Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (26 [2])

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Volume 26, Issue 2; February 1, 2006

Editorials
Brief Reviews
Vascular Biology
Atherosclerosis and Lipoproteins
Thrombosis
Letters to the Editor

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	Editorials
	Adiponectin: Vascular Protection From the Fat? Peter F. Bodary and Daniel T. Eitzman Arterioscler Thromb Vasc Biol. 2006;26:235-236, doi:10.1161/01.ATV.0000200222.55680.df Extract \| Full Text \| PDF
	Arginine/Arginase NO NO NO Godfrey S. Getz and Catherine A. Reardon Arterioscler Thromb Vasc Biol. 2006;26:237-239, doi:10.1161/01.ATV.0000202014.54609.9d Extract \| Full Text \| PDF
	Leukocyte and Endothelial Angiotensin II Type 1 Receptors and Microvascular Thrombotic and Inflammatory Responses to Hypercholesterolemia R. Wayne Alexander Arterioscler Thromb Vasc Biol. 2006;26:240-241, doi:10.1161/01.ATV.0000199680.42737.ca Extract \| Full Text \| PDF
	Brief Reviews
	Diet and Murine Atherosclerosis Godfrey S. Getz and Catherine A. Reardon Arterioscler Thromb Vasc Biol. 2006;26:242-249; published online before print December 22 2005, doi:10.1161/01.ATV.0000201071.49029.17 Abstract \| Full Text \| PDF Murine models of atherosclerosis have been fed a variety of diets that vary in the level of cholesterol, the level and type of fatty acid, and the absence and presence of cholate. This review summarizes what is known about the effect of these dietary components on lipoprotein levels and/or atherosclerosis.
	Smoking, Metalloproteinases, and Vascular Disease Todd S. Perlstein and Richard T. Lee Arterioscler Thromb Vasc Biol. 2006;26:250-256; published online before print December 8 2005, doi:10.1161/01.ATV.0000199268.27395.4f Abstract \| Full Text \| PDF The matrix metalloproteinases are emerging as strong candidate mediators of smoking-associated vascular disease. Smoking-induced inflammation and oxidative stress may increase metalloproteinase transcription, increase pro-enzyme activation, and limit endogenous inhibition of metalloproteinase activity. The relationship between smoking, metalloproteinases, and vascular disease is discussed in this brief review.
	Influence of Cardiovascular Risk Factors on Endothelial Progenitor Cells: Limitations for Therapy? Nikos Werner and Georg Nickenig Arterioscler Thromb Vasc Biol. 2006;26:257-266; published online before print December 1 2005, doi:10.1161/01.ATV.0000198239.41189.5d Abstract \| Full Text \| PDF Circulating endothelial progenitor cells play an important role in restoration of the endothelium after endothelial cell damage. The current review focuses on the role of cardiovascular risk factors on endothelial cell apoptosis and progenitor cell-mediated vasculoprotection.
	Endothelial Nitric Oxide Synthase: Host Defense Enzyme of the Endothelium? Ton J. Rabelink and Thomas F. Luscher Arterioscler Thromb Vasc Biol. 2006;26:267-271; published online before print November 17 2005, doi:10.1161/01.ATV.0000196554.85799.77 Abstract \| Full Text \| PDF This article explores the physiology of superoxide generation by endothelial nitric oxide synthase, the so-called "uncoupled" state of the enzyme. The fact that this alternative chemistry of the eNOS enzyme is evolutionary strongly conserved, suggests that it may play a physiological role. It is proposed that this uncoupled state may contribute to defense against infections, and the central role of uncoupled eNOS in redox signaling in the endothelium may open up new avenues for therapy to prevent atherosclerosis.
	Vascular Biology
