Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (28 [10])

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Volume 28, Issue 10; October 1, 2008

Editorials
Brief Reviews
Integrative Physiology/Experimental Medicine
Cell Biology/Signaling
Clinical and Population Studies
Letters to the Editor

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

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	Editorials
	Kinetic Studies of the Metabolism of Rapidly Exchangeable Apolipoproteins May Leave Investigators and Readers With Exchangeable Results Henry N. Ginsberg and Rajasekhar Ramakrishnan Arterioscler Thromb Vasc Biol. 2008;28:1685-1686, doi:10.1161/ATVBAHA.108.174185 Extract \| Full Text \| PDF
	Apelin-APJ Signaling in Retinal Angiogenesis Yoko Kojima and Thomas Quertermous Arterioscler Thromb Vasc Biol. 2008;28:1687-1688, doi:10.1161/ATVBAHA.108.174847 Extract \| Full Text \| PDF
	A New Kid on the Block: PKD1: A Promising Target for Antiangiogenic Therapy? Joachim Altschmied and Judith Haendeler Arterioscler Thromb Vasc Biol. 2008;28:1689-1690, doi:10.1161/ATVBAHA.108.174250 Extract \| Full Text \| PDF
	Endothelial H₂O₂: A Bad Guy Turning Good? Wolfgang F. Graier and Markus Hecker Arterioscler Thromb Vasc Biol. 2008;28:1691-1693, doi:10.1161/ATVBAHA.108.173963 Extract \| Full Text \| PDF
	Brief Reviews
	Death Receptors and Their Ligands in Atherosclerosis Mary M. Kavurma, Nicole Y. Tan, and Martin R. Bennett Arterioscler Thromb Vasc Biol. 2008;28:1694-1702; published online before print July 31 2008, doi:10.1161/ATVBAHA.107.155143 Abstract \| Full Text \| PDF On binding to their ligands, death receptors transmit apoptotic signals leading to irreversible programmed cell death. Recent studies also implicate death receptors in survival/activation signals, and consequently their role in atherosclerosis is unclear. This review encapsulates our recent understanding of death receptor signaling in atherosclerosis and related disorders.
	Integrins: The Keys to Unlocking Angiogenesis Rita Silva, Gabriela D'Amico, Kairbaan M. Hodivala-Dilke, and Louise E. Reynolds Arterioscler Thromb Vasc Biol. 2008;28:1703-1713; published online before print July 24 2008, doi:10.1161/ATVBAHA.108.172015 Abstract \| Full Text \| PDF
	Integrative Physiology/Experimental Medicine
	Brief Report: Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice Lacking the Membrane-Bound Complement Regulator CD59 Sheng Yun, Viola W.Y. Leung, Marina Botto, Joseph J. Boyle, and Dorian O. Haskard Arterioscler Thromb Vasc Biol. 2008;28:1714-1716; published online before print July 10 2008, doi:10.1161/ATVBAHA.108.169912 Abstract \| Full Text \| PDF \| Data Supplement
	Retardation of Retinal Vascular Development in Apelin-Deficient Mice Atsushi Kasai, Norihito Shintani, Hideaki Kato, Satoshi Matsuda, Fumi Gomi, Ryota Haba, Hitoshi Hashimoto, Michiya Kakuda, Yasuo Tano, and Akemichi Baba Arterioscler Thromb Vasc Biol. 2008;28:1717-1722; published online before print July 3 2008, doi:10.1161/ATVBAHA.108.163402 Abstract \| Full Text \| PDF \| Data Supplement To identify the roles of endogenous apelin, we investigated the phenotype of apelin-KO mice. Our results suggest that spatiotemporally regulated apelin/APJ signaling participates in retinal vascularization in a cooperative manner with VEGF or FGF2 and contributes to normal ocular development.
