Chemokines Control Mobilization, Recruitment, and Fate of Monocytes in Atherosclerosis
Atherosclerosis is a chronic inflammatory disease of large arteries and, among others, characterized by continuous influx of monocytes into the subendothelial space, subsequent macrophage accumulation, and foam cell formation. Chemokines and their receptors tightly orchestrate monocyte trafficking and fate from birth to death. This brief review summarizes our current understanding of the interplay between monocytes and chemokines entertaining crucial processes in atherosclerosis development, progression, and regression.
- Received December 1, 2014.
- Accepted March 5, 2015.
- © 2015 American Heart Association, Inc.