Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (27 [2])

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Volume 27, Issue 2; February 1, 2007

Editorials
Brief Reviews
Vascular Biology
Atherosclerosis and Lipoproteins
Thrombosis
Letters to the Editor
Corrections

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	Editorials
	The Failure of Torcetrapib: Was it the Molecule or the Mechanism? Alan R. Tall, Laurent Yvan-Charvet, and Nan Wang Arterioscler Thromb Vasc Biol. 2007;27:257-260, doi:10.1161/01.ATV.0000256728.60226.77. Full Text \| PDF
	Emerging Thrombotic Effects of Drug Eluting Stents Ninian N. Lang and David E. Newby Arterioscler Thromb Vasc Biol. 2007;27:261-262, doi:10.1161/01.ATV.0000255308.41576.ae. Full Text \| PDF
	CXCR4, a Key Modulator of Vascular Progenitor Cells Julie Sainz and Masataka Sata Arterioscler Thromb Vasc Biol. 2007;27:263-265, doi:10.1161/01.ATV.0000256727.34148.e2. Full Text \| PDF
	Brief Reviews
	Implications of Early Structural-Functional Changes in the Endothelium for Vascular Disease Maya Simionescu Arterioscler Thromb Vasc Biol. 2007;27:266-274; published online before print November 30 2006, doi:10.1161/01.ATV.0000253884.13901.e4. Abstract \| Full Text \| PDF The initial key events in atherosclerosis are the dyslipidemia-induced subtle modulation of endothelial constitutive functions and the subendothelial progressive accumulation of modified and reassembled lipoproteins that trigger an inflammatory reaction manifested by the expression of endothelial cell adhesion molecules and intimal accrual of macrophages, smooth muscle cells, and inflammatory molecules.
	Vascular Biology
	Sphingosine-1-Phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR₄-Dependent Signaling Pathway via the S1P₃ Receptor Dirk H. Walter, Ulrich Rochwalsky, Johannes Reinhold, Florian Seeger, Alexandra Aicher, Carmen Urbich, Ioakim Spyridopoulos, Jerold Chun, Volker Brinkmann, Petra Keul, Bodo Levkau, Andreas M. Zeiher, Stefanie Dimmeler, and Judith Haendeler Arterioscler Thromb Vasc Biol. 2007;27:275-282; published online before print December 7 2006, doi:10.1161/01.ATV.0000254669.12675.70. Abstract \| Full Text \| PDF \| Data Supplement Treatment of progenitor cells with sphingosine-1-phosphate (S1P), a bioactive lipid, improved blood flow recovery in ischemic hind limbs via the S1P3 receptor. Mechanistically, S1P induced phosphorylation of the CXCR4 receptor, the Src kinase, and JAK2. S1P failed to stimulate in vivo blood flow recovery of bone marrow-derived mononuclear cells from CXCR4+/- mice. The activation of the CXCR4 receptor is mediated via the S1P3 receptor because S1P did not induce Src phosphorylation in progenitor cells from S1P3-/- mice.
	M-CSF Accelerates Neointimal Formation in the Early Phase After Vascular Injury in Mice: The Critical Role of the SDF-1–CXCR4 System Yuji Shiba, Masafumi Takahashi, Toru Yoshioka, Noriyuki Yajima, Hajime Morimoto, Atsushi Izawa, Hirohiko Ise, Kiyohiko Hatake, Kazuo Motoyoshi, and Uichi Ikeda Arterioscler Thromb Vasc Biol. 2007;27:283-289; published online before print October 19 2006, doi:10.1161/01.ATV.0000250606.70669.14. Abstract \| Full Text \| PDF \| Data Supplement We tested the effects of M-CSF on the recruitment of bone marrow-derived progenitor cells in neointimal formation after vascular injury in mice. The findings obtained from this study demonstrated that M-CSF accelerated neointimal formation in the early phase after vascular injury via the SDF-1-CXCR4 system.
	Regulation of Thromboxane Receptor Trafficking Through the Prostacyclin Receptor in Vascular Smooth Muscle Cells: Role of Receptor Heterodimerization Stephen J. Wilson, Jennifer K. Dowling, Lei Zhao, Erin Carnish, and Emer M. Smyth Arterioscler Thromb Vasc Biol. 2007;27:290-296; published online before print November 16 2006, doi:10.1161/01.ATV.0000252667.53790.4e. Abstract \| Full Text \| PDF Interaction of the G protein-coupled receptors for prostacyclin (IP) and thromboxane (TP) permits reciprocal regulation of receptor endocytosis via a trafficking pathway determined by the activated dimeric partner. This represents a further mechanism by which dimerization may effect the IP-TP counterbalance.
