Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (28 [11])

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Volume 28, Issue 11; November 1, 2008

Editorials
Brief Reviews
Integrative Physiology/Experimental Medicine
Cell Biology/Signaling
Clinical and Population Studies
2008 Midwest Platelet Conference Young Investigator Award Abstract Winners

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

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	Editorials
	From Systemic Shotgun to Site-Specific Nanoparticle-Targeted Delivery: A New Paradigm for Drug Delivery Ian J. Sarembock Arterioscler Thromb Vasc Biol. 2008;28:1879-1881, doi:10.1161/ATVBAHA.108.175190 Extract \| Full Text \| PDF
	Nanoscale Architecture in Atherosclerotic Calcification Linda L. Demer, Andrew P. Sage, and Yin Tintut Arterioscler Thromb Vasc Biol. 2008;28:1882-1884, doi:10.1161/ATVBAHA.108.175711 Extract \| Full Text \| PDF
	Sharing Tissue Factor: A Winning Strategy in Tumorigenesis L. Vijaya Mohan Rao and Usha R. Pendurthi Arterioscler Thromb Vasc Biol. 2008;28:1885-1886, doi:10.1161/ATVBAHA.108.176149 Extract \| Full Text \| PDF
	Morphing the Topography of Atherosclerosis: An Unexpected Role for PECAM-1 Myron I. Cybulsky Arterioscler Thromb Vasc Biol. 2008;28:1887-1889, doi:10.1161/ATVBAHA.108.174029 Extract \| Full Text \| PDF
	Antiinflammatory Actions of HDL: A New Insight Kerry-Anne Rye and Philip J. Barter Arterioscler Thromb Vasc Biol. 2008;28:1890-1891, doi:10.1161/ATVBAHA.108.173575 Extract \| Full Text \| PDF
	Of Mice and Men: Blowing Away the Cobwebs From the Mechanism of Action of Niacin on HDL Metabolism G.F. Watts and D.C. Chan Arterioscler Thromb Vasc Biol. 2008;28:1892-1895, doi:10.1161/ATVBAHA.108.175224 Extract \| Full Text \| PDF
	Brief Reviews
	Chemokines in Atherosclerosis, Thrombosis, and Vascular Biology Christian Weber Arterioscler Thromb Vasc Biol. 2008;28:1896, doi:10.1161/ATVBAHA.108.177311 Extract \| Full Text \| PDF
	Chemokines in Atherosclerosis: An Update Alma Zernecke, Erdenechimeg Shagdarsuren, and Christian Weber Arterioscler Thromb Vasc Biol. 2008;28:1897-1908; published online before print June 19 2008, doi:10.1161/ATVBAHA.107.161174 Abstract \| Full Text \| PDF
	Chemokines and Cardiovascular Risk Pål Aukrust, Bente Halvorsen, Arne Yndestad, Thor Ueland, Erik Øie, Kari Otterdal, Lars Gullestad, and Jan K. Damås Arterioscler Thromb Vasc Biol. 2008;28:1909-1919; published online before print July 31 2008, doi:10.1161/ATVBAHA.107.161240 Abstract \| Full Text \| PDF
	Platelet Chemokines in Vascular Disease Christian A. Gleissner, Philipp von Hundelshausen, and Klaus Ley Arterioscler Thromb Vasc Biol. 2008;28:1920-1927; published online before print August 21 2008, doi:10.1161/ATVBAHA.108.169417 Abstract \| Full Text \| PDF
	Chemokines as Mediators of Neovascularization Ellen C. Keeley, Borna Mehrad, and Robert M. Strieter Arterioscler Thromb Vasc Biol. 2008;28:1928-1936; published online before print August 28 2008, doi:10.1161/ATVBAHA.108.162925 Abstract \| Full Text \| PDF
	The Role of Chemokines in Transplant Graft Arterial Disease Koichi Shimizu and Richard N. Mitchell Arterioscler Thromb Vasc Biol. 2008;28:1937-1949; published online before print September 18 2008, doi:10.1161/ATVBAHA.107.161232 Abstract \| Full Text \| PDF
	Chemokines in Vascular Dysfunction and Remodeling Andreas Schober Arterioscler Thromb Vasc Biol. 2008;28:1950-1959; published online before print September 25 2008, doi:10.1161/ATVBAHA.107.161224 Abstract \| Full Text \| PDF
	Integrative Physiology/Experimental Medicine
	Site-Specific Targeting of Nanoparticle Prednisolone Reduces In-Stent Restenosis in a Rabbit Model of Established Atheroma Michael Joner, Katsumi Morimoto, Hiroaki Kasukawa, Kristin Steigerwald, Sabine Merl, Gaku Nakazawa, Michael C. John, Aloke V. Finn, Eduardo Acampado, Frank D. Kolodgie, Herman K. Gold, and Renu Virmani Arterioscler Thromb Vasc Biol. 2008;28:1960-1966; published online before print August 7 2008, doi:10.1161/ATVBAHA.108.170662 Abstract \| Full Text \| PDF \| Data Supplement
