Abstract 446: Divergent Trajectory Patterns of Systemic Versus Vascular Inflammation over Age in Healthy Caucasian and African-American Families
Objectives: Age and inflammation both are risk factors for cardiovascular disease. The association between these two risk factors across lifespan and ethnicity in the general population is poorly understood.
Methods: We assessed the relationship of systemic (C-reactive protein, serum amyloid A, fibrinogen, haptoglobin and α-acid glycoprotein) and vascular (pentraxin-3, soluble intercellular adhesion molecule-1 and soluble vascular adhesion molecule-1) inflammatory burden with age in healthy Caucasian and African-American families with members aged 6 to 74 years (n=267). To collectively assess systemic and vascular risk factors across the age spectrum, a composite z-score for each category of inflammatory markers was calculated based on individual levels.
Results: We observed a contrasting pattern in systemic vs. vascular inflammatory burden over age with an increase in systemic but a decrease in vascular inflammatory markers in both ethnic groups (p<0.05 for all). There were no significant differences in trends between the two ethnic groups. These observations remained significant after taking the correlations of siblings and parents from the same family into account. In multivariate analyses adjusting for covariates (BMI, blood pressure, total, LDL and HDL cholesterol, triglyceride and glucose), the trajectory patterns of fibrinogen and α-acid glycoprotein levels were no longer regulated with age in either ethnic group, whereas the results for vascular inflammation remained unchanged. The results based on the composite z-score for each marker category confirmed the findings of individual markers as the composite z-score for systemic inflammation increased with age (p=0.005), while the composite z-score for vascular inflammation declined with age (p=0.0002) regardless of ethnicity.
Conclusions: There was a diverging pattern in systemic vs. vascular inflammatory burden as function of age, which was independent of ethnicity, family correlation and individuals’ metabolic burden. The findings illustrate the complex relationship between age and inflammation, and suggest that a perceived elevation of vascular markers among the very young may be an indication of dynamic growth rather than a disease process.
Author Disclosures: E. Byambaa: None. A. Erdembileg: None. W. Zhang: None. T. Fung: None. A. Abbuthalha: None. K. Kim: None. L. Berglund: None.
- © 2014 by American Heart Association, Inc.