ATVB in Focus: Epigenetics of Cardiovascular Disease

Histone Deacetylases and Cardiometabolic DiseasesSignificance

Kan Hui Yiew, Tapan K. Chatterjee, David Y. Hui, Neal L. Weintraub
https://doi.org/10.1161/ATVBAHA.115.305046
Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:1914-1919
Originally published July 16, 2015

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Abstract

Cardiometabolic disease, emerging as a worldwide epidemic, is a combination of metabolic derangements leading to type 2 diabetes mellitus and cardiovascular disease. Genetic and environmental factors are linked through epigenetic mechanisms to the pathogenesis of cardiometabolic disease. Post-translational modifications of histone tails, including acetylation and deacetylation, epigenetically alter chromatin structure and dictate cell-specific gene expression patterns. The histone deacetylase family comprises 18 members that regulate gene expression by altering the acetylation status of nucleosomal histones and by functioning as nuclear transcriptional corepressors. Histone deacetylases regulate key aspects of metabolism, inflammation, and vascular function pertinent to cardiometabolic disease in a cell- and tissue-specific manner. Histone deacetylases also likely play a role in the metabolic memory of diabetes mellitus, an important clinical aspect of the disease. Understanding the molecular, cellular, and physiological functions of histone deacetylases in cardiometabolic disease is expected to provide insight into disease pathogenesis, risk factor control, and therapeutic development.

Introduction

Epigenetic processes influence gene expression and regulation without altering the information encoded by the primary DNA sequence. In the 1960s, Allfrey et al1 discovered that chemical modification of histones influenced chromatin structure and RNA synthesis in eukaryotic cells, thus laying the foundation for modern epigenetics research. Subsequently, proteins that possess intrinsic histone acetylase and deacetylase activities were identified,2,3 followed by enzymes involved in histone methylation, ubiquitination, and sumoylation.4 Reversible modification of histone proteins is a fundamental mechanism of gene regulation in cell differentiation, organogenesis, growth, aging, etc.

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Histone deacetylases (HDACs) are a class of enzymes that remove acetyl groups from an ε-N-acetyl lysine amino acid on histone or nonhistone proteins. Deacetylation of histones promotes a closed chromatin structure, thereby impairing access of transcription factors to their regulatory sites and silencing gene expression. Some HDACs are multifunctional proteins that can also suppress gene expression by functioning as transcriptional corepressors, independent of their deacetylase activity.5,6 To date, 18 evolutionary conserved mammalian HDACs have been identified and are grouped into 4 classes based on their phylogenetic conservation.7 HDACs exhibit a wide variety of functional activities and cellular and tissue distribution (Table I in the online-only Data Supplement). Numerous studies describing HDAC protein regulation, structure, and functions pertinent to cardiovascular and metabolic diseases have been summarized in recent publications.8–12 This review will highlight cellular mechanisms of HDAC action, in vivo data in animal models of cardiometabolic disease, and studies linking HDACs to cardiometabolic disease in humans.

There is a strong interplay between metabolic disease, inflammation, and cardiovascular risk factors. Metabolic syndrome is a proinflammatory state that is tightly linked to C-reactive protein levels in humans,13 and vascular inflammation plays a role in all stages of atherosclerosis.14 Dyslipidemia, hypertension, and insulin resistance, major components of metabolic syndrome, are powerful cardiovascular disease risk factors.15,16 Data from the longitudinal Framingham heart study suggest that hypertension and glucose intolerance are interrelated phenomena that predispose to the development of premature atherosclerotic disease.17 Additionally, growing evidence suggests that insulin resistance predisposes to heart failure.18 A better understanding of the molecular mechanisms whereby HDACs regulate the interplay between metabolic disease, inflammation, and cardiovascular risk factors could lead to novel therapeutic approaches for cardiometabolic disease.

Potential Role of HDACs in Metabolic Disease

Class I and II HDACs have been reported to regulate a variety of metabolic processes, including differentiation of pancreatic islet cells and adipocytes.11,12 HDAC5 or HDAC9 gene deletion increased pancreatic β-cell mass and insulin secretion but not β-cell proliferation, consistent with a primary effect on pancreatic β-cell differentiation.19 This may have important clinical implications for optimization of stem cell transplantation therapy for diabetes mellitus.20 In addition to the pancreas, adipose tissues factor prominently in metabolic disease. Failure of white adipocytes to differentiate and properly store excess calories in obesity is associated with adipose tissue inflammation, insulin resistance, and type 2 diabetes mellitus.21 Conversely, thermogenic beige and brown adipocytes promote insulin sensitivity and weight loss.22 HDAC3 inhibition was reported to regulate PPARγ (peroxisome proliferator-activated receptor gamma) acetylation and activity, thereby enhancing insulin signaling and glucose uptake in white adipocytes and improving insulin sensitivity in diet-induced obese (DIO) mice.23 Adipose HDAC3 was also demonstrated to repress phosphoenolpyruvate carboxykinase, the key enzyme controlling glyceroneogenesis, resulting in reduced triglyceride biosynthesis and lipodystrophy. The mechanism was linked to activation of NF-κB (nuclear factor kappa-light-chain-enhancer of activated B) by HDAC3.24

HDAC9 overexpression repressed, whereas HDAC9 gene deletion accelerated, white adipocyte differentiation in vitro.25 Interestingly, DIO was associated with upregulated HDAC9 expression in white adipose tissues and impaired adipocyte differentiation, which was abrogated by HDAC9 gene deletion. HDAC9 gene deletion led to diminished weight gain and hepatic steatosis along with improved glucose tolerance and insulin sensitivity.25,26 Additionally, HDAC9 deficiency promoted accumulation of beige adipocytes in subcutaneous adipose, which likely contributed to the lean body mass in these mice.26

