Arteriosclerosis, Thrombosis, and Vascular Biology -- Table of Contents (24 [9])

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Volume 24, Issue 9; September 1, 2004

Editorials
Brief Reviews
Vascular Biology
Atherosclerosis and Lipoproteins
Thrombosis
Letters to the Editor

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	Editorials
	Myocardin—Not Quite MyoD Michael S. Parmacek Arterioscler Thromb Vasc Biol. 2004;24:1535-1537, doi:10.1161/01.ATV.0000141044.03875.7f. Full Text \| PDF
	Unique Pathway for Cholesterol Uptake in Fat Cells Sergio Fazio and MacRae F. Linton Arterioscler Thromb Vasc Biol. 2004;24:1538-1539, doi:10.1161/01.ATV.0000140821.25572.1b. Full Text \| PDF
	How Vascular NAD(P)H Oxidase Activity and Nox Isoform Expression are Regulated Mitsuhiro Yokoyama and Nobutaka Inoue Arterioscler Thromb Vasc Biol. 2004;24:1540-1541, doi:10.1161/01.ATV.0000142356.48952.33. Full Text \| PDF
	Brief Reviews
	Lipid Inflammatory Mediators in Diabetic Vascular Disease Rama Natarajan and Jerry L. Nadler Arterioscler Thromb Vasc Biol. 2004;24:1542-1548; published online before print May 27 2004, doi:10.1161/01.ATV.0000133606.69732.4c. Abstract \| Full Text \| PDF Evidence suggests that inflammatory responses in the vasculature can be elicited by small oxidized lipids that are components of oxidized low-density lipoprotein or products of the lipoxygenase and cyclooxygenase pathways of arachidonic and linoleic acid metabolism. This review evaluates these inflammatory and proatherogenic pathways in the pathogenesis of diabetic vascular disease.
	Heparin-Binding Domains in Vascular Biology Eva M. Muñoz and Robert J. Linhardt Arterioscler Thromb Vasc Biol. 2004;24:1549-1557; published online before print July 1 2004, doi:10.1161/01.ATV.0000137189.22999.3f. Abstract \| Full Text \| PDF Heparin and structurally related heparan sulfate bind a large number of proteins, taking part in a wide range of biological processes, particularly ones involved in vascular biology. Heparin-binding domains share certain common structural features, but there is no absolute dependency on specific sequences or protein folds.
	Genetic and Environmental Determinants of Fibrin Structure and Function: Relevance to Clinical Disease Eleanor M. Scott, Robert A.S. Ariëns, and Peter J. Grant Arterioscler Thromb Vasc Biol. 2004;24:1558-1566; published online before print June 24 2004, doi:10.1161/01.ATV.0000136649.83297.bf. Abstract \| Full Text \| PDF The formation of a fibrin clot is one of the key events in atherothrombotic vascular disease. This review discusses how genetic and environmental factors alter fibrin structure and function and the implications this has for the clinical presentation of vascular disease.
	Genetics of Ultrasonographic Carotid Atherosclerosis Teri A. Manolio, Eric Boerwinkle, Christopher J. O’Donnell, and Alexander F. Wilson Arterioscler Thromb Vasc Biol. 2004;24:1567-1577; published online before print July 15 2004, doi:10.1161/01.ATV.0000138789.11433.c1. Abstract \| Full Text \| PDF \| Data Supplement Only 1 genetic variant, MMP 3, has shown consistently positive associations with ultrasonographic carotid disease, although it has not been studied widely. Another, PON1 L55 mol/L, is weakly associated in subgroups only. Genetic variants reported to be associated with clinical cardiovascular disease show weak or no relationship to carotid atherosclerosis.
