Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (27 [7])

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Volume 27, Issue 7; July 1, 2007

Editorials
Brief Reviews
Vascular Biology
Atherosclerosis and Lipoproteins
Thrombosis
Letters to the Editor
AHA News
AHA Meetings
AHA Fellows

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	Editorials
	Endothelial GTPCH in eNOS Uncoupling and Atherosclerosis Tohru Fukai Arterioscler Thromb Vasc Biol. 2007;27:1493-1495, doi:10.1161/ATVBAHA.107.148239 Full Text \| PDF
	Posttranslational Protein Palmitoylation: Promoting Platelet Purpose Adam D. Munday and José A. López Arterioscler Thromb Vasc Biol. 2007;27:1496-1499, doi:10.1161/ATVBAHA.106.136226 Full Text \| PDF
	Brief Reviews
	Vascular Responses to Drug Eluting Stents: Importance of Delayed Healing Aloke V. Finn, Gaku Nakazawa, Michael Joner, Frank D. Kolodgie, Erik K. Mont, Herman K. Gold, and Renu Virmani Arterioscler Thromb Vasc Biol. 2007;27:1500-1510; published online before print May 17 2007, doi:10.1161/ATVBAHA.107.144220 Abstract \| Full Text \| PDF \| Data Supplement Late thrombosis after polymer-based sirolimus- (Cypher) and paclitaxel-eluting (Taxus) drug eluting stents has emerged as a major safety concern. This review will summarize our current understanding of the vascular response to these DES in both humans and animals, especially as it pertains to the issue of late DES thrombosis.
	Platelet Receptor Proteolysis: A Mechanism for Downregulating Platelet Reactivity Robert K. Andrews, Denuja Karunakaran, Elizabeth E. Gardiner, and Michael C. Berndt Arterioscler Thromb Vasc Biol. 2007;27:1511-1520; published online before print April 26 2007, doi:10.1161/ATVBAHA.107.141390 Abstract \| Full Text \| PDF This review focuses on key proteolytic mechanisms regulating the surface expression, adheso-signaling function and plasma levels of platelet receptors involved in thrombosis, inflammation and other vascular processes, in particular using platelet collagen receptor, glycoprotein (GP)VI, shedding to illustrate the implications for normal physiology or future therapeutics.
	Vascular Biology
	Loss-of-Function Deletion of the Steroid Receptor Coactivator-1 Gene in Mice Reduces Estrogen Effect on the Vascular Injury Response Yuhui Yuan and Jianming Xu Arterioscler Thromb Vasc Biol. 2007;27:1521-1527; published online before print April 19 2007, doi:10.1161/ATVBAHA.107.144477 Abstract \| Full Text \| PDF Using SRC-1 knockout mice and a common carotid ligation model, we demonstrated that SRC-1 deficiency reduced the inhibitory effect of estrogen on the neointima formation and on the neointimal cell proliferation after a vascular injury. Our results indicate that SRC-1 dysfunction may result in partial impairment of the vasoprotective effect of estrogen.
	Cooperation of SRC-1 and p300 With NF- ${kappa}$ B and CREB in Angiotensin II-Induced IL-6 Expression in Vascular Smooth Muscle Cells Saurabh Sahar, Marpadga A. Reddy, Cynthie Wong, Li Meng, Mei Wang, and Rama Natarajan Arterioscler Thromb Vasc Biol. 2007;27:1528-1534; published online before print May 10 2007, doi:10.1161/ATVBAHA.107.145862 Abstract \| Full Text \| PDF \| Data Supplement In vascular smooth muscle cells Angiotensin II-induced IL-6 expression involves histone H3 lysine acetylation mediated by histone acetyl transferases p300 and SRC-1 and their cooperation with transcription factors NF-{kappa}B and CREB. ERK signaling plays a key role by regulating the activation of these transcription factors and histone acetyl transferases.