Class III HDACs (sirtuins, or SIRTs) have been reported to favorably regulate key metabolic pathways, including adipogenesis, fatty acid metabolism, amino acid metabolism, and gluconeogenesis.27,28 For example, SIRT1 was reported to repress visceral white adipogenic genes associated with insulin resistance and stimulate brown adipogenic gene expression.29 Mice lacking SIRT1 that were fed a high-fat diet developed excessive hepatic lipid accumulation, altered gut microbiota, insulin resistance, and hypertrophic white and brown adipose tissues.30 Likewise, loss of SIRT3 promoted hyperacetylation of mitochondrial proteins, resulting in metabolic perturbations and increased susceptibility to metabolic disease.31 Additionally, SIRT3 was demonstrated to regulate systemic oxidative stress, limit expedited weight gain, and promote metabolic adaptation.32 Thus, animal studies suggest that SIRTs may protect against the development of metabolic disease. An ongoing clinical trial is testing the anti-diabetic efficacy of SIRT1 activation in humans.33

The liver has emerged as an important target of HDACs’ metabolic effects. Liver-specific HDAC3 and SIRT6 have been shown to regulate hepatic lipid synthesis, glycolysis, and fatty acid oxidation.34,35 Mice lacking SIRT1 specifically in the liver displayed impaired mTORC2/Akt signaling, resulting in oxidative damage, insulin resistance, and hyperglycemia.36 Hepatic SIRT1 deficiency also impaired PPARα signaling and decreased fatty acid β-oxidation, resulting in hepatic steatosis, hepatic inflammation, and endoplasmic reticulum stress in high fat–fed mice.37 Conversely, loss of hepatic class IIa HDACs (HDAC4, -5, -7) was metabolically protective because it lowered fasting blood glucose levels and improved glucose tolerance in diabetic mouse models.38

Skeletal muscle, which is responsible for >30% of resting metabolic rate and 80% of whole-body glucose uptake,39 is also emerging as a target of HDACs. Skeletal muscle is composed of heterogeneous myofibers with characteristic metabolic properties. Class II HDACs have been shown to suppress the formation of type I myofibers, which stimulate insulin-mediated glucose uptake and protect against glucose intolerance, through the repression of MEF2 (myocyte enhancer factor-2) activity.40,41 Overexpression of HDAC5 was reported to suppress skeletal muscle glucose uptake by repressing GLUT4 gene expression.42 Conversely, deletion of SIRT3 in skeletal muscle perturbed mitochondrial function and promoted oxidative stress and insulin resistance.43

Mounting evidence suggests that both peripheral and central mechanisms act in concert to maintain energy balance. The hypothalamic/pituitary axis is essential to the central control of whole-body metabolism. Delivery of a SIRT1 activator, resveratrol, into the central nervous system was shown to attenuate hyperglycemia and hyperinsulinemia in diabetic and DIO mice.44 SIRT1 in pro-opiomelanocortin neurons was reported to be required for leptin’s central functions and for energy expenditure adaptations to DIO.45 Furthermore, SIRT1 was found to act on steroidogenic factor 1 neurons to protect against the development of DIO and hyperglycemia via promoting energy expenditure and skeletal muscle insulin sensitivity.46

The concept of metabolic memory was proposed by Nathan et al47 in relation to their clinical findings that the benefits of tight glycemic control on micro- and macrovascular complications in diabetic patients might not be immediately obvious but become more evident with time. Consistently, metabolic memory has been demonstrated in experimental models; transient hyperglycemia resulted in persistent epigenetic changes leading to aberrant antioxidant and inflammatory gene expressions in vascular smooth muscle cell (VSMC) and endothelial cells during subsequent normoglycemia.48 With regard to HDACs, SIRT1 was shown to mediate high glucose–induced cellular metabolic memory via the liver kinase B1/AMPK/ROS pathway.49

HDACs and Inflammation

Inflammation is a pivotal factor that underlies both cardiovascular and metabolic diseases, and HDACs have been implicated in regulating both the innate and adaptive immune systems. HDAC3, HDAC4, and HDAC9 have been associated with proinflammatory responses in macrophages and monocytes. HDAC3 was reported to promote inflammatory gene expression in lipopolysaccharide-stimulated macrophages50 and HDAC4 to contribute to tumor necrosis factor-α–induced monocyte adhesion to VSMCs.51 HDAC9 was reported to induce inflammatory gene expression in macrophages and prevent polarization to anti-inflammatory M2 phenotype.52 With regards to adaptive immunity, HDAC7 and HDAC2 have been reported to maintain B cell and CD4+ T cell identity, respectively.53,54 Interestingly, HDAC9 and HDAC3 were shown to control CD4+ Foxp3+ T regulatory cell development and function.55,56 HDAC9-deficient mice exhibited enhanced expression of Foxp3, a master regulator of T regulatory differentiation,55 whereas deletion of HDAC3 disrupted T regulatory cell development and function, restored interleukin (IL)-2 production, and upregulated proinflammatory IL-6.56 The pan-HDAC inhibitor SAHA (vorinistat) enhanced oxidized low-density lipoprotein–induced interleukin-8 and monocyte-chemoattractant protein-1 expression in human vascular endothelial cells.57 However, vorinistat is remarkably effective at preventing allogeneic transplant rejection; allogeneic hematopoietic cell transplant patients treated with vorinostat have increased T regulatory cell numbers with greater suppressive function and reduced plasma levels of proinflammatory cytokines, such as IL-1β, tumor necrosis factor-α, IL-6, and IL-8.58 Thus, pan HDAC inhibition produces complex effects on the immune system that can potentially modulate pro- and anti-inflammatory pathways in the context of specific diseases.

Potential Role of HDACs in Cardiovascular Diseases

The link between HDACs and cardiovascular disease is less well developed compared with metabolic disease. However, the body of data is growing dramatically, and evidence of link to human cardiovascular disease is also emerging. HDACs clearly have the potential to regulate many aspects of cardiovascular disease, including inflammation, as discussed earlier.