	Hereditary Vascular Anomalies: New Insights Into Their Pathogenesis J.-C. Tille and M.S. Pepper Arterioscler Thromb Vasc Biol. 2004;24:1578-1590; published online before print July 1 2004, doi:10.1161/01.ATV.0000137390.56554.df. Abstract \| Full Text \| PDF Increased understanding of the mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular malformations. This review focuses on recent advances in our understanding of the mechanisms of angiogenesis/lymphangiogenesis and the differentiation of arterial, venous, and lymphatic vessels. We integrate this knowledge with new data obtained from genetic studies in humans, which have revealed a number of heretofore-unsuspected candidates involved in the development of familial vascular anomalies. We present a common infantile vascular tumor, hemangioma, and then focus on hereditary familial vascular and lymphatic malformations. We also summarize transgenic mouse models for some of these malformations. It seems reasonable to believe that novel therapeutic strategies will soon emerge for the treatment of hemangiomas and vascular malformations.
	Laminopathies and Atherosclerosis Khalid Z. Al-Shali and Robert A. Hegele Arterioscler Thromb Vasc Biol. 2004;24:1591-1595; published online before print June 17 2004, doi:10.1161/01.ATV.0000136392.59656.8b. Abstract \| Full Text \| PDF Dunnigan-type familial partial lipodystrophy and Hutchinson-Gilford progeria syndrome are laminopathies caused by mutation in LMNA that feature atherosclerosis, which is related to proatherogenic metabolic disturbances and to the generalized process of accelerated aging, respectively. These monogenic diseases may provide clues about new pathways for atherogenesis.
	Vascular Biology
	Forced Expression of Myocardin Is Not Sufficient for Induction of Smooth Muscle Differentiation in Multipotential Embryonic Cells Tadashi Yoshida, Keiko Kawai-Kowase, and Gary K. Owens Arterioscler Thromb Vasc Biol. 2004;24:1596-1601; published online before print July 1 2004, doi:10.1161/01.ATV.0000137190.63214.c5. Abstract \| Full Text \| PDF \| Data Supplement We examined whether myocardin induces the entire smooth muscle cell (SMC) differentiation program. Results of the present study showed that myocardin knockdown or overexpression affected only a subset of SMC marker genes in multipotential cells, indicating that myocardin is required but not sufficient to induce SMC lineage.
	Homeobox Protein Hex Facilitates Serum Responsive Factor–Mediated Activation of the SM22 ${alpha}$ Gene Transcription in Embryonic Fibroblasts Yuko Oyama, Keiko Kawai-Kowase, Kenichi Sekiguchi, Mahito Sato, Hiroko Sato, Miki Yamazaki, Yoshio Ohyama, Yasushi Aihara, Tatsuya Iso, Eichi Okamaoto, Ryozo Nagai, and Masahiko Kurabayashi Arterioscler Thromb Vasc Biol. 2004;24:1602-1607; published online before print July 8 2004, doi:10.1161/01.ATV.0000138404.17519.45. Abstract \| Full Text \| PDF This study demonstrates that Hex, a hematopoietically expressed homeobox protein, induces transcription of the SM22{alpha} gene by facilitating the interaction between SRF and its cognate binding site in embryonic fibroblasts. These findings will provide the clue for understanding the mechanisms by which bone marrow-derived SMC precursor cells undergo differentiation.