	Acid Sphingomyelinase Promotes Lipoprotein Retention Within Early Atheromata and Accelerates Lesion Progression Cecilia M. Devlin, Andrew R. Leventhal, George Kuriakose, Edward H. Schuchman, Kevin Jon Williams, and Ira Tabas Arterioscler Thromb Vasc Biol. 2008;28:1723-1730; published online before print July 31 2008, doi:10.1161/ATVBAHA.108.173344 Abstract \| Full Text \| PDF \| Data Supplement
	Overexpression of Human ABCG1 Does Not Affect Atherosclerosis in Fat-Fed ApoE-Deficient Mice Braydon Burgess, Kathryn Naus, Jeniffer Chan, Veronica Hirsch-Reinshagen, Gavin Tansley, Lisa Matzke, Benny Chan, Anna Wilkinson, Jianjia Fan, James Donkin, Danielle Balik, Tracie Tanaka, George Ou, Roger Dyer, Sheila Innis, Bruce McManus, Dieter Lütjohann, and Cheryl Wellington Arterioscler Thromb Vasc Biol. 2008;28:1731-1737; published online before print July 3 2008, doi:10.1161/ATVBAHA.108.168542 Abstract \| Full Text \| PDF \| Data Supplement We developed transgenic mice expressing functional human ABCG1. Elevated ABCG1 levels did not affect plasma lipids, macrophage cholesterol efflux, atherosclerotic lesion area in apoE-/- mice, or levels of tissue cholesterol, cholesterol ester, phospholipids, or triglycerides. Transgenic ABCG1 was, however, associated with altered sterol intermediate levels in liver.
	Alterations in Hepatic Metabolism in fld Mice Reveal a Role for Lipin 1 in Regulating VLDL-Triacylglyceride Secretion Zhouji Chen, Matthew C. Gropler, Jin Norris, John C. Lawrence, Jr, Thurl E. Harris, and Brian N. Finck Arterioscler Thromb Vasc Biol. 2008;28:1738-1744; published online before print July 31 2008, doi:10.1161/ATVBAHA.108.171538 Abstract \| Full Text \| PDF \| Data Supplement
	Absence of Hyperlipidemia in LDL Receptor-Deficient Mice Having Apolipoprotein B100 Without the Putative Receptor-Binding Sequences Lance A. Johnson, Michael K. Altenburg, Rosemary L. Walzem, Lori T. Scanga, and Nobuyo Maeda Arterioscler Thromb Vasc Biol. 2008;28:1745-1752; published online before print July 10 2008, doi:10.1161/ATVBAHA.108.169680 Abstract \| Full Text \| PDF \| Data Supplement Mice that lack the LDLR and ApoB editing enzyme (Ldlr-/- Apobec1-/-) accumulate LDL and develop severe atherosclerosis. Conversely, Ldlr-/- Apobec1-/- mice carrying Apob100-β with altered sequences in the putative LDLR-binding domains of apoB neither accumulate LDL nor develop atherosclerosis. This finding highlights a potential therapeutic target for patients with familial hypercholesterolemia.
	Adenovirus-Mediated VEGF Gene Therapy Enhances Venous Thrombus Recanalization and Resolution B. Modarai, J. Humphries, J.A. Gossage, M. Waltham, K.G. Burnand, G.S. Kanaganayagam, A. Afuwape, E. Paleolog, A. Smith, and A. Wadoodi Arterioscler Thromb Vasc Biol. 2008;28:1753-1759; published online before print July 31 2008, doi:10.1161/ATVBAHA.108.170571 Abstract \| Full Text \| PDF \| Data Supplement
	Air Pollution Exposure Potentiates Hypertension Through Reactive Oxygen Species-Mediated Activation of Rho/ROCK Qinghua Sun, Peibin Yue, Zhekang Ying, Arturo J. Cardounel, Robert D. Brook, Robert Devlin, Jing-Shiang Hwang, Jay L. Zweier, Lung Chi Chen, and Sanjay Rajagopalan Arterioscler Thromb Vasc Biol. 2008;28:1760-1766; published online before print July 3 2008, doi:10.1161/ATVBAHA.108.166967 Abstract \| Full Text \| PDF \| Data Supplement Short-term exposure to ambient fine particles in an angiotensin II rat model exaggerates vasoconstriction and blood pressure through increases in vascular superoxide production and upregulation of the Rho/ROCK pathway.