	Acyclic Retinoid Inhibits Neointima Formation Through Retinoic Acid Receptor Beta-Induced Apoptosis Nanae Kada, Toru Suzuki, Kenichi Aizawa, Takayoshi Matsumura, Naoto Ishibashi, Naomi Suzuki, Norifumi Takeda, Yoshiko Munemasa, Daigo Sawaki, Takashi Ishikawa, and Ryozo Nagai Arterioscler Thromb Vasc Biol. 2007;27:1535-1541; published online before print May 3 2007, doi:10.1161/ATVBAHA.106.134114 Abstract \| Full Text \| PDF \| Data Supplement Acyclic retinoid (ACR) is a synthetic retinoid with a high safety profile that has been pursued with high expectations for therapeutic use in prevention (recurrence) and treatment of malignancies. With the objective of addressing the therapeutic potential in the cardiovasculature, namely neointima formation, effects of ACR on neointima formation and the involved mechanisms were investigated.
	CYP26 Inhibitor R115866 Increases Retinoid Signaling in Intimal Smooth Muscle Cells Pauline Ocaya, Andreas C. Gidlöf, Peder S. Olofsson, Hans Törmä, and Allan Sirsjö Arterioscler Thromb Vasc Biol. 2007;27:1542-1548; published online before print May 17 2007, doi:10.1161/ATVBAHA.106.138602 Abstract \| Full Text \| PDF \| Data Supplement atRA regulates proliferation and differentiation of various cell types. We show that inhibition of CYP26 by R115866 in intimal SMCs results in increased cellular retinoids and retinoidal effects, ie, inhibition of DNA synthesis and alteration of cell morphology. Therefore, CYP26 inibitors offer a potential new therapeutic approach to vascular proliferative disorders.
	Inducible cAMP Early Repressor Inhibits Growth of Vascular Smooth Muscle Cell Hideki Ohtsubo, Toshihiro Ichiki, Ryohei Miyazaki, Keita Inanaga, Ikuyo Imayama, Yasuko Hashiguchi, Junichi Sadoshima, and Kenji Sunagawa Arterioscler Thromb Vasc Biol. 2007;27:1549-1555; published online before print April 26 2007, doi:10.1161/ATVBAHA.107.145011 Abstract \| Full Text \| PDF Inducible cAMP early repressor (ICER) is involved in beraprost-induced growth inhibition of vascular smooth muscle cells. Overexpression of ICER suppressed neointimal formation in balloon-injured artery, suggesting that ICER may be an important negative regulator of the vascular remodeling process and an effective therapeutic tool to treat vascular proliferative disease.
	Histamine Upregulates the Expression of Inducible Nitric Oxide Synthase in Human Intimal Smooth Muscle Cells via Histamine H1 Receptor and NF- ${kappa}$ B Signaling Pathway Akihide Tanimoto, Ke-Yong Wang, Yoshitaka Murata, Satoshi Kimura, Masako Nomaguchi, Sei Nakata, Masato Tsutsui, and Yasuyuki Sasaguri Arterioscler Thromb Vasc Biol. 2007;27:1556-1561; published online before print May 3 2007, doi:10.1161/ATVBAHA.106.139089 Abstract \| Full Text \| PDF Histamine increases endothelial nitric oxide (NO) production as an endothelium-dependent vasodilator, which acts as a vasoconstrictor in atherosclerotic coronary arteries. To investigate the relation between histamine and NO production in intimal smooth muscle cells (SMCs), we studied the effect of histamine on inducible NO synthase (iNOS) expression in the SMCs.
	Venous Identity Is Lost but Arterial Identity Is Not Gained During Vein Graft Adaptation Fabio A. Kudo, Akihito Muto, Stephen P. Maloney, Jose M. Pimiento, Sonia Bergaya, Tamara N. Fitzgerald, Tormod S. Westvik, Jared C. Frattini, Christopher K. Breuer, Charles H. Cha, Toshiya Nishibe, George Tellides, William C. Sessa, and Alan Dardik Arterioscler Thromb Vasc Biol. 2007;27:1562-1571; published online before print April 26 2007, doi:10.1161/ATVBAHA.107.143032 Abstract \| Full Text \| PDF \| Data Supplement In human and aged rat vein graft adaptation, Eph-B4, a marker of venous identity, is downregulated, whereas markers of arterial identity such as Ephrin-B2 are not induced. These results suggest that markers of vessel identity that are developmentally regulated are plastic in adults.
