Carotid Artery Longitudinal Displacement Predicts 1-Year Cardiovascular Outcome in Patients With Suspected Coronary Artery Disease
Objective—Total longitudinal displacement (tLoD) of the common carotid artery can be measured using the ultrasound-based velocity vector imaging (VVI) technique. This study aimed to investigate clinical correlates and the possible predictive value of tLoD for cardiovascular outcome.
Methods and Results—Four hundred forty-one patients referred for myocardial perfusion scintigraphy examination for suspected coronary artery disease were recruited and underwent VVI-assisted tLoD measurement. Patients were followed up with regard to major adverse cardiovascular event (MACE) 1 year later. Low tLoD (<0.055 mm) was associated with greater clinically determined myocardial ischemia (P<0.01). During a median follow-up time of 372 days, 61 MACEs occurred. In a Kaplan–Meier survival analysis, high tLoD (>0.055 mm) predicted 1-year event-free survival (P<0.01, highest versus lowest tertile odds ratio [OR]=1.9). In a Cox regression model adjusting for age, gender, intima-media thickness, radial strain, pulse pressure, and percentage reversibility mass of myocardium, low tLoD remained a significant independent predictor of MACE (P=0.03). Finally, low tLoD provided additional predictive value in subjects with increased intima-media thickness.
Conclusion—VVI-derived tLoD seems to reflect cardiovascular status and predicts short-term event-free survival in medium- to high-risk patients. Finally, tLoD per se or in combination with intima-media thickness measurement may be a novel cardiovascular surrogate biomarker.
- Received October 25, 2010.
- Accepted April 14, 2011.
- © 2011 American Heart Association, Inc.