Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (27 [10])

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Volume 27, Issue 10; October 1, 2007

Editorials
Brief Reviews
Vascular Biology
Atherosclerosis and Lipoproteins
Thrombosis

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	Editorials
	Reactive Hyperemia and Cardiovascular Risk Andrew Philpott and Todd J. Anderson Arterioscler Thromb Vasc Biol. 2007;27:2065-2067, doi:10.1161/ATVBAHA.107.149740 Extract \| Full Text \| PDF
	Brief Reviews
	Genetic Susceptibility to Peripheral Arterial Disease: A Dark Corner in Vascular Biology Joshua W. Knowles, Themistocles L. Assimes, Jun Li, Thomas Quertermous, and John P. Cooke Arterioscler Thromb Vasc Biol. 2007;27:2068-2078; published online before print July 26 2007, doi:10.1161/01.ATV.0000282199.66398.8c Abstract \| Full Text \| PDF
	Murine Models of Vascular Thrombosis Randal J. Westrick, Mary E. Winn, and Daniel T. Eitzman Arterioscler Thromb Vasc Biol. 2007;27:2079-2093; published online before print June 28 2007, doi:10.1161/ATVBAHA.107.142810 Abstract \| Full Text \| PDF Thrombotic complications of vascular disease remain a leading cause of mortality worldwide. Effective chronic treatment strategies are limited in part because of an inadequate understanding of the factors that influence thrombosis. This review focuses on models of thrombosis useful for elucidating important regulators of thrombosis in mice.
	New Insights Into the Role of Lipoprotein(a)-Associated Lipoprotein-Associated Phospholipase A₂ in Atherosclerosis and Cardiovascular Disease Sotirios Tsimikas, Loukas D. Tsironis, and Alexandros D. Tselepis Arterioscler Thromb Vasc Biol. 2007;27:2094-2099; published online before print July 12 2007, doi:10.1161/01.ATV.0000280571.28102.d4 Abstract \| Full Text \| PDF
	The Problem of Passenger Genes in Transgenic Mice Aldons J. Lusis, Janet Yu, and Susanna S. Wang Arterioscler Thromb Vasc Biol. 2007;27:2100-2103; published online before print August 9 2007, doi:10.1161/ATVBAHA.107.147918 Abstract \| Full Text \| PDF
	JAM Family and Related Proteins in Leukocyte Migration (Vestweber Series) Paul F. Bradfield, Sussan Nourshargh, Michel Aurrand-Lions, and Beat A. Imhof Arterioscler Thromb Vasc Biol. 2007;27:2104-2112; published online before print July 5 2007, doi:10.1161/ATVBAHA.107.147694 Abstract \| Full Text \| PDF
	Vascular Biology
	Predictive Value of Reactive Hyperemia for Cardiovascular Events in Patients With Peripheral Arterial Disease Undergoing Vascular Surgery Alex L. Huang, Annemarie E. Silver, Elena Shvenke, David W. Schopfer, Eiman Jahangir, Megan A. Titas, Alex Shpilman, James O. Menzoian, Michael T. Watkins, Joseph D. Raffetto, Gary Gibbons, Jonathan Woodson, Palma M. Shaw, Mandeep Dhadly, Robert T. Eberhardt, John F. Keaney, Jr, Noyan Gokce, and Joseph A. Vita Arterioscler Thromb Vasc Biol. 2007;27:2113-2119; published online before print August 23 2007, doi:10.1161/ATVBAHA.107.147322 Abstract \| Full Text \| PDF We examined the relationship between reactive hyperemia and cardiovascular events in 267 patients with peripheral arterial disease undergoing vascular surgery. There were 50 cardiovascular events during a 309-day median follow-up period. Patients with lower reactive hyperemia had increased adjusted risk for cardiovascular events (OR 2.7, 95% CI 1.2 to 5.9, P=0.018).
	Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events Julie Dumont, Mahmoud Zureik, Christophe Bauters, Marie-Catherine Grupposo, Dominique Cottel, Michèle Montaye, Martial Hamon, Pierre Ducimetière, Philippe Amouyel, and Thierry Brousseau Arterioscler Thromb Vasc Biol. 2007;27:2120-2126; published online before print August 30 2007, doi:10.1161/ATVBAHA.107.150458 Abstract \| Full Text \| PDF \| Data Supplement The impact of OAZ1 gene polymorphisms on coronary in-stent restenosis risk, common carotid intima-media thickness, and coronary heart disease was evaluated in 3 independent studies. Our results showed that the OAZ1+2222A/G polymorphism is consistently associated with all the 3 phenotypes, suggesting an involvement of the polyamine pathway in vascular diseases.