	Endothelial Outgrowth Cells Are Not Derived From CD133⁺ Cells or CD45⁺ Hematopoietic Precursors Frank Timmermans, Filip Van Hauwermeiren, Magda De Smedt, Robrecht Raedt, Frank Plasschaert, Marc L. De Buyzere, Thierry C. Gillebert, Jean Plum, and Bart Vandekerckhove Arterioscler Thromb Vasc Biol. 2007;27:1572-1579; published online before print May 10 2007, doi:10.1161/ATVBAHA.107.144972 Abstract \| Full Text \| PDF \| Data Supplement Two types of endothelial progenitor cells (EPCs) were previously described. In the present article, we dissect the relation of the cell surface markers CD34, CD133, VEGFR2, and CD45 on fresh isolated human cells with respect to both in vitro generated EPC populations.
	Removal of Fkbp12/12.6 From Endothelial Ryanodine Receptors Leads to an Intracellular Calcium Leak and Endothelial Dysfunction Cheng Long, Leslie G. Cook, Gang-Yi Wu, and Brett M. Mitchell Arterioscler Thromb Vasc Biol. 2007;27:1580-1586; published online before print May 3 2007, doi:10.1161/ATVBAHA.107.144808 Abstract \| Full Text \| PDF We tested whether rapamycin or FK506 alters intracellular Ca2+ in endothelial cells and whether this affects endothelial function and blood pressure regulation. Complete removal of FKBP12 and 12.6 from endothelial RyRs induced an intracellular Ca2+ leak which may contribute to the pathogenesis of rapamycin/FK506-induced endothelial dysfunction and hypertension.
	Vascular Endothelial Growth Factor Is Induced by the Inflammatory Cytokines Interleukin-6 and Oncostatin M in Human Adipose Tissue In Vitro and in Murine Adipose Tissue In Vivo G. Rega, C. Kaun, S. Demyanets, S. Pfaffenberger, K. Rychli, P.J. Hohensinner, S.P. Kastl, W.S. Speidl, T.W. Weiss, J.M. Breuss, A. Furnkranz, P. Uhrin, J. Zaujec, V. Zilberfarb, M. Frey, R. Roehle, G. Maurer, K. Huber, and J. Wojta Arterioscler Thromb Vasc Biol. 2007;27:1587-1595; published online before print May 24 2007, doi:10.1161/ATVBAHA.107.143081 Abstract \| Full Text \| PDF \| Data Supplement Recent studies found that adipose tissue mass could be regulated through the vasculature. We show that the inflammatory cytokines IL-6 and OSM upregulate VEGF in human adipose tissue via JAK/STAT. We hypothesize that a link between adipokines, vascularization, adipose tissue growth, and thus possibly also cardiovascular diseases could exist.
	Atherosclerosis and Lipoproteins
	Elevated Cholesterol Levels in the Plasma Membranes of Macrophages Inhibit Migration by Disrupting RhoA Regulation Tomokazu Nagao, Chunbo Qin, Inna Grosheva, Frederick R. Maxfield, and Lynda M. Pierini Arterioscler Thromb Vasc Biol. 2007;27:1596-1602; published online before print May 10 2007, doi:10.1161/ATVBAHA.107.145086 Abstract \| Full Text \| PDF \| Data Supplement We tested the hypothesis that elevated membrane cholesterol levels affect macrophage migration. The results suggest that increases in cholesterol levels interfere with RhoA activation, resulting in inhibition of migration attributable to reduced contractile force generation. These findings provide one possible explanation for the retention of foam cells in atherosclerotic lesions.
	ABCA1-Induced Cell Surface Binding Sites for ApoA-I Charulatha Vedhachalam, Amy B. Ghering, W. Sean Davidson, Sissel Lund-Katz, George H. Rothblat, and Michael C. Phillips Arterioscler Thromb Vasc Biol. 2007;27:1603-1609; published online before print May 3 2007, doi:10.1161/ATVBAHA.107.145789 Abstract \| Full Text \| PDF \| Data Supplement 15-LO-I is expressed in rabbit aorta. 15-LO regulates vasodilatory eicosanoid synthesis and vascular tone. The current study demonstrates that ABCA1 activity creates 2 types of high affinity apoA-I binding sites at the cell surface. The low capacity site formed by direct apoA-I/ABCA1 interaction functions in a regulatory role, whereas the much higher capacity site generated by apoA-I/lipid interactions functions in the assembly of nascent HDL particles.