	Caffeine Enhances Endothelial Repair by an AMPK-Dependent Mechanism Ioakim Spyridopoulos, Stephan Fichtlscherer, Rüdiger Popp, Stefan W. Toennes, Beate Fisslthaler, Thomas Trepels, Alma Zernecke, Elisa A. Liehn, Christian Weber, Andreas M. Zeiher, Stefanie Dimmeler, and Judith Haendeler Arterioscler Thromb Vasc Biol. 2008;28:1967-1974; published online before print August 28 2008, doi:10.1161/ATVBAHA.108.174060 Abstract \| Full Text \| PDF We demonstrate that caffeine in physiologically relevant concentrations (50 to 100 {micro}mol/L) induces migration of human endothelial progenitor cells as well as mature endothelial cells. The enhancement of reendothelialization by caffeine in a mouse-model after denudation of the carotid artery was significantly reduced in AMPK knockout mice compared to wild-type animals.
	Contribution of Host-Derived Tissue Factor to Tumor Neovascularization Joanne Yu, Linda May, Chloe Milsom, G. Mark Anderson, Jeffrey I. Weitz, James P. Luyendyk, George Broze, Nigel Mackman, and Janusz Rak Arterioscler Thromb Vasc Biol. 2008;28:1975-1981; published online before print September 4 2008, doi:10.1161/ATVBAHA.108.175083 Abstract \| Full Text \| PDF Tumor angiogenesis in animals with low levels of TF (low-TF mice) has not been studied. We report that reduced levels of host-related TF impaired growth of TF-deficient teratomas, but not TF-proficient tumors. We suggest that TF can be shared between tumor and host cells via microvesicles.
	Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance Francis Kim, Matilda Pham, Ezekiel Maloney, Norma O. Rizzo, Gregory J. Morton, Brent E. Wisse, Elizabeth A. Kirk, Alan Chait, and Michael W. Schwartz Arterioscler Thromb Vasc Biol. 2008;28:1982-1988; published online before print September 4 2008, doi:10.1161/ATVBAHA.108.169722 Abstract \| Full Text \| PDF \| Data Supplement
	Angiopoietin-2 Stimulates Blood Flow Recovery After Femoral Artery Occlusion by Inducing Inflammation and Arteriogenesis Sarah L. Tressel, Hyongbum Kim, Chih-Wen Ni, Kyunghwa Chang, Juan C. Velasquez-Castano, W. Robert Taylor, Young-sup Yoon, and Hanjoong Jo Arterioscler Thromb Vasc Biol. 2008;28:1989-1995; published online before print September 4 2008, doi:10.1161/ATVBAHA.108.175463 Abstract \| Full Text \| PDF \| Data Supplement We investigated the role of Angiopoietin-2 in neovascularization during ischemia. We found that inhibiting Angiopoietin-2 impaired blood flow recovery during hindlimb ischemia and reduced arteriogenesis and inflammation. Angiopoietin-2 inhibition caused reduced ICAM-1 and VCAM-1 expression, resulting in reduced monocyte migration into the tissue and increased monocytes in the circulation.
	Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor–Deficient Mice Reema Goel, Benjamin R. Schrank, Shikha Arora, Brian Boylan, Barbara Fleming, Hiroto Miura, Peter J. Newman, Robert C. Molthen, and Debra K. Newman Arterioscler Thromb Vasc Biol. 2008;28:1996-2002; published online before print July 31 2008, doi:10.1161/ATVBAHA.108.172270 Abstract \| Full Text \| PDF
	Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice Brian L. Harry, John M. Sanders, Ryan E. Feaver, Melissa Lansey, Tracy L. Deem, Alexander Zarbock, Anthony C. Bruce, Andrew W. Pryor, Bradley D. Gelfand, Brett R. Blackman, Martin A. Schwartz, and Klaus Ley Arterioscler Thromb Vasc Biol. 2008;28:2003-2008; published online before print August 7 2008, doi:10.1161/ATVBAHA.108.164707 Abstract \| Full Text \| PDF \| Data Supplement Platelet endothelial cell adhesion molecule-1 (PECAM-1) is an essential element of a mechanosensory complex that mediates endothelial responses to fluid shear stress. This study showed that PECAM-1 on the endothelium contributes to atherosclerotic lesion formation in regions of disturbed flow by regulating NF-{kappa}B-mediated gene expression.
