Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (25 [3])

Volume 25, Issue 3; March 1, 2005

Editorials
Brief Reviews
Vascular Biology
Atherosclerosis and Lipoproteins
Thrombosis
Letters to the Editor
AHA Scientific Statements

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	Editorials
	Congratulations to Dr Elizabeth G. Nabel Linda K. Curtiss Arterioscler Thromb Vasc Biol. 2005;25:473, doi:10.1161/01.ATV.0000158757.11676.08. Full Text \| PDF
	Increased ApoB in Small Dense LDL Particles Predicts Premature Coronary Artery Disease John D. Brunzell Arterioscler Thromb Vasc Biol. 2005;25:474-475, doi:10.1161/01.ATV.0000156537.78366.1d. Full Text \| PDF
	Aortic Stenosis and Statins: More Evidence of "Pleotropy"? Jeffrey S. Borer Arterioscler Thromb Vasc Biol. 2005;25:476-477, doi:10.1161/01.ATV.0000157932.72212.de. Full Text \| PDF
	Recommendations for Blood Pressure Measurement in Animals: Summary of an AHA Scientific Statement From the Council on High Blood Pressure Research, Professional and Public Education Subcommittee Theodore W. Kurtz, Karen A. Griffin, Anil K. Bidani, Robin L. Davisson, and John E. Hall Arterioscler Thromb Vasc Biol. 2005;25:478-479, doi:10.1161/01.ATV.0000153088.15433.8f. Full Text \| PDF
	ATVB In Focus: Novel Approaches to the Treatment of Dyslipidemia Daniel J. Rader Arterioscler Thromb Vasc Biol. 2005;25:480-481, doi:10.1161/01.ATV.0000154483.28595.a3. Full Text \| PDF
	Brief Reviews
	Inhibition of Triglyceride Synthesis as a Treatment Strategy for Obesity: Lessons From DGAT1-Deficient Mice Hubert C. Chen and Robert V. Farese, Jr Arterioscler Thromb Vasc Biol. 2005;25:482-486; published online before print November 29 2004, doi:10.1161/01.ATV.0000151874.81059.ad. Abstract \| Full Text \| PDF Acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in the mammalian triglyceride synthesis pathway. Because mice lacking DGAT1 are resistant to obesity and have increased sensitivity to insulin, pharmacologic inhibition of DGAT1 may represent a feasible therapeutic strategy for human obesity and type 2 diabetes.
	Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance Christian Rask-Madsen and George L. King Arterioscler Thromb Vasc Biol. 2005;25:487-496; published online before print January 6 2005, doi:10.1161/01.ATV.0000155325.41507.e0. Abstract \| Full Text \| PDF In diabetes and insulin resistance, activation of PKC in vascular cells may be a key link between elevated plasma and tissue concentrations of glucose and nonesterified fatty acids and abnormal vascular cell signaling. This review summarizes studies that implicate PKC in promoting proatherogenic mechanisms or inhibiting antiatherogenic mechanisms.
	LDL Receptor–Related Protein and the Vascular Wall: Implications for Atherothrombosis Vicenta Llorente-Cortés and Lina Badimon Arterioscler Thromb Vasc Biol. 2005;25:497-504; published online before print February 10 2005, doi:10.1161/01.ATV.0000154280.62072.fd. Abstract \| Full Text \| PDF \| Data Supplement Our group has contributed to elucidate the physiopathological role of LRP1 in vascular wall by demonstrating that LRP1-mediated matrix-retained LDL internalization is crucial for VSMC-foam cell formation, that LRP1 is upregulated by lipid during human atherosclerotic lesion progression and that LRP1-mediated agLDL uptake causes prothrombotic transformation of the vascular wall.
	Vascular Biology