	A Novel Sartan Derivative With Very Low Angiotensin II Type 1 Receptor Affinity Protects the Kidney in Type 2 Diabetic Rats Yuko Izuhara, Toshio Sada, Hiroaki Yanagisawa, Hiroyuki Koike, Shuichi Ohtomo, Takashi Dan, Sadayoshi Ito, Masaomi Nangaku, Charles van Ypersele de Strihou, and Toshio Miyata Arterioscler Thromb Vasc Biol. 2008;28:1767-1773; published online before print July 24 2008, doi:10.1161/ATVBAHA.108.172841 Abstract \| Full Text \| PDF \| Data Supplement We have designed an ARB-derivative, R-147176, with a marked inhibitory effect on oxidative stress and advanced glycation but an extremely low affinity for the angiotensin II type 1 receptor. Despite a minimal blood pressure lowering effect, R-147176 provides significant renoprotection in three different experimental rat models with renal injury.
	Hydrogen Peroxide Potentiates the EDHF Phenomenon by Promoting Endothelial Ca²⁺ Mobilization David H. Edwards, Yiwen Li, and Tudor M. Griffith Arterioscler Thromb Vasc Biol. 2008;28:1774-1781; published online before print July 31 2008, doi:10.1161/ATVBAHA.108.172692 Abstract \| Full Text \| PDF \| Data Supplement Pharmacological analysis of relaxation and imaging of intracellular Ca2+ mobilization has shown that H2O2 can contribute to electrotonically-mediated EDHF-type relaxations by promoting Ca2+ release from stores and secondary opening of KCa channels. The thiol oxidant thimerosal mimics this previously unrecognized endothelial action of H2O2, consistent with sensitization of the InsP3 receptor.
	Cell Biology/Signaling
	VEGF Stimulates HDAC7 Phosphorylation and Cytoplasmic Accumulation Modulating Matrix Metalloproteinase Expression and Angiogenesis Chang Hoon Ha, Bong Sook Jhun, Hung-Ying Kao, and Zheng-Gen Jin Arterioscler Thromb Vasc Biol. 2008;28:1782-1788; published online before print July 10 2008, doi:10.1161/ATVBAHA.108.172528 Abstract \| Full Text \| PDF \| Data Supplement This study investigated the role of HDAC7 in VEGF signaling and angiogenesis. We found that VEGF stimulated PKD1-dependent HDAC7 phosphorylation and cytoplasmic accumulation in endothelial cells modulating expression of genes including MT1-MMP and MMP10. Furthermore, our results showed that PKD1-HDAC7 pathway regulates VEGF-induced endothelial cell migration, tube formation, and microvessel sprouting.
	AMP-Activated Protein Kinase Promotes the Differentiation of Endothelial Progenitor Cells Xiaoxia Li, Yingying Han, Wei Pang, Chenghong Li, Xuefen Xie, John Y.-J. Shyy, and Yi Zhu Arterioscler Thromb Vasc Biol. 2008;28:1789-1795; published online before print July 3 2008, doi:10.1161/ATVBAHA.108.172452 Abstract \| Full Text \| PDF \| Data Supplement In human cord blood-derived EPCs, VEGF caused the phosphorylation of AMPK and eNOS, increased the expression of EC markers, and increased the angiogenesis of EPCs in vitro and in vivo. Similar effects were observed with lovastatin and AMPK agonist. The activation of AMPK provides a novel mechanism for EPC differentiation.
	Transcriptional Activation of HIF-1 by ROR ${alpha}$ and its Role in Hypoxia Signaling Eun-Jin Kim, Young-Gun Yoo, Woo-Kyeom Yang, Young-Soun Lim, Tae-Young Na, In-Kyu Lee, and Mi-Ock Lee Arterioscler Thromb Vasc Biol. 2008;28:1796-1802; published online before print July 24 2008, doi:10.1161/ATVBAHA.108.171546 Abstract \| Full Text \| PDF \| Data Supplement
	Protein Kinase G Phosphorylates Soluble Guanylyl Cyclase on Serine 64 and Inhibits Its Activity Zongmin Zhou, Nazish Sayed, Anastasia Pyriochou, Charis Roussos, David Fulton, Annie Beuve, and Andreas Papapetropoulos Arterioscler Thromb Vasc Biol. 2008;28:1803-1810; published online before print July 17 2008, doi:10.1161/ATVBAHA.108.165043 Abstract \| Full Text \| PDF \| Data Supplement
