Abstract 255: Association of 24-Hour Heart Rate and Rate Pressure Product With Atherosclerosis Risk Factors in Nonhypertensive Individuals
Heart rate (HR) is an established marker of sympathetic nervous system (SNS) activity and an independent predictor of cardiovascular morbidity and mortality. However, the exact mechanism by which the SNS mediates its deleterious effects remains unknown. The main objective of this study was to determine if 24-hour mean HR and heart rate pressure product (HR24 and RPP24) obtained using ambulatory blood pressure (BP) monitoring are associated with atherosclerosis risk factors in young-middle aged non-hypertensive patients in the preclinical phase of disease.
Data were obtained from 186 non-hypertensive individuals aged 18-45. HR24 and RPP24 were significantly associated with known atherosclerosis risk factors (elevated SBP/DBP (p< 0.001), endothelial dysfunction (p< 0.05), insulin resistance (p< 0.001), and inflammatory adipokines: CRP (p< 0.001), IL-6 (p< 0.001), and PAI-1 (p< 0.001). These data suggest that elevated HR and RPP may be potential markers of elevated risk for future atherosclerotic events in these asymptomatic individuals, prior to the development of clinically defined hypertension.
Author Disclosures: C. Cheng: None. C. Daskalakis: None.
- © 2014 by American Heart Association, Inc.