Abstract 408: The Importance of Vascular Risk Factors for Development of Dementia
Background: Since prevention and therapy of Alzheimer dementia turned out to be problematic, more attention should be paid to the vascular component of mixed pathologies, since this includes the possibility to decisively reduce the incidence of dementiae. ALP and GGT are indispensable constituents of brain microvessel endothelial cells, expressed and induced by IL-6. High values are entangled in affecting blood-brain barrier functionality. In a pilot study of 11 patients with metabolic syndrome, we examined whether these biomarkers can be beneficially influenced through an antioxidant phytochemical approach with Ginkgo biloba (EGb 761, 2 x 120 mg/d, 2 months).
Methods: Photometric methods, ELISAs, EIAs and laser ellipsometry were applied.
Results: Brain/liver biomarkers: ALP -14.8% (p < 0.004), GGT -11.3% (< 0.010). (Anti)oxidative biomarkers: SOD +17.7% (< 0.009), GPx +11.6% (< 0.001), oxLDL/LDL -21.0% (< 0.002), 8-iso-PGF2α -39.8% (< 0.003), MPO -29.6% (< 0.014). Inflammatory biomarkers: IL-6 -12.9% (< 0.041), Lp(a) -26.3% (< 0.001), hs-CRP -39.3% (< 0.005), WBC -6.3% (< 0.023), MMP-9 -32.9% (< 0.042). Vasodilator biomarkers: cAMP +43.5% (< 0.001), cGMP +32.9% (< 0.001), nanoplaque formation -14.3% (< 0.008), nanoplaque size -23.4% (< 0.0004). ALP and GGT were correlated to each other (r = 0.71; < 0.0225) as well as to a decrease of oxidative, inflammatory and diabetic biomarkers (Table).
Conclusion: Since under ginkgo, ALP and GGT were downregulated, SOD upregulated and plasma biomarkers beneficially altered, this phytochemical may be estimated as complementary drug with potentially preventive character for cardio-cerebro-vascular diseases including dementiae.
Author Disclosures: G. Siegel: Research Grant; Modest; Schwabe Pharmaceuticals, Karlsruhe, Germany. E. Ermilov: None. I. Lubitz: None.
- © 2014 by American Heart Association, Inc.