	Importance of Junctional Adhesion Molecule-A for Neointimal Lesion Formation and Infiltration in Atherosclerosis-Prone Mice Alma Zernecke, Elisa A. Liehn, Line Fraemohs, Philipp von Hundelshausen, Rory R. Koenen, Monica Corada, Elisabetta Dejana, and Christian Weber Arterioscler Thromb Vasc Biol. 2006;26:e10-e13; published online before print November 23 2005, doi:10.1161/01.ATV.0000197852.24529.4f Abstract \| Full Text \| PDF
	Aspirin Has A Gender-Dependent Impact on Antiinflammatory 15-Epi-Lipoxin A₄ Formation: A Randomized Human Trial Nan Chiang, Shelley Hurwitz, Paul M. Ridker, and Charles N. Serhan Arterioscler Thromb Vasc Biol. 2006;26:e14-e17; published online before print November 17 2005, doi:10.1161/01.ATV.0000196729.98651.bf Abstract \| Full Text \| PDF
	Physiological Concentrations of Insulin Induce Endothelin-Dependent Vasoconstriction of Skeletal Muscle Resistance Arteries in the Presence of Tumor Necrosis Factor- ${alpha}$ Dependence on c-Jun N-Terminal Kinase Etto C. Eringa, Coen D. A. Stehouwer, Kimberley Walburg, Andrew D. Clark, Geerten P. van Nieuw Amerongen, Nico Westerhof, and Pieter Sipkema Arterioscler Thromb Vasc Biol. 2006;26:274-280; published online before print December 1 2005, doi:10.1161/01.ATV.0000198248.19391.3e Abstract \| Full Text \| PDF \| Data Supplement
	Isolation of "Side Population" Progenitor Cells From Healthy Arteries of Adult Mice Julie Sainz, Ayman Al Haj Zen, Giuseppina Caligiuri, Corinne Demerens, Dominique Urbain, Mathilde Lemitre, and Antoine Lafont Arterioscler Thromb Vasc Biol. 2006;26:281-286; published online before print November 23 2005, doi:10.1161/01.ATV.0000197793.83391.91 Abstract \| Full Text \| PDF \| Data Supplement
	Radiation Induces Endothelial Dysfunction in Murine Intestinal Arterioles via Enhanced Production of Reactive Oxygen Species Ossama A. Hatoum, Mary F. Otterson, Doron Kopelman, Hiroto Miura, Igor Sukhotnik, Brandon T. Larsen, Rebecca M. Selle, John E. Moulder, and David D. Gutterman Arterioscler Thromb Vasc Biol. 2006;26:287-294; published online before print December 1 2005, doi:10.1161/01.ATV.0000198399.40584.8c Abstract \| Full Text \| PDF In irradiated gut from rats, a profound microvascular endothelial dysfunction was demonstrated. Excess levels of superoxide and peroxides were found to play a key role in this endothelial dysfunction. Defining the mechanisms that underlie microvascular dysfunction after radiated tissue should yield important insight into the pathogenesis of radiation-induced gastrointestinal complications.
	Interleukin-18 and Macrophage Migration Inhibitory Factor Are Associated With Increased Carotid Intima–Media Thickening Vyacheslav A. Korshunov, Tatiana A. Nikonenko, Vsevolod A. Tkachuk, Andrew Brooks, and Bradford C. Berk Arterioscler Thromb Vasc Biol. 2006;26:295-300; published online before print November 17 2005, doi:10.1161/01.ATV.0000196544.73761.82 Abstract \| Full Text \| PDF \| Data Supplement The role of inflammation was studied in progression of intima-media thickening (IMT) in response to low blood flow in 2 inbred strains of mice. Significantly higher expression of IL-18 and macrophage migratory inhibitor factor proteins was associated with significant differences in IMT between SJL/J and C3HeB/FeJ mice.
	Bile Acids Decrease Hepatic Paraoxonase 1 Expression and Plasma High-Density Lipoprotein Levels Via FXR-Mediated Signaling of FGFR4 Alejandra Gutierrez, Eric P. Ratliff, Allen M. Andres, Xinqiang Huang, Wallace L. McKeehan, and Roger A. Davis Arterioscler Thromb Vasc Biol. 2006;26:301-306; published online before print November 10 2005, doi:10.1161/01.ATV.0000195793.73118.b4 Abstract \| Full Text \| PDF \| Data Supplement Experiments using genetically modified mice show that bile acid activation of FXR induces ileal expression of FGF15, which, through signaling of hepatic receptor FGFR4, reduces PON1 and CYP7A1 mRNAs and high-density lipoprotein cholesterol while enhancing susceptibility to atherosclerosis.