	B-Myb Represses Vascular Smooth Muscle Cell Collagen Gene Expression and Inhibits Neointima Formation After Arterial Injury Claudia S. Hofmann, Christopher P. Sullivan, Hao-Yuan Jiang, Phillip J. Stone, Paul Toselli, Ernane D. Reis, Igor Chereshnev, Barbara M. Schreiber, and Gail E. Sonenshein Arterioscler Thromb Vasc Biol. 2004;24:1608-1613; published online before print July 15 2004, doi:10.1161/01.ATV.0000139010.71779.f3. Abstract \| Full Text \| PDF \| Data Supplement To analyze B-Myb function in the vasculature, mice overexpressing B-myb were generated. Neonates displayed normal {alpha}1(I) collagen mRNA levels, whereas adults expressed decreased collagen mRNA in aortas and isolated vascular SMCs. On femoral artery denudation, neointima formation was dramatically reduced in B-myb transgenic mice.
	Systemic Regulation of Vascular NAD(P)H Oxidase Activity and Nox Isoform Expression in Human Arteries and Veins Tomasz J. Guzik, Jerzy Sadowski, Boguslaw Kapelak, Andrzej Jopek, Pawel Rudzinski, Ravi Pillai, Richard Korbut, and Keith M. Channon Arterioscler Thromb Vasc Biol. 2004;24:1614-1620; published online before print July 15 2004, doi:10.1161/01.ATV.0000139011.94634.9d. Abstract \| Full Text \| PDF \| Data Supplement Endothelial dysfunction is characterized by increased superoxide production. NAD(P)H oxidase activity and endothelial function are correlated in veins and arteries in coronary artery disease, suggesting regulation by systemic factors. The expression of the NAD(P)H oxidase subunits p22phox and nox4, although different in veins and arteries, are also correlated.
	Oxidized Omega-3 Fatty Acids Inhibit NF- ${kappa}$ B Activation Via a PPAR ${alpha}$ -Dependent Pathway Archana Mishra, Ashok Chaudhary, and Sanjeev Sethi Arterioscler Thromb Vasc Biol. 2004;24:1621-1627; published online before print July 1 2004, doi:10.1161/01.ATV.0000137191.02577.86. Abstract \| Full Text \| PDF \| Data Supplement
	Estrogen, Heat Shock Proteins, and NF ${kappa}$ B in Human Vascular Endothelium Karyn L. Hamilton, F.N. Mbai, S. Gupta, and A.A. Knowlton Arterioscler Thromb Vasc Biol. 2004;24:1628-1633; published online before print July 1 2004, doi:10.1161/01.ATV.0000137188.76195.fb. Abstract \| Full Text \| PDF \| Data Supplement We hypothesized that estrogen would increase HSP72 in human coronary artery endothelial cells (HCAEC). Both early and chronic treatment increased HSP72. EMSA showed activation of HSF-1 with early, but not chronic, 17ß-estradiol. Transcription factor decoys blocked estrogen-related HSP72 induction. Estrogen decreased LDH release with hypoxia. An NF-{kappa}B decoy blocked the HSP72 increase and estrogen-associated protection.
	cAMP-Response Element-Binding Protein Mediates Tumor Necrosis Factor- ${alpha}$ –Induced Vascular Smooth Muscle Cell Migration Hiroki Ono, Toshihiro Ichiki, Kae Fukuyama, Naoko Iino, Satoko Masuda, Kensuke Egashira, and Akira Takeshita Arterioscler Thromb Vasc Biol. 2004;24:1634-1639; published online before print July 8 2004, doi:10.1161/01.ATV.0000138052.86051.0d. Abstract \| Full Text \| PDF \| Data Supplement Migration of vascular smooth muscle cells (VSMCs) contributes to formation of vascular stenotic lesions. TNF-{alpha}, a potent migration factor for VSMCs, activated CREB through p38 mitogen-activated protein kinase (p38-MAPK). CREB inhibition suppressed TNF-{alpha}-induced VSMC migration and Rac1 expression. These results suggest p38-MAPK/CREB/Rac1 pathway mediates TNF-{alpha}-induced VSMC migration.
