Abstract 503: Osteoporosis and Aterial Calcification: Are These Processes Related?
The relationship between arterial calcification and osteoporosis has been referred to in several studies. However, its temporal relationship has scarcely been analyzed.
Hypothesis: We assessed the hypothesis that temporal evolution of Ca content in the carotid bifurcation is related with densitometric variation in bone calcium mass, in order to assess the possible connection of both processes through the Ca/P metabolism.
Patients and methods: Design: Prospective cohort study. Population: 32 asymptomatic patients with stenosis of the internal carotid artery (ICA)>50% (duplex scanningr). Determinations: Ca content (quantitative Angio-CT) in 3D reconstruction of the carotid bifurcation, basal and at 12+/-2 months. Bone densitometry of spine and femur, basal and 12+/-2 months, biochemistry and Ca-P metabolism (Ca, P, vit.D, PTH, OPG, OPG). Statistical analysis: Descriptive statistics, comparison of means (t-test), uni-and multivariate linear regression (Intraplaque Ca/ bone densitometry, Ca-P metabolism).
Results: An increase of intraplaque Ca respect to baseline values (79.2 (55) vs 64.58 (49.2) mm3.xU.H., p = 0.12) and a significant decrease in bone mass respect to baseline determination (2.08 (0.22) vs 2.06 (0.23) g/cm2, p = 0.013) were observed. However, a positive correlation was identified between the relative variation of the Ca content and bone mass (r= 0.574, p= 0.003). In other words, a greater tendency to osteoporosis was associated with a reduced tendency to intraplaque calcium progression. In Addition, an inverse relationship between plasma levels of Vit D and basal densitometry (r= -0.459; p=0.036) were found. Only P concentration in urine showed a moderate positive correlation with increased intraplaque Ca (r = 0.488, p = 0.015). No other variable, was related to arterial calcification.
Conclusions: As in other published series, an independent tendency to progressive arterialcalcification and bone decalcification was found in this study. However, these results suggest a direct temporal relation in calcium deposit evolution of both localizations, so it is not possible to rule out that their modulation is governed by similar activation and regulation mechanisms.
Author Disclosures: M. Miralles: None. M. Arrebola: None. E. Plana: None. I. Sanchez-Nevarez: None.
- © 2015 by American Heart Association, Inc.