The Lipid Hypothesis in Calcific Aortic Valve Disease
The Role of the Multi-Ethnic Study of Atherosclerosis
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- aortic valve, calcification of
- aortic valve stenosis
- heart defects, congenital
Calcific aortic valve disease (CAVD) is the most common indication for valve intervention in the world.1 The cellular mechanisms, cardiovascular risk factors, and therapeutic interventions have been under intense investigation in the 21st century. In the study published in ATVB, Cao et al2 tested the Multi-Ethnic Study of Atherosclerosis (MESA) database to define the calcification phenotype associated with unique lipoprotein mechanisms in the development of calcification. MESA was designed to test subclinical atherosclerosis markers and measure calcification burden in the aortic valve using computed tomography measurements. The study group included individuals from age 45 to 84 years, who were free of any clinical cardiovascular disease and treated diabetes mellitus.3,4 The database is robust to test for subclinical risk factors in the development of calcific aortic valve disease.
See accompanying article on page 1003
Lipoproteins as Novel Risk Factors in Calcific Aortic Valve Disease
O’Brien et al5 and Otto et al6 publish studies to define the role of lipoproteins in ex vivo calcified aortic valves. Over the next 20 years, studies in the field of calcific aortic valve disease have determined that the calcific aortic valve disease is not a degenerative process, but an active cellular biology. …