both Monocytes and Lymphocytes in Patients With Impaired Glucose Tolerance Wei-Yang Zhang, Eric A. Schwartz, Paska A. Permana, and Peter D. Reaven Arterioscler Thromb Vasc Biol. 2008;28:2312-2318; published online before print September 25 2008, doi:10.1161/ATVBAHA.108.175687 Abstract \| Full Text \| PDF \| Data Supplement
	ANGPTL4 E40K and T266M: Effects on Plasma Triglyceride and HDL Levels, Postprandial Responses, and CHD Risk Philippa J. Talmud, Melissa Smart, Edward Presswood, Jackie A. Cooper, Viviane Nicaud, Fotios Drenos, Jutta Palmen, Michael G. Marmot, S. Matthijs Boekholdt, Nicholas J. Wareham, Kay-Tee Khaw, Meena Kumari, Steve E. Humphries on behalf of the EARSII Consortium and the HIFMECH Consortium Arterioscler Thromb Vasc Biol. 2008;28:2319-2325; published online before print October 30 2008, doi:10.1161/ATVBAHA.108.176917 Abstract \| Full Text \| PDF \| Data Supplement Examination 7 ANGPTL4 SNPs on the pooled data from 5 studies (>13 500 individuals) showed only E40K with consistent TG-lowering and HDL-raising effects, yet associated with increased CHD risk, independent of TG levels. T266M showed effects on postprandial responses. Functional studies on these 2 "loss of function" SNPs are necessary.
	Author Index
	Volume 28, January–December 2008 Arterioscler Thromb Vasc Biol. 2008;28:2326-2333, doi:10.1161/01.ATV.0000341506.87292.d7 PDF
	Letters to the Editor
	Cathepsin K and Metabolic Abnormalities in Schizophrenia Hans-Gert Bernstein, Bernhard Bogerts, and Uwe Lendeckel Arterioscler Thromb Vasc Biol. 2008;28:e163, doi:10.1161/ATVBAHA.108.178160 Extract \| Full Text \| PDF

Spotlight

TOC Spotlight File

Volume 28, Issue 12; December 1, 2008

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

Editorials

"FRNKly, Smooth Muscle, I Don’t Give a CArG!": A Novel Mechanism for Smooth Muscle Cell Differentiation

Ninein Leads the Way in Vessel Sprouting

Macrophage Glucocorticoid Receptors Join the Intercellular Dialogue in Atherosclerotic Lesion Calcification

Affirmative Action of Osteopontin on Endothelial Progenitors

Brief Reviews

The Role of Cellular Adaptation to Mechanical Forces in Atherosclerosis

Metalloproteinase Expression in Monocytes and Macrophages and its Relationship to Atherosclerotic Plaque Instability

Integrative Physiology/Experimental Medicine

FRNK Expression Promotes Smooth Muscle Cell Maturation During Vascular Development and After Vascular Injury

Ninein Is Expressed in the Cytoplasm of Angiogenic Tip-Cells and Regulates Tubular Morphogenesis of Endothelial Cells

Estrogen-Stimulated Endothelial Repair Requires Osteopontin

Bone Morphogenetic Proteins 2 and 4 Are Selectively Expressed by Late Outgrowth Endothelial Progenitor Cells and Promote Neoangiogenesis

Myocyte Specific Overexpression of Myoglobin Impairs Angiogenesis After Hind-Limb Ischemia

Contribution of Bone Marrow–Derived Cells Associated With Brain Angiogenesis Is Primarily Through CD69+

Critical Role of Macrophages in Glucocorticoid Driven Vascular Calcification in a Mouse-Model of Atherosclerosis

Clones of Interstitial Cells From Bovine Aortic Valve Exhibit Different Calcifying Potential When Exposed to Endotoxin and Phosphate

In Vivo and In Vitro Inhibition of Monocyte Adhesion to Endothelial Cells and Endothelial Adhesion Molecules by Eicosapentaenoic Acid

Athsq1 Is an Atherosclerosis Modifier Locus With Dramatic Effects on Lesion Area and Prominent Accumulation of Versican

Molecular Mechanisms of Atherosclerosis in Metabolic Syndrome: Role of Reduced IRS2-Dependent Signaling

Inhibition of CCR2 Ameliorates Insulin Resistance and Hepatic Steatosis in db/db Mice

Deficiency and Inhibition of Cathepsin K Reduce Body Weight Gain and Increase Glucose Metabolism in Mice

Hypercholesterolemia Enhances 15-Lipoxygenase–Mediated Vasorelaxation and Acetylcholine-Induced Hypotension

Notch3 Is a Major Regulator of Vascular Tone in Cerebral and Tail Resistance Arteries

Differential Role of von Willebrand Factor and P-Selectin on Microvascular Thrombosis in Endotoxemia

Amiodarone Inhibits Arterial Thrombus Formation and Tissue Factor Translation

Cell Biology/Signaling

C-Reactive Protein Isoforms Differ in Their Effects on Thrombus Growth

Cellular Procoagulant Activity Dictates Clot Structure and Stability as a Function of Distance From the Cell Surface

Inhibition of Tumor Necrosis Factor –Stimulated Monocyte Adhesion to Human Aortic Endothelial Cells by AMP-Activated Protein Kinase

Impaired Notch4 Activity Elicits Endothelial Cell Activation and Apoptosis: Implication for Transplant Arteriosclerosis

High-Density Lipoproteins Affect Endothelial BMP-Signaling by Modulating Expression of the Activin-Like Kinase Receptor 1 and 2

Advanced Glycation End-Product of Low Density Lipoprotein Activates the Toll-Like 4 Receptor Pathway Implications for Diabetic Atherosclerosis

Involvement of Protein Kinase D in Phosphorylation and Increase of DNA Binding of Activator Protein 2 to Downregulate ATP-Binding Cassette Transporter A1

Liver X Receptor Activation Induces the Uptake of Cholesteryl Esters From High Density Lipoproteins in Primary Human Macrophages

Clinical and Population Studies

Parental Smoking and Vascular Damage in Young Adult Offspring: Is Early Life Exposure Critical?: The Atherosclerosis Risk in Young Adults Study

Intramuscular Administration of AAV1-Lipoprotein LipaseS447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients

Expansion of T-Cell Receptor dim Effector T Cells in Acute Coronary Syndromes

Pioglitazone Inhibits the Expression of Inflammatory Cytokines From Both Monocytes and Lymphocytes in Patients With Impaired Glucose Tolerance

ANGPTL4 E40K and T266M: Effects on Plasma Triglyceride and HDL Levels, Postprandial Responses, and CHD Risk

Author Index

Volume 28, January–December 2008

Letters to the Editor

Cathepsin K and Metabolic Abnormalities in Schizophrenia

Spotlight

Contribution of Bone Marrow–Derived Cells Associated With Brain Angiogenesis Is Primarily Through CD69⁺

Inhibition of Tumor Necrosis Factor ${alpha}$ –Stimulated Monocyte Adhesion to Human Aortic Endothelial Cells by AMP-Activated Protein Kinase

Involvement of Protein Kinase D in Phosphorylation and Increase of DNA Binding of Activator Protein 2 ${alpha}$ to Downregulate ATP-Binding Cassette Transporter A1

Intramuscular Administration of AAV1-Lipoprotein Lipase^S447X Lowers Triglycerides in Lipoprotein Lipase–Deficient Patients

Expansion of T-Cell Receptor ${zeta}$ ^dim Effector T Cells in Acute Coronary Syndromes