	Conjugated Linoleic Acid Impairs Endothelial Function Justin S.W. Taylor, Simon R.P. Williams, Rhian Rhys, Phillip James, and Michael P. Frenneaux Arterioscler Thromb Vasc Biol. 2006;26:307-312; published online before print December 8 2005, doi:10.1161/01.ATV.0000199679.40501.ac Abstract \| Full Text \| PDF Twelve-week supplementation with isomeric conjugated linoleic acid (CLA) did not change BMI or total body fat compared with olive oil. There was a decrease in limb, but not torso skin fold thicknesses, a decrease in FMD of the brachial artery, and an increase in plasma F2-isoprostanes. Isomeric CLA cannot be recommended as a dietary supplement to aid weight loss.
	Role of Blood Cell–Associated AT1 Receptors in the Microvascular Responses to Hypercholesterolemia Thomas Petnehazy, Karen Y. Stokes, Katherine C. Wood, Janice Russell, and D. Neil Granger Arterioscler Thromb Vasc Biol. 2006;26:313-318; published online before print October 27 2005, doi:10.1161/01.ATV.0000193625.32499.71 Abstract \| Full Text \| PDF We used AT1a-R-deficient mice and AT1a-R bone marrow chimeras, where blood cells (but not endothelial cells) lacked AT1a-R, to define the contributions of blood cell-associated versus endothelium-associated AT1a-R to hypercholesterolemia-induced microvascular alterations. Endothelium-associated (not platelet-associated) AT1a-R mediated the platelet adhesion, whereas AT1a-R on blood cells modulated the leukocyte recruitment.
	Atherosclerosis and Lipoproteins
	Expression Profiling Identifies Smooth Muscle Cell Diversity Within Human Intima and Plaque Fibrous Cap: Loss of RGS5 Distinguishes the Cap Lawrence D. Adams, Randolph L. Geary, Jing Li, Anthony Rossini, and Stephen M. Schwartz Arterioscler Thromb Vasc Biol. 2006;26:319-325; published online before print November 17 2005, doi:10.1161/01.ATV.0000196647.45718.d6 Abstract \| Full Text \| PDF \| Data Supplement Expression profiles of whole plaque and plaque subcomponents (media; adjacent nonatherosclerotic intima; and fibrous cap) were obtained on filter sets containing 21 000 or 26 000 Unigene clusters. Unique patters of gene expression characterized each layer. One remarkable difference was the loss of RGS5 expression in the fibrous cap compared with adjacent nonatherosclerotic intima and media.
	Phenotypic Modulation of Intima and Media Smooth Muscle Cells in Fatal Cases of Coronary Artery Lesion Hiroyuki Hao, Giulio Gabbiani, Edoardo Camenzind, Marc Bacchetta, Renu Virmani, and Marie-Luce Bochaton-Piallat Arterioscler Thromb Vasc Biol. 2006;26:326-332; published online before print December 8 2005, doi:10.1161/01.ATV.0000199393.74656.4c Abstract \| Full Text \| PDF \| Data Supplement A systematic study of smooth muscle cell (SMC) differentiation marker expression was performed in mildly stenotic plaques, stable plaques, erosions, and restenotic lesions of coronary arteries. An important medial atrophy occurred in restenotic lesions and stable plaques. The dedifferentiated features of intimal SMCs suggest they have modulated into myofibroblasts.
	Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease Tomasz J. Guzik, Jerzy Sadowski, Bartlomiej Guzik, Andrew Jopek, Boguslaw Kapelak, Piotr Przybylowski, Karol Wierzbicki, Ryszard Korbut, David G. Harrison, and Keith M. Channon Arterioscler Thromb Vasc Biol. 2006;26:333-339; published online before print November 17 2005, doi:10.1161/01.ATV.0000196651.64776.51 Abstract \| Full Text \| PDF \| Data Supplement Vascular oxidative stress is increased in coronary artery disease and in the absence of coronary plaque. It is doubled within vessel branching. NAD(P)H oxidases are the primary sources of O2{middle dot}- and are regulated by protein kinase C and angiotensin II. Oxidase subunit mRNA levels are correlated with vascular NAD(P)H oxidase activity.
	Lesional Overexpression of Matrix Metalloproteinase-9 Promotes Intraplaque Hemorrhage in Advanced Lesions But Not at Earlier Stages of Atherogenesis R. de Nooijer, C.J.N. Verkleij, J.H. von der Thüsen, J.W. Jukema, E.E. van der Wall, Th. J.C. van Berkel, A.H. Baker, and E.A.L. Biessen Arterioscler Thromb Vasc Biol. 2006;26:340-346; published online before print November 23 2005, doi:10.1161/01.ATV.0000197795.56960.64 Abstract \| Full Text \| PDF \| Data Supplement The effect of MMP-9 overexpression at various stages of atherosclerotic lesion development was studied in apoE-deficient mice. In intermediate lesions, MMP-9 results in outward remodeling. In advanced lesions this causes vulnerable plaque morphology accompanied with increased incidence of intraplaque hemorrhage.
	Correlation of Vasa Vasorum Neovascularization and Plaque Progression in Aortas of Apolipoprotein E^–/–/Low-Density Lipoprotein^–/– Double Knockout Mice Alexander C. Langheinrich, Agata Michniewicz, Daniel G. Sedding, Gerhard Walker, Patricia E. Beighley, Wigbert S. Rau, Rainer M. Bohle, and Erik L. Ritman Arterioscler Thromb Vasc Biol. 2006;26:347-352; published online before print November 17 2005, doi:10.1161/01.ATV.0000196565.38679.6d Abstract \| Full Text \| PDF \| Data Supplement Lesion volume is closely associated with ectopic neovascularization in the aorta of apoE-/-/LDL-/- double knockout mice, suggesting that there may be a direct relationship between lesion growth and VV development.
	The Proatherogenic Role of T Cells Requires Cell Division and Is Dependent on the Stage of the Disease Jamila Khallou-Laschet, Giuseppina Caligiuri, Emilie Groyer, Emanuel Tupin, Anh-Thu Gaston, Bruno Poirier, Mitchell Kronenberg, José L. Cohen, David Klatzmann, Srini V. Kaveri, and Antonino Nicoletti Arterioscler Thromb Vasc Biol. 2006;26:353-358; published online before print December 1 2005, doi:10.1161/01.ATV.0000198401.05221.13 Abstract \| Full Text \| PDF \| Data Supplement Atherosclerosis-prone ApoE{degrees}TK mice in which targeted ablation of dividing T cells can be achieved were used to show that the proatherogenic potential of T cells is crucial in the progression from fatty streaks to mature plaques and requires cell division.
	Increased Apolipoprotein Deposits in Early Atherosclerotic Lesions Distinguish Symptomatic From Asymptomatic Patients Moritz Wyler von Ballmoos, Denise Dubler, Martina Mirlacher, Gieri Cathomas, Jürgen Muser, and Barbara C. Biedermann Arterioscler Thromb Vasc Biol. 2006;26:359-364; published online before print December 1 2005, doi:10.1161/01.ATV.0000198250.91406.6d Abstract \| Full Text \| PDF
	Identification of Macrophage Arginase I as a New Candidate Gene of Atherosclerosis Resistance Daniel Teupser, Ralph Burkhardt, Wolfgang Wilfert, Ivonne Haffner, Klaus Nebendahl, and Joachim Thiery Arterioscler Thromb Vasc Biol. 2006;26:365-371; published online before print November 10 2005, doi:10.1161/01.ATV.0000195791.83380.4c Abstract \| Full Text \| PDF \| Data Supplement Arginase I was identified as a new candidate gene of atherosclerosis resistance using suppression subtractive hybridization in macrophages of rabbits with low and high atherosclerotic response. High expression of arginase I in macrophages may contribute to atherosclerosis resistance, possibly by conferring antiinflammatory effects in the vessel wall.
