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Poster Abstract PresentationsSession Title: Poster Session III

Abstract 652: Coronary Capillaries in Ischemic Congestive Heart Failure in Rats Exhibit Significant Morphological Disorder

Heather J Kagan, Jiqiu Chen, Peter Backeris, Irene C Turnbull, Kevin D Costa, Lifan Liang, Roger J Hajjar
Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:A652
Heather J Kagan
Cardiovascular Rsch Institute, Mount Sinai Sch of Medicine, New York, NY
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Jiqiu Chen
Cardiovascular Rsch Institute, Mount Sinai Sch of Medicine, New York, NY
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Peter Backeris
Cardiovascular Cell and Tissue Engineering Laboratory, Mount Sinai Sch of Medicine, New York, NY
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Irene C Turnbull
Cardiovascular Cell and Tissue Engineering Laboratory, Mount Sinai Sch of Medicine, New York, NY
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Kevin D Costa
Cardiovascular Cell and Tissue Engineering Laboratory, Mount Sinai Sch of Medicine, New York, NY
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Lifan Liang
Cardiovascular Rsch Institute, Mount Sinai Sch of Medicine, New York, NY
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Roger J Hajjar
Cardiovascular Rsch Institute, Mount Sinai Sch of Medicine, New York, NY
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Abstract

In ischemic congestive heart failure (CHF), the heart is damaged and undergoes compensatory remodeling, a pathological process associated with harmful effects. The goal of this study is to explore the manifestation of CHF by examining the morphological changes occurring in the coronary microvasculature in CHF versus normal rat hearts. We tested the hypothesis that coronary capillaries in rats with CHF exhibit significantly more morphological disorder than those in control rats. Methods: CHF was induced by aortic banding, ischemia/reperfusion injury two months post-banding (left coronary artery ligation for 30 minutes) and aortic debanding one month post-injury. Resin polymer containing fluorescent dye was injected into coronary vasculature of excised hearts. Muscle tissue was digested using NaOH to reveal vascular casts that were sputter coated with gold for imaging under a Scanning Electron Microscope (SEM). A total of 93 SEM images from 14 rats (7 control, 7 CHF) were analyzed for structural alignment using an automated gradient detection algorithm and circular statistics implemented using MATLAB software; Mean Vector Length (MVL) was calculated for each image as a measure of capillary organization (0<MVL<0. MVL->1 perfect alignment, MVL->0 random disarray). Results: CHF capillaries exhibit significantly more structural disorder than control (MVL 0.35±0.02 for 61 CHF, 0.58±0.02 for 32 control. p<0.01). Conclusions: Coronary capillaries in CHF rats exhibit significant abnormal morphological disarray that may impair blood flow hemodynamics and material and oxygen exchange in myocytes. Such disordered capillary remodeling could have detrimental consequences for the progression and prognosis of heart failure.

  • Heart failure
  • Coronary microcirculation
  • Author Disclosures: H.J. Kagan: None. J. Chen: None. P. Backeris: None. I.C. Turnbull: None. K.D. Costa: None. L. Liang: None. R.J. Hajjar: None.

  • © 2015 by American Heart Association, Inc.
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Arteriosclerosis, Thrombosis, and Vascular Biology
May 2015, Volume 35, Issue Suppl 1
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    Abstract 652: Coronary Capillaries in Ischemic Congestive Heart Failure in Rats Exhibit Significant Morphological Disorder
    Heather J Kagan, Jiqiu Chen, Peter Backeris, Irene C Turnbull, Kevin D Costa, Lifan Liang and Roger J Hajjar
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:A652, originally published August 11, 2015

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    Abstract 652: Coronary Capillaries in Ischemic Congestive Heart Failure in Rats Exhibit Significant Morphological Disorder
    Heather J Kagan, Jiqiu Chen, Peter Backeris, Irene C Turnbull, Kevin D Costa, Lifan Liang and Roger J Hajjar
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:A652, originally published August 11, 2015
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