	Modulation of Estrogen Signaling by the Novel Interaction of Heat Shock Protein 27, a Biomarker for Atherosclerosis, and Estrogen Receptor ß: Mechanistic Insight Into the Vascular Effects of Estrogens Harvey Miller, Stephanie Poon, Benjamin Hibbert, Katey Rayner, Yong-Xiang Chen, and Edward R. O’Brien Arterioscler Thromb Vasc Biol. 2005;25:e10-e14; published online before print January 20 2005, doi:10.1161/01.ATV.0000156536.89752.8e. Abstract \| Full Text \| PDF \| Data Supplement We sought to discover proteins that associate with estrogen receptor beta (ERß) and modulate estrogen signaling. We identified heat shock protein 27 (HSP27) as an ERß-associated protein and confirmed the specific interaction of HSP27 with ERß and not ER{alpha}. HSP27 expression was absent in coronary arteries with complex atherosclerotic lesions. Moreover, the absence of HSP27 in these normal or minimally diseased arteries coincided with the loss of ERß expression. HSP27, an ERß-associated protein, shows attenuated expression with coronary atherosclerosis and modulates estrogen signaling.
	In Vivo Expression of Recombinant Vascular Endothelial Growth Factor in Rabbit Carotid Artery Increases Production of Superoxide Anion Osamu Suda, Leslie A. Smith, Livius V. d’Uscio, Timothy E. Peterson, and Zvonimir S. Katusic Arterioscler Thromb Vasc Biol. 2005;25:506-511; published online before print December 16 2004, doi:10.1161/01.ATV.0000153284.81572.f0. Abstract \| Full Text \| PDF In vivo adenovirus-mediated expression of recombinant vascular endothelial growth factor (VEGF) in endothelial cells of the rabbit carotid artery increases production of superoxide anion. This finding suggests that superoxide anion is an important mediator of vascular effects of VEGF. Therapeutic effect of VEGF may depend on redox state of the vascular wall.
	p47phox Associates With the Cytoskeleton Through Cortactin in Human Vascular Smooth Muscle Cells: Role in NAD(P)H Oxidase Regulation by Angiotensin II R.M. Touyz, G. Yao, M.T. Quinn, P.J. Pagano, and E.L. Schiffrin Arterioscler Thromb Vasc Biol. 2005;25:512-518; published online before print December 23 2004, doi:10.1161/01.ATV.0000154141.66879.98. Abstract \| Full Text \| PDF \| Data Supplement We demonstrate that p47phox:actin interaction, through cortactin, is involved in Ang II-mediated site-directed assembly of NAD(P)H oxidase, ROS generation, and activation of redox-sensitive p38MAPK and Akt, but not ERK1/2. These findings demonstrate the importance of an intact actin-cytoskeleton in NAD(P)H oxidase regulation and redox-signaling by Ang II in human VSMCs.
	Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells Talija Djordjevic, Rachida S. BelAiba, Steve Bonello, Josef Pfeilschifter, John Hess, and Agnes Görlach Arterioscler Thromb Vasc Biol. 2005;25:519-525; published online before print December 23 2004, doi:10.1161/01.ATV.0000154279.98244.eb. Abstract \| Full Text \| PDF Human urotensin-II (hU-II) is a potent vasoactive peptide with largely unknown effects on pulmonary artery smooth muscle cells. hU-II activated NADPH oxidase and elevated the levels of p22phox and NOX4, leading to enhanced phosphorylation of MAP kinases and protein kinase B and subsequently increased PAI-1 expression and cell proliferation.