	12/15-Lipoxygenase Activity Increases the Degradation of Macrophage ATP-Binding Cassette Transporter G1 Melissa H. Nagelin, Suseela Srinivasan, Jianyi Lee, Jerry L. Nadler, and Catherine C. Hedrick Arterioscler Thromb Vasc Biol. 2008;28:1811-1819; published online before print July 17 2008, doi:10.1161/ATVBAHA.108.167908 Abstract \| Full Text \| PDF \| Data Supplement
	ApoA-I Facilitates ABCA1 Recycle/Accumulation to Cell Surface by Inhibiting Its Intracellular Degradation and Increases HDL Generation Rui Lu, Reijiro Arakawa, Chisato Ito-Osumi, Noriyuki Iwamoto, and Shinji Yokoyama Arterioscler Thromb Vasc Biol. 2008;28:1820-1824; published online before print July 10 2008, doi:10.1161/ATVBAHA.108.169482 Abstract \| Full Text \| PDF \| Data Supplement
	Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes Takashi Ito, Ko-ichi Kawahara, Kohji Okamoto, Shingo Yamada, Minetsugu Yasuda, Hitoshi Imaizumi, Yuko Nawa, Xiaojie Meng, Binita Shrestha, Teruto Hashiguchi, and Ikuro Maruyama Arterioscler Thromb Vasc Biol. 2008;28:1825-1830; published online before print July 3 2008, doi:10.1161/ATVBAHA.107.150631 Abstract \| Full Text \| PDF \| Data Supplement Thrombomodulin (TM), an endothelial thrombin-binding protein, can bind and sequester high mobility group box 1 (HMGB1). In the present study, we examined the end results of this binding, and found that thrombin-TM complexes degrade HMGB1 to a less proinflammatory form.
	Clinical and Population Studies
	Atorvastatin and Fenofibrate Have Comparable Effects on VLDL-Apolipoprotein C-III Kinetics in Men With the Metabolic Syndrome Dick C. Chan, Gerald F. Watts, Esther M.M. Ooi, Juying Ji, Anthony G. Johnson, and P. Hugh R. Barrett Arterioscler Thromb Vasc Biol. 2008;28:1831-1837; published online before print June 19 2008, doi:10.1161/ATVBAHA.108.170530 Abstract \| Full Text \| PDF
	Gender-Specific Differences in the Kinetics of Nonfasting TRL, IDL, and LDL Apolipoprotein B-100 in Men and Premenopausal Women Nirupa R. Matthan, Susan M. Jalbert, P. Hugh R. Barrett, Gregory G. Dolnikowski, Ernst J. Schaefer, and Alice H. Lichtenstein Arterioscler Thromb Vasc Biol. 2008;28:1838-1843; published online before print July 24 2008, doi:10.1161/ATVBAHA.108.163931 Abstract \| Full Text \| PDF To determine mechanism(s) responsible for the gender related differences in plasma lipoprotein concentrations, apolipoprotein kinetic studies were conducted. Compared to men, premenopausal women had lower TRL and LDL pool sizes as a consequence of higher TRL- and LDL-apoB-100 catabolic rates rather than changes in production rates.
	Macrophages and Platelets Are the Major Source of Protease Nexin-1 in Human Atherosclerotic Plaque Silvana Mansilla, Yacine Boulaftali, Laurence Venisse, Véronique Arocas, Olivier Meilhac, Jean-Baptiste Michel, Martine Jandrot-Perrus, and Marie-Christine Bouton Arterioscler Thromb Vasc Biol. 2008;28:1844-1850; published online before print July 10 2008, doi:10.1161/ATVBAHA.108.171389 Abstract \| Full Text \| PDF \| Data Supplement Protease nexin-1 expression was analyzed in atherosclerotic carotid arteries. This serpin was highly expressed in the cap and in the necrotic core present in advanced lesions. Monocytes/macrophages and platelets are its main sources within the atherothrombotic lesion. Protease nexin-1 may thus have an impact in the development of atherosclerosis.
	Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area Jonathan H. Klein, Robert A. Hegele, Daniel G. Hackam, Marlys L. Koschinsky, Murray W. Huff, and J. David Spence Arterioscler Thromb Vasc Biol. 2008;28:1851-1856; published online before print July 3 2008, doi:10.1161/ATVBAHA.108.169292 Abstract \| Full Text \| PDF We investigated the effect of lipoprotein(a) and traditional risk factors on carotid ultrasound phenotypes. Lipoprotein(a) significantly predicted baseline stenosis and occlusion, but not baseline plaque area, and traditional risk factors predicted these 3 phenotypes differently, supporting the concept that stenosis and plaque are fundamentally different processes. Much of the effect of Lp(a) was related to occlusion, suggesting that its effect on atherogenesis is largely attributable to thrombosis and impaired fibrinolysis.
	Longitudinal Change in Serum Gamma-Glutamyltransferase and Cardiovascular Disease Mortality: A Prospective Population-Based Study in 76 113 Austrian Adults Alexander M. Strasak, Cecily C. Kelleher, Jochen Klenk, Larry J. Brant, Elfriede Ruttmann, Kilian Rapp, Hans Concin, Günter Diem, Karl P. Pfeiffer, Hanno Ulmer, and the VHM&PP Study Group Arterioscler Thromb Vasc Biol. 2008;28:1857-1865; published online before print July 10 2008, doi:10.1161/ATVBAHA.108.170597 Abstract \| Full Text \| PDF \| Data Supplement We prospectively investigated the association of longitudinal GGT change with CVD mortality in 76 113 men and women. We found increasing GGT, even within its normal range, to significantly increase risk of fatal CVD, independently of baseline GGT and other classical CVD risk factors.
	Effects of Six APOA5 Variants, Identified in Patients With Severe Hypertriglyceridemia, on In Vitro Lipoprotein Lipase Activity and Receptor Binding B. Dorfmeister, W.W. Zeng, A. Dichlberger, S.K. Nilsson, F.G. Schaap, J.A. Hubacek, M. Merkel, J.A. Cooper, A. Lookene, W. Putt, R. Whittall, P.J. Lee, L. Lins, N. Delsaux, M. Nierman, J.A. Kuivenhoven, J.J.P. Kastelein, M. Vrablik, G. Olivecrona, W.J. Schneider, J. Heeren, S.E. Humphries, and P.J. Talmud Arterioscler Thromb Vasc Biol. 2008;28:1866-1871; published online before print July 17 2008, doi:10.1161/ATVBAHA.108.172866 Abstract \| Full Text \| PDF \| Data Supplement Sequencing APOA5 in 130 severe hypertriglyceridemic patients identified 3 novel heterozygous mutations E255G, G271C, and H321L. Together with the previously reported G185C, Q139X, Q148X, and novel {Delta}139 to 147 their impact in vitro, on LPL activity and receptor binding (LR8 and LRP1), was studied.
	Mechanisms of the Factor V Leiden Paradox K.J. van Stralen, C.J.M. Doggen, I.D. Bezemer, E.R. Pomp, T. Lisman, and F.R. Rosendaal Arterioscler Thromb Vasc Biol. 2008;28:1872-1877; published online before print July 10 2008, doi:10.1161/ATVBAHA.108.169524 Abstract \| Full Text \| PDF Carriers of the factor V Leiden mutation have substantial risk of deep venous thrombosis but a mild pulmonary embolism risk. Five potential mechanisms were explored; thrombus location, number of affected veins, time between provocation and diagnosis, in vitro coagulation time, and thrombus density. None of the mechanisms offered a clear explanation.
	Letters to the Editor
	Homocysteine Is Not So Paradoxical Leslie M. Klevay Arterioscler Thromb Vasc Biol. 2008;28:e160, doi:10.1161/ATVBAHA.108.172072 Extract \| Full Text \| PDF
	Many Potential Explanations for the Homocysteine Paradox Roman N. Rodionov and Steven R. Lentz Arterioscler Thromb Vasc Biol. 2008;28:e161, doi:10.1161/ATVBAHA.108.172494 Extract \| Full Text \| PDF

