Abstract 157: Association Between Monocyte Count and Coronary Calcification in Patients Without a History of Coronary Artery Disease
Introduction: This study aimed to investigate associations between monocyte count derived from complete blood count and coronary artery calcium score (CACS) in patients without history of coronary artery disease (CAD).
Methods: In this cross-sectional study, 831 consecutive patients without history of CAD who presented with chest pain and underwent coronary artery calcium scoring by MDCT were included. Patients with any clinical signs of infection were excluded. High monocyte count was defined as absolute monocyte count of > 950/uL. Presence of coronary calcification and moderate-to-severe coronary calcification were determined when CACS>0 and CACS>100 respectively.
Results: The cohort comprised of 60% men with mean age of 59±14 years. Median Framingham’s 10-year risk for cardiovascular disease was 4% (Interquartile range; IQR 1%-16%). Sixty percent of patients had zero CACS followed by 21.5% with CACS 1-100, 9.9% with CACS 101-400 and 8.1% with CACS>400. Mean ± SD absolute monocyte count was 588±379 /uL. There was no statistically significant difference in rate of CACS>0 between high monocyte count group and normal monocyte count group (p 0.83). In patients with non-zero CACS (N=328), those with absolute monocyte count > 90 percentile had higher rate of CACS>100 than those in the bottom 10 percentile (55.9% VS 30%; p 0.037) as shown in the left figure. Those with high monocyte count had higher rate of CACS>100 than those with normal monocyte count (68.4% VS 44%; p = 0.038) as shown in the right figure. In multivariate regression analysis, high monocyte count was associated with CACS>100 (HR 2.84; 95% confidence interval 1.05, 7.73; p = 0.040).
Conclusion: In patients without history of CAD, high monocyte count was not associated with presence of coronary calcification. However, high monocyte count is independently associated with more severe calcification in those with coronary calcification.
Author Disclosures: K. Chaikriangkrai: None. R. Adigun: None. S. Khaleel bala: None. S. Alchalabi: None. S. Botero: None. S. Chang: None.
- © 2014 by American Heart Association, Inc.