	Molecular Mechanisms Underlying the Proangiogenic Effect of Factor XIII Rima Dardik, Joseph Loscalzo, Regina Eskaraev, and Aida Inbal Arterioscler Thromb Vasc Biol. 2005;25:526-532; published online before print December 23 2004, doi:10.1161/01.ATV.0000154137.21230.80. Abstract \| Full Text \| PDF \| Data Supplement Factor XIIIa (FXIIIa) was previously shown by us to induce angiogenesis. In the present work we show that the proangiogenic effect of FXIIIa is mediated by (1) enhancement of crosslinked and noncovalent {alpha}vß3/vascular endothelial growth factor 2 (VEGFR-2) complex formation; (2) activation of VEGFR-2; (3) upregulation of cyclin D-1, Egr-1, and c-Jun; and (4) downregulation of thrombospondin-1 by WT-1.
	Regulation of Vascular Smooth Muscle Cell Proliferation and Migration by Human Sprouty 2 Chunxiang Zhang, Deepti Chaturvedi, Laura Jaggar, Debra Magnuson, John M. Lee, and Tarun B. Patel Arterioscler Thromb Vasc Biol. 2005;25:533-538; published online before print January 13 2005, doi:10.1161/01.ATV.0000155461.50450.5a. Abstract \| Full Text \| PDF \| Data Supplement The aim of this study was to determine whether the human sprouty 2 (hSPRY2) protein, an inhibitor of receptor tyrosine kinase actions regulates vascular smooth muscle cell (VSMC) proliferation, migration and neointima formation in injured carotid artery. We conclude that TAT-tagged proteins are efficiently transduced into VSMCs in vitro and in vivo, that hSPRY2 inhibits growth and migration of VSMCs, and that this protein can decrease neointimal growth after blood vessel injury.
	High Glucose Induces Human Endothelial Cell Apoptosis Through a Phosphoinositide 3-Kinase–Regulated Cyclooxygenase-2 Pathway Meei Ling Sheu, Feng Ming Ho, Rong Sen Yang, Kuo Fang Chao, Wan Wan Lin, Shoei Yn Lin-Shiau, and Shing-Hwa Liu Arterioscler Thromb Vasc Biol. 2005;25:539-545; published online before print January 13 2005, doi:10.1161/01.ATV.0000155462.24263.e4. Abstract \| Full Text \| PDF We demonstrated for the first time that the signaling pathway of PI3K/Akt-regulated upregulation of COX-2 was involved in glucose-induced apoptosis in human endothelial cells. These findings were supported by results that PI3K inhibition prevented the glucose-caused COX-2-mediated PGE2 production, which subsequently led to the induction of caspase-3 activity and apoptosis.
	Stable Knock-Down of the Sphingosine 1-Phosphate Receptor S1P₁ Influences Multiple Functions of Human Endothelial Cells Vera Krump-Konvalinkova, Satoshi Yasuda, Tina Rubic, Natalia Makarova, Jörg Mages, Wolfgang Erl, Claudia Vosseler, C. James Kirkpatrick, Gabor Tigyi, and Wolfgang Siess Arterioscler Thromb Vasc Biol. 2005;25:546-552; published online before print December 23 2004, doi:10.1161/01.ATV.0000154360.36106.d9. Abstract \| Full Text \| PDF \| Data Supplement Stable silencing by RNA interference of S1P1 expression in human endothelial cell lines demonstrates the involvement of S1P1 in key functions of human endothelial cells and identifies new S1P1-dependent gene targets.
	Atherosclerosis and Lipoproteins
	Low-Density Lipoprotein Subfractions and the Long-Term Risk of Ischemic Heart Disease in Men: 13-Year Follow-Up Data From the Québec Cardiovascular Study Annie C. St-Pierre, Bernard Cantin, Gilles R. Dagenais, Pascale Mauriège, Paul-Marie Bernard, Jean-Pierre Després, and Benoît Lamarche Arterioscler Thromb Vasc Biol. 2005;25:553-559; published online before print December 23 2004, doi:10.1161/01.ATV.0000154144.73236.f4. Abstract \| Full Text \| PDF Results from this large population-based study indicated that large LDL were not associated with an increased long-term risk of ischemic heart disease in men and that the risk attributable to variations in the LDL size phenotype was largely related to markers of a preferential accumulation of small dense LDL particles.