	Elevated Plasma Membrane Cholesterol Content Alters Macrophage Signaling and Function Chunbo Qin, Tomokazu Nagao, Inna Grosheva, Frederick R. Maxfield, and Lynda M. Pierini Arterioscler Thromb Vasc Biol. 2006;26:372-378; published online before print November 23 2005, doi:10.1161/01.ATV.0000197848.67999.e1 Abstract \| Full Text \| PDF \| Data Supplement
	Vascular Function and Mild Renal Impairment in Stable Coronary Artery Disease Pim van der Harst, Tom D.J. Smilde, Hendrik Buikema, Adriaan A. Voors, Gerjan Navis, Dirk J. van Veldhuisen, and Wiek H. van Gilst Arterioscler Thromb Vasc Biol. 2006;26:379-384; published online before print November 23 2005, doi:10.1161/01.ATV.0000197844.06411.22 Abstract \| Full Text \| PDF \| Data Supplement
	Role of the Estrogen and Progestin in Hormonal Replacement Therapy on Apolipoprotein A-I Kinetics in Postmenopausal Women Stefania Lamon-Fava, Borbala Postfai, Margaret Diffenderfer, Carl DeLuca, John O’Connor, Jr, Francine K. Welty, Gregory G. Dolnikowski, P. Hugh R. Barrett, and Ernst J. Schaefer Arterioscler Thromb Vasc Biol. 2006;26:385-391; published online before print December 8 2005, doi:10.1161/01.ATV.0000199248.53590.e1 Abstract \| Full Text \| PDF We studied the effect of estrogen and progestin in HRT on the metabolism of apoA-I in 8 postmenopausal women. Estrogen increased apoA-I levels and production rate, whereas the progestin counteracted the estrogen effect by reducing apoA-I levels and production rate.
	Evidence for a Gene Influencing High-Density Lipoprotein Cholesterol on Chromosome 4q31.21 Zari Dastani, Leigh Quiogue, Christopher Plaisier, James C. Engert, Michel Marcil, Jacques Genest, and Päivi Pajukanta Arterioscler Thromb Vasc Biol. 2006;26:392-397; published online before print December 1 2005, doi:10.1161/01.ATV.0000198243.83781.a3 Abstract \| Full Text \| PDF \| Data Supplement To identify novel genes regulating plasma HDL-C levels, we analyzed multigenerational French Canadian families for genome-wide signals, which we subsequently fine mapped. We identified a 2.37-Mb region on chromosome 4q31.21 likely containing a gene influencing HDL-C levels.
	Elevated Markers of Endothelial Dysfunction Predict Type 2 Diabetes Mellitus in Middle-Aged Men and Women From the General Population Barbara Thorand, Jens Baumert, Lloyd Chambless, Christa Meisinger, Hubert Kolb, Angela Döring, Hannelore Löwel, Wolfgang Koenig for the MONICA/KORA Study Group Arterioscler Thromb Vasc Biol. 2006;26:398-405; published online before print December 1 2005, doi:10.1161/01.ATV.0000198392.05307.aa Abstract \| Full Text \| PDF Using a case-cohort design, markers of endothelial dysfunction (soluble E-selectin and soluble intercellular adhesion molecule-1) predicted incident type 2 diabetes mellitus in a large population-based sample of middle-aged men and women. These data support a role for endothelial dysfunction in the etiology of type 2 diabetes.
	The Apolipoprotein B/AI Ratio and the Metabolic Syndrome Independently Predict Risk for Myocardial Infarction in Middle-Aged Men Lars Lind, Bengt Vessby, and Johan Sundström Arterioscler Thromb Vasc Biol. 2006;26:406-410; published online before print November 23 2005, doi:10.1161/01.ATV.0000197827.12431.d0 Abstract \| Full Text \| PDF \| Data Supplement
	Socioeconomic Differences in Progression of Carotid Intima-Media Thickness in the Atherosclerosis Risk in Communities Study Nalini Ranjit, Ana V. Diez-Roux, Lloyd Chambless, David R. Jacobs, Jr, F. Javier Nieto, and Moyses Szklo Arterioscler Thromb Vasc Biol. 2006;26:411-416; published online before print December 1 2005, doi:10.1161/01.ATV.0000198245.16342.3d Abstract \| Full Text \| PDF