	Lysophosphatidylcholine Enhances Cytokine Production of Endothelial Cells via Induction of L-Type Amino Acid Transporter 1 and Cell Surface Antigen 4F2 Wakako Takabe, Yoshikatsu Kanai, Arthit Chairoungdua, Noriyuki Shibata, Sono Toi, Makio Kobayashi, Tatsuhiko Kodama, and Noriko Noguchi Arterioscler Thromb Vasc Biol. 2004;24:1640-1645; published online before print June 3 2004, doi:10.1161/01.ATV.0000134377.17680.26. Abstract \| Full Text \| PDF \| Data Supplement
	Functional Analysis of Genomic DNA, cDNA, and Nucleotide Sequence of the Mature C-Type Natriuretic Peptide Gene in Vascular Cells Jaroslav Pelisek, Andreas Kuehnl, Pierre H. Rolland, Choukri Mekkaoui, Alexandra Fuchs, Greg F. Walker, Manfred Ogris, Ernst Wagner, and Sigrid Nikol Arterioscler Thromb Vasc Biol. 2004;24:1646-1651; published online before print July 1 2004, doi:10.1161/01.ATV.0000137387.78515.61. Abstract \| Full Text \| PDF \| Data Supplement Functional analysis of various C-type natriuretic peptide (CNP) sequences on growth of vascular cells. For the first time, dual therapeutic effects of CNP with inhibition of smooth muscle cell proliferation and stimulation of re-endothelialization were demonstrated in a pig restenosis model using liposome-mediated gene transfer and local adventitial delivery.
	Effect of Exposure to Cigarette Smoke on Carotid Artery Intimal Thickening: The Role of Inducible NO Synthase Takeo Anazawa, Paul C. Dimayuga, Hongyan Li, Shigemasa Tani, Jason Bradfield, Kuang-Yuh Chyu, Sanjay Kaul, Prediman K. Shah, and Bojan Cercek Arterioscler Thromb Vasc Biol. 2004;24:1652-1658; published online before print July 22 2004, doi:10.1161/01.ATV.0000139925.84444.ad. Abstract \| Full Text \| PDF We investigated the role of inducible nitric oxide synthase (iNOS) in intimal thickening with exposure to cigarette smoke (CS) exposure in WT mice was associated with increased arterial iNOS expression, superoxide production, AP-1 activation, serum NO, and intimal thickening. Inhibition or deletion of iNOS abrogated the effects of CS.
	Correlation of NO Metabolites and 8-Iso-Prostaglandin F_2a With Periventricular Hyperintensity Severity Hiroshi Shibata, Toru Nabika, Hidehiko Moriyama, Junichi Masuda, and Shotai Kobayashi Arterioscler Thromb Vasc Biol. 2004;24:1659-1663; published online before print July 1 2004, doi:10.1161/01.ATV.0000137415.67349.3c. Abstract \| Full Text \| PDF Oxidative stress and NO levels were evaluated in a general population with or without mild periventricular hyperintensity under a cross-sectional study design. Serum NOx (NO metabolites) and urinary 8-iso-PG F2{alpha} (a marker for oxidative stress) correlated with the severity of periventricular hyperintensity in a multivariate analysis.
