Response by Daugherty et al to Letter Regarding Article, “Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Arteriosclerosis, Thrombosis, and Vascular Biology Council”
The ATVB editors appreciate the comments of Ramirez and Hibbert on the recently published article “Consideration of Sex Differences in Design and Reporting of Experimental Arterial Pathology Studies: A Statement From the Arteriosclerosis, Thrombosis, and Vascular Biology Council.”1 They provide distinctive insight into the rationale of the focus that is needed to systematically modify the scientific literature in addressing important issues of defining the role of sex in vascular pathologies.
It is the explicit duty of ATVB to publish data that advances the scientific field with experimental designs that provide meaningful insight into biological mechanisms. This requires that our publications are reported in accord with generally accepted guidelines for preclinical, clinical, and population research. In regard to preclinical research, in 2015, National Institutes of Health (NIH) emphasized the consideration of sex as a biological variable in NIH-funded research (NOT-OD-15–102). The NIH also promoted enhanced rigor and reproducibility through the statement of the principles and guidelines for reporting preclinical research. These guidelines …