	Mass-Spectrometric Identification of a Novel Angiotensin Peptide in Human Plasma Vera Jankowski, Raymond Vanholder, Markus van der Giet, Markus Tölle, Sevil Karadogan, Johan Gobom, Jens Furkert, Alexander Oksche, Eberhard Krause, Thi Nguyet Anh Tran, Martin Tepel, Mirjam Schuchardt, Hartmut Schlüter, Annette Wiedon, Michael Beyermann, Michael Bader, Mihail Todiras, Walter Zidek, and Joachim Jankowski Arterioscler Thromb Vasc Biol. 2007;27:297-302; published online before print November 30 2006, doi:10.1161/01.ATV.0000253889.09765.5f. Abstract \| Full Text \| PDF \| Data Supplement In this study, a new angiotensin-peptide of human plasma is described, which is characterized as a strong AT2-receptor agonist.
	Cerebrovascular Nitrosative Stress Mediates Neurovascular and Endothelial Dysfunction Induced by Angiotensin II Helene Girouard, Laibaik Park, Josef Anrather, Ping Zhou, and Costantino Iadecola Arterioscler Thromb Vasc Biol. 2007;27:303-309; published online before print November 30 2006, doi:10.1161/01.ATV.0000253885.41509.25. Abstract \| Full Text \| PDF \| Data Supplement Angiotensin II attenuates the increase in cerebral blood flow produced by acetylcholine or whisker stimulation. We found that these effects require nitric oxide and nox2-derived radicals, and are prevented by peroxynitrite antagonists. The data point to the involvement of peroxynitrite in the cerebrovascular dysfunction induced by angiotensin II.
	Adenovirus-Mediated Expression of Tissue Factor Pathway Inhibitor-2 Inhibits Endothelial Cell Migration and Angiogenesis Lacramioara Ivanciu, Robert D. Gerard, Haiwang Tang, Florea Lupu, and Cristina Lupu Arterioscler Thromb Vasc Biol. 2007;27:310-316; published online before print November 30 2006, doi:10.1161/01.ATV.0000254147.89321.cf. Abstract \| Full Text \| PDF \| Data Supplement This study shows that overexpression of TFPI-2 is an effective strategy to suppress angiogenesis. The mechanism apparently involves inhibition by TFPI-2 of plasmin and/or MMPs, thus reducing cell migration, promoting extracellular matrix deposition, and inhibiting neovascularization. The present data raise the possibility that TFPI-2 is a negative regulator of physiological angiogenesis.
	Key Role of the NO-Pathway and Matrix Metalloprotease-9 in High Blood Flow-Induced Remodeling of Rat Resistance Arteries Odile Dumont, Laurent Loufrani, and Daniel Henrion Arterioscler Thromb Vasc Biol. 2007;27:317-324; published online before print December 7 2006, doi:10.1161/01.ATV.0000254684.80662.44. Abstract \| Full Text \| PDF \| Data Supplement Blood flow is altered in metabolic and ischemic diseases with dramatic consequences. A chronic increase in blood flow (shear stress) in mesenteric resistance arteries induced outward hypertrophic remodeling attributable to the sequential activation of eNOS and MMP9. Lowering blood flow induced a diameter reduction reflecting the loss of flow-dependent dilation.
	A Causal Role for Endothelin-1 in the Vascular Adaptation to Skeletal Muscle Deconditioning in Spinal Cord injury Dick H.J. Thijssen, Reinier Ellenkamp, Miriam Kooijman, Peter Pickkers, Gerard A. Rongen, Maria T.E. Hopman, and Paul Smits Arterioscler Thromb Vasc Biol. 2007;27:325-331; published online before print November 22 2006, doi:10.1161/01.ATV.0000253502.83167.31. Abstract \| Full Text \| PDF We examined the contribution of endothelin-1 to leg vascular tone in controls and in spinal cord injury (representing inactivity), before and after 6-weeks training. Endothelin-1 is responsible for the increased leg vascular tone in spinal cord injury. Interestingly, 6 weeks cycling training normalized leg vascular tone, partially mediated by the reduced contribution of endothelin-1.
	Atherosclerosis and Lipoproteins