	Elevated Fluid Shear Stress Enhances Postocclusive Collateral Artery Growth and Gene Expression in the Pig Hind Limb Frederic Pipp, Stefanie Boehm, Wei-Jun Cai, Farzin Adili, Bela Ziegler, Gordana Karanovic, Ralf Ritter, Jörn Balzer, Christian Scheler, Wolfgang Schaper, and Thomas Schmitz-Rixen Arterioscler Thromb Vasc Biol. 2004;24:1664-1668; published online before print July 8 2004, doi:10.1161/01.ATV.0000138028.14390.e4. Abstract \| Full Text \| PDF \| Data Supplement The role of fluid shear stress on the development of a collateral circulation was studied by abruptly increasing collateral blood flow by a distal femoral artery-to-vein anastomosis. This increased number and size of collateral vessels to a hitherto unknown degree. Fluid shear stress is the primary and strongest arteriogenic stimulus.
	Atherosclerosis and Lipoproteins
	A Novel Efflux–Recapture Process Underlies the Mechanism of High-Density Lipoprotein Cholesteryl Ester-Selective Uptake Mediated by the Low-Density Lipoprotein Receptor–Related Protein Gerard Vassiliou and Ruth McPherson Arterioscler Thromb Vasc Biol. 2004;24:1669-1675; published online before print June 3 2004, doi:10.1161/01.ATV.0000134295.09932.60. Abstract \| Full Text \| PDF In adipocytes, the LDL receptor-related protein contributes to selective uptake when it recaptures and internalizes HDL-derived cholesteryl esters that are otherwise lost by apoE-mediated efflux. This novel "efflux-recapture" process explains some conflicting observations of selective uptake and underscores the bi-directional nature of efflux.
	Potential Role for Mitogen-Activated Protein Kinase Phosphatase-1 in the Development of Atherosclerotic Lesions in Mouse Models Srinivasa T. Reddy, Julie T. Nguyen, Victor Grijalva, Greg Hough, Susan Hama, Mohamad Navab, and Alan M. Fogelman Arterioscler Thromb Vasc Biol. 2004;24:1676-1681; published online before print July 8 2004, doi:10.1161/01.ATV.0000138342.94314.64. Abstract \| Full Text \| PDF \| Data Supplement MKP-1 is required for Ox-PAPC-mediated endothelial/monocyte interactions; however, an in vivo role of MKP-1 in atherogenesis has not been investigated. We now report that MKP-1 protein is expressed in the atherosclerotic lesions of mice and inhibition of tyrosine phosphatase activity and MKP-1 protein reduce atherosclerotic lesions in mouse models.
	Asymmetric Dimethylarginine Produces Vascular Lesions in Endothelial Nitric Oxide Synthase–Deficient Mice: Involvement of Renin-Angiotensin System and Oxidative Stress Osamu Suda, Masato Tsutsui, Tsuyoshi Morishita, Hiromi Tasaki, Susumu Ueno, Sei Nakata, Takashi Tsujimoto, Yumiko Toyohira, Yoshiaki Hayashida, Yasuyuki Sasaguri, Yoichi Ueta, Yasuhide Nakashima, and Nobuyuki Yanagihara Arterioscler Thromb Vasc Biol. 2004;24:1682-1688; published online before print June 24 2004, doi:10.1161/01.ATV.0000136656.26019.6e. Abstract \| Full Text \| PDF \| Data Supplement This study demonstrates that asymmetrical dimethylarginine (ADMA) causes arteriosclerotic coronary lesions in mice in vivo through mechanisms other than simple inhibition of endothelial NO synthesis. Our findings should contribute to a better understanding of the pathophysiological role of ADMA in arteriosclerosis.
