Abstract 66: Small Dense LDL Cholesterol Predicts Incident Diabetes Mellitus: The Atherosclerosis Risk in Communities Study
Background: Small dense low-density lipoprotein cholesterol (sd-LDL-C) is an independent predictor of vascular events even in individuals with lower levels of LDL-C. Diabetics in particular tend to have higher levels of sd-LDL-C compared to those without diabetes. It is not known if sd-LDL-C predicts incident diabetes mellitus (DM).
Objectives: We tested the hypothesis that elevated levels of sd-LDL-C measured using a new automated assay predict incident DM in the biracial ARIC study.
Methods: Plasma sd-LDL-C was measured in 9,451 men and women without prevalent DM using a newly developed automated homogeneous assay. A Cox proportional hazards model was used to examine the association of sd-LDL-C with risk for incident DM.
Results: More individuals in the highest vs. lowest sd-LDL-C quartiles were men, Caucasians, had hypertension and higher mean body mass index (BMI) (P<0.001 for all comparisons). Similarly more individuals in the highest vs. lowest sd-LDL-C quartiles had parental history of DM (31.2 vs. 28.8%, P=0.012) and higher mean fasting blood glucose (116 vs. 102 mg/dL, P<0.001). Over a period of 10.4 years 911 individuals developed new onset DM at a rate of 9.27 per thousand person years. In a fully adjusted model, individuals in highest vs. lowest sd-LDL-C quartiles have a 44% increased risk for the development of incident DM even after adjusting for fasting blood glucose (Table).
Conclusion: sd-LDL-C predicts incident DM in the biracial ARIC study.
Author Disclosures: Y. Pokharel: None. W. Sun: None. S.S. Virani: None. C.M. Ballantyne: None. R.C. Hoogeveen: Research Grant; Significant; Denka Seiken Co., LTD..
- © 2014 by American Heart Association, Inc.