HDACs are fundamentally important in cardiac development and regulate hypertrophy, fibrosis, ischemia/reperfusion injury, and other aspects of cardiac function.59,60 HDAC inhibitors have shown promise in experimental studies for their ability to prevent heart failure.61 As is the case for metabolic disease and inflammation, the mechanisms whereby HDACs modulate cardiac function are complex. For example, HDACs were recently identified as part of a chromatin repressor complex that inhibits transcription of a long noncoding RNA, which in turn protects the heart against pathological hypertrophy.62 It is tempting to speculate that HDACs could play a particularly important role in cardiomyopathy associated with metabolic diseases, such as uncontrolled diabetes mellitus,63 but in vivo experimental data are lacking.

Modulation of inflammation by HDACs has important implications for both cardiac and vascular diseases. For example, in spontaneously hypertensive rats, HDAC inhibition (valproic acid) led to reduced left ventricular expression of IL-1β and tumor necrosis factor-α, attenuation of cardiac hypertrophy and fibrosis, and improved cardiac function.64 Conversely, SIRT1 has been reported to protect against atherosclerosis in part through its anti-inflammatory effects. Its expression in endothelial cells and macrophages was reported to diminish foam cell formation and vascular reactive oxygen species and promote ABCA1-driven reverse cholesterol transport.65,66

Moreover, SIRT1 expression in VSMC protected against DNA damage, medial degeneration, and atherosclerosis.67 In diabetic patients, incretin therapy was associated with SIRT6 induction, reduced inflammation and oxidative stress, and a more stable plaque phenotype.68 Interestingly, mice treated with the HDAC inhibitor trichostatin A showed a significant and dose-dependent improvement in high-density lipoprotein cholesterol levels and reduced serum glucose, triglycerides, and total cholesterol, suggesting favorable metabolic effects with regard to the pathogenesis of vascular disease.69

A recent genome-wide association study identified HDAC9 to be associated with large vessel ischemic stroke70 and atherosclerosis.71 Elevated expression of HDAC9 was also noted in human atherosclerotic plaques. A polymorphism in the intergenic region between HDAC9 and TWIST1/FERD3L in humans was associated with selectively increased HDAC9 expression and an increased incidence of atherosclerosis.72 In animal models, HDAC9 gene deficiency was shown to be atheroprotective, favorably modulating inflammatory and lipid homeostatic gene expression while polarizing macrophages toward a protective M2 phenotype.52

Experimental studies have established the relevance of HDACs in hypertension and neointima formation. SIRT1 in VSMC was shown to protect against angiotensin II–induced vascular remodeling, oxidative stress, inflammation, and hypertension in mice.73 Conversely, in isolated mesenteric arteries, trichostatin A reversed angiotensin II–induced contraction and increased endothelium-dependent relaxation stimulated by acetylcholine in spontaneously hypertensive rats.51 HDAC4 has been implicated in hypertension through its effects on VSMCs51; HDAC4 gene silencing inhibited tumor necrosis factor–induced monocyte adhesion, vascular cell adhesion protein 1 expression, transcriptional activity of NF-κB, and oxidative stress in VSMC.51 Additionally, HDAC4 has been suggested to control neointima hyperplasia by promoting the activation of p38 mitogen–activated protein kinase/heat shock protein 27 signaling and inducing VSMC proliferation and migration.74 In contrast, HDAC7 (unspliced isoform) was shown to suppress VSMC proliferation and neointima formation by preventing β-catenin nuclear translocation and activity.75 Class I/II HDAC inhibition increased neointimal thickening in a murine model of postangioplasty restenosis,76 whereas class IIa HDAC inhibition prevented neointimal hyperplasia in a murine carotid ligation model.74 These conflicting results may reflect the diverse functions of HDACs and nonspecificity of HDAC inhibitors.

Perspective/Future Research

Recent scientific advances have improved our understanding of HDAC function and its potential role in cardiometabolic disease (Figure). Several issues remain to be resolved, however. Most contemporary HDAC inhibitors lack selectivity toward individual HDACs and have limited efficacy against class II HDACs. Nonselectively inhibiting HDACs could yield adverse effects given their broad contributions to cell differentiation, development, and tissue homeostasis. Furthermore, HDACs may produce divergent, cell-specific actions. For instance, endothelial HDAC3 is atheroprotective in response to exposure to disturbed flow, whereas myeloid HDAC3 prevents collagen deposition and induction of a stable plaque phenotype.77,78 Selectively targeting HDAC isoforms in a tissue-specific manner may thus be beneficial but would require identification of tissue-specific mechanisms whereby HDACs function (ie, histone deacetylase enzymatic activity, transcriptional repression, and interactions with other epigenetic regulatory mechanisms). Subsequently, designing inhibitors to target key HDAC functional domains (rather than full-length protein function) could enhance selectivity and minimize unwanted side effects. Also, designing inhibitors against key HDACs (such as HDAC9), which produce consistent cell-specific actions in metabolic and vascular tissues, is a compelling approach.

Figure.
Figure.

The role of histone deacetylases (HDACs) in cardiometabolic disease. ER indicates endoplasmic reticulum; Foxp3+, forkhead box p3; NO, nitric oxide; ROS, reactive oxygen species; T reg cells, T regulatory cell; VCAM-1, vascular cell adhesion protein 1; and VSMC, vascular smooth muscle cells.

Further studies are needed to understand the interplay between histone post-translational modifications, DNA methylation, and noncoding RNAs and the consequence of their dysregulation in disease phenotype. Additionally, more work is required to dissect the mechanisms of cellular and transgenerational epigenetic memory. Advancing such studies will likely refine our knowledge of the role of HDACs in cardiometabolic disease and their potential as therapeutic targets.

Sources of Funding

This work was supported by National Institute of Health grants HL076684 and HL112640 (to N.L. Weintraub), HL086555 (to Y. Tang), and DK74932 (to D.Y. Hui) and an American Heart Association predoctoral fellowship 15PRE21580003 (to K.H. Yiew).