	Acyl-Coenzyme A:Cholesterol Acyltransferase-2 (ACAT-2) Is Responsible for Elevated Intestinal ACAT Activity in Diabetic Rats Masaharu Hori, Maki Satoh, Kohichiro Furukawa, Yu-ichiro Sakamoto, Hideki Hakamata, Yoshihiro Komohara, Motohiro Takeya, Yutaka Sasaki, Akira Miyazaki, and Seikoh Horiuchi Arterioscler Thromb Vasc Biol. 2004;24:1689-1695; published online before print July 8 2004, doi:10.1161/01.ATV.0000137976.88533.13. Abstract \| Full Text \| PDF \| Data Supplement Diabetic rats exhibit dyslipidemia caused, in part, by elevated intestinal acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity. We determined which ACAT isozyme (ACAT-1 or ACAT-2) was involved in the elevated intestinal ACAT activity in diabetic rats. We demonstrated an important role of ACAT-2, implicating its involvement in dyslipidemia in diabetic patients.
	Divergent Effects of the Catalytic and Bridging Functions of Hepatic Lipase on Atherosclerosis Helén L. Dichek, Kun Qian, and Nalini Agrawal Arterioscler Thromb Vasc Biol. 2004;24:1696-1702; published online before print June 17 2004, doi:10.1161/01.ATV.0000135981.61827.9d. Abstract \| Full Text \| PDF \| Data Supplement These studies demonstrate that high levels of catalytically active human hepatic lipase (HL) reduce atherosclerosis, whereas high levels of a catalytically inactive HL do not affect atherosclerosis in mice genetically deficient in low-density lipoprotein receptor and mouse HL.
	Interrelationships Between Human Apolipoprotein A-I and Apolipoproteins B-48 and B-100 Kinetics Using Stable Isotopes Francine K. Welty, Alice H. Lichtenstein, P. Hugh R. Barrett, Gregory G. Dolnikowski, and Ernst J. Schaefer Arterioscler Thromb Vasc Biol. 2004;24:1703-1707; published online before print July 8 2004, doi:10.1161/01.ATV.0000137975.14996.df. Abstract \| Full Text \| PDF Using stable isotopes in humans, 2 links were observed between apoA-I and apoB kinetics: (1) when LDL apoB-100 PS is high, there is increased apoA-I PR; and (2) delayed chylomicron remnant clearance is associated with enhanced apoA-I FCR, indicating that alterations in intestinal lipoproteins may be more important in determining HDL-C levels than changes in liver lipoprotein particles.
	Variation in the Lamin A/C Gene: Associations With Metabolic Syndrome Nanette I. Steinle, Rasa Kazlauskaite, Ikhide G. Imumorin, Wen-Chi Hsueh, Toni I. Pollin, Jeffrey R. O’Connell, Braxton D. Mitchell, and Alan R. Shuldiner Arterioscler Thromb Vasc Biol. 2004;24:1708-1713; published online before print June 17 2004, doi:10.1161/01.ATV.0000136384.53705.c9. Abstract \| Full Text \| PDF \| Data Supplement To determine whether polymorphisms in LMNA influence susceptibility to metabolic syndrome and its constituent components, we performed DNA analysis of polymorphisms in LMNA. The H566H polymorphism was associated with metabolic syndrome and also higher mean fasting triglyceride and lower mean HDL-cholesterol concentrations in the Old Order Amish.
	Serial Studies of Mouse Atherosclerosis by In Vivo Magnetic Resonance Imaging Detect Lesion Regression After Correction of Dyslipidemia Eugene Trogan, Zahi A. Fayad, Vitalii V. Itskovich, Juan-Gilberto S. Aguinaldo, Venkatesh Mani, John T. Fallon, Igor Chereshnev, and Edward A. Fisher Arterioscler Thromb Vasc Biol. 2004;24:1714-1719; published online before print July 15 2004, doi:10.1161/01.ATV.0000139313.69015.1c. Abstract \| Full Text \| PDF \| Data Supplement Serial in vivo MRI of mouse arterial plaque after correction of dyslipidemia revealed a monotonic decrease in lesion size (regression) and changes in lesion composition consistent with a stable plaque phenotype. Serial in vivo MRI will enhance studies of plaque regression in animal models in response to therapeutic interventions.
