Skip to main content
  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

  • Home
  • About this Journal
    • Editorial Board
    • Meet the Editors
    • ATVB Journal History
    • General Statistics
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • Cover Art Award
    • ATVB Early Career Award
    • ATVB in Focus
    • Recent Brief Reviews of ATVB
    • Lecture Series
    • Collections
    • Recent Highlights of ATVB
    • Commentaries
    • Browse Abstracts
    • Insight into ATVB Authors
  • Resources
    • Instructions for Authors
    • Online Submission/Peer Review Site
    • Council on ATVB
    • Permissions and Rights Q&A
    • AHA Guidelines and Statements
    • Customer Service and Ordering Information
    • Author Reprints
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
  • Facebook
  • LinkedIn
  • Twitter

  • My alerts
  • Sign In
  • Join

  • Advanced search

Header Publisher Menu

  • American Heart Association
  • Science Volunteer
  • Warning Signs
  • Advanced Search
  • Donate

Arteriosclerosis, Thrombosis, and Vascular Biology

  • My alerts
  • Sign In
  • Join

  • Facebook
  • LinkedIn
  • Twitter
  • Home
  • About this Journal
    • Editorial Board
    • Meet the Editors
    • ATVB Journal History
    • General Statistics
  • All Issues
  • Subjects
    • All Subjects
    • Arrhythmia and Electrophysiology
    • Basic, Translational, and Clinical Research
    • Critical Care and Resuscitation
    • Epidemiology, Lifestyle, and Prevention
    • Genetics
    • Heart Failure and Cardiac Disease
    • Hypertension
    • Imaging and Diagnostic Testing
    • Intervention, Surgery, Transplantation
    • Quality and Outcomes
    • Stroke
    • Vascular Disease
  • Browse Features
    • Cover Art Award
    • ATVB Early Career Award
    • ATVB in Focus
    • Recent Brief Reviews of ATVB
    • Lecture Series
    • Collections
    • Recent Highlights of ATVB
    • Commentaries
    • Browse Abstracts
    • Insight into ATVB Authors
  • Resources
    • Instructions for Authors
    • Online Submission/Peer Review Site
    • Council on ATVB
    • Permissions and Rights Q&A
    • AHA Guidelines and Statements
    • Customer Service and Ordering Information
    • Author Reprints
    • International Users
    • AHA Newsroom
  • AHA Journals
    • AHA Journals Home
    • Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB)
    • Circulation
    • → Circ: Arrhythmia and Electrophysiology
    • → Circ: Genomic and Precision Medicine
    • → Circ: Cardiovascular Imaging
    • → Circ: Cardiovascular Interventions
    • → Circ: Cardiovascular Quality & Outcomes
    • → Circ: Heart Failure
    • Circulation Research
    • Hypertension
    • Stroke
    • Journal of the American Heart Association
Poster Abstract Presentations

Abstract 378: Global MicroRNA Evaluation of The Brains and Aortas of a Prenatal Stress Murine Model With Vulnerable Plaque Show Sexual Dimorphism

Sunny Jhamnani, Nima Aghili, Roberta Lassance-Soares, Subeena Sood, Joseph Devaney, Mary Susan Burnett, Stephen Epstein
Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A378
Sunny Jhamnani
Internal Medicine, Georgetown Univ Hosp/Washington Hosp Cntr, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nima Aghili
Cardiology Rsch Institute, MedStar Health Rsch Institute, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roberta Lassance-Soares
Cardiovascular Rsch Institute, MedStar Health Rsch Institute, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Subeena Sood
Cardiovascular Rsch Insitute, MedStar Health Rsch Institute, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph Devaney
Pediatrics, Children’s National Med Cntr, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mary Susan Burnett
Cardiovascular Rsch Institute, MedStar Health Rsch Institute, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephen Epstein
Cardiovascular Rsch Institute, MedStar Health Rsch Institute, Washington, DC
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics

Jump to

  • Article
  • Info & Metrics
  • eLetters
Loading

Abstract

Introduction and Hypothesis Stress is a major cardiovascular risk factor. Preliminary studies in our lab demonstrated that prenatal stress in a murine model is associated with accelerated atherosclerosis and a vulnerable plaque phenotype at 20 weeks of age. Here, we hypothesized that prenatal stress is associated with global microRNA (miRNA) changes, possibly gender specific, and we sought to determine them by seeking such changes in two different tissues (brain and aorta) in both sexes.

