Abstract 218: Dynamics of Blood Leukocytes Following ST Segment Elevation Myocardial Infarction
Blood leukocyte counts are linked to cardiovascular risk stratification, and excess activation of neutrophil and monocytes has been observed in patients of myocardial infarction (MI). However, the profile of major subsets of leukocyte following ST Segment Elevation MI (STEMI) is still unclear. It was aimed to compare relative change of neutrophil, monocytes, T and B lymphocytes in blood leukocytes in patients of STEMI undergoing percutaneous coronary intervention (PCI). STEMI patients subject to PCI were consecutively recruited. Peripheral blood was collected upon patient admission to hospital (referred to as T0), one day(T1), and/or four days (T4) after PCI, and were measured by flow cytometry (n=12, 18, 34 for T0, T1 and T4, respectively). Compared to T0, percentage of neutrophil (CD45+CD66b+) decreased, whereas T cell (CD3+CD45+) increased, at both T1 and T4. Percentage of monocytes (CD14+CD45+) and B cells (CD19+CD45+) both increased at T4 relative to T0. Interestingly, monocyte- and neutrophil- expression of CD11c, an inducible integrin alpha subunit, increased significantly at T4 compared to T1, despite a dichotomous change in population percentage for these two cell types. A dynamic shift in different leukocyte subsets, as well as in their activation status, occurs in STEMI patients underwent PCI. Such changes might reflect different aspects of biology in patients of STEMI with concurrent standard therapy, and might inform selection of new markers for cardiovascular risk stratification.
Author Disclosures: J. Yuan: None. F. Chu: None. Y. Yao: None. J. Xu: None. M. Wang: None.
This research has received full or partial funding support from the American Heart Association.
- © 2015 by American Heart Association, Inc.