	Thrombosis
	Platelet Inhibition by Insulin Is Absent in Type 2 Diabetes Mellitus Irlando Andrade Ferreira, Astrid I.M. Mocking, Marion A.H. Feijge, Gertie Gorter, Timon W. van Haeften, Johan W.M. Heemskerk, and Jan-Willem N. Akkerman Arterioscler Thromb Vasc Biol. 2006;26:417-422; published online before print December 8 2005, doi:10.1161/01.ATV.0000199519.37089.a0 Abstract \| Full Text \| PDF \| Data Supplement Insulin inhibits Ca2+ mobilization in platelets by interfering with P2y12-mediated cAMP suppression. Here we show that DM2 platelets have lost responsiveness to insulin and also show increased P2y12 signaling. This might explain the increased platelet deposition and procoagulant activity under flow of DM2 platelets on contact with collagen.
	Development of ELISAs Measuring the Extent of TAFI Activation Erik Ceresa, Els Brouwers, Miet Peeters, Christina Jern, Paul J. Declerck, and Ann Gils Arterioscler Thromb Vasc Biol. 2006;26:423-428; published online before print December 8 2005, doi:10.1161/01.ATV.0000199246.08616.98 Abstract \| Full Text \| PDF \| Data Supplement We developed immunologic assays that allow to measure the extent of TAFI activation. These ELISAs constitute more sensitive markers in studies on the relationship between TAFI and cardiovascular related diseases.
	Letters to the Editor
	Letter to the Editor: Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events Christopher J. Boos and Gregory Y.H. Lip Arterioscler Thromb Vasc Biol. 2006;26:e18, doi:10.1161/01.ATV.0000199298.80771.1f Extract \| Full Text \| PDF
	CD8⁺ T-Cell Subpopulations in Human Abdominal Aortic Aneurysm Lesion Cécile Galle, Liliane Schandené, Jean-Pierre Dereume, Michel Goldman, Christina Duftner, Christian Dejaco, and Michael Schirmer Arterioscler Thromb Vasc Biol. 2006;26:e19-e20, doi:10.1161/01.ATV.0000199249.15199.80 Extract \| Full Text \| PDF
	Letter to the Editor: Vitamin E Limits AAA Ronald L. Dalman and (for the coauthors) Arterioscler Thromb Vasc Biol. 2006;26:e21, doi:10.1161/01.ATV.0000200080.37069.b6 Extract \| Full Text \| PDF
	Leukocytosis, Vascular Disease, and Adenine Nucleotide Metabolism Stan Heptinstall, Jacqueline R. Glenn, Andrew Johnson, Bethan Myers, Ann E. White, and Lian Zhao Arterioscler Thromb Vasc Biol. 2006;26:e22-e23, doi:10.1161/01.ATV.0000197801.28944.41 Extract \| Full Text \| PDF
	Letter to the Editor: Quantification of Abdominal Aortic Calcification on CT Rumal W. Jayalath, Peter Jackson, and Jonathan Golledge Arterioscler Thromb Vasc Biol. 2006;26:429-430, doi:10.1161/01.ATV.0000198390.34524.ba Extract \| Full Text \| PDF \| Data Supplement
	Letter to the Editor: Insulin Resistance and Increased Intimal Medial Thickness in Glucose Tolerant Offspring of Type 2 Diabetic Subjects Carrying the D298D Genotype of Endothelial Nitric Oxide Synthase Stefano Rizza, Manfredi Tesauro, Marina Cardellini, Rossella Menghini, Alfonso Bellia, Maria Adelaide Marini, Davide Lauro, Paolo Sbraccia, Giorgio Sesti, Renato Lauro, and Massimo Federici Arterioscler Thromb Vasc Biol. 2006;26:431-432, doi:10.1161/01.ATV.0000196552.84475.fc Extract \| Full Text \| PDF
	Letter to the Editor: Salivary Lysozyme and Prevalent Coronary Heart Disease. Possible Effects of Oral Health on Endothelial Dysfunction Sok-Ja Janket, Jukka H. Meurman, Pekka Nuutinen, Markku Qvarnström, Martha E. Nunn, Alison E. Baird, Thomas E. Van Dyke, and Judith A. Jones Arterioscler Thromb Vasc Biol. 2006;26:433-434, doi:10.1161/01.ATV.0000198249.67996.e0 Extract \| Full Text \| PDF \| Data Supplement

