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Abstract 526: Angiogenesis and Kallikrein-kinin System Activation after Exercise Training in Rats with Sustained Adrenergic Hyperactivity

Eduardo T Santana, Andrey J Serra, Martha T Manchini, Ednei L Antonio, Paulo J Tucci, Jose A Silva
Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A526
Eduardo T Santana
Med Sciences, Universidade Nove de Julho, Sao Paulo, Brazil
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Andrey J Serra
Med Sciences, Universidade Nove de Julho, Sao Paulo, Brazil
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Martha T Manchini
Med Sciences, Universidade Nove de Julho, Sao Paulo, Brazil
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Ednei L Antonio
Physiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
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Paulo J Tucci
Cardiac Physiology, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
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Jose A Silva
Med Sciences, Universidade Nove de Julho, Sao Paulo, Brazil
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Abstract

Several mechanisms are involved to exercise-related cardioprotection.

Purpose Kallikrein-kinin system may contribute to this effect inducing endothelial vascular growth factor (VEGF) and endothelial nitric oxide synthase (eNOS) expression.

Methods In a model of β-adrenergic hyperactivity, male Wistar rats were assigned into four groups: sedentary non-treated (Con); sedentary isoproterenol-treated (Iso); exercised only (Ex); and exercised isoproterenol-treated (Iso+Ex). Left ventricles were processed for Real time PCR and Western blot analysis in order to quantify the expression of kinins and angiogenic molecules.

Results In Iso+Ex, a significant increase of tissue kallikrein gene and protein expression was observed (p<0.01). In the same group, an augmented eNOS (p<0.05), VEGF and VEGF receptor mRNA expression (p<0.01) was observed. The expression of angiogenic IL-1 and Il-8 were increased after exercise (p<0.01). Expression of integrin linked kinase (ILK), another angiogenesis promoter, also augmented after training (p<0.01).

Conclusion Our results represent the first demonstration that exercise increases the tissue kallikrein gene and protein expression in rat myocardium after β-adrenergic hyperactivity. Together with the observed augmented eNOS and VEGF and angiogenesis-related molecules mRNA expression, a feasibly pathway might be drawn to understand the kallikrein-kinin system protective role to avoid the abnormalities developed due excessive catecholaminergic activation as observed in cardiac failure. Our data suggest a strong evidence of beneficial exercise action, particularly related to angiogenesis, in response of myocardium towards β-adrenergic hyperactivity.

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  • Kinins
  • Vascular Endothelial Growth Factor
  • © 2013 by American Heart Association, Inc.
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Arteriosclerosis, Thrombosis, and Vascular Biology
April 2018, Volume 38, Issue 4
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    Abstract 526: Angiogenesis and Kallikrein-kinin System Activation after Exercise Training in Rats with Sustained Adrenergic Hyperactivity
    Eduardo T Santana, Andrey J Serra, Martha T Manchini, Ednei L Antonio, Paulo J Tucci and Jose A Silva
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A526, originally published October 20, 2015

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    Abstract 526: Angiogenesis and Kallikrein-kinin System Activation after Exercise Training in Rats with Sustained Adrenergic Hyperactivity
    Eduardo T Santana, Andrey J Serra, Martha T Manchini, Ednei L Antonio, Paulo J Tucci and Jose A Silva
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A526, originally published October 20, 2015
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