Abstract 556: Significant Interaction of Smoking and Metabolic Syndrome for Subclinical Vascular Inflammation
BACKGROUND Emerging data suggest an additive interaction of current smoking and metabolic syndrome (MS) on cardiovascular risk. In this study we aim to assess if this increased risk can be explained by an increased risk of subclinical vascular inflammation.
METHODS We evaluated 6,464 healthy non-diabetic Brazilian subjects (43±10 years, 79% males). Participants were divided into 4 subgroups by MS and smoking status. High-sensitivity C reactive protein (hs-CRP) was measured to assess degree of underlying inflammation. We excluded 945
(14%) individuals with missing hs-CRP levels.
RESULTS Overall 1,062/5,519 (19%) had hs-CRP≥3 mg/dl. The figures show prevalence of high CRP across smoking and MS status. As compared with never smokers without MS, in multivariate
analysis the adjusted OR’s for elevated hs-CRP were 1.28 (95% CI: 0.98-1.67), 2.09 (95% CI: 1.76-2.48), and 4.24 (95% CI:2.95-6.08) for smokers without MS, nonsmokers with MS, and current
smokers with MS. The interaction for MS and smoking with high hs-CRP was statistically significant(p=0.05) The risk of hsCRP≥3 with smoking was 1.58 (1.00-2.52) fold vs smokers among non MS
CONCLUSION The current study further demonstrates a synergistic interaction of current smoking and MS for vascular inflammation, highlighting those with MS are at higher risk and needed to be
aggressively targeted for smoking cessation.
- © 2013 by American Heart Association, Inc.