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Atherosclerosis

Association of Atherosclerosis With Expression of the LILRB1 Receptor By Human NK and T-Cells Supports the Infectious Burden Hypothesis

Neus Romo, Montserrat Fitó, Mónica Gumá, Joan Sala, Cosme García, Rafel Ramos, Aura Muntasell, Rafel Masiá, Jordi Bruguera, Isaac Subirana, Joan Vila, Eric de Groot, Roberto Elosua, Jaume Marrugat, Miguel López-Botet
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https://doi.org/10.1161/ATVBAHA.111.233288
Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;ATVBAHA.111.233288
Originally published August 4, 2011
Neus Romo
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Montserrat Fitó
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Mónica Gumá
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Joan Sala
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Cosme García
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Rafel Ramos
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Aura Muntasell
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Rafel Masiá
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Jordi Bruguera
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Isaac Subirana
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Joan Vila
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Eric de Groot
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Roberto Elosua
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Jaume Marrugat
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Miguel López-Botet
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Abstract

Objective—The contribution of human cytomegalovirus (HCMV) to vascular disease may depend on features of the immune response not reflected by the detection of specific antibodies. Persistent HCMV infection in healthy blood donors has been associated with changes in the distribution of NK cell receptors (NKR). The putative relationship among HCMV infection, NKR distribution, subclinical atherosclerosis, and coronary heart disease was assessed.

Methods and Results—NKR expression was compared in acute myocardial infarction (AMI) patients (n=70) and a population-based control sample (n=209). The relationship between NKR expression and carotid intima-media thickness (CIMT) in controls (n=149) was also studied. HCMV infection was associated with higher proportions of NKG2C+ and LILRB1+ NK and T-cells. In contrast, only LILRB1+ NK and CD56+ T-cells were found to be increased in AMI patients, independent of age, sex, conventional vascular risk factors, and HCMV seropositivity. Remarkably, LILRB1 expression in NK and T-cells significantly correlated with CIMT in controls.

Conclusion—The association of overt and subclinical atherosclerotic disease with LILRB1+ NK and T-cells likely reflects a relationship between the immune challenge by infections and cardiovascular disease risk, without attributing a dominant role for HCMV. Our findings may lead to the identification of novel biomarkers of vascular disease.

  • atherosclerosis
  • leukocytes
  • risk factors
  • viruses
  • Received March 12, 2011.
  • Accepted July 18, 2011.
  • © 2011 American Heart Association, Inc.
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    Association of Atherosclerosis With Expression of the LILRB1 Receptor By Human NK and T-Cells Supports the Infectious Burden Hypothesis
    Neus Romo, Montserrat Fitó, Mónica Gumá, Joan Sala, Cosme García, Rafel Ramos, Aura Muntasell, Rafel Masiá, Jordi Bruguera, Isaac Subirana, Joan Vila, Eric de Groot, Roberto Elosua, Jaume Marrugat and Miguel López-Botet
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;ATVBAHA.111.233288, originally published August 4, 2011
    https://doi.org/10.1161/ATVBAHA.111.233288

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    Association of Atherosclerosis With Expression of the LILRB1 Receptor By Human NK and T-Cells Supports the Infectious Burden Hypothesis
    Neus Romo, Montserrat Fitó, Mónica Gumá, Joan Sala, Cosme García, Rafel Ramos, Aura Muntasell, Rafel Masiá, Jordi Bruguera, Isaac Subirana, Joan Vila, Eric de Groot, Roberto Elosua, Jaume Marrugat and Miguel López-Botet
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2011;ATVBAHA.111.233288, originally published August 4, 2011
    https://doi.org/10.1161/ATVBAHA.111.233288
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