Spotlight

TOC Spotlight File

Volume 26, Issue 2; February 1, 2006

Editorials

Adiponectin: Vascular Protection From the Fat?

Arginine/Arginase NO NO NO

Leukocyte and Endothelial Angiotensin II Type 1 Receptors and Microvascular Thrombotic and Inflammatory Responses to Hypercholesterolemia

Brief Reviews

Diet and Murine Atherosclerosis

Smoking, Metalloproteinases, and Vascular Disease

Influence of Cardiovascular Risk Factors on Endothelial Progenitor Cells: Limitations for Therapy?

Endothelial Nitric Oxide Synthase: Host Defense Enzyme of the Endothelium?

Vascular Biology

Importance of Junctional Adhesion Molecule-A for Neointimal Lesion Formation and Infiltration in Atherosclerosis-Prone Mice

Aspirin Has A Gender-Dependent Impact on Antiinflammatory 15-Epi-Lipoxin A4 Formation: A Randomized Human Trial

Physiological Concentrations of Insulin Induce Endothelin-Dependent Vasoconstriction of Skeletal Muscle Resistance Arteries in the Presence of Tumor Necrosis Factor- Dependence on c-Jun N-Terminal Kinase

Isolation of "Side Population" Progenitor Cells From Healthy Arteries of Adult Mice

Radiation Induces Endothelial Dysfunction in Murine Intestinal Arterioles via Enhanced Production of Reactive Oxygen Species

Interleukin-18 and Macrophage Migration Inhibitory Factor Are Associated With Increased Carotid Intima–Media Thickening

Bile Acids Decrease Hepatic Paraoxonase 1 Expression and Plasma High-Density Lipoprotein Levels Via FXR-Mediated Signaling of FGFR4

Conjugated Linoleic Acid Impairs Endothelial Function

Role of Blood Cell–Associated AT1 Receptors in the Microvascular Responses to Hypercholesterolemia

Atherosclerosis and Lipoproteins

Expression Profiling Identifies Smooth Muscle Cell Diversity Within Human Intima and Plaque Fibrous Cap: Loss of RGS5 Distinguishes the Cap

Phenotypic Modulation of Intima and Media Smooth Muscle Cells in Fatal Cases of Coronary Artery Lesion

Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease

Lesional Overexpression of Matrix Metalloproteinase-9 Promotes Intraplaque Hemorrhage in Advanced Lesions But Not at Earlier Stages of Atherogenesis

Correlation of Vasa Vasorum Neovascularization and Plaque Progression in Aortas of Apolipoprotein E–/–/Low-Density Lipoprotein–/– Double Knockout Mice

The Proatherogenic Role of T Cells Requires Cell Division and Is Dependent on the Stage of the Disease

Increased Apolipoprotein Deposits in Early Atherosclerotic Lesions Distinguish Symptomatic From Asymptomatic Patients

Identification of Macrophage Arginase I as a New Candidate Gene of Atherosclerosis Resistance

Elevated Plasma Membrane Cholesterol Content Alters Macrophage Signaling and Function

Vascular Function and Mild Renal Impairment in Stable Coronary Artery Disease

Role of the Estrogen and Progestin in Hormonal Replacement Therapy on Apolipoprotein A-I Kinetics in Postmenopausal Women

Evidence for a Gene Influencing High-Density Lipoprotein Cholesterol on Chromosome 4q31.21

Elevated Markers of Endothelial Dysfunction Predict Type 2 Diabetes Mellitus in Middle-Aged Men and Women From the General Population

The Apolipoprotein B/AI Ratio and the Metabolic Syndrome Independently Predict Risk for Myocardial Infarction in Middle-Aged Men

Socioeconomic Differences in Progression of Carotid Intima-Media Thickness in the Atherosclerosis Risk in Communities Study

Thrombosis

Platelet Inhibition by Insulin Is Absent in Type 2 Diabetes Mellitus

Development of ELISAs Measuring the Extent of TAFI Activation

Letters to the Editor

Letter to the Editor: Assessment of Hemostatic Risk Factors in Predicting Arterial Thrombotic Events

CD8+ T-Cell Subpopulations in Human Abdominal Aortic Aneurysm Lesion

Letter to the Editor: Vitamin E Limits AAA

Leukocytosis, Vascular Disease, and Adenine Nucleotide Metabolism

Letter to the Editor: Quantification of Abdominal Aortic Calcification on CT

Letter to the Editor: Insulin Resistance and Increased Intimal Medial Thickness in Glucose Tolerant Offspring of Type 2 Diabetic Subjects Carrying the D298D Genotype of Endothelial Nitric Oxide Synthase

Letter to the Editor: Salivary Lysozyme and Prevalent Coronary Heart Disease. Possible Effects of Oral Health on Endothelial Dysfunction

Spotlight

Aspirin Has A Gender-Dependent Impact on Antiinflammatory 15-Epi-Lipoxin A₄ Formation: A Randomized Human Trial

Physiological Concentrations of Insulin Induce Endothelin-Dependent Vasoconstriction of Skeletal Muscle Resistance Arteries in the Presence of Tumor Necrosis Factor- ${alpha}$ Dependence on c-Jun N-Terminal Kinase

Correlation of Vasa Vasorum Neovascularization and Plaque Progression in Aortas of Apolipoprotein E^–/–/Low-Density Lipoprotein^–/– Double Knockout Mice

CD8⁺ T-Cell Subpopulations in Human Abdominal Aortic Aneurysm Lesion