	Effect of Macrophage Overexpression of Murine Liver X Receptor- ${alpha}$ (LXR- ${alpha}$ ) on Atherosclerosis in LDL-Receptor Deficient Mice Daniel Teupser, Daniel Kretzschmar, Carsten Tennert, Ralph Burkhardt, Wolfgang Wilfert, Dörte Fengler, Ronald Naumann, Albrecht E. Sippel, and Joachim Thiery Arterioscler Thromb Vasc Biol. 2008;28:2009-2015; published online before print September 11 2008, doi:10.1161/ATVBAHA.108.175257 Abstract \| Full Text \| PDF \| Data Supplement We demonstrate for the first time that macrophage overexpression of murine LXR-{alpha} in LDLR-/- mice reduces the development of peripheral atherosclerosis, modulates inflammatory response, and enhances cholesterol efflux in bone marrow-derived macrophages.
	Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein in APOE3Leiden.CETP* Mice José W.A. van der Hoorn, Willeke de Haan, Jimmy F.P. Berbée, Louis M. Havekes, J. Wouter Jukema, Patrick C.N. Rensen, and Hans M.G. Princen Arterioscler Thromb Vasc Biol. 2008;28:2016-2022; published online before print July 31 2008, doi:10.1161/ATVBAHA.108.171363 Abstract \| Full Text \| PDF \| Data Supplement To elucidate the mechanism underlying the HDL-raising effect of niacin, APOE*3Leiden.CETP mice received increasing doses of niacin. Niacin markedly increased HDL-cholesterol by reducing the CETP-dependent transfer of cholesterol from HDL to (V)LDL, as related to a reduced hepatic CETP expression and plasma (V)LDL pool, and by decreasing the apoAI clearance.
	Anticoagulant Effect of Dietary Fish Oil in Hyperlipidemia: A Study of Hepatic Gene Expression in APOE2 Knock-in Mice Kristof Vanschoonbeek, Kristiaan Wouters, Paola E.J. van der Meijden, Patrick J. van Gorp, Marion A.H. Feijge, Marjolein Herfs, Leon J. Schurgers, Marten H. Hofker, Moniek P.M. de Maat, and Johan W.M. Heemskerk Arterioscler Thromb Vasc Biol. 2008;28:2023-2029; published online before print August 28 2008, doi:10.1161/ATVBAHA.107.156992 Abstract \| Full Text \| PDF In hyperlipidemic APOE2 knock-in mice, dietary fish oil containing n-3 polyunsaturated fatty acids (PUFA) provokes plasma triacylglycerol lowering and hypocoagulant activity. The hypocoagulant effect results from retention of uncarboxylated coagulation factors, whereas the lipid-lowering effect links to altered expression of genes that regulate fatty acid metabolism.
	Cell Biology/Signaling
	Mineral Surface in Calcified Plaque Is Like That of Bone: Further Evidence for Regulated Mineralization Melinda J. Duer, Tomislav Friscic, Diane Proudfoot, David G. Reid, Michael Schoppet, Catherine M. Shanahan, Jeremy N. Skepper, and Erica R. Wise Arterioscler Thromb Vasc Biol. 2008;28:2030-2034; published online before print August 14 2008, doi:10.1161/ATVBAHA.108.172387 Abstract \| Full Text \| PDF \| Data Supplement NMR techniques show that bone and vascular calcifications are very similar with respect to constituents of the mineral/matrix interface, a predominant component being glycosaminoglycans. This implies that regulation of both is very similar, supporting cell biological studies showing pathological calcification of vascular smooth muscle cells to be a regulated process.
	Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries Is Controlled by Shear Rate Feng Shen, Christian J. Kastrup, Ying Liu, and Rustem F. Ismagilov Arterioscler Thromb Vasc Biol. 2008;28:2035-2041; published online before print August 14 2008, doi:10.1161/ATVBAHA.108.173930 Abstract \| Full Text \| PDF \| Data Supplement Initiation of blood coagulation on surfaces containing tissue factor depended on shear rate, not volumetric flow rate or flow velocity. Coagulation of plasma initiated only at shear rates below a critical value. At constant shear rate, coagulation also showed a threshold response to the size of patches of tissue factor.
	Hepatocyte Growth Factor Inhibits VEGF-Forkhead–Dependent Gene Expression in Endothelial Cells Md. Ruhul Abid, Robert J. Nadeau, Katherine C. Spokes, Takashi Minami, Dan Li, Shou-Ching Shih, and William C. Aird Arterioscler Thromb Vasc Biol. 2008;28:2042-2048; published online before print September 11 2008, doi:10.1161/ATVBAHA.108.175109 Abstract \| Full Text \| PDF \| Data Supplement