Disclosures

None.

Footnotes

  • Received March 31, 2015.
  • Accepted July 1, 2015.

References

  1. 1.↵
    1. Allfrey VG,
    2. Faulkner R,
    3. Mirsky AE
    . Acetylation and methylation of histones and their possible role in the regulation of RNA synthesis. Proc Natl Acad Sci U S A. 1964;51:786–794.
    OpenUrlFREE Full Text
  2. 2.↵
    1. Brownell JE,
    2. Allis CD
    . An activity gel assay detects a single, catalytically active histone acetyltransferase subunit in Tetrahymena macronuclei. Proc Natl Acad Sci U S A. 1995;92:6364–6368.
    OpenUrlAbstract/FREE Full Text
  3. 3.↵
    1. Taunton J,
    2. Hassig CA,
    3. Schreiber SL
    . A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science. 1996;272:408–411.
    OpenUrlAbstract
  4. 4.↵
    1. Strahl BD,
    2. Allis CD
    . The language of covalent histone modifications. Nature. 2000;403:41–45. doi: 10.1038/47412.
    OpenUrlCrossRefPubMed
  5. 5.↵
    1. Sun Z,
    2. Feng D,
    3. Fang B,
    4. Mullican SE,
    5. You SH,
    6. Lim HW,
    7. Everett LJ,
    8. Nabel CS,
    9. Li Y,
    10. Selvakumaran V,
    11. Won KJ,
    12. Lazar MA
    . Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell. 2013;52:769–782. doi: 10.1016/j.molcel.2013.10.022.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Zhao X,
    2. Sternsdorf T,
    3. Bolger TA,
    4. Evans RM,
    5. Yao TP
    . Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. Mol Cell Biol. 2005;25:8456–8464. doi: 10.1128/MCB.25.19.8456-8464.2005.
    OpenUrlAbstract/FREE Full Text
  7. 7.↵
    1. Gregoretti IV,
    2. Lee YM,
    3. Goodson HV
    . Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol. 2004;338:17–31. doi: 10.1016/j.jmb.2004.02.006.
    OpenUrlCrossRefPubMed
  8. 8.↵
    1. Mihaylova MM,
    2. Shaw RJ
    . Metabolic reprogramming by class I and II histone deacetylases. Trends Endocrinol Metab. 2013;24:48–57. doi: 10.1016/j.tem.2012.09.003.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. Tang J,
    2. Yan H,
    3. Zhuang S
    . Histone deacetylases as targets for treatment of multiple diseases. Clin Sci (Lond). 2013;124:651–662. doi: 10.1042/CS20120504.
    OpenUrlCrossRefPubMed
  10. 10.↵
    1. Zhou B,
    2. Margariti A,
    3. Zeng L,
    4. Xu Q
    . Role of histone deacetylases in vascular cell homeostasis and arteriosclerosis. Cardiovasc Res. 2011;90:413–420. doi: 10.1093/cvr/cvr003.
    OpenUrlAbstract/FREE Full Text
  11. 11.↵
    1. Haberland M,
    2. Montgomery RL,
    3. Olson EN
    . The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet. 2009;10:32–42. doi: 10.1038/nrg2485.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Houtkooper RH,
    2. Pirinen E,
    3. Auwerx J
    . Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol. 2012;13:225–238. doi: 10.1038/nrm3293.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Ridker PM,
    2. Buring JE,
    3. Cook NR,
    4. Rifai N
    . C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation. 2003;107:391–397.
    OpenUrlAbstract/FREE Full Text
  14. 14.↵
    1. Albert CM,
    2. Ma J,
    3. Rifai N,
    4. Stampfer MJ,
    5. Ridker PM
    . Prospective study of C-reactive protein, homocysteine, and plasma lipid levels as predictors of sudden cardiac death. Circulation. 2002;105:2595–2599.
    OpenUrlAbstract/FREE Full Text
  15. 15.↵
    1. Kannel WB
    . Blood pressure as a cardiovascular risk factor: prevention and treatment. JAMA. 1996;275:1571–1576.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Pöss J,
    2. Custodis F,
    3. Werner C,
    4. Weingärtner O,
    5. Böhm M,
    6. Laufs U
    . Cardiovascular disease and dyslipidemia: beyond LDL. Curr Pharm Des. 2011;17:861–870.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. Kannel WB,
    2. McGee DL
    . Diabetes and cardiovascular disease. The Framingham study. JAMA. 1979;241:2035–2038.
    OpenUrlCrossRefPubMed
  18. 18.↵
    1. Ashrafian H,
    2. Frenneaux MP,
    3. Opie LH
    . Metabolic mechanisms in heart failure. Circulation. 2007;116:434–448. doi: 10.1161/CIRCULATIONAHA.107.702795.
    OpenUrlAbstract/FREE Full Text
  19. 19.↵
    1. Lenoir O,
    2. Flosseau K,
    3. Ma FX,
    4. Blondeau B,
    5. Mai A,
    6. Bassel-Duby R,
    7. Ravassard P,
    8. Olson EN,
    9. Haumaitre C,
    10. Scharfmann R
    . Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes. 2011;60:2861–2871. doi: 10.2337/db11-0440.
    OpenUrlAbstract/FREE Full Text
  20. 20.↵
    1. Chen S,
    2. Borowiak M,
    3. Fox JL,
    4. Maehr R,
    5. Osafune K,
    6. Davidow L,
    7. Lam K,
    8. Peng LF,
    9. Schreiber SL,
    10. Rubin LL,
    11. Melton D
    . A small molecule that directs differentiation of human ESCs into the pancreatic lineage. Nat Chem Biol. 2009;5:258–265. doi: 10.1038/nchembio.154.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Ma X,