	Thrombosis
	Reduced Vascular NO Bioavailability in Diabetes Increases Platelet Activation In Vivo Andreas Schäfer, Nicholas J. Alp, Shije Cai, Craig A. Lygate, Stefan Neubauer, Martin Eigenthaler, Johann Bauersachs, and Keith M. Channon Arterioscler Thromb Vasc Biol. 2004;24:1720-1726; published online before print July 8 2004, doi:10.1161/01.ATV.0000138072.76902.dd. Abstract \| Full Text \| PDF Endothelial dysfunction caused by uncoupling of endothelial NO synthase is well described in diabetes mellitus and may lead to platelet activation. Acute loss of systemic NO bioavailability causes platelet activation. eNOS uncoupling prevention in diabetes preserved systemic NO bioavailability and maintained a physiological platelet state without activation in vivo.
	Principal Role of Glycoprotein VI in ${alpha}$ 2ß1 and ${alpha}$ IIbß3 Activation During Collagen-Induced Thrombus Formation Christelle Lecut, Anne Schoolmeester, Marijke J.E. Kuijpers, Jos L.V. Broers, Marc A.M.J. van Zandvoort, Karen Vanhoorelbeke, Hans Deckmyn, Martine Jandrot-Perrus, and Johan W.M. Heemskerk Arterioscler Thromb Vasc Biol. 2004;24:1727-1733; published online before print July 1 2004, doi:10.1161/01.ATV.0000137974.85068.93. Abstract \| Full Text \| PDF \| Data Supplement Integrin activation during thrombus formation on collagen was studied using fluorescent-labeled antibodies IAC-1 and PAC1 directed against activation-dependent epitopes of {alpha}2ß1 and {alpha}IIbß3 integrin, respectively. Glycoprotein VI blockade by 9O12 antibody or P2Y ADP receptors reduced integrin activation along with aggregate formation and fibrinogen binding but not {alpha}2ß1-dependent adhesion.
	Variable Hypocoagulant Effect of Fish Oil Intake in Humans: Modulation of Fibrinogen Level and Thrombin Generation Kristof Vanschoonbeek, Marion A.H. Feijge, Martine Paquay, Jan Rosing, Wim Saris, Cornelis Kluft, Peter L.A. Giesen, Moniek P.M. de Maat, and Johan W.M. Heemskerk Arterioscler Thromb Vasc Biol. 2004;24:1734-1740; published online before print June 24 2004, doi:10.1161/01.ATV.0000137119.28893.0b. Abstract \| Full Text \| PDF \| Data Supplement Intake of fish oil reduced fibrinogen and factor V levels as well as thrombin generation in plasma. The effects on thrombin generation and fibrinogen clustered around subjects with high fibrinogen carrying {alpha}-chain fibrinogen polymorphism. Thus, dietary fish oil can provoke a hypocoagulant effect depending on the fibrinogen level.
	Letters to the Editor
	CD40L-Positive Platelets Induce CD40L Expression De Novo in Endothelial Cells: Adding a Loop to Microvascular Inflammation Silvio Danese, Franco Scaldaferri, Alfredo Papa, Roberto Pola, Antonio Gasbarrini, Allesandro Sgambato, and Achille Cittadini Arterioscler Thromb Vasc Biol. 2004;24:e162, doi:10.1161/01.ATV.0000138073.91195.70. Full Text \| PDF
	Subantimicrobial Doses of Tetracycline Thomas Pallasch, David L. Brown, Lorne M. Golub, and John G. Thomas Arterioscler Thromb Vasc Biol. 2004;24:e163, doi:10.1161/01.ATV.0000138071.21565.7e. Full Text \| PDF

