Letter by Ramirez and Hibbert Regarding Article, “Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Arteriosclerosis, Thrombosis, and Vascular Biology Council”
To the Editor:
We read with interest the recent article titled “Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Arteriosclerosis, Thrombosis, and Vascular Biology Council” in which Robinet et al1 review sex differences in arterial diseases in both humans and animal models. The authors provide suggestions for examining the influence of sex when designing and reporting preclinical arterial pathology experiments. They propose that both sexes should be included in experiments unless scientifically justified, the sex of the animals should be clearly reported, the studies should be adequately powered to observe sex differences, and the data should be analyzed and reported separately by sex. We commend the authors for their initiative and expect that their article will inform preclinical research in the field.
However, linked to the authors’ recommendations is the perception that preclinical arterial disease researchers do not consider or report on sex as a biological variable—at least not sufficiently. Yet, data to support this are notably limited in their report. It has been suggested that cardiovascular researchers may already be more attuned to the …