Methods Pregnant mixed background female mice were divided into stressed (chronic cold stress for the last 17 days of gestation) and non-stressed groups. Prenatally stressed and non-prenatally stressed offspring had urine corticosteroid levels measured at six weeks to see the effects of stress. At eight weeks the offspring were sacrificed and global miRNA levels were measured using the Affymetrix 2.0 miRNA chip on the brains and aorta.

Results Urine corticosteroid levels were decreased in both genders at six weeks (p≤0.01), which has been shown in previous severe stress murine models. These were more significant in males (p=0.006) than in females (p=0.01). In eight-week-old males, there were 84 miRNAs in the brain that were dysregulated between prenatally stressed and non-stressed (p<0.05). The top miRNAs in males by p-value were miR-26, miR-21, and miR-346. Females that were eight weeks old had 89 dysregulated miRNAs (p<0.005) in the brain with miR-154 and miR-331 as the top miRNAs by p-value. Analysis of the aortas revealed 74 and 92 dysregulated miRNAs (p<0.05) with miR-326 and miR-15 as the top hits in males and females by p-value, respectively. Of interest, these top miRNAs have, in prior published studies, been implicated in playing a role in ischemia, ischemic preconditioning, stress and endothelial degeneration.

Conclusions Prenatal stress leads to variety of miRNA changes that persist into at least the eighth postnatal week of life. These alterations in miRNA levels may contribute to the development of a vulnerable plaque phenotype that we have shown to be present at 20 weeks of age in a previous study. Prenatal stress also appears to exert gender specific effects, a finding that may provide insight into gender differences in cardiovascular outcomes.

  • miRNA
  • Vulnerable Plaque
  • Sexual Dimorphism
  • © 2013 by American Heart Association, Inc.
Back to top

Current Issue

Arteriosclerosis, Thrombosis, and Vascular Biology
April 2018, Volume 38, Issue 4
  • Table of Contents

Jump to

  • Article
  • Info & Metrics

Article Tools

  • Citation Tools
    Abstract 378: Global MicroRNA Evaluation of The Brains and Aortas of a Prenatal Stress Murine Model With Vulnerable Plaque Show Sexual Dimorphism
    Sunny Jhamnani, Nima Aghili, Roberta Lassance-Soares, Subeena Sood, Joseph Devaney, Mary Susan Burnett and Stephen Epstein
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A378, originally published October 20, 2015

    Citation Manager Formats

    • BibTeX
    • Bookends
    • EasyBib
    • EndNote (tagged)
    • EndNote 8 (xml)
    • Medlars
    • Mendeley
    • Papers
    • RefWorks Tagged
    • Ref Manager
    • RIS
    • Zotero
  • Article Alerts
    Log in to Email Alerts with your email address.
  • Save to my folders

Share this Article

  • Email

    Thank you for your interest in spreading the word on Arteriosclerosis, Thrombosis, and Vascular Biology.

    NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

    Enter multiple addresses on separate lines or separate them with commas.
    Abstract 378: Global MicroRNA Evaluation of The Brains and Aortas of a Prenatal Stress Murine Model With Vulnerable Plaque Show Sexual Dimorphism
    (Your Name) has sent you a message from Arteriosclerosis, Thrombosis, and Vascular Biology
    (Your Name) thought you would like to see the Arteriosclerosis, Thrombosis, and Vascular Biology web site.
  • Share on Social Media
    Abstract 378: Global MicroRNA Evaluation of The Brains and Aortas of a Prenatal Stress Murine Model With Vulnerable Plaque Show Sexual Dimorphism
    Sunny Jhamnani, Nima Aghili, Roberta Lassance-Soares, Subeena Sood, Joseph Devaney, Mary Susan Burnett and Stephen Epstein
    Arteriosclerosis, Thrombosis, and Vascular Biology. 2013;33:A378, originally published October 20, 2015
    del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo

Related Articles

Cited By...

Arteriosclerosis, Thrombosis, and Vascular Biology

  • About ATVB
  • AHA CME
  • Meeting Abstracts
  • Permissions
  • Email Alerts
  • Open Access Information
  • AHA Journals RSS
  • AHA Newsroom

Contact the Editorial Office:
email: atvb