	Complete Deficiency of the Low-Density Lipoprotein Receptor Is Associated With Increased Apolipoprotein B-100 Production John S. Millar, Cyrille Maugeais, Katsunori Ikewaki, Daniel M. Kolansky, P.Hugh R. Barrett, Elaine C. Budreck, Raymond C. Boston, Norio Tada, Seibu Mochizuki, Joep C. Defesche, James M. Wilson, and Daniel J. Rader Arterioscler Thromb Vasc Biol. 2005;25:560-565; published online before print January 6 2005, doi:10.1161/01.ATV.0000155323.18856.a2. Abstract \| Full Text \| PDF \| Data Supplement Kinetic studies on apoB were conducted in genetically defined patients with homozygous FH. FH patients had significantly decreased clearance of LDL apoB. Receptor-null FH had a significantly increased apoB production. We conclude that the LDL receptor primarily mediates clearance of LDL apoB from plasma and can influence apoB production in vivo.
	Role of ADP Ribosylation Factor 1 in the Assembly and Secretion of ApoB-100–Containing Lipoproteins Lennart Asp, Björn Magnusson, Mikael Rutberg, Lu Li, Jan Borén, and Sven-Olof Olofsson Arterioscler Thromb Vasc Biol. 2005;25:566-570; published online before print December 23 2004, doi:10.1161/01.ATV.0000154135.21689.47. Abstract \| Full Text \| PDF \| Data Supplement The assembly of VLDL depends on the ARF1-driven anterograde transport. Overexpression of ARF1 increases the secretion of VLDL 2 but not of VLDL 1, which is highly dependent on of fatty acids. The secretion of both VLDL 1 and VLDL 2 are increased by phospholipase D 1.
	Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation: Evidence for Grp78-Mediated Targeting to Proteasomal Degradation Wei Qiu, Rita Kohen-Avramoglu, Shailen Mhapsekar, Julie Tsai, Richard C. Austin, and Khosrow Adeli Arterioscler Thromb Vasc Biol. 2005;25:571-577; published online before print December 23 2004, doi:10.1161/01.ATV.0000154142.61859.94. Abstract \| Full Text \| PDF \| Data Supplement The role of Grp78 (BiP) in the intracellular degradation of apolipoprotein B100 (apoB100) was investigated in cultured hepatocytes after glucosamine-induced ER stress and Grp78 overexpression. Our findings suggest that binding and retention by Grp78 may play a critical role in proteasomal targeting and the ER quality-control of misfolded apoB.
	Identification of Unique Lipoprotein Subclasses for Visceral Obesity by Component Analysis of Cholesterol Profile in High-Performance Liquid Chromatography Mitsuyo Okazaki, Shinichi Usui, Masato Ishigami, Naohiko Sakai, Tadashi Nakamura, Yuji Matsuzawa, and Shizuya Yamashita Arterioscler Thromb Vasc Biol. 2005;25:578-584; published online before print January 6 2005, doi:10.1161/01.ATV.0000155017.60171.88. Abstract \| Full Text \| PDF Different contribution of visceral fat accumulation to each of the lipoprotein subclasses was clearly demonstrated in men with visceral fat accumulation. The high-performance liquid chromatography method described in this study might therefore be a useful tool.