    2. Lee P,
    3. Chisholm DJ,
    4. James DE
    . Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy. Front Endocrinol (Lausanne). 2015;6:1. doi: 10.3389/fendo.2015.00001.
    OpenUrlPubMed
  22. 22.↵
    1. Wu J,
    2. Cohen P,
    3. Spiegelman BM
    . Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev. 2013;27:234–250. doi: 10.1101/gad.211649.112.
    OpenUrlAbstract/FREE Full Text
  23. 23.↵
    1. Jiang X,
    2. Ye X,
    3. Guo W,
    4. Lu H,
    5. Gao Z
    . Inhibition of HDAC3 promotes ligand-independent PPARγ activation by protein acetylation. J Mol Endocrinol. 2014;53:191–200. doi: 10.1530/JME-14-0066.
    OpenUrlAbstract/FREE Full Text
  24. 24.↵
    1. Zhang J,
    2. Henagan TM,
    3. Gao Z,
    4. Ye J
    . Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation. Endocrinology. 2011;152:1829–1838. doi: 10.1210/en.2010-0828.
    OpenUrlCrossRefPubMed
  25. 25.↵
    1. Chatterjee TK,
    2. Idelman G,
    3. Blanco V,
    4. et al
    . Histone deacetylase 9 is a negative regulator of adipogenic differentiation. J Biol Chem. 2011;286:27836–27847. doi: 10.1074/jbc.M111.262964.
    OpenUrlAbstract/FREE Full Text
  26. 26.↵
    1. Chatterjee TK,
    2. Basford JE,
    3. Knoll E,
    4. Tong WS,
    5. Blanco V,
    6. Blomkalns AL,
    7. Rudich S,
    8. Lentsch AB,
    9. Hui DY,
    10. Weintraub NL
    . HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding. Diabetes. 2014;63:176–187. doi: 10.2337/db13-1148.
    OpenUrlAbstract/FREE Full Text
  27. 27.↵
    1. Parihar P,
    2. Solanki I,
    3. Mansuri ML,
    4. Parihar MS
    . Mitochondrial sirtuins: emerging roles in metabolic regulations, energy homeostasis and diseases. Exp Gerontol. 2015;61:130–141. doi: 10.1016/j.exger.2014.12.004.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Wang F,
    2. Tong Q
    . SIRT2 suppresses adipocyte differentiation by deacetylating FOXO1 and enhancing FOXO1’s repressive interaction with PPARgamma. Mol Biol Cell. 2009;20:801–808. doi: 10.1091/mbc.E08-06-0647.
    OpenUrlAbstract/FREE Full Text
  29. 29.↵
    1. Qiang L,
    2. Wang L,
    3. Kon N,
    4. Zhao W,
    5. Lee S,
    6. Zhang Y,
    7. Rosenbaum M,
    8. Zhao Y,
    9. Gu W,
    10. Farmer SR,
    11. Accili D
    . Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ. Cell. 2012;150:620–632. doi: 10.1016/j.cell.2012.06.027.
    OpenUrlCrossRefPubMed
  30. 30.↵
    1. Caron AZ,
    2. He X,
    3. Mottawea W,
    4. Seifert EL,
    5. Jardine K,
    6. Dewar-Darch D,
    7. Cron GO,
    8. Harper ME,
    9. Stintzi A,
    10. McBurney MW
    . The SIRT1 deacetylase protects mice against the symptoms of metabolic syndrome. FASEB J. 2014;28:1306–1316. doi: 10.1096/fj.13-243568.
    OpenUrlAbstract/FREE Full Text
  31. 31.↵
    1. Lombard DB,
    2. Alt FW,
    3. Cheng HL,
    4. et al
    . Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007;27:8807–8814. doi: 10.1128/MCB.01636-07.
    OpenUrlAbstract/FREE Full Text
  32. 32.↵
    1. Winnik S,
    2. Gaul DS,
    3. Preitner F,
    4. Lohmann C,
    5. Weber J,
    6. Miranda MX,
    7. Liu Y,
    8. van Tits LJ,
    9. Mateos JM,
    10. Brokopp CE,
    11. Auwerx J,
    12. Thorens B,
    13. Lüscher TF,
    14. Matter CM
    . Deletion of Sirt3 does not affect atherosclerosis but accelerates weight gain and impairs rapid metabolic adaptation in LDL receptor knockout mice: implications for cardiovascular risk factor development. Basic Res Cardiol. 2014;109:399. doi: 10.1007/s00395-013-0399-0.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. Jiang WJ
    . Sirtuins: novel targets for metabolic disease in drug development. Biochem Biophys Res Commun. 2008;373:341–344. doi: 10.1016/j.bbrc.2008.06.048.
    OpenUrlCrossRefPubMed
  34. 34.↵
    1. Sun Z,
    2. Miller RA,
    3. Patel RT,
    4. Chen J,
    5. Dhir R,
    6. Wang H,
    7. Zhang D,
    8. Graham MJ,
    9. Unterman TG,
    10. Shulman GI,
    11. Sztalryd C,
    12. Bennett MJ,
    13. Ahima RS,
    14. Birnbaum MJ,
    15. Lazar MA
    . Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration. Nat Med. 2012;18:934–942. doi: 10.1038/nm.2744.
    OpenUrlCrossRefPubMed
  35. 35.↵
    1. Kim HS,
    2. Xiao C,
    3. Wang RH,
    4. Lahusen T,
    5. Xu X,
    6. Vassilopoulos A,
    7. Vazquez-Ortiz G,
    8. Jeong WI,
    9. Park O,
    10. Ki SH,
    11. Gao B,
    12. Deng CX
    . Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. Cell Metab. 2010;12:224–236. doi: 10.1016/j.cmet.2010.06.009.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Wang RH,
    2. Kim HS,
    3. Xiao C,
    4. Xu X,
    5. Gavrilova O,
    6. Deng CX
    . Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance. J Clin Invest. 2011;121:4477–4490. doi: 10.1172/JCI46243.
