Abstract 277: Perivascular Adipose Adiponectin Correlates with Symptom Status of Patients Undergoing Carotid Endarterectomy
Introduction: Recent symptoms stand as a major determinant of stroke risk in carotid stenosis patients, likely reflective of atherosclerotic plaque destabilization.
Hypothesis: In view of emerging links between vascular and adipose biology, we hypothesized that human perivascular adipose characteristics associate with carotid disease symptom status.
Methods: Clinical history, carotid plaques, blood, and subcutaneous and perivascular adipose tissues were prospectively collected from consented patients undergoing carotid endarterectomy (CEA). Nine adipose associated biologic mediators (adiponectin, IL-1 beta, IL-6, IL-8, leptin, monocyte chemoattractant protein-1, plasminogen activator inhibitor-1, resistin, and tumor necrosis factor) protein levels were quantified, and compared in patients with symptomatic (n=15) versus asymptomatic (n=19) disease. Bonferroni correction was performed for multiple testing (alpha/9=0.006).
Results: Symptomatic patients had 1.9-fold higher perivascular adiponectin levels (median [interquartile range] of symptomatic versus asymptomatic patients was 478.4 ng/ml [315.4-603.9 ng/ml] versus 251.9 ng/ml [212.7-365.4ng/ml], p=0.005). Other circulating, subcutaneous, and perivascular biomarkers, as well as microscopic plaque characteristics, did not differ between symptomatic and asymptomatic patients.
Conclusions: Symptomatic and asymptomatic CEA patients display a tissue-specific difference in perivascular adipose adiponectin. This biomarker signature, which was not seen in plasma or subcutaneous compartments, supports a potential local paracrine relationship to vascular disease processes which may relate to stroke mechanisms. Future study of these adipose based paracrine effects may point to novel therapeutic targets and inform patient selection for preventative interventions.
Author Disclosures: G. Sharma: None. M. Tao: None. K. Ding: None. D. Yu: None. W. King: None. G. Deyneko: None. X. Wang: None. A. Longchamp: None. F.J. Schoen: None. C. Ozaki: None. M.E. Semel: None.
- © 2015 by American Heart Association, Inc.