Abstract 498: A Single Nucleotide Polymorphism in the CDKN1B Gene is Associated With Carotid Plaque Progression
Objective: Studies suggest that a SNP in the promoter region of the CDKN1B gene (-838 C>A; rs36228499), a cell cycle inhibitor, may be associated with decreased vascular SMC proliferation and increased risk of MI. Our objective was to test the hypothesis that the -838A allele is associated with decreased carotid plaque progression.
Methods: 214 AIM-HIGH participants underwent annual carotid MRI over 2 years using a standardized protocol. Images were analyzed by Core Lab reviewers blinded to the genotyping results. Plaques with ulceration or hemorrhage were excluded as these local features may contribute excess variability or override genotype. Changes in wall thickness (WT) and lumen, wall, fibrous tissue and total vessel volumes were measured. Associations between number of A alleles and remodeling patterns were tested using linear regression.
Results: Of the 214 subjects, 161 had suitable MRI and genotype data available for analysis. There was a significant trend toward less growth (more regression) in mean WT for each A allele (p=0.043) (Figure 1). Other plaque variables were not significantly associated with genotype but directionally showed weak trends toward more expansive remodeling for each C allele.
Conclusions: These data suggest that -838 C>A SNP of the CDKN1B gene is significantly associated with carotid mean WT progression among subjects with established vascular disease well treated for LDL-C and blood pressure.
Author Disclosures: T.S. Hatsukami: Research Grant; Modest; Philips Healthcare. Research Grant; Significant; AbbVie. X. Zhao: Research Grant; Significant; AbbVie, Merck, Pfizer. D. Rader: None. D.S. Hippe: Research Grant; Significant; AbbVie. S. Tuteja-Stevens: None. C. Yuan: Research Grant; Modest; Philips Healthcare. Consultant/Advisory Board; Modest; Bristol Myers Squibb Medical Imaging, Philips Healthcare - Radiology Medical Advice Network. A. Clowes: None.
- © 2014 by American Heart Association, Inc.