    OpenUrlCrossRefPubMed
  37. 37.↵
    1. Purushotham A,
    2. Schug TT,
    3. Xu Q,
    4. Surapureddi S,
    5. Guo X,
    6. Li X
    . Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 2009;9:327–338. doi: 10.1016/j.cmet.2009.02.006.
    OpenUrlCrossRefPubMed
  38. 38.↵
    1. Mihaylova MM,
    2. Vasquez DS,
    3. Ravnskjaer K,
    4. Denechaud PD,
    5. Yu RT,
    6. Alvarez JG,
    7. Downes M,
    8. Evans RM,
    9. Montminy M,
    10. Shaw RJ
    . Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis. Cell. 2011;145:607–621. doi: 10.1016/j.cell.2011.03.043.
    OpenUrlCrossRefPubMed
  39. 39.↵
    1. de Lange P,
    2. Moreno M,
    3. Silvestri E,
    4. Lombardi A,
    5. Goglia F,
    6. Lanni A
    . Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms. FASEB J. 2007;21:3431–3441. doi: 10.1096/fj.07-8527rev.
    OpenUrlAbstract/FREE Full Text
  40. 40.↵
    1. Potthoff MJ,
    2. Wu H,
    3. Arnold MA,
    4. Shelton JM,
    5. Backs J,
    6. McAnally J,
    7. Richardson JA,
    8. Bassel-Duby R,
    9. Olson EN
    . Histone deacetylase degradation and MEF2 activation promote the formation of slow-twitch myofibers. J Clin Invest. 2007;117:2459–2467. doi: 10.1172/JCI31960.
    OpenUrlCrossRefPubMed
  41. 41.↵
    1. Ryder JW,
    2. Bassel-Duby R,
    3. Olson EN,
    4. Zierath JR
    . Skeletal muscle reprogramming by activation of calcineurin improves insulin action on metabolic pathways. J Biol Chem. 2003;278:44298–44304. doi: 10.1074/jbc.M304510200.
    OpenUrlAbstract/FREE Full Text
  42. 42.↵
    1. McGee SL,
    2. van Denderen BJ,
    3. Howlett KF,
    4. Mollica J,
    5. Schertzer JD,
    6. Kemp BE,
    7. Hargreaves M
    . AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5. Diabetes. 2008;57:860–867. doi: 10.2337/db07-0843.
    OpenUrlAbstract/FREE Full Text
  43. 43.↵
    1. Jing E,
    2. Emanuelli B,
    3. Hirschey MD,
    4. Boucher J,
    5. Lee KY,
    6. Lombard D,
    7. Verdin EM,
    8. Kahn CR
    . Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A. 2011;108:14608–14613. doi: 10.1073/pnas.1111308108.
    OpenUrlAbstract/FREE Full Text
  44. 44.↵
    1. Ramadori G,
    2. Gautron L,
    3. Fujikawa T,
    4. Vianna CR,
    5. Elmquist JK,
    6. Coppari R
    . Central administration of resveratrol improves diet-induced diabetes. Endocrinology. 2009;150:5326–5333. doi: 10.1210/en.2009-0528.
    OpenUrlCrossRefPubMed
  45. 45.↵
    1. Ramadori G,
    2. Fujikawa T,
    3. Fukuda M,
    4. Anderson J,
    5. Morgan DA,
    6. Mostoslavsky R,
    7. Stuart RC,
    8. Perello M,
    9. Vianna CR,
    10. Nillni EA,
    11. Rahmouni K,
    12. Coppari R
    . SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity. Cell Metab. 2010;12:78–87. doi: 10.1016/j.cmet.2010.05.010.
    OpenUrlCrossRefPubMed
  46. 46.↵
    1. Ramadori G,
    2. Fujikawa T,
    3. Anderson J,
    4. Berglund ED,
    5. Frazao R,
    6. Michán S,
    7. Vianna CR,
    8. Sinclair DA,
    9. Elias CF,
    10. Coppari R
    . SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance. Cell Metab. 2011;14:301–312. doi: 10.1016/j.cmet.2011.06.014.
    OpenUrlCrossRefPubMed
  47. 47.↵
    1. Nathan DM,
    2. Cleary PA,
    3. Backlund JY,
    4. Genuth SM,
    5. Lachin JM,
    6. Orchard TJ,
    7. Raskin P,
    8. Zinman B
    ; Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353:2643–2653. doi: 10.1056/NEJMoa052187.
    OpenUrlCrossRefPubMed
  48. 48.↵
    1. Reddy MA,
    2. Zhang E,
    3. Natarajan R
    . Epigenetic mechanisms in diabetic complications and metabolic memory. Diabetologia. 2015;58:443–455. doi: 10.1007/s00125-014-3462-y.
    OpenUrlCrossRefPubMed
  49. 49.↵
    1. Zheng Z,
    2. Chen H,
    3. Li J,
    4. Li T,
    5. Zheng B,
    6. Zheng Y,
    7. Jin H,
    8. He Y,
    9. Gu Q,
    10. Xu X
    . Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin. Diabetes. 2012;61:217–228. doi: 10.2337/db11-0416.
    OpenUrlAbstract/FREE Full Text
  50. 50.↵
    1. Chen X,
    2. Barozzi I,
    3. Termanini A,
    4. Prosperini E,
    5. Recchiuti A,
    6. Dalli J,
    7. Mietton F,
    8. Matteoli G,
    9. Hiebert S,
    10. Natoli G
    . Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A. 2012;109:E2865–E2874. doi: 10.1073/pnas.1121131109.
    OpenUrlAbstract/FREE Full Text
  51. 51.↵
    1. Usui T,
    2. Okada M,
    3. Mizuno W,
    4. Oda M,
    5. Ide N,
    6. Morita T,
    7. Hara Y,
    8. Yamawaki H
    . HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats. Am J Physiol Heart Circ Physiol. 2012;302:H1894–H1904. doi: 10.1152/ajpheart.01039.2011.
    OpenUrlAbstract/FREE Full Text
  52. 52.↵
    1. Cao Q,
    2. Rong S,
    3. Repa JJ,
    4. St Clair R,
    5. Parks JS,
    6. Mishra N
    . Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development. Arterioscler Thromb Vasc Biol. 2014;34:1871–1879. doi: 10.1161/ATVBAHA.114.303393.
    OpenUrlAbstract/FREE Full Text
  53. 53.↵
    1. Barneda-Zahonero B,
    2. Román-González L,
    3. Collazo O,
    4. Rafati H,
    5. Islam AB,
    6. Bussmann LH,
    7. di Tullio A,
    8. De Andres L,
    9. Graf T,
    10. López-Bigas N,
    11. Mahmoudi T,
    12. Parra M
    . HDAC7 is a repressor of myeloid genes whose downregulation is required for transdifferentiation of pre-B cells into macrophages. PLoS Genet. 2013;9:e1003503. doi: 10.1371/journal.pgen.1003503.
    OpenUrlCrossRefPubMed
  54. 54.↵
    1. Boucheron N,
    2. Tschismarov R,
    3. Göschl L,
    4. et al
    . CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2. Nat Immunol. 2014;15:439–448. doi: 10.1038/ni.2864.
    OpenUrlCrossRefPubMed
  55. 55.↵
    1. Tao R,
    2. de Zoeten EF,
    3. Ozkaynak E,
    4. Chen C,
    5. Wang L,
    6. Porrett PM,
    7. Li B,
    8. Turka LA,
    9. Olson EN,
    10. Greene MI,
    11. Wells AD,
    12. Hancock WW
    . Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat Med. 2007;13:1299–1307. doi: 10.1038/nm1652.
    OpenUrlCrossRefPubMed
  56. 56.↵
    1. Wang L,
    2. Liu Y,
    3. Han R,
    4. Beier UH,
    5. Bhatti TR,
    6. Akimova T,
    7. Greene MI,
    8. Hiebert SW,
    9. Hancock WW
    . FOXP3+ regulatory T cell development and function require histone/protein deacetylase 3. J Clin Invest. 2015;125:1111–1123. doi: 10.1172/JCI77088.
    OpenUrlCrossRefPubMed
  57. 57.↵
    1. Dje N’Guessan P,
    2. Riediger F,
    3. Vardarova K,
    4. Scharf S,
    5. Eitel J,
    6. Opitz B,
    7. Slevogt H,
    8. Weichert W,
    9. Hocke AC,
    10. Schmeck B,
    11. Suttorp N,
    12. Hippenstiel S
    . Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arterioscler Thromb Vasc Biol. 2009;29:380–386. doi: 10.1161/ATVBAHA.108.178319.
    OpenUrlAbstract/FREE Full Text
  58. 58.↵
    1. Choi SW,
    2. Gatza E,
    3. Hou G,
    4. Sun Y,
    5. Whitfield J,
    6. Song Y,
    7. Oravecz-Wilson K,
    8. Tawara I,
    9. Dinarello CA,
    10. Reddy P
    . Histone deacetylase inhibition regulates inflammation and enhances Tregs after allogeneic hematopoietic cell transplantation in humans. Blood. 2015;125:815–819. doi: 10.1182/blood-2014-10-605238.
    OpenUrlAbstract/FREE Full Text
  59. 59.↵
    1. Xie M,
    2. Hill JA
    . HDAC-dependent ventricular remodeling. Trends Cardiovasc Med. 2013;23:229–235. doi: 10.1016/j.tcm.2012.12.006.
    OpenUrlCrossRefPubMed
  60. 60.↵
    1. Bush EW,
    2. McKinsey TA
    . Protein acetylation in the cardiorenal axis: the promise of histone deacetylase inhibitors. Circ Res. 2010;106:272–284. doi: 10.1161/CIRCRESAHA.109.209338.
    OpenUrlAbstract/FREE Full Text
  61. 61.↵
    1. Ferguson BS,
    2. McKinsey TA
    . Non-sirtuin histone deacetylases in the control of cardiac aging. J Mol Cell Cardiol. 2015;83:14–20. doi: 10.1016/j.yjmcc.2015.03.010.
    OpenUrlCrossRefPubMed
  62. 62.↵
    1. Han P,
    2. Li W,
    3. Lin CH,
    4. et al
    . A long noncoding RNA protects the heart from pathological hypertrophy. Nature. 2014;514:102–106. doi: 10.1038/nature13596.
    OpenUrlCrossRefPubMed
  63. 63.↵
    1. Yu XY,
    2. Geng YJ,
    3. Liang JL,
    4. Lin QX,
    5. Lin SG,
    6. Zhang S,
    7. Li Y
    . High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor. Exp Cell Res. 2010;316:2903–2909. doi: 10.1016/j.yexcr.2010.07.004.
    OpenUrlCrossRefPubMed
  64. 64.↵
    1. Cardinale JP,
    2. Sriramula S,
    3. Pariaut R,
    4. Guggilam A,
    5. Mariappan N,
    6. Elks CM,
    7. Francis J
    . HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats. Hypertension. 2010;56:437–444. doi: 10.1161/HYPERTENSIONAHA.110.154567.
    OpenUrlCrossRef
  65. 65.↵
    1. Zhang QJ,
    2. Wang Z,
    3. Chen HZ,
    4. Zhou S,
    5. Zheng W,
    6. Liu G,
    7. Wei YS,
    8. Cai H,
    9. Liu DP,
    10. Liang CC
    . Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice. Cardiovasc Res. 2008;80:191–199. doi: 10.1093/cvr/cvn224.
    OpenUrlAbstract/FREE Full Text
  66. 66.↵
    1. Stein S,
    2. Matter CM
    . Protective roles of SIRT1 in atherosclerosis. Cell Cycle. 2011;10:640–647.
    OpenUrlCrossRefPubMed
  67. 67.↵
    1. Gorenne I,
    2. Kumar S,
    3. Gray K,
    4. Figg N,
    5. Yu H,
    6. Mercer J,
    7. Bennett M
    . Vascular smooth muscle cell sirtuin 1 protects against DNA damage and inhibits atherosclerosis. Circulation. 2013;127:386–396. doi: 10.1161/CIRCULATIONAHA.112.124404.
    OpenUrlAbstract/FREE Full Text
  68. 68.↵
    1. Balestrieri ML,
    2. Rizzo MR,
    3. Barbieri M,
    4. et al