	Apolipoprotein E Interrupts Interleukin-1ß Signaling in Vascular Smooth Muscle Cells Akira Kawamura, Daniel Baitsch, Ralph Telgmann, Renata Feuerborn, Gabriele Weissen-Plenz, Claudia Hagedorn, Keijiro Saku, Stefan-Martin Brand-Herrmann, Arnold von Eckardstein, Gerd Assmann, and Jerzy-Roch Nofer Arterioscler Thromb Vasc Biol. 2007;27:1610-1617; published online before print May 17 2007, doi:10.1161/ATVBAHA.106.129957 Abstract \| Full Text \| PDF \| Data Supplement Apolipoprotein E (apoE) exerts antiatherogenic effects, but precise mechanisms remain unclear. The present study demonstrates that apoE suppress IL-1ß-induced inflammatory activation of vascular smooth muscle cells by targeting IL receptor-associated kinase-1 (IRAK-1) and transcription factors NF-{kappa}B and AP-1 in a process dependent on protein kinase A (PKA).
	Expression of Human OSBP-Related Protein 1L in Macrophages Enhances Atherosclerotic Lesion Development in LDL Receptor–Deficient Mice Daoguang Yan, Matti Jauhiainen, Reeni B. Hildebrand, Ko Willems van Dijk, Theo J.C. Van Berkel, Christian Ehnholm, Miranda Van Eck, and Vesa M. Olkkonen Arterioscler Thromb Vasc Biol. 2007;27:1618-1624; published online before print May 3 2007, doi:10.1161/ATVBAHA.107.144121 Abstract \| Full Text \| PDF \| Data Supplement LDLr-/- animals that received bone marrow of mice expressing human ORP1L in macrophages displayed a 2.1-fold increase in aortic root lesion size relative to controls. Decreased macrophage ABCG1 and apoE expression and cholesterol efflux to HDL2, as well as increased PLTP expression, provide plausible explanations for the increased lesion size.
	Enhanced Immune System Activation and Arterial Inflammation Accelerates Atherosclerosis in Lupus-Prone Mice Emmanuel L. Gautier, Thierry Huby, Betty Ouzilleau, Chantal Doucet, Flora Saint-Charles, Guilaine Gremy, M. John Chapman, and Philippe Lesnik Arterioscler Thromb Vasc Biol. 2007;27:1625-1631; published online before print April 19 2007, doi:10.1161/ATVBAHA.107.142430 Abstract \| Full Text \| PDF \| Data Supplement Premature atherosclerosis is a feature of autoimmune disease but the mechanisms that underlie such accelerated atherosclerosis are indeterminate. Our experimental findings highlight enhanced immune system activation, aortic inflammation, and lesional accumulation of apoptotic cells, macrophages, and CD4 T cells as central mechanisms in the progression of atherosclerosis in autoimmune mice.
	A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression Tomofumi Takaya, Ken-ichi Hirata, Tomoya Yamashita, Masakazu Shinohara, Naoto Sasaki, Nobutaka Inoue, Toyotaka Yada, Masami Goto, Akiko Fukatsu, Toshio Hayashi, Nicholas J. Alp, Keith M. Channon, Mitsuhiro Yokoyama, and Seinosuke Kawashima Arterioscler Thromb Vasc Biol. 2007;27:1632-1637; published online before print April 26 2007, doi:10.1161/ATVBAHA.107.142182 Abstract \| Full Text \| PDF In apolipoprotein E-deficient mice overexpressing eNOS in the endothelium, augmenting BH4 levels in the endothelium by GTP-cyclohydrolase I overexpression was more efficient to reduce the accelerated atherosclerotic lesion formation and superoxide production from uncoupled eNOS compared with chronic vitamin C treatment.