Spotlight

TOC Spotlight File

Volume 28, Issue 10; October 1, 2008

Key: VB = Vascular Biology AL = Atherosclerosis/Lipoproteins TH = Thrombosis

Editorials

Kinetic Studies of the Metabolism of Rapidly Exchangeable Apolipoproteins May Leave Investigators and Readers With Exchangeable Results

Apelin-APJ Signaling in Retinal Angiogenesis

A New Kid on the Block: PKD1: A Promising Target for Antiangiogenic Therapy?

Endothelial H2O2: A Bad Guy Turning Good?

Brief Reviews

Death Receptors and Their Ligands in Atherosclerosis

Integrins: The Keys to Unlocking Angiogenesis

Integrative Physiology/Experimental Medicine

Brief Report: Accelerated Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice Lacking the Membrane-Bound Complement Regulator CD59

Retardation of Retinal Vascular Development in Apelin-Deficient Mice

Acid Sphingomyelinase Promotes Lipoprotein Retention Within Early Atheromata and Accelerates Lesion Progression

Overexpression of Human ABCG1 Does Not Affect Atherosclerosis in Fat-Fed ApoE-Deficient Mice

Alterations in Hepatic Metabolism in fld Mice Reveal a Role for Lipin 1 in Regulating VLDL-Triacylglyceride Secretion

Absence of Hyperlipidemia in LDL Receptor-Deficient Mice Having Apolipoprotein B100 Without the Putative Receptor-Binding Sequences

Adenovirus-Mediated VEGF Gene Therapy Enhances Venous Thrombus Recanalization and Resolution

Air Pollution Exposure Potentiates Hypertension Through Reactive Oxygen Species-Mediated Activation of Rho/ROCK

A Novel Sartan Derivative With Very Low Angiotensin II Type 1 Receptor Affinity Protects the Kidney in Type 2 Diabetic Rats

Hydrogen Peroxide Potentiates the EDHF Phenomenon by Promoting Endothelial Ca2+ Mobilization

Cell Biology/Signaling

VEGF Stimulates HDAC7 Phosphorylation and Cytoplasmic Accumulation Modulating Matrix Metalloproteinase Expression and Angiogenesis

AMP-Activated Protein Kinase Promotes the Differentiation of Endothelial Progenitor Cells

Transcriptional Activation of HIF-1 by ROR and its Role in Hypoxia Signaling

Protein Kinase G Phosphorylates Soluble Guanylyl Cyclase on Serine 64 and Inhibits Its Activity

12/15-Lipoxygenase Activity Increases the Degradation of Macrophage ATP-Binding Cassette Transporter G1

ApoA-I Facilitates ABCA1 Recycle/Accumulation to Cell Surface by Inhibiting Its Intracellular Degradation and Increases HDL Generation

Proteolytic Cleavage of High Mobility Group Box 1 Protein by Thrombin-Thrombomodulin Complexes

Clinical and Population Studies

Atorvastatin and Fenofibrate Have Comparable Effects on VLDL-Apolipoprotein C-III Kinetics in Men With the Metabolic Syndrome

Gender-Specific Differences in the Kinetics of Nonfasting TRL, IDL, and LDL Apolipoprotein B-100 in Men and Premenopausal Women

Macrophages and Platelets Are the Major Source of Protease Nexin-1 in Human Atherosclerotic Plaque

Lipoprotein(a) Is Associated Differentially With Carotid Stenosis, Occlusion, and Total Plaque Area

Longitudinal Change in Serum Gamma-Glutamyltransferase and Cardiovascular Disease Mortality: A Prospective Population-Based Study in 76 113 Austrian Adults

Effects of Six APOA5 Variants, Identified in Patients With Severe Hypertriglyceridemia, on In Vitro Lipoprotein Lipase Activity and Receptor Binding

Mechanisms of the Factor V Leiden Paradox

Letters to the Editor

Homocysteine Is Not So Paradoxical

Many Potential Explanations for the Homocysteine Paradox

Spotlight

Endothelial H₂O₂: A Bad Guy Turning Good?

Hydrogen Peroxide Potentiates the EDHF Phenomenon by Promoting Endothelial Ca²⁺ Mobilization

Transcriptional Activation of HIF-1 by ROR ${alpha}$ and its Role in Hypoxia Signaling