	Regulation of Human ApoA-I by Gemfibrozil and Fenofibrate Through Selective Peroxisome Proliferator-Activated Receptor ${alpha}$ Modulation Hélène Duez, Bruno Lefebvre, Philippe Poulain, Inés Pineda Torra, Frédéric Percevault, Gérald Luc, Jeffrey M. Peters, Frank J. Gonzalez, Romain Gineste, Stéphane Helleboid, Vladimir Dzavik, Jean-Charles Fruchart, Catherine Fiévet, Philippe Lefebvre, and Bart Staels Arterioscler Thromb Vasc Biol. 2005;25:585-591; published online before print December 23 2004, doi:10.1161/01.ATV.0000154140.73570.00. Abstract \| Full Text \| PDF \| Data Supplement In hyperlipidemic patients and human apolipoprotein A-Itransgenic (hA-ITg) mice, fenofibrate (FF) and gemfibrozil (GF) increase HDL cholesterol, whereas apoA-I levels only increased after FF. Because of differential coactivator recruitment to the promoter, FF and GF, respectively, behave as full and partial PPAR{alpha} agonists, likely explaining the clinical differences in the activity of these fibrates on apoA-I.
	Paradoxical Effects of Statins on Aortic Valve Myofibroblasts and Osteoblasts: Implications for End-Stage Valvular Heart Disease Bing Wu, Sammy Elmariah, Frederick S. Kaplan, Guanjun Cheng, and Emile R. Mohler, III Arterioscler Thromb Vasc Biol. 2005;25:592-597; published online before print December 23 2004, doi:10.1161/01.ATV.0000154278.01871.64. Abstract \| Full Text \| PDF \| Data Supplement We evaluated the effects of statins on AVMF and osteoblast calcification in vitro. Statins were found to inhibit cardiac valve calcification in AVMFs but to stimulate bone cell calcification. Consequently, statins may differentially regulate calcification within a valve, limiting dystrophic calcification but promoting ossification of formed bone.
	Rosuvastatin, but not Simvastatin, Provides End-Organ Protection in Stroke-Prone Rats by Antiinflammatory Effects Luigi Sironi, Elisabetta Gianazza, Paolo Gelosa, Uliano Guerrini, Elena Nobili, Anita Gianella, Benedetta Cremonesi, Rodolfo Paoletti, and Elena Tremoli Arterioscler Thromb Vasc Biol. 2005;25:598-603; published online before print January 27 2005, doi:10.1161/01.ATV.0000157145.98200.55. Abstract \| Full Text \| PDF \| Data Supplement Stroke-prone rats have brain abnormalities preceded by the development of systemic inflammation. In this animal model, rosuvastatin, a hydrophilic statin, attenuates the release of inflammatory mediators and delays the appearance of brain damage. In the same model, simvastatin, a lipophilic statin, fails to exert any beneficial effect.
	Associations of the UCP2 Gene Locus With Asymptomatic Carotid Atherosclerosis in Middle-Aged Women H. Oberkofler, B. Iglseder, K. Klein, J. Unger, M. Haltmayer, F. Krempler, B. Paulweber, and W. Patsch Arterioscler Thromb Vasc Biol. 2005;25:604-610; published online before print December 16 2004, doi:10.1161/01.ATV.0000153141.42033.22. Abstract \| Full Text \| PDF \| Data Supplement Uncoupling protein 2 (UCP2) reduces mitochondrial reactive oxygen species production and protects against atherosclerosis in animal models. We report that the UCP2 gene locus is associated with asymptomatic carotid atherosclerosis in females of a cross-sectional study and that a common promoter polymorphism affects UCP2 gene expression in endothelial cells and macrophages.