	Pathway for Differentiation of Human Embryonic Stem Cells to Vascular Cell Components and Their Potential for Vascular Regeneration Masakatsu Sone, Hiroshi Itoh, Kenichi Yamahara, Jun K. Yamashita, Takami Yurugi-Kobayashi, Akane Nonoguchi, Yutaka Suzuki, Ting-Hsing Chao, Naoki Sawada, Yasutomo Fukunaga, Kazutoshi Miyashita, Kwijun Park, Naofumi Oyamada, Naoya Sawada, Daisuke Taura, Naohisa Tamura, Yasushi Kondo, Shinji Nito, Hirofumi Suemori, Norio Nakatsuji, Shin-Ichi Nishikawa, and Kazuwa Nakao Arterioscler Thromb Vasc Biol. 2007;27:2127-2134; published online before print September 13 2007, doi:10.1161/ATVBAHA.107.143149 Abstract \| Full Text \| PDF We investigated differentiation kinetics of human ES cells to vascular cell components. We identified the differentiation process from human ES cells to endothelial cells and mural cells and demonstrated the potential of endothelial cells in the early differentiation stage as a cell source for vascular regeneration.
	Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos Caroline Gray, Ian M. Packham, François Wurmser, Nicholas C. Eastley, Paul G. Hellewell, Philip W. Ingham, David C. Crossman, and Timothy J.A. Chico Arterioscler Thromb Vasc Biol. 2007;27:2135-2141; published online before print July 26 2007, doi:10.1161/ATVBAHA.107.143990 Abstract \| Full Text \| PDF \| Data Supplement We developed a model of arteriogenesis using the zebrafish embryo, and we show that these develop collateral vessels in response to arterial occlusion in a nitric oxide- and myeloid cell-dependent manner. This occurs in the absence of hypoxia, implying that ischemia is not required for arteriogenesis.
	Platelet-Derived Growth Factor Receptor-β Constitutive Activity Promotes Angiogenesis In Vivo and In Vitro Peetra U. Magnusson, Camilla Looman, Aive Åhgren, Yan Wu, Lena Claesson-Welsh, and Rainer L. Heuchel Arterioscler Thromb Vasc Biol. 2007;27:2142-2149; published online before print July 26 2007, doi:10.1161/01.ATV.0000282198.60701.94 Abstract \| Full Text \| PDF \| Data Supplement Embryonic stem cells carrying a knock-in for an activating mutation in the platelet-derived growth factor receptor-beta are characterized by significantly elevated ligand-independent receptor phosphorylation and downstream signaling. This results in increased vasculogenesis and angiogenesis in an in vitro differentiation system as well as in vivo forming teratomas.
	Laminar Shear Inhibits Tubule Formation and Migration of Endothelial Cells by an Angiopoietin-2–Dependent Mechanism Sarah L. Tressel, Ruo-Pan Huang, Nicholas Tomsen, and Hanjoong Jo Arterioscler Thromb Vasc Biol. 2007;27:2150-2156; published online before print August 2 2007, doi:10.1161/ATVBAHA.107.150920 Abstract \| Full Text \| PDF \| Data Supplement Laminar shear stress promotes endothelial quiescence, whereas oscillatory shear promotes endothelial turnover and dysfunction, which could lead to angiogenesis. We found that Angiopoietin-2 produced by oscillatory shear plays a critical role in migration and tubule formation, which maybe important in diseases with disturbed flow and angiogenesis such as atherosclerosis.
	TAFI and Pancreatic Carboxypeptidase B Modulate In Vitro Capillary Tube Formation by Human Microvascular Endothelial Cells Ana H.C. Guimarães, Nancy Laurens, Ester M. Weijers, Pieter Koolwijk, Victor W.M. van Hinsbergh, and Dingeman C. Rijken Arterioscler Thromb Vasc Biol. 2007;27:2157-2162; published online before print August 2 2007, doi:10.1161/ATVBAHA.107.150144 Abstract \| Full Text \| PDF \| Data Supplement Both TAFI and pancreatic CPB inhibited the formation of capillary-like tubular structures into a 3D-plasma clot matrix by human microvascular endothelial cells stimulated with bFGF/TNF-{alpha}. Carboxypeptidase B-induced inhibition of the plasminogen system in the matrix and on the cell surface caused the inhibition of endothelial cell movement and tube formation.