	Vascular Endothelial Growth Factor Receptor 2 Plays a Role in the Activation of Aortic Endothelial Cells by Oxidized Phospholipids Alejandro Zimman, Kevin P. Mouillesseaux, Thang Le, Nima M. Gharavi, Ann Ryvkin, Thomas G. Graeber, Tom T. Chen, Andrew D. Watson, and Judith A. Berliner Arterioscler Thromb Vasc Biol. 2007;27:332-338; published online before print November 16 2006, doi:10.1161/01.ATV.0000252842.57585.df. Abstract \| Full Text \| PDF \| Data Supplement We identified VEGFR2 as a regulator of the transcription of IL-8, LDL-R, and TF induced by Ox-PAPC in human aortic endothelial cells. The activation of VEGFR2 is rapid, sustained, and depends on the activation of c-Src kinase.
	Apolipoprotein E3- and Nitric Oxide–Dependent Modulation of Endothelial Cell Inflammatory Responses Adam E. Mullick, Andrew F. Powers, Rama S. Kota, Sarada D. Tetali, Jason P. Eiserich, and John C. Rutledge Arterioscler Thromb Vasc Biol. 2007;27:339-345; published online before print November 30 2006, doi:10.1161/01.ATV.0000253947.70438.99. Abstract \| Full Text \| PDF \| Data Supplement Endothelial-specific effects of apolipoprotein E3 (apoE3), apoE4, and nitric oxide (NO) were assessed with functional and genomic assays of cell inflammation. Herein, we describe a potent antiinflammatory role of apoE3 that is related to modulation of NO. These results have mechanistic implications of the atheroprotective roles of apoE3 and NO.
	Hemodynamic Shear Stresses in Mouse Aortas: Implications for Atherogenesis Jin Suo, Dardo E. Ferrara, Dan Sorescu, Robert E. Guldberg, W. Robert Taylor, and Don P. Giddens Arterioscler Thromb Vasc Biol. 2007;27:346-351; published online before print November 22 2006, doi:10.1161/01.ATV.0000253492.45717.46. Abstract \| Full Text \| PDF We have demonstrated that wall shear stresses in the mouse aorta are much higher than in humans. Despite this difference in magnitude, the spatial distributions of atherogenic molecules in the mouse aorta are similar to plaque localization found in the human aorta.
	Serum Amyloid P and Cardiovascular Disease in Older Men and Women: Results from the Cardiovascular Health Study Nancy Swords Jenny, Alice M. Arnold, Lewis H. Kuller, Russell P. Tracy, and Bruce M. Psaty Arterioscler Thromb Vasc Biol. 2007;27:352-358; published online before print November 30 2006, doi:10.1161/01.ATV.0000254150.97741.fe. Abstract \| Full Text \| PDF Serum amyloid P (SAP) is a pentraxin similar to C-reactive protein. We examined the association of SAP with cardiovascular disease (CVD) in older adults. SAP was associated with inflammatory markers, CVD risk factors, measures of subclinical CVD, and incident angina and MI.
	Triglyceride:High-Density Lipoprotein Cholesterol Effects in Healthy Subjects Administered a Peroxisome Proliferator Activated Receptor ${delta}$ Agonist Dennis L. Sprecher, Christine Massien, Greg Pearce, Andrew N. Billin, Itay Perlstein, Timothy M. Willson, David G. Hassall, Nicolas Ancellin, Scott D. Patterson, David C. Lobe, and Tony G. Johnson Arterioscler Thromb Vasc Biol. 2007;27:359-365; published online before print November 16 2006, doi:10.1161/01.ATV.0000252790.70572.0c. Abstract \| Full Text \| PDF \| Data Supplement A specific PPAR{delta} agonist was administered to human volunteers for the first time, revealing a decline in serum TG, an improvement in TG-clearance post-fat feeding, and an elevation in HDLc compared with placebo. Consistent with these findings, in vitro PPAR{delta}-treated human skeletal muscle cells induced fatty acid oxidation, and upregulated ABCA1 expression.
	Angiopoietin-Like Protein3 Regulates Plasma HDL Cholesterol Through Suppression of Endothelial Lipase Mitsuru Shimamura, Morihiro Matsuda, Hiroaki Yasumo, Mitsuyo Okazaki, Kazunori Fujimoto, Keita Kono, Tetsuya Shimizugawa, Yosuke Ando, Ryuta Koishi, Takafumi Kohama, Naohiko Sakai, Kazuaki Kotani, Ryutaro Komuro, Tatsuo Ishida, Kenichi Hirata, Shizuya Yamashita, Hidehiko Furukawa, and Iichiro Shimomura Arterioscler Thromb Vasc Biol. 2007;27:366-372; published online before print November 16 2006, doi:10.1161/01.ATV.0000252827.51626.89. Abstract \| Full Text \| PDF \| Data Supplement Current studies investigated the potential involvement of angptl3, previously known as a plasma suppressor of lipoprotein lipase, in HDL metabolism and its effects on endothelial lipase (EL) activity. The results suggest that angptl3 should be involved in the regulation of plasma HDL levels through the inhibition of EL activity.
	Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice Vincent Braunersreuther, Alma Zernecke, Claire Arnaud, Elisa A. Liehn, Sabine Steffens, Erdenechimeg Shagdarsuren, Kiril Bidzhekov, Fabienne Burger, Graziano Pelli, Bruno Luckow, François Mach, and Christian Weber Arterioscler Thromb Vasc Biol. 2007;27:373-379; published online before print November 30 2006, doi:10.1161/01.ATV.0000253886.44609.ae. Abstract \| Full Text \| PDF \| Data Supplement Although general blockade of CCL5 receptors reduces atherosclerosis, specific roles of CCR1 and CCR5 have not been unequivocally determined. Genetic deletion of Ccr5 but not Ccr1 in ApoE-/- mice protects from diet-induced atherosclerosis, resulting in a more stable plaque phenotype with reduced mononuclear cell infiltration and Th1-type immune responses.
	Bone Marrow Transplantation Reveals That Recipient AT1a Receptors Are Required to Initiate Angiotensin II–Induced Atherosclerosis and Aneurysms Lisa A. Cassis, Debra L. Rateri, Hong Lu, and Alan Daugherty Arterioscler Thromb Vasc Biol. 2007;27:380-386; published online before print December 7 2006, doi:10.1161/01.ATV.0000254680.71485.92. Abstract \| Full Text \| PDF \| Data Supplement AngII infusion into hyperlipidemic mice leads to augmentation of atherosclerosis and formation of AAAs. The absence of AT1a receptors ablated the development of both these pathologies. Bone marrow transplantation studies demonstrated that the AT1a receptor genotype of the recipient was required to initiate these vascular diseases.
	In Vivo Plaque Characterization Using Intravascular Ultrasound–Virtual Histology in a Porcine Model of Complex Coronary Lesions Juan F. Granada, David Wallace-Bradley, Htut K. Win, Carlos L. Alviar, Angela Builes, Eli I. Lev, Roberto Barrios, Daryl G. Schulz, Albert E. Raizner, and Greg L. Kaluza Arterioscler Thromb Vasc Biol. 2007;27:387-393; published online before print November 30 2006, doi:10.1161/01.ATV.0000253907.51681.0e. Abstract \| Full Text \| PDF Coronary lesions were developed by adventitial injection of lipid-rich liposomes in porcine coronary arteries. IVUS-VH analysis was performed at 8.2{+/-}1.6 weeks after injection. Linear regression models showed that IVUS-VH was not accurate in detecting the relative amount of specific plaque components within each individual corresponding histological specimen.
	Association Between A Leukotriene C₄ Synthase Gene Promoter Polymorphism and Coronary Artery Calcium in Young Women: The Muscatine Study David M. Iovannisci, Edward J. Lammer, Lori Steiner, Suzanne Cheng, Larry T. Mahoney, Patricia H. Davis, Ronald M. Lauer, and Trudy L. Burns Arterioscler Thromb Vasc Biol. 2007;27:394-399; published online before print November 16 2006, doi:10.1161/01.ATV.0000252680.72734.10. Abstract \| Full Text \| PDF An age-adjusted increased risk for coronary artery calcium associated with the (-444)A>C promoter polymorphism of Leukotriene C4 Synthase (LTC4S) was identified in women (OR 4.29; 95% CI 1.78, 10.31). LTC4S is the rate limiting enzyme in the conversion of arachidonic acid to the proinflammatory cysteinyl-leukotrienes.
	Thrombosis
	Antiproliferative Agents Alter Vascular Plasminogen Activator Inhibitor-1 Expression: A Potential Prothrombotic Mechanism of Drug-Eluting Stents James A.S. Muldowney, III, John R. Stringham, Shawn E. Levy, Linda A. Gleaves, Mesut Eren, Robert N. Piana, and Douglas E. Vaughan Arterioscler Thromb Vasc Biol. 2007;27:400-406; published online before print December 7 2006, doi:10.1161/01.ATV.0000254677.12861.b8. Abstract \| Full Text \| PDF \| Data Supplement To examine the prothrombotic effects of antiproliferative agents on endothelial gene expression, coronary endothelial cells were treated with paclitaxel or rapamycin. Transcriptional profiling was performed and confirmed by RT-PCR, ELISA, and a murine model. Rapamycin and paclitaxel induced increases in endothelial PAI-1 in the coronary arteries and aortas of mice.