	Type A Eagerness-Energy Across Developmental Periods Predicts Adulthood Carotid Intima-Media Thickness: The Cardiovascular Risk in Young Finns Study Liisa Keltikangas-Järvinen, Taina Hintsa, Mika Kivimäki, Sampsa Puttonen, Markus Juonala, Jorma S.A. Viikari, and Olli T. Raitakari Arterioscler Thromb Vasc Biol. 2007;27:1638-1644; published online before print May 10 2007, doi:10.1161/ATVBAHA.107.145524 Abstract \| Full Text \| PDF Type A behavior as a predictor of adult carotid artery intima-media thickness (IMT) was examined in a population-based sample of 408 men and 606 women. It was shown that eagerness-energy component of Type A behavior over different developmental transitions seems to be a robust predictor of IMT in men.
	Thrombosis
	Impact of Serum Amyloid A on Tissue Factor and Tissue Factor Pathway Inhibitor Expression and Activity in Endothelial Cells Yulan Zhao, Shuli Zhou, and Chew-Kiat Heng Arterioscler Thromb Vasc Biol. 2007;27:1645-1650; published online before print April 26 2007, doi:10.1161/ATVBAHA.106.137455 Abstract \| Full Text \| PDF This study investigates the impact of SAA on the expression and activity of TF and TFPI in endothelial cells. The stimulating effect of SAA was faster-acting on TF and the inhibitory effect was slower-acting on TFPI. The effects are mediated through FPRL1, MAP kinases and NF{kappa}B.
	Endothelial Fibrinolytic Capacity Predicts Future Adverse Cardiovascular Events in Patients With Coronary Heart Disease Simon D. Robinson, Christopher A. Ludlam, Nicholas A. Boon, and David E. Newby Arterioscler Thromb Vasc Biol. 2007;27:1651-1656; published online before print April 26 2007, doi:10.1161/ATVBAHA.107.143248 Abstract \| Full Text \| PDF We show that endothelial tissue plasminogen activator (t-PA) release is a distinct marker of endothelial function and that in patients with stable coronary heart disease acute t-PA release predicts an increased risk of future adverse cardiovascular events.
	Activation of Human Platelets by Misfolded Proteins Eszter Herczenik, Barend Bouma, Suzanne J.A. Korporaal, Remo Strangi, Qinghong Zeng, Piet Gros, Miranda Van Eck, Theo J.C. Van Berkel, Martijn F.B.G. Gebbink, and Jan-Willem N. Akkerman Arterioscler Thromb Vasc Biol. 2007;27:1657-1665; published online before print May 17 2007, doi:10.1161/ATVBAHA.107.143479 Abstract \| Full Text \| PDF \| Data Supplement Protein misfolding is a common feature in Alzheimer disease, atherosclerosis, diabetes mellitus, and systemic amyloidosis. These diseases are associated with platelet hyperactivity. This study demonstrates that amyloid properties in proteins represent a novel platelet activating property. These properties explain the increased platelet activation in many diseases with appearance of misfolded proteins.
	Letters to the Editor
	Elevated Endothelial Microparticles in Fabry Children Decreased After Enzyme Replacement Therapy Monique P. Gelderman, Raphael Schiffmann, and Jan Simak Arterioscler Thromb Vasc Biol. 2007;27:e138-e139, doi:10.1161/ATVBAHA.107.143511 Full Text \| PDF
	Animal Models and Virtual Histology Renu Virmani and Gaku Nakazawa Arterioscler Thromb Vasc Biol. 2007;27:1666, doi:10.1161/ATVBAHA.107.143198 Full Text \| PDF
	Animal Models and Virtual Histology Juan F. Granada, Albert E. Raizner, and Greg L. Kaluza Arterioscler Thromb Vasc Biol. 2007;27:1667-1668, doi:10.1161/ATVBAHA.107.146837 Full Text \| PDF
	AHA News
	AHA News Arterioscler Thromb Vasc Biol. 2007;27:B1-B2, doi:10.1161/01.ATVBAHA.0000278629.94381.91 PDF
	AHA Meetings
	AHA Meetings Arterioscler Thromb Vasc Biol. 2007;27:B3-B4, doi:10.1161/01.ATVBAHA.0000278630.02005.0f PDF
	AHA Fellows
	AHA Fellows Arterioscler Thromb Vasc Biol. 2007;27:B5-B6, doi:10.1161/01.ATVBAHA.0000278631.79134.0d PDF