	Carotid Plaque Composition Differs Between Ethno-Racial Groups: An MRI Pilot Study Comparing Mainland Chinese and American Caucasian Patients T. Saam, J.M. Cai, Y.Q. Cai, N.Y. An, A. Kampschulte, D. Xu, W.S. Kerwin, N. Takaya, N.L. Polissar, T.S. Hatsukami, and C. Yuan Arterioscler Thromb Vasc Biol. 2005;25:611-616; published online before print January 13 2005, doi:10.1161/01.ATV.0000155965.54679.79. Abstract \| Full Text \| PDF Twenty Chinese patients and 20 American Caucasian patients, all recently symptomatic, were imaged by MRI. Carotid lesions were bilaterally evaluated for plaque composition and plaque morphology. Plaque composition and morphology differed significantly between the ethno-racial groups. MRI is a promising tool to noninvasively study differences in atherosclerotic lesions across distinctive populations.
	Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Are Associated With Early Carotid Atherosclerosis Shin-ichi Kawachi, Noriyuki Takeda, Akihiko Sasaki, Yoshiaki Kokubo, Kazuhisa Takami, Hiroshi Sarui, Makoto Hayashi, Noriyoshi Yamakita, and Keigo Yasuda Arterioscler Thromb Vasc Biol. 2005;25:617-621; published online before print December 29 2004, doi:10.1161/01.ATV.0000154486.03017.35. Abstract \| Full Text \| PDF The role of growth hormone-insulin-like growth factor (IGF)-1 axis in cardiovascular disease is controversial. We have found that IGF-1 and IGF binding protein (IGFBP)-3 were associated with carotid intima-media thickness independent of age, body mass index, blood pressure, and insulin in 330 apparently healthy Japanese men. Circulating IGF-1 and IGFBP-3 may be stimulators of atherosclerosis.
	Expression of the LXR ${alpha}$ Protein in Human Atherosclerotic Lesions Yuichiro Watanabe, Shuying Jiang, Wakako Takabe, Riuko Ohashi, Toshiya Tanaka, Yasutoshi Uchiyama, Keiko Katsumi, Hiroko Iwanari, Noriko Noguchi, Makoto Naito, Takao Hamakubo, and Tatsuhiko Kodama Arterioscler Thromb Vasc Biol. 2005;25:622-627; published online before print December 29 2004, doi:10.1161/01.ATV.0000154489.53077.4e. Abstract \| Full Text \| PDF \| Data Supplement We established the monoclonal antibody recognizing native human LXR{alpha} protein PPZ0412 and studied the expression of LXR{alpha} protein. In the human body, the LXR{alpha} protein is highly expressed in macrophage lineage and atherosclerotic lesion foam cells and is identified as a target for intervention in atherosclerotic disease.
	Transient Role for CD1d-Restricted Natural Killer T Cells in the Formation of Atherosclerotic Lesions Ara M. Aslanian, Harold A. Chapman, and Israel F. Charo Arterioscler Thromb Vasc Biol. 2005;25:628-632; published online before print December 9 2004, doi:10.1161/01.ATV.0000153046.59370.13. Abstract \| Full Text \| PDF Mice deficient in CD1d-restricted natural killer T cells have reduced atherosclerosis only during the earliest stages of fatty streak formation, indicating that the contribution of natural killer T cells to lesion formation is transient.
	Oxidized Phospholipids Trigger Atherogenic Inflammation in Murine Arteries Alexander Furnkranz, Andreas Schober, Valery N. Bochkov, Pavel Bashtrykov, Gerhard Kronke, Alexandra Kadl, Bernd R. Binder, Christian Weber, and Norbert Leitinger Arterioscler Thromb Vasc Biol. 2005;25:633-638; published online before print December 9 2004, doi:10.1161/01.ATV.0000153106.03644.a0. Abstract \| Full Text \| PDF \| Data Supplement Oxidized phospholipids have been implied to play a role in atherogenesis; however, whether they trigger vascular inflammation in vivo is not known. Using a novel experimental approach, we demonstrate that oxidized phospholipids elicit atherogenic inflammation in murine arteries in vivo, implicating oxidized phospholipids as triggers of vascular inflammation.