	Platelet Activity, Coagulation, and Fibrinolysis During Exercise in Healthy Males: Effects of Thrombin Inhibition by Argatroban and Enoxaparin Nailin Li, Shu He, Margareta Blombäck, and Paul Hjemdahl Arterioscler Thromb Vasc Biol. 2007;27:407-413; published online before print November 30 2006, doi:10.1161/01.ATV.0000253906.19648.ac. Abstract \| Full Text \| PDF Studies of thrombin inhibition by argatroban or enoxaparin showed that strenuous exercise enhances platelet activation thrombin independently. Exercise augmented both coagulation and fibrinolysis, but appeared to maintain the balance between them. Argatroban or enoxaparin treatment had strong anticoagulant effects and enhanced fibrinolysis; argatroban inhibited thrombin-induced platelet activation most efficiently.
	Lysophosphatidic Acid Induces Thrombogenic Activity Through Phosphatidylserine Exposure and Procoagulant Microvesicle Generation in Human Erythrocytes Seung-Min Chung, Ok-Nam Bae, Kyung-Min Lim, Ji-Yoon Noh, Moo-Yeol Lee, Yi-Sook Jung, and Jin-Ho Chung Arterioscler Thromb Vasc Biol. 2007;27:414-421; published online before print November 16 2006, doi:10.1161/01.ATV.0000252898.48084.6a. Abstract \| Full Text \| PDF \| Data Supplement Although erythrocytes have been suggested to play a role in blood clotting, mediated through phosphatidylserine (PS) exposure and/or PS-bearing microvesicle generation, an endogenous substance that triggers the membrane alterations leading to a procoagulant activity in erythrocytes has not been reported. We now demonstrated that lysophosphatidic acid (LPA), an important lipid mediator in various pathophysiological processes, induces PS exposure and procoagulant microvesicle generation in erythrocytes, which represent a biological significance resulting in induction of thrombogenic activity.
	GPVI Potentiation of Platelet Activation by Thrombin and Adhesion Molecules Independent of Src Kinases and Syk Sascha C. Hughan, Craig E. Hughes, Owen J.T. McCarty, Edina Schweighoffer, Izoumroud Soultanova, Jerry Ware, Victor L.J. Tybulewicz, and Steve P. Watson Arterioscler Thromb Vasc Biol. 2007;27:422-429; published online before print November 16 2006, doi:10.1161/01.ATV.0000252826.96134.21. Abstract \| Full Text \| PDF \| Data Supplement We show a critical role for Syk in platelet spreading mediated by adhesion receptors that can be overcome by addition of G protein agonists. In addition, we demonstrate for the first time a synergistic pathway between GPVI and thrombin which promotes integrin {alpha}IIbß3 activation independent of Syk and Src kinases.
	Cholesterol Enrichment of Human Monocyte/Macrophages Induces Surface Exposure of Phosphatidylserine and the Release of Biologically-Active Tissue Factor–Positive Microvesicles Ming-Lin Liu, Michael P. Reilly, Peter Casasanto, Steven E. McKenzie, and Kevin Jon Williams Arterioscler Thromb Vasc Biol. 2007;27:430-435; published online before print December 7 2006, doi:10.1161/01.ATV.0000254674.47693.e8. Abstract \| Full Text \| PDF \| Data Supplement Cellular cholesterol accumulation is an important feature of atherosclerosis. In the current study, we found that cholesterol enrichment of human monocytes and macrophages substantially induced the generation of biologically-active microvesicles, including a subset that is tissue factor-positive and highly procoagulant. We conclude that cholesterol-induced monocyte/macrophage microvesicles may be novel contributors to atherothrombosis.
	Letters to the Editor
	Letter to the Editor: Monocyte cAMP Content Is Decreased in Patients With Stable Angina Marie Anne Punchard, Aranzazu Ortega Pozzi, Teresa Perez de Prada, Monica Torres Coronado, Pablo Gonzalez, and Panayotis Fantidis Arterioscler Thromb Vasc Biol. 2007;27:436-437, doi:10.1161/01.ATV.0000252709.13329.7c. Full Text \| PDF
	Corrections
	Correction Arterioscler Thromb Vasc Biol. 2007;27:e8. Full Text \| PDF