	Thrombospondin-1 Activates Medial Smooth Muscle Cells and Triggers Neointima Formation Upon Mouse Carotid Artery Ligation Rute Moura, Marc Tjwa, Petra Vandervoort, Katrien Cludts, and Marc F. Hoylaerts Arterioscler Thromb Vasc Biol. 2007;27:2163-2169; published online before print August 30 2007, doi:10.1161/ATVBAHA.107.151282 Abstract \| Full Text \| PDF \| Data Supplement We analyzed WT and Tsp1-/- mice in a neointima model without endothelial denudation. Early proliferation and migration of medial SMCs were delayed and impaired. As a result, Tsp1-/- arteries developed smaller neointimas, thicker media, but comparably attenuated patency as in WT arteries. Tsp1-/- SMCs had a modified profibrotic phenotype.
	Antagonism of Lipopolysaccharide-Induced Blood Pressure Attenuation and Vascular Contractility S. Ehrentraut, S. Frede, H. Stapel, T. Mengden, C. Grohé, J. Fandrey, R. Meyer, and G. Baumgarten Arterioscler Thromb Vasc Biol. 2007;27:2170-2176; published online before print July 26 2007, doi:10.1161/ATVBAHA.107.146100 Abstract \| Full Text \| PDF LPS decreases blood pressure as well as vascular contractility and increases vascular cytokine expression via a Toll-like receptor 4 (TLR4) pathway in mice. This local vascular Signaling contributes to septic shock. Lowered vascular contractility can be restored by inhibition of iNOS or prevented by the application of a TLR4 antagonist.
	Pathogenic Sequence for Dissecting Aneurysm Formation in a Hypomorphic Polycystic Kidney Disease 1 Mouse Model Sabrine Hassane, Nanna Claij, Irma S. Lantinga-van Leeuwen, J. Conny Van Munsteren, Natascha Van Lent, Roeland Hanemaaijer, Martijn H. Breuning, Dorien J.M. Peters, and Marco C. DeRuiter Arterioscler Thromb Vasc Biol. 2007;27:2177-2183; published online before print July 26 2007, doi:10.1161/ATVBAHA.107.149252 Abstract \| Full Text \| PDF \| Data Supplement Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common genetic disease associated with dissecting aneurysms. We characterized dissecting aneurysm formation in a Pkd1 mouse model. It reveals the importance of polycystin1 in the maintenance of the vessel wall integrity, and it is a useful model to study dissections in ADPKD.
	Ubiquitin Carboxyl-Terminal Hydrolase L1, a Novel Deubiquitinating Enzyme in the Vasculature, Attenuates NF- ${kappa}$ B Activation Yoichi Takami, Hironori Nakagami, Ryuichi Morishita, Tomohiro Katsuya, Tai-Xing Cui, Tomonaga Ichikawa, Yukihiro Saito, Hiroki Hayashi, Yasushi Kikuchi, Tomoyuki Nishikawa, Yoshichika Baba, Osamu Yasuda, Hiromi Rakugi, Toshio Ogihara, and Yasufumi Kaneda Arterioscler Thromb Vasc Biol. 2007;27:2184-2190; published online before print August 9 2007, doi:10.1161/ATVBAHA.107.142505 Abstract \| Full Text \| PDF \| Data Supplement The ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) gene encodes for a deubiquitinating enzyme and is associated with Parkinson disease. UCHL1 gene expression was characterized in the neointima of the balloon-injured artery and in human atherosclerotic lesions. In vascular cells, UCHL1 attenuated TNF-{alpha}-induced NF-{kappa}B activity, possibly through the attenuation of I{kappa}B-{alpha} ubiquitination.
	Atherosclerosis and Lipoproteins
	Studies on the Cholesterol-Free Mouse: Strong Activation of LXR-Regulated Hepatic Genes When Replacing Cholesterol With Desmosterol Maura Heverin, Steve Meaney, Anat Brafman, Millicent Shafir, Maria Olin, Marjan Shafaati, Sara von Bahr, Lilian Larsson, Anita Lövgren-Sandblom, Ulf Diczfalusy, Paolo Parini, Elena Feinstein, and Ingemar Björkhem Arterioscler Thromb Vasc Biol. 2007;27:2191-2197; published online before print August 30 2007, doi:10.1161/ATVBAHA.107.149823 Abstract \| Full Text \| PDF \| Data Supplement Disruption of the 3β-hydroxysteroid-{Delta}24-reductase gene in mouse results in replacement of cholesterol with desmosterol. This inactivation leads to a markedly increased fecal loss of neutral sterols, a compensatory increase in hepatic sterol synthesis, and activation of LXR-targeted genes.
