The ABC of Thrombopoiesis
Platelets play an important role in atherogenesis and atherothrombosis. At early stages of atherosclerosis, platelet-borne chemokines and platelet–leukocyte complexes contribute to the recruitment of neutrophils and monocytes to inflamed arteries.1,2 At late stages, platelets orchestrate additional processes such as thrombosis by direct mechanisms and possibly by indirect mechanisms such as the induction of neutrophil extracellular traps.3,4 Although mechanisms of platelet-driven atherosclerosis have been studied widely, little is known about their production during atherosclerosis-promoting conditions.
See accompanying article on page 751
In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Murphy et al5 show that the lack of ABCB6 in the bone marrow leads to thrombocytosis, enhanced proinflammatory platelet activity, and accelerated atherosclerosis in atherosclerosis-prone hyperlipidemic low-density lipoprotein receptor–deficient mice (see the Figure). Interestingly, ABCB6 was found to be highly expressed in bone marrow …