	Two Distinct Calcium-Dependent Mitochondrial Pathways Are Involved in Oxidized LDL-Induced Apoptosis Cécile Vindis, Meyer Elbaz, Isabelle Escargueil-Blanc, Nathalie Augé, Aurelia Heniquez, Jean-Claude Thiers, Anne Nègre-Salvayre, and Robert Salvayre Arterioscler Thromb Vasc Biol. 2005;25:639-645; published online before print December 23 2004, doi:10.1161/01.ATV.0000154359.60886.33. Abstract \| Full Text \| PDF \| Data Supplement We investigated the potential relationship between calcium signaling, proteolytic cascade, and mitochondrial apoptotic pathways involved in oxidized low-density lipoprotein (oxLDL)-induced apoptosis. OxLDL-induced apoptosis was mediated by 2 distinct mitochondrial pathways, one involving calcium/calpain/mitochondrial permeability transition pore/cytochrome C/caspase-3 and the other calcium-dependent release of apoptosis inducing factor.
	Thrombosis
	Daily and Circadian Rhythms of Tissue Factor Pathway Inhibitor and Factor VII Activity Mirko Pinotti, Cristiano Bertolucci, Francesco Portaluppi, Ilaria Colognesi, Elena Frigato, Augusto Foà, and Francesco Bernardi Arterioscler Thromb Vasc Biol. 2005;25:646-649; published online before print December 16 2004, doi:10.1161/01.ATV.0000153140.13148.e0. Abstract \| Full Text \| PDF \| Data Supplement In healthy humans, tissue factor pathway inhibitor (TFPI) and factor VII (FVII) activity levels showed significant diurnal variations. Parallel daily fluctuations in TFPI and FVII activity, influenced by the feeding schedule, were shown in mice. Only FVII rhythms were circadian. These chronobiological patterns should be considered to analyze activity levels of these factors.
	Letters to the Editor
	Adiponectin and Coronary Heart Disease: The Strong Heart Study Robert S. Lindsay, Helaine E. Resnick, Jianhui Zhu, Min L. Tun, Barbara V. Howard, Ying Zhang, Jeunliang Yeh, and Lyle G. Best Arterioscler Thromb Vasc Biol. 2005;25:e15-e16, doi:10.1161/01.ATV.0000153090.21990.8c. Full Text \| PDF
	Human Atherosclerotic Plaque Contains Viable Invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis Emil V. Kozarov, Brian R. Dorn, Charles E. Shelburne, William A. Dunn, Jr, and Ann Progulske-Fox Arterioscler Thromb Vasc Biol. 2005;25:e17-e18; published online before print January 20 2005, doi:10.1161/01.ATV.0000155018.67835.1a. Full Text \| PDF \| Data Supplement
	Dyslipidemia and Thrombosis: Causal Relationship or Epiphenomenon of Sedentary Lifestyle? Wolfgang Sturm, Anton Sandhofer, Carine J.M. Doggen, Nicholas L. Smith, Rozenn N. Lemaitre, Susan R. Heckbert, Frits R. Rosendaal, and Bruce M. Psaty Arterioscler Thromb Vasc Biol. 2005;25:e19, doi:10.1161/01.ATV.0000157142.64490.e9. Full Text \| PDF
	Fitness Versus Fatness: the Debate Continues Katherine Esposito, Raffaele Marfella, Dario Giugliano, Thomas O. Obisesan, James M. Hagberg, Koichi Okita, Hirotaka Nishijima, and Takeshi Murakami Arterioscler Thromb Vasc Biol. 2005;25:e20-e21, doi:10.1161/01.ATV.0000154485.24356.5a. Full Text \| PDF
	AHA Scientific Statements
	Recommendations for Blood Pressure Measurement in Humans and Experimental Animals: Part 2: Blood Pressure Measurement in Experimental Animals. A Statement for Professionals From the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research Theodore W. Kurtz, Karen A. Griffin, Anil K. Bidani, Robin L. Davisson, and John E. Hall Arterioscler Thromb Vasc Biol. 2005;25:e22-e33, doi:10.1161/01.ATV.0000158419.98675.d7. Abstract \| Full Text \| PDF