Spotlight

TOC Spotlight File

Volume 24, Issue 9; September 1, 2004

Editorials

Myocardin—Not Quite MyoD

Unique Pathway for Cholesterol Uptake in Fat Cells

How Vascular NAD(P)H Oxidase Activity and Nox Isoform Expression are Regulated

Brief Reviews

Lipid Inflammatory Mediators in Diabetic Vascular Disease

Heparin-Binding Domains in Vascular Biology

Genetic and Environmental Determinants of Fibrin Structure and Function: Relevance to Clinical Disease

Genetics of Ultrasonographic Carotid Atherosclerosis

Hereditary Vascular Anomalies: New Insights Into Their Pathogenesis

Laminopathies and Atherosclerosis

Vascular Biology

Forced Expression of Myocardin Is Not Sufficient for Induction of Smooth Muscle Differentiation in Multipotential Embryonic Cells

Homeobox Protein Hex Facilitates Serum Responsive Factor–Mediated Activation of the SM22 Gene Transcription in Embryonic Fibroblasts

B-Myb Represses Vascular Smooth Muscle Cell Collagen Gene Expression and Inhibits Neointima Formation After Arterial Injury

Systemic Regulation of Vascular NAD(P)H Oxidase Activity and Nox Isoform Expression in Human Arteries and Veins

Oxidized Omega-3 Fatty Acids Inhibit NF-B Activation Via a PPAR-Dependent Pathway

Estrogen, Heat Shock Proteins, and NFB in Human Vascular Endothelium

cAMP-Response Element-Binding Protein Mediates Tumor Necrosis Factor-–Induced Vascular Smooth Muscle Cell Migration

Lysophosphatidylcholine Enhances Cytokine Production of Endothelial Cells via Induction of L-Type Amino Acid Transporter 1 and Cell Surface Antigen 4F2

Functional Analysis of Genomic DNA, cDNA, and Nucleotide Sequence of the Mature C-Type Natriuretic Peptide Gene in Vascular Cells

Effect of Exposure to Cigarette Smoke on Carotid Artery Intimal Thickening: The Role of Inducible NO Synthase

Correlation of NO Metabolites and 8-Iso-Prostaglandin F2a With Periventricular Hyperintensity Severity

Elevated Fluid Shear Stress Enhances Postocclusive Collateral Artery Growth and Gene Expression in the Pig Hind Limb

Atherosclerosis and Lipoproteins

A Novel Efflux–Recapture Process Underlies the Mechanism of High-Density Lipoprotein Cholesteryl Ester-Selective Uptake Mediated by the Low-Density Lipoprotein Receptor–Related Protein

Potential Role for Mitogen-Activated Protein Kinase Phosphatase-1 in the Development of Atherosclerotic Lesions in Mouse Models

Asymmetric Dimethylarginine Produces Vascular Lesions in Endothelial Nitric Oxide Synthase–Deficient Mice: Involvement of Renin-Angiotensin System and Oxidative Stress

Acyl-Coenzyme A:Cholesterol Acyltransferase-2 (ACAT-2) Is Responsible for Elevated Intestinal ACAT Activity in Diabetic Rats

Divergent Effects of the Catalytic and Bridging Functions of Hepatic Lipase on Atherosclerosis

Interrelationships Between Human Apolipoprotein A-I and Apolipoproteins B-48 and B-100 Kinetics Using Stable Isotopes

Variation in the Lamin A/C Gene: Associations With Metabolic Syndrome

Serial Studies of Mouse Atherosclerosis by In Vivo Magnetic Resonance Imaging Detect Lesion Regression After Correction of Dyslipidemia

Thrombosis

Reduced Vascular NO Bioavailability in Diabetes Increases Platelet Activation In Vivo

Principal Role of Glycoprotein VI in 2ß1 and IIbß3 Activation During Collagen-Induced Thrombus Formation

Variable Hypocoagulant Effect of Fish Oil Intake in Humans: Modulation of Fibrinogen Level and Thrombin Generation

Letters to the Editor

CD40L-Positive Platelets Induce CD40L Expression De Novo in Endothelial Cells: Adding a Loop to Microvascular Inflammation

Subantimicrobial Doses of Tetracycline

Spotlight

Homeobox Protein Hex Facilitates Serum Responsive Factor–Mediated Activation of the SM22 ${alpha}$ Gene Transcription in Embryonic Fibroblasts

Oxidized Omega-3 Fatty Acids Inhibit NF- ${kappa}$ B Activation Via a PPAR ${alpha}$ -Dependent Pathway

Estrogen, Heat Shock Proteins, and NF ${kappa}$ B in Human Vascular Endothelium

cAMP-Response Element-Binding Protein Mediates Tumor Necrosis Factor- ${alpha}$ –Induced Vascular Smooth Muscle Cell Migration

Correlation of NO Metabolites and 8-Iso-Prostaglandin F_2a With Periventricular Hyperintensity Severity

Principal Role of Glycoprotein VI in ${alpha}$ 2ß1 and ${alpha}$ IIbß3 Activation During Collagen-Induced Thrombus Formation