	Involvement of Native TRPC3 Proteins in ATP-Dependent Expression of VCAM-1 and Monocyte Adherence in Coronary Artery Endothelial Cells Kathryn Smedlund and Guillermo Vazquez Arterioscler Thromb Vasc Biol. 2008;28:2049-2055; published online before print September 11 2008, doi:10.1161/ATVBAHA.108.175356 Abstract \| Full Text \| PDF We examined the role of Ca2+ influx and native TRPC3 proteins in regulated expression of VCAM-1 in coronary artery endothelial cells. The evidence shows that TRPC3 forms Ca2+-permeable channels whose expression and function are fundamental to VCAM-1 expression and monocyte adhesion, suggesting a potential pathophysiological role of TRPC3 in atherogenesis.
	Lysosomal Targeting and Trafficking of Acid Sphingomyelinase to Lipid Raft Platforms in Coronary Endothelial Cells Si Jin, Fan Yi, Fan Zhang, Justin L. Poklis, and Pin-Lan Li Arterioscler Thromb Vasc Biol. 2008;28:2056-2062; published online before print September 4 2008, doi:10.1161/ATVBAHA.108.172478 Abstract \| Full Text \| PDF \| Data Supplemental
	Apolipoprotein A-I Tryptophan Substitution Leads to Resistance to Myeloperoxidase-Mediated Loss of Function Dao-Quan Peng, Gregory Brubaker, Zhiping Wu, Lemin Zheng, Belinda Willard, Michael Kinter, Stanley L. Hazen, and Jonathan D. Smith Arterioscler Thromb Vasc Biol. 2008;28:2063-2070; published online before print August 7 2008, doi:10.1161/ATVBAHA.108.173815 Abstract \| Full Text \| PDF \| Data Supplement
	High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response Andrew J. Murphy, Kevin J. Woollard, Anh Hoang, Nigora Mukhamedova, Roslynn A. Stirzaker, Sally P.A. McCormick, Alan T. Remaley, Dmitri Sviridov, and Jaye Chin-Dusting Arterioscler Thromb Vasc Biol. 2008;28:2071-2077; published online before print July 10 2008, doi:10.1161/ATVBAHA.108.168690 Abstract \| Full Text \| PDF \| Data Supplement High-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I) exhibit a potent antiinflammatory effect on human monocytes, inhibiting expression of the adhesion molecule CD11b, an effect mediated through cholesterol efflux. The effect of apoA-I was dependent on ABCA1, whereas HDL may act through multiple receptors.
	Clinical and Population Studies
	Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13 Ralph Burkhardt, Eimear E. Kenny, Jennifer K. Lowe, Andrew Birkeland, Rebecca Josowitz, Martha Noel, Jacqueline Salit, Julian B. Maller, Itsik Pe'er, Mark J. Daly, David Altshuler, Markus Stoffel, Jeffrey M. Friedman, and Jan L. Breslow Arterioscler Thromb Vasc Biol. 2008;28:2078-2084; published online before print September 18 2008, doi:10.1161/ATVBAHA.108.172288 Abstract \| Full Text \| PDF \| Data Supplement In a genome-wide association study we identified variants in the HMG-CoA reductase gene that were associated with LDL-C across populations. Further, functional studies revealed that a common intronic SNP (rs384662) that is in linkage disequilibrium with the variants typed in the genome scan modulates alternative splicing of HMGCR mRNA.
	Associations Between Single Nucleotide Polymorphisms on Chromosome 9p21 and Risk of Coronary Heart Disease in Chinese Han Population Li Zhou, Xiaomin Zhang, Mei'an He, Longxian Cheng, Ying Chen, Frank B. Hu, and Tangchun Wu Arterioscler Thromb Vasc Biol. 2008;28:2085-2089; published online before print August 28 2008, doi:10.1161/ATVBAHA.108.176065 Abstract \| Full Text \| PDF We determined genotypes of rs2383206 and rs2383207 on chromosome 9p21 in 1360 CHD patients and matched controls. Our results indicate that rs2383207 is significantly associated with higher risk of CHD in a Chinese Han population. The risk allele of rs2383207 plus a family history have a cumulative association with CHD.
	2008 Midwest Platelet Conference Young Investigator Award Abstract Winners
	2008 Midwest Platelet Conference Young Investigator Award Abstract Winners Arterioscler Thromb Vasc Biol. 2008;28:e162, doi:10.1161/01.atv.0000338607.56487.0e PDF