Spotlight

TOC Spotlight File

Volume 27, Issue 2; February 1, 2007

Editorials

The Failure of Torcetrapib: Was it the Molecule or the Mechanism?

Emerging Thrombotic Effects of Drug Eluting Stents

CXCR4, a Key Modulator of Vascular Progenitor Cells

Brief Reviews

Implications of Early Structural-Functional Changes in the Endothelium for Vascular Disease

Vascular Biology

Sphingosine-1-Phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR4-Dependent Signaling Pathway via the S1P3 Receptor

M-CSF Accelerates Neointimal Formation in the Early Phase After Vascular Injury in Mice: The Critical Role of the SDF-1–CXCR4 System

Regulation of Thromboxane Receptor Trafficking Through the Prostacyclin Receptor in Vascular Smooth Muscle Cells: Role of Receptor Heterodimerization

Mass-Spectrometric Identification of a Novel Angiotensin Peptide in Human Plasma

Cerebrovascular Nitrosative Stress Mediates Neurovascular and Endothelial Dysfunction Induced by Angiotensin II

Adenovirus-Mediated Expression of Tissue Factor Pathway Inhibitor-2 Inhibits Endothelial Cell Migration and Angiogenesis

Key Role of the NO-Pathway and Matrix Metalloprotease-9 in High Blood Flow-Induced Remodeling of Rat Resistance Arteries

A Causal Role for Endothelin-1 in the Vascular Adaptation to Skeletal Muscle Deconditioning in Spinal Cord injury

Atherosclerosis and Lipoproteins

Vascular Endothelial Growth Factor Receptor 2 Plays a Role in the Activation of Aortic Endothelial Cells by Oxidized Phospholipids

Apolipoprotein E3- and Nitric Oxide–Dependent Modulation of Endothelial Cell Inflammatory Responses

Hemodynamic Shear Stresses in Mouse Aortas: Implications for Atherogenesis

Serum Amyloid P and Cardiovascular Disease in Older Men and Women: Results from the Cardiovascular Health Study

Triglyceride:High-Density Lipoprotein Cholesterol Effects in Healthy Subjects Administered a Peroxisome Proliferator Activated Receptor Agonist

Angiopoietin-Like Protein3 Regulates Plasma HDL Cholesterol Through Suppression of Endothelial Lipase

Ccr5 But Not Ccr1 Deficiency Reduces Development of Diet-Induced Atherosclerosis in Mice

Bone Marrow Transplantation Reveals That Recipient AT1a Receptors Are Required to Initiate Angiotensin II–Induced Atherosclerosis and Aneurysms

In Vivo Plaque Characterization Using Intravascular Ultrasound–Virtual Histology in a Porcine Model of Complex Coronary Lesions

Association Between A Leukotriene C4 Synthase Gene Promoter Polymorphism and Coronary Artery Calcium in Young Women: The Muscatine Study

Thrombosis

Antiproliferative Agents Alter Vascular Plasminogen Activator Inhibitor-1 Expression: A Potential Prothrombotic Mechanism of Drug-Eluting Stents

Platelet Activity, Coagulation, and Fibrinolysis During Exercise in Healthy Males: Effects of Thrombin Inhibition by Argatroban and Enoxaparin

Lysophosphatidic Acid Induces Thrombogenic Activity Through Phosphatidylserine Exposure and Procoagulant Microvesicle Generation in Human Erythrocytes

GPVI Potentiation of Platelet Activation by Thrombin and Adhesion Molecules Independent of Src Kinases and Syk

Cholesterol Enrichment of Human Monocyte/Macrophages Induces Surface Exposure of Phosphatidylserine and the Release of Biologically-Active Tissue Factor–Positive Microvesicles

Letters to the Editor

Letter to the Editor: Monocyte cAMP Content Is Decreased in Patients With Stable Angina

Corrections

Correction

Spotlight

Sphingosine-1-Phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR₄-Dependent Signaling Pathway via the S1P₃ Receptor

Triglyceride:High-Density Lipoprotein Cholesterol Effects in Healthy Subjects Administered a Peroxisome Proliferator Activated Receptor ${delta}$ Agonist

Association Between A Leukotriene C₄ Synthase Gene Promoter Polymorphism and Coronary Artery Calcium in Young Women: The Muscatine Study