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Poster Abstract PresentationsSession Title: Poster Session III

Abstract 683: Serum Myeloperoxidase/Paraoxonase 1 Ratio Predicts Recurrent Coronary Artery Disease

Shigeyasu Tsuda, Ryuji Toh, Kenta Mori, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Hideto Nakajima, Tomoyuki Honjo, Masakazu Shinohara, Kunihiro Nishimura, Tatsuro Ishida, Ken-ichi Hirata
Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:A683
Shigeyasu Tsuda
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Ryuji Toh
Evidence-based Laboratory Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Kenta Mori
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Manabu Nagao
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Nobuaki Tanaka
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Takeshige Mori
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Tomoko Monguchi
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Hideto Nakajima
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Tomoyuki Honjo
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Masakazu Shinohara
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Kunihiro Nishimura
Preventive Medicine and Epidemiologic informatics, National Cerebral and Cardiovascular Cntr, Osaka, Japan
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Tatsuro Ishida
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Ken-ichi Hirata
Cardiovascular Medicine, Kobe Univ Graduate Sch of Medicine, Kobe, Japan
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Abstract

Objective: Myeloperoxidase (MPO) is known as major leukocyte enzyme that oxidizes lipoproteins. High density lipoprotein (HDL) contains paraoxonase 1 (PON1), which hydrolyzes oxidized phospholipids. HDL requires PON1 to attenuate accumulation of lipid peroxides in LDL. We recently reported that serum MPO/PON1 ratio could be used as a useful marker for dysfunctional HDL and showed elevated ratios in patients undergoing recurrent percutaneous coronary intervention (PCI). However, it remains obscure whether serum MPO/PON1 ratio can predict relapsing coronary atherosclerotic lesions after PCI.

Methods and Results: Total 111 patients who had a history of successful PCI were enrolled. Their serum MPO mass and PON1 activities were measured at the time point of enrollment, and they had angiographical follow-up evaluation. Fourteen patients needed repeat-PCI due to restenosis and/or de novo lesions during the follow up period (143±730 days). With the established cut off value of 1.59 based on our previous work, Kaplan-Meier analysis showed significantly higher recurrence rate of coronary lesions which required PCI treatment in patients with higher MPO/PON1 ratio at enrollment than that in patients with lower MPO/PON1 ratio (66.7% vs. 6.0%, p<0.001). High MPO/PON1 ratio was independently associated with recurrent coronary atherosclerotic lesions in multivariate Cox regression analysis after adjusting for age, gender, hypertension, diabetes mellitus, dyslipidemia, and smoking (Hazard ratio 15.8, 95% CI 4.20-59.07, p <0.001), while conventional lipid profiles failed to show any statistical relationships to disease recurrence. In addition, C-index of MPO/PON1 ratio was significantly larger than that of MPO alone, indicating that combination of MPO and PON1 provides greater improvement than single application of MPO in predicting coronary lesions (0.787 vs. 0.719, p<0.05).

Conclusions: This study demonstrated that higher MPO/PON1 ratio (>1.59) could predict future recurrence of coronary lesions after PCI. This ratio could be useful marker for secondary prevention of coronary artery disease.

  • Atherosclerosis
  • Cardiovascular disease prevention
  • HDL
  • Author Disclosures: S. Tsuda: None. R. Toh: None. K. Mori: None. M. Nagao: None. N. Tanaka: None. T. Mori: None. T. Monguchi: None. H. Nakajima: None. T. Honjo: None. M. Shinohara: None. K. Nishimura: None. T. Ishida: None. K. Hirata: None.

  • © 2015 by American Heart Association, Inc.
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Arteriosclerosis, Thrombosis, and Vascular Biology
May 2015, Volume 35, Issue Suppl 1
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    Abstract 683: Serum Myeloperoxidase/Paraoxonase 1 Ratio Predicts Recurrent Coronary Artery Disease
    Shigeyasu Tsuda, Ryuji Toh, Kenta Mori, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Hideto Nakajima, Tomoyuki Honjo, Masakazu Shinohara, Kunihiro Nishimura, Tatsuro Ishida and Ken-ichi Hirata
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:A683, originally published August 11, 2015

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    Abstract 683: Serum Myeloperoxidase/Paraoxonase 1 Ratio Predicts Recurrent Coronary Artery Disease
    Shigeyasu Tsuda, Ryuji Toh, Kenta Mori, Manabu Nagao, Nobuaki Tanaka, Takeshige Mori, Tomoko Monguchi, Hideto Nakajima, Tomoyuki Honjo, Masakazu Shinohara, Kunihiro Nishimura, Tatsuro Ishida and Ken-ichi Hirata
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:A683, originally published August 11, 2015
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