    . Sirtuin 6 expression and inflammatory activity in diabetic atherosclerotic plaques: effects of incretin treatment. Diabetes. 2015;64:1395–1406. doi: 10.2337/db14-1149.
    OpenUrlAbstract/FREE Full Text
  69. 69.↵
    1. Sharma S,
    2. Taliyan R,
    3. Ramagiri S
    . Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice. J Mol Neurosci. 2015;56:1–11. doi: 10.1007/s12031-014-0461-x.
    OpenUrlCrossRefPubMed
  70. 70.↵
    1. International Stroke Genetics Consortium, Wellcome Trust Case Control Consortium 2,
    2. Bellenguez C,
    3. Bevan S,
    4. Gschwendtner A,
    5. et al
    . Genome-wide association study identifies a variant in hdac9 associated with large vessel ischemic stroke. Nat Genet. 2012;44:328–333. doi: 10.1038/ng.1081.
    OpenUrlCrossRefPubMed
  71. 71.↵
    1. Markus HS,
    2. Mäkelä KM,
    3. Bevan S,
    4. Raitoharju E,
    5. Oksala N,
    6. Bis JC,
    7. O’Donnell C,
    8. Hainsworth A,
    9. Lehtimäki T
    . Evidence HDAC9 genetic variant associated with ischemic stroke increases risk via promoting carotid atherosclerosis. Stroke. 2013;44:1220–1225. doi: 10.1161/STROKEAHA.111.000217.
    OpenUrlAbstract/FREE Full Text
  72. 72.↵
    1. Azghandi S,
    2. Prell C,
    3. van der Laan SW,
    4. Schneider M,
    5. Malik R,
    6. Berer K,
    7. Gerdes N,
    8. Pasterkamp G,
    9. Weber C,
    10. Haffner C,
    11. Dichgans M
    . Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke. 2015;46:197–202. doi: 10.1161/STROKEAHA.114.007213.
    OpenUrlAbstract/FREE Full Text
  73. 73.↵
    1. Gao P,
    2. Xu TT,
    3. Lu J,
    4. Li L,
    5. Xu J,
    6. Hao DL,
    7. Chen HZ,
    8. Liu DP
    . Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice. J Mol Med (Berl). 2014;92:347–357. doi: 10.1007/s00109-013-1111-4.
    OpenUrlCrossRefPubMed
  74. 74.↵
    1. Usui T,
    2. Morita T,
    3. Okada M,
    4. Yamawaki H
    . Histone deacetylase 4 controls neointimal hyperplasia via stimulating proliferation and migration of vascular smooth muscle cells. Hypertension. 2014;63:397–403. doi: 10.1161/HYPERTENSIONAHA.113.01843.
    OpenUrlCrossRef
  75. 75.↵
    1. Zhou B,
    2. Margariti A,
    3. Zeng L,
    4. Habi O,
    5. Xiao Q,
    6. Martin D,
    7. Wang G,
    8. Hu Y,
    9. Wang X,
    10. Xu Q
    . Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation. Arterioscler Thromb Vasc Biol. 2011;31:2676–2684. doi: 10.1161/ATVBAHA.111.230888.
    OpenUrlAbstract/FREE Full Text
  76. 76.↵
    1. Song S,
    2. Kang SW,
    3. Choi C
    . Trichostatin A enhances proliferation and migration of vascular smooth muscle cells by downregulating thioredoxin 1. Cardiovasc Res. 2010;85:241–249. doi: 10.1093/cvr/cvp263.
    OpenUrlAbstract/FREE Full Text
  77. 77.↵
    1. Zampetaki A,
    2. Zeng L,
    3. Margariti A,
    4. Xiao Q,
    5. Li H,
    6. Zhang Z,
    7. Pepe AE,
    8. Wang G,
    9. Habi O,
    10. deFalco E,
    11. Cockerill G,
    12. Mason JC,
    13. Hu Y,
    14. Xu Q
    . Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow. Circulation. 2010;121:132–142. doi: 10.1161/CIRCULATIONAHA.109.890491.
    OpenUrlAbstract/FREE Full Text
  78. 78.↵
    1. Hoeksema MA,
    2. Gijbels MJ,
    3. Van den Bossche J,
    4. et al
    . Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions. EMBO Mol Med. 2014;6:1124–1132. doi: 10.15252/emmm.201404170.
    OpenUrlAbstract/FREE Full Text

Significance

Cardiometabolic disease, emerging as a worldwide epidemic, is a combination of metabolic derangements leading to type 2 diabetes mellitus and cardiovascular disease. These derangements are generally long lasting and resistant to conventional therapies. Histone deacetylases are a class of enzymes that alter chromatin structure and epigenetically reprogram gene expression, thereby influencing key metabolic pathways, such as differentiation and function of pancreatic islet cells, adipocytes, hepatocytes, and skeletal muscle. Histone deacetylases also play complex roles in regulating the immune and cardiovascular systems. Increasing evidence suggests that histone deacetylases are centrally positioned to regulate the interplay between metabolic disease, inflammation, and cardiovascular risk factors. Understanding the molecular, cellular, and physiological functions of histone deacetylases in cardiometabolic disease is expected to provide insight into disease pathogenesis, risk factor control, and therapeutic development.

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  • Histone Deacetylases and Cardiometabolic DiseasesSignificance
    Kan Hui Yiew, Tapan K. Chatterjee, David Y. Hui and Neal L. Weintraub
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:1914-1919, originally published July 16, 2015
    https://doi.org/10.1161/ATVBAHA.115.305046
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