Spotlight

TOC Spotlight File

Volume 25, Issue 3; March 1, 2005

Editorials

Congratulations to Dr Elizabeth G. Nabel

Increased ApoB in Small Dense LDL Particles Predicts Premature Coronary Artery Disease

Aortic Stenosis and Statins: More Evidence of "Pleotropy"?

Recommendations for Blood Pressure Measurement in Animals: Summary of an AHA Scientific Statement From the Council on High Blood Pressure Research, Professional and Public Education Subcommittee

ATVB In Focus: Novel Approaches to the Treatment of Dyslipidemia

Brief Reviews

Inhibition of Triglyceride Synthesis as a Treatment Strategy for Obesity: Lessons From DGAT1-Deficient Mice

Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance

LDL Receptor–Related Protein and the Vascular Wall: Implications for Atherothrombosis

Vascular Biology

Modulation of Estrogen Signaling by the Novel Interaction of Heat Shock Protein 27, a Biomarker for Atherosclerosis, and Estrogen Receptor ß: Mechanistic Insight Into the Vascular Effects of Estrogens

In Vivo Expression of Recombinant Vascular Endothelial Growth Factor in Rabbit Carotid Artery Increases Production of Superoxide Anion

p47phox Associates With the Cytoskeleton Through Cortactin in Human Vascular Smooth Muscle Cells: Role in NAD(P)H Oxidase Regulation by Angiotensin II

Human Urotensin II Is a Novel Activator of NADPH Oxidase in Human Pulmonary Artery Smooth Muscle Cells

Molecular Mechanisms Underlying the Proangiogenic Effect of Factor XIII

Regulation of Vascular Smooth Muscle Cell Proliferation and Migration by Human Sprouty 2

High Glucose Induces Human Endothelial Cell Apoptosis Through a Phosphoinositide 3-Kinase–Regulated Cyclooxygenase-2 Pathway

Stable Knock-Down of the Sphingosine 1-Phosphate Receptor S1P1 Influences Multiple Functions of Human Endothelial Cells

Atherosclerosis and Lipoproteins

Low-Density Lipoprotein Subfractions and the Long-Term Risk of Ischemic Heart Disease in Men: 13-Year Follow-Up Data From the Québec Cardiovascular Study

Complete Deficiency of the Low-Density Lipoprotein Receptor Is Associated With Increased Apolipoprotein B-100 Production

Role of ADP Ribosylation Factor 1 in the Assembly and Secretion of ApoB-100–Containing Lipoproteins

Glucosamine-Induced Endoplasmic Reticulum Stress Promotes ApoB100 Degradation: Evidence for Grp78-Mediated Targeting to Proteasomal Degradation

Identification of Unique Lipoprotein Subclasses for Visceral Obesity by Component Analysis of Cholesterol Profile in High-Performance Liquid Chromatography

Regulation of Human ApoA-I by Gemfibrozil and Fenofibrate Through Selective Peroxisome Proliferator-Activated Receptor Modulation

Paradoxical Effects of Statins on Aortic Valve Myofibroblasts and Osteoblasts: Implications for End-Stage Valvular Heart Disease

Rosuvastatin, but not Simvastatin, Provides End-Organ Protection in Stroke-Prone Rats by Antiinflammatory Effects

Associations of the UCP2 Gene Locus With Asymptomatic Carotid Atherosclerosis in Middle-Aged Women

Carotid Plaque Composition Differs Between Ethno-Racial Groups: An MRI Pilot Study Comparing Mainland Chinese and American Caucasian Patients

Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 Are Associated With Early Carotid Atherosclerosis

Expression of the LXR Protein in Human Atherosclerotic Lesions

Transient Role for CD1d-Restricted Natural Killer T Cells in the Formation of Atherosclerotic Lesions

Oxidized Phospholipids Trigger Atherogenic Inflammation in Murine Arteries

Two Distinct Calcium-Dependent Mitochondrial Pathways Are Involved in Oxidized LDL-Induced Apoptosis

Thrombosis

Daily and Circadian Rhythms of Tissue Factor Pathway Inhibitor and Factor VII Activity

Letters to the Editor

Adiponectin and Coronary Heart Disease: The Strong Heart Study

Human Atherosclerotic Plaque Contains Viable Invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis

Dyslipidemia and Thrombosis: Causal Relationship or Epiphenomenon of Sedentary Lifestyle?

Fitness Versus Fatness: the Debate Continues

AHA Scientific Statements

Spotlight

Stable Knock-Down of the Sphingosine 1-Phosphate Receptor S1P₁ Influences Multiple Functions of Human Endothelial Cells

Regulation of Human ApoA-I by Gemfibrozil and Fenofibrate Through Selective Peroxisome Proliferator-Activated Receptor ${alpha}$ Modulation

Expression of the LXR ${alpha}$ Protein in Human Atherosclerotic Lesions