	Transcriptional Activation of Hepatic ACSL3 and ACSL5 by Oncostatin M Reduces Hypertriglyceridemia Through Enhanced β-Oxidation Yue Zhou, Parveen Abidi, Aekyong Kim, Wei Chen, Ting-Ting Huang, Fredric B. Kraemer, and Jingwen Liu Arterioscler Thromb Vasc Biol. 2007;27:2198-2205; published online before print August 30 2007, doi:10.1161/ATVBAHA.107.148429 Abstract \| Full Text \| PDF \| Data Supplement In this study we investigated the mechanisms underlying the direct TG-lowering effects of OM in hyperlipidemic hamsters and in HepG2 cells. We demonstrate that OM activates ACSL3/5 transcription through the ERK signaling pathway. The increased ACSL3/5 enzymatic activities in liver cells stimulate fatty acid partition toward β-oxidation with a fall in TG synthesis.
	Chronic Immune Reactivity Against Persisting Microbial Antigen in the Vasculature Exacerbates Atherosclerotic Lesion Formation Philippe Krebs, Elke Scandella, Beatrice Bolinger, Daniel Engeler, Simone Miller, and Burkhard Ludewig Arterioscler Thromb Vasc Biol. 2007;27:2206-2213; published online before print July 26 2007, doi:10.1161/ATVBAHA.107.141846 Abstract \| Full Text \| PDF \| Data Supplement This study demonstrates that T cell responses directed against persisting microbial antigen within the vasculature favor the development of an inflammatory environment that is important for the acceleration of atherosclerotic lesion development.
	Transforming Growth Factor Activity Is a Key Determinant for the Effect of Estradiol on Fatty Streak Deposit in Hypercholesterolemic Mice Pierre Gourdy, Alexia Schambourg, Cédric Filipe, Victorine Douin-Echinard, Barbara Garmy-Susini, Bertrand Calippe, François Tercé, Francis Bayard, and Jean-François Arnal Arterioscler Thromb Vasc Biol. 2007;27:2214-2221; published online before print August 9 2007, doi:10.1161/ATVBAHA.107.150300 Abstract \| Full Text \| PDF \| Data Supplement The role of several cytokines involved in the atheromatous process was evaluated in the protective effect of estradiol on fatty streak constitution. We demonstrate that the integrity of the TGF-beta pathway is absolutely required for this beneficial property of estradiol, whereas neither IFN-gamma, IL-12 or, IL-10 deficiency altered this effect.
	USF1 Contributes to High Serum Lipid Levels in Dutch FCHL Families and U.S. Whites With Coronary Artery Disease Jenny C. Lee, Daphna Weissglas-Volkov, Mira Kyttälä, Janet S. Sinsheimer, Anne Jokiaho, Tjerk W.A. de Bruin, Aldons J. Lusis, Marie-Luise Brennan, Marleen M.J. van Greevenbroek, Carla J.H. van der Kallen, Stanley L. Hazen, and Päivi Pajukanta Arterioscler Thromb Vasc Biol. 2007;27:2222-2227; published online before print August 2 2007, doi:10.1161/ATVBAHA.107.151530 Abstract \| Full Text \| PDF A variant of USF1 originally associated with FCHL in Finnish FCHL families was shown to be significantly associated with lipids and related metabolic traits in Dutch FCHL families and in a U.S. White cohort with CAD. Furthermore, a significant sex-genotype interaction was observed in both study samples.
	Intrauterine Exposure to Maternal Atherosclerotic Risk Factors Increases the Susceptibility to Atherosclerosis in Adult Life Fanneke E. Alkemade, Adriana C. Gittenberger-de Groot, Anja E. Schiel, J. Conny VanMunsteren, Bianca Hogers, Leontien S. J. van Vliet, Robert E. Poelmann, Louis M. Havekes, Ko Willems van Dijk, and Marco C. DeRuiter Arterioscler Thromb Vasc Biol. 2007;27:2228-2235; published online before print July 26 2007, doi:10.1161/01.ATV.0000282193.31936.fd Abstract \| Full Text \| PDF \| Data Supplement In utero exposure of heterozygous apoE-deficient fetuses to maternal atherosclerotic risk factors results in priming of the vessels to accelerated development of cardiovascular disease in adult life after challenge by additional atherogenic risk factors. Elucidation of the mechanisms involved in the priming process is important for development of prevention strategies.
	Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A₂ Vasilios G. Saougos, Afroditi P. Tambaki, Mihalis Kalogirou, Michael Kostapanos, Irene F. Gazi, Robert L. Wolfert, Moses Elisaf, and Alexandros D. Tselepis Arterioscler Thromb Vasc Biol. 2007;27:2236-2243; published online before print July 26 2007, doi:10.1161/ATVBAHA.107.147280 Abstract \| Full Text \| PDF \| Data Supplement We investigated the effect of ezetimibe, rosuvastatin, and fenofibrate on the lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and mass, in hyperlipidemic patients. All drugs reduced Lp-PLA2 activity and mass associated with the atherogenic apoB-lipoproteins, whereas fenofibrate was the only drug that improved the specific activity of the enzyme associated with these lipoproteins and significantly induced the HDL-Lp-PLA2. The clinical implications of these effects remain to be established.
	Carotid Intima-Media Thickness in Confirmed Prehypertensive Subjects: Predictors and Progression Romana Femia, Michaela Kozakova, Monica Nannipieri, Clicerio Gonzales-Villalpando, Michael P. Stern, Steven M. Haffner, and Ele Ferrannini Arterioscler Thromb Vasc Biol. 2007;27:2244-2249; published online before print July 26 2007, doi:10.1161/ATVBAHA.107.149641 Abstract \| Full Text \| PDF \| Data Supplement In 136 confirmed prehypertensives CCA far-wall IMT is increased--to values intermediate between normotensives and hypertensives--independently of known determinants of wall thickness. The 45T/G polymorphism in the adiponectin gene confers independent risk; gender, age, mean BP, diabetes, but not converter status were independent predictors of a faster CCA-IMT progression.
	Thrombosis
	Association of Plasminogen Activator Inhibitor (PAI)-1 (SERPINE1) SNPs With Myocardial Infarction, Plasma PAI-1, and Metabolic Parameters: The HIFMECH Study P.E. Morange, N. Saut, M.C. Alessi, J.S. Yudkin, M. Margaglione, G. Di Minno, A. Hamsten, S.E. Humphries, D.A. Tregouet, and I. Juhan-Vague Arterioscler Thromb Vasc Biol. 2007;27:2250-2257; published online before print July 26 2007, doi:10.1161/ATVBAHA.107.149468 Abstract \| Full Text \| PDF \| Data Supplement HIFMECH is a European case-control study for myocardial infarction (MI). In the 510 male cases and their 543 age-matched controls, SERPINE1 haplotypes were mildly associated with plasma levels of PAI-1 and with the risk of MI in nonsmokers. They were also associated with insulin levels and BMI.
	No-Reflow Phenomenon After Acute Myocardial Infarction Is Associated With Reduced Clot Permeability and Susceptibility to Lysis Jaroslaw Zalewski, Anetta Undas, Jacek Godlewski, Ewa Stepien, and Krzysztof Zmudka Arterioscler Thromb Vasc Biol. 2007;27:2258-2265; published online before print August 2 2007, doi:10.1161/ATVBAHA.107.149633 Abstract \| Full Text \| PDF Fibrin clot properties were assessed in patients after primary coronary angioplasty in acute myocardial infarction. The clots composed of a more compact fibrin network with attenuated fibrinolysis were detected in patients with impaired reperfusion. Reduced clot permeability and fibrinolysis may be a novel prothrombotic mechanism, which might contribute to the pathogenesis of the no-reflow phenomenon.
	Silencing of a Targeted Protein in In Vivo Platelets Using a Lentiviral Vector Delivering Short Hairpin RNA Sequence Tsukasa Ohmori, Yuji Kashiwakura, Akira Ishiwata, Seiji Madoiwa, Jun Mimuro, and Yoichi Sakata Arterioscler Thromb Vasc Biol. 2007;27:2266-2272; published online before print September 13 2007, doi:10.1161/ATVBAHA.107.149872 Abstract \| Full Text \| PDF \| Data Supplement The expression of short hairpin RNA (shRNA) in hematopoietic stem cells by a lentiviral vector resulted in inhibition of targeted protein in platelets, suggesting that shRNA expression driven by the U6 promoter is preserved during megakaryopoiesis. Talin silencing by this method caused significant reduction of inside-out {alpha}IIbβ3 signaling in platelets.