Spotlight

TOC Spotlight File

Volume 28, Issue 11; November 1, 2008

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

Editorials

From Systemic Shotgun to Site-Specific Nanoparticle-Targeted Delivery: A New Paradigm for Drug Delivery

Nanoscale Architecture in Atherosclerotic Calcification

Sharing Tissue Factor: A Winning Strategy in Tumorigenesis

Morphing the Topography of Atherosclerosis: An Unexpected Role for PECAM-1

Antiinflammatory Actions of HDL: A New Insight

Of Mice and Men: Blowing Away the Cobwebs From the Mechanism of Action of Niacin on HDL Metabolism

Brief Reviews

Chemokines in Atherosclerosis, Thrombosis, and Vascular Biology

Chemokines in Atherosclerosis: An Update

Chemokines and Cardiovascular Risk

Platelet Chemokines in Vascular Disease

Chemokines as Mediators of Neovascularization

The Role of Chemokines in Transplant Graft Arterial Disease

Chemokines in Vascular Dysfunction and Remodeling

Integrative Physiology/Experimental Medicine

Site-Specific Targeting of Nanoparticle Prednisolone Reduces In-Stent Restenosis in a Rabbit Model of Established Atheroma

Caffeine Enhances Endothelial Repair by an AMPK-Dependent Mechanism

Contribution of Host-Derived Tissue Factor to Tumor Neovascularization

Vascular Inflammation, Insulin Resistance, and Reduced Nitric Oxide Production Precede the Onset of Peripheral Insulin Resistance

Angiopoietin-2 Stimulates Blood Flow Recovery After Femoral Artery Occlusion by Inducing Inflammation and Arteriogenesis

Site-Specific Effects of PECAM-1 on Atherosclerosis in LDL Receptor–Deficient Mice

Endothelial Cell PECAM-1 Promotes Atherosclerotic Lesions in Areas of Disturbed Flow in ApoE-Deficient Mice

Effect of Macrophage Overexpression of Murine Liver X Receptor- (LXR-) on Atherosclerosis in LDL-Receptor Deficient Mice

Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein in APOE*3Leiden.CETP Mice

Anticoagulant Effect of Dietary Fish Oil in Hyperlipidemia: A Study of Hepatic Gene Expression in APOE2 Knock-in Mice

Cell Biology/Signaling

Mineral Surface in Calcified Plaque Is Like That of Bone: Further Evidence for Regulated Mineralization

Threshold Response of Initiation of Blood Coagulation by Tissue Factor in Patterned Microfluidic Capillaries Is Controlled by Shear Rate

Hepatocyte Growth Factor Inhibits VEGF-Forkhead–Dependent Gene Expression in Endothelial Cells

Involvement of Native TRPC3 Proteins in ATP-Dependent Expression of VCAM-1 and Monocyte Adherence in Coronary Artery Endothelial Cells

Lysosomal Targeting and Trafficking of Acid Sphingomyelinase to Lipid Raft Platforms in Coronary Endothelial Cells

Apolipoprotein A-I Tryptophan Substitution Leads to Resistance to Myeloperoxidase-Mediated Loss of Function

High-Density Lipoprotein Reduces the Human Monocyte Inflammatory Response

Clinical and Population Studies

Common SNPs in HMGCR in Micronesians and Whites Associated With LDL-Cholesterol Levels Affect Alternative Splicing of Exon13

Associations Between Single Nucleotide Polymorphisms on Chromosome 9p21 and Risk of Coronary Heart Disease in Chinese Han Population

2008 Midwest Platelet Conference Young Investigator Award Abstract Winners

2008 Midwest Platelet Conference Young Investigator Award Abstract Winners

Spotlight

Effect of Macrophage Overexpression of Murine Liver X Receptor- ${alpha}$ (LXR- ${alpha}$ ) on Atherosclerosis in LDL-Receptor Deficient Mice

Niacin Increases HDL by Reducing Hepatic Expression and Plasma Levels of Cholesteryl Ester Transfer Protein in APOE3Leiden.CETP* Mice