Abstract 262: Association of Lipoprotein Subclasses with Arterial Stiffness in a High Risk Working Population: The Baptist Employee Healthy Heart Study (BEHHS)
Introduction: Arterial stiffness is an independent predictor of cardiovascular disease (CVD) morbidity and mortality, and has been shown to be of prognostic value in CVD. A risk factor independent association between arterial stiffness and traditional lipids has been described extensively but it is unclear whether an independent relationship exists with lipoprotein subclasses.
Methods: The Baptist Employee Healthy Heart Study (BEHHS) is a lifestyle intervention study examining the effects of web-based programs on reducing CVD risk in high-risk persons. Participants had their brachial arterial augmentation index (AIx, a measure arterial stiffness) assessed using the EndoPAT 2000 device. The AIx is standardized to gender-matched non-selective populations. Cardio IQ™ Ion Mobility lipoprotein fractionation was utilized for advanced lipid subclass measurement.
Results: The population consisted of 182 participants, (74% women, 49% Hispanic) with a mean age of 52 ± 9 years. There was a significant trend association between quartiles of AIx and total LDL, small LDL, small and large IDL, small, large and total HDL, and small VLDL. In multivariate analysis, only small and large IDL, total LDL and small VLDL showed independent significant association with AIx.
Conclusions: Several lipoprotein subclasses demonstrate independent significant associations with arterial stiffness. Thus, a safe and relatively inexpensive blood test may be useful in identifying probable vascular disease in a relatively young high traditional CVD risk population. Longitudinal studies are required to fully understand the temporal relationship between the lipoprotein subclasses and arterial stiffness.
Author Disclosures: M. Aziz: None. E. Aneni: None. E. Oni: None. L. Roberson: None. S. Shaharyar: None. S.S. Ali: None. O. Jamal: None. M.A. Latif: None. A. Younus: None. R. Ahmad: None. R. Malik: None. O. Ogunmoroti: None. S.A. Khan: None. J. Post: None. D.D. Campo: None. H. Guzman: None. R. Cury: None. A.S. Agatston: None. E. Veledar: None. J. Fialkow: None. T. Feldman: None. K. Nasir: None.
- © 2015 by American Heart Association, Inc.