Abstract 717: An Association between Frontal Non-hemorrhagic Stroke and Atrial Fibrillation.
Background: Atrial fibrillation is a known risk factor for thromboembolic events. We sought to investigate an association between arrhythmia and stroke location in patients with non-hemorrhagic stroke.
Materials and methods: The study cohort included 514 consecutive patients with non-hemorrhagic stroke treated at a single academic center. Stroke location was classified as frontal, occipital, lacunar, brainstem, left or right temporal, left or right parietal, cerebellar and insular. ANOVA, chi-square and logistic regression analyses were used. The study was approved by the institutional IRB.
Results: Frontal embolic stroke was noted more frequently in patients with atrial fibrillation (29% vs. 15% in normal sinus rhythm, NSR, p<0.0001). No other anatomic location of the stroke was associated with arrhythmia.
Frontal strokes were more likely in patients with history of coronary artery disease (23% vs. 12%, p<0.005). However, there was no association between frontal stroke location and gender, age, history of hypertension, diabetes, dyslipidemia, peripheral vascular disease, or chronic renal insufficiency.
In multivariate logistic regression analysis, atrial fibrillation (HR 2.3; 95% CI 1.2-4.5, p=0.018) and history of coronary artery disease (HR 2; 95%CI 1.2-3.4, p=0.012) remained important predictors of frontal strokes.
Discussion: Non-hemorrhagic strokes are common in patients with atrial fibrillation. We found increased prevalence of frontal embolic strokes in atrial fibrillation, possible due to the dual blood supply the frontal cerebrum from both the middle and anterior cerebral arteries. This association is intriguing and requires further studies.
Author Disclosures: D. Sedhom: None. N. Yager: None. M. Ashamalla: None. K. Ghate: None. J. Pieper: None. V. Nguyen: None. B. Shkolnik: None. M. Torosoff: None.
- © 2015 by American Heart Association, Inc.