Spotlight

TOC Spotlight File

Volume 27, Issue 7; July 1, 2007

Editorials

Endothelial GTPCH in eNOS Uncoupling and Atherosclerosis

Posttranslational Protein Palmitoylation: Promoting Platelet Purpose

Brief Reviews

Vascular Responses to Drug Eluting Stents: Importance of Delayed Healing

Platelet Receptor Proteolysis: A Mechanism for Downregulating Platelet Reactivity

Vascular Biology

Loss-of-Function Deletion of the Steroid Receptor Coactivator-1 Gene in Mice Reduces Estrogen Effect on the Vascular Injury Response

Cooperation of SRC-1 and p300 With NF-B and CREB in Angiotensin II-Induced IL-6 Expression in Vascular Smooth Muscle Cells

Acyclic Retinoid Inhibits Neointima Formation Through Retinoic Acid Receptor Beta-Induced Apoptosis

CYP26 Inhibitor R115866 Increases Retinoid Signaling in Intimal Smooth Muscle Cells

Inducible cAMP Early Repressor Inhibits Growth of Vascular Smooth Muscle Cell

Histamine Upregulates the Expression of Inducible Nitric Oxide Synthase in Human Intimal Smooth Muscle Cells via Histamine H1 Receptor and NF-B Signaling Pathway

Venous Identity Is Lost but Arterial Identity Is Not Gained During Vein Graft Adaptation

Endothelial Outgrowth Cells Are Not Derived From CD133+ Cells or CD45+ Hematopoietic Precursors

Removal of Fkbp12/12.6 From Endothelial Ryanodine Receptors Leads to an Intracellular Calcium Leak and Endothelial Dysfunction

Vascular Endothelial Growth Factor Is Induced by the Inflammatory Cytokines Interleukin-6 and Oncostatin M in Human Adipose Tissue In Vitro and in Murine Adipose Tissue In Vivo

Atherosclerosis and Lipoproteins

Elevated Cholesterol Levels in the Plasma Membranes of Macrophages Inhibit Migration by Disrupting RhoA Regulation

ABCA1-Induced Cell Surface Binding Sites for ApoA-I

Apolipoprotein E Interrupts Interleukin-1ß Signaling in Vascular Smooth Muscle Cells

Expression of Human OSBP-Related Protein 1L in Macrophages Enhances Atherosclerotic Lesion Development in LDL Receptor–Deficient Mice

Enhanced Immune System Activation and Arterial Inflammation Accelerates Atherosclerosis in Lupus-Prone Mice

A Specific Role for eNOS-Derived Reactive Oxygen Species in Atherosclerosis Progression

Type A Eagerness-Energy Across Developmental Periods Predicts Adulthood Carotid Intima-Media Thickness: The Cardiovascular Risk in Young Finns Study

Thrombosis

Impact of Serum Amyloid A on Tissue Factor and Tissue Factor Pathway Inhibitor Expression and Activity in Endothelial Cells

Endothelial Fibrinolytic Capacity Predicts Future Adverse Cardiovascular Events in Patients With Coronary Heart Disease

Activation of Human Platelets by Misfolded Proteins

Letters to the Editor

Elevated Endothelial Microparticles in Fabry Children Decreased After Enzyme Replacement Therapy

Animal Models and Virtual Histology

Animal Models and Virtual Histology

AHA News

AHA News

AHA Meetings

AHA Meetings

AHA Fellows

AHA Fellows

Spotlight

Cooperation of SRC-1 and p300 With NF- ${kappa}$ B and CREB in Angiotensin II-Induced IL-6 Expression in Vascular Smooth Muscle Cells

Histamine Upregulates the Expression of Inducible Nitric Oxide Synthase in Human Intimal Smooth Muscle Cells via Histamine H1 Receptor and NF- ${kappa}$ B Signaling Pathway

Endothelial Outgrowth Cells Are Not Derived From CD133⁺ Cells or CD45⁺ Hematopoietic Precursors