Abstract 572: Relationship of Aortic Stiffness Measured by Cardiac MRI with Left Ventricular Geometry and Function
Background: The association of aortic stiffness parameters measured by MRI with cardiac structure and function remains poorly explored. We investigated how central aortic stiffness assessed by MRI relates to Left ventricular (LV) structure and function in broad rage aged subjects free for cardiovascular disease.
Methods: 79 asymptomatic subjects (37 men, age range: 20 - 78 years) were studied. Ascending aortic distensibility (AAD) and aortic pulse wave velocity (PWV) was measured by phase contrast (PC) cine MRI at the level of the pulmonary artery bifurcation. LV mass and LV volume indexed to body surface area, LV ejection fraction (LVEF) and LV mass volume ratio (M/V ratio) were determined by cine MRI. LV circumferential strain (Ecc), longitudinal strain (Ell) and LV torsion were determined from tagged MRI. Central pressures were used to calculate AAD. Linear regression analysis was used to evaluate the association between arterial measures and LV measures. Distributions of AAD and PWV were skewed, so they were logarithmically transformed (logAAD and logPWV) for regression models.
Results: Lower AAD and higher PWV, both indicating greater aortic stiffness, was associated with less/worse myocardial systolic function parameters; Ecc, Ell, and M/V ratio. After adjustment for age, gender and hypertension, only AAD was associated with LV deformation while PWV was not (Table).
Conclusion: Our observations indicate that the association of increased aortic stiffness with LV dysfunction because of aging and hypertension may be captured by PWV but the association with decreased distensibility could be because of common atherosclerosis risk factors in healthy population.
Author Disclosures: Y. Ohyama: None. K. Rezzadeh: None. B. Ambale-Venkatesh: None. K. Yoneyama: None. A. Redheuil: None. W. Yu: None. C. Wu: None. D. Bluemke: None. J. Lima: None.
- © 2015 by American Heart Association, Inc.