Spotlight

TOC Spotlight File

Volume 27, Issue 10; October 1, 2007

Editorials

Reactive Hyperemia and Cardiovascular Risk

Brief Reviews

Genetic Susceptibility to Peripheral Arterial Disease: A Dark Corner in Vascular Biology

Murine Models of Vascular Thrombosis

New Insights Into the Role of Lipoprotein(a)-Associated Lipoprotein-Associated Phospholipase A2 in Atherosclerosis and Cardiovascular Disease

The Problem of Passenger Genes in Transgenic Mice

JAM Family and Related Proteins in Leukocyte Migration (Vestweber Series)

Vascular Biology

Predictive Value of Reactive Hyperemia for Cardiovascular Events in Patients With Peripheral Arterial Disease Undergoing Vascular Surgery

Association of OAZ1 Gene Polymorphisms With Subclinical and Clinical Vascular Events

Pathway for Differentiation of Human Embryonic Stem Cells to Vascular Cell Components and Their Potential for Vascular Regeneration

Ischemia Is Not Required for Arteriogenesis in Zebrafish Embryos

Platelet-Derived Growth Factor Receptor-β Constitutive Activity Promotes Angiogenesis In Vivo and In Vitro

Laminar Shear Inhibits Tubule Formation and Migration of Endothelial Cells by an Angiopoietin-2–Dependent Mechanism

TAFI and Pancreatic Carboxypeptidase B Modulate In Vitro Capillary Tube Formation by Human Microvascular Endothelial Cells

Thrombospondin-1 Activates Medial Smooth Muscle Cells and Triggers Neointima Formation Upon Mouse Carotid Artery Ligation

Antagonism of Lipopolysaccharide-Induced Blood Pressure Attenuation and Vascular Contractility

Pathogenic Sequence for Dissecting Aneurysm Formation in a Hypomorphic Polycystic Kidney Disease 1 Mouse Model

Ubiquitin Carboxyl-Terminal Hydrolase L1, a Novel Deubiquitinating Enzyme in the Vasculature, Attenuates NF-B Activation

Atherosclerosis and Lipoproteins

Studies on the Cholesterol-Free Mouse: Strong Activation of LXR-Regulated Hepatic Genes When Replacing Cholesterol With Desmosterol

Transcriptional Activation of Hepatic ACSL3 and ACSL5 by Oncostatin M Reduces Hypertriglyceridemia Through Enhanced β-Oxidation

Chronic Immune Reactivity Against Persisting Microbial Antigen in the Vasculature Exacerbates Atherosclerotic Lesion Formation

Transforming Growth Factor Activity Is a Key Determinant for the Effect of Estradiol on Fatty Streak Deposit in Hypercholesterolemic Mice

USF1 Contributes to High Serum Lipid Levels in Dutch FCHL Families and U.S. Whites With Coronary Artery Disease

Intrauterine Exposure to Maternal Atherosclerotic Risk Factors Increases the Susceptibility to Atherosclerosis in Adult Life

Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A2

Carotid Intima-Media Thickness in Confirmed Prehypertensive Subjects: Predictors and Progression

Thrombosis

Association of Plasminogen Activator Inhibitor (PAI)-1 (SERPINE1) SNPs With Myocardial Infarction, Plasma PAI-1, and Metabolic Parameters: The HIFMECH Study

No-Reflow Phenomenon After Acute Myocardial Infarction Is Associated With Reduced Clot Permeability and Susceptibility to Lysis

Silencing of a Targeted Protein in In Vivo Platelets Using a Lentiviral Vector Delivering Short Hairpin RNA Sequence

Spotlight

New Insights Into the Role of Lipoprotein(a)-Associated Lipoprotein-Associated Phospholipase A₂ in Atherosclerosis and Cardiovascular Disease

Ubiquitin Carboxyl-Terminal Hydrolase L1, a Novel Deubiquitinating Enzyme in the Vasculature, Attenuates NF- ${kappa}$ B Activation

Differential Effect of Hypolipidemic Drugs on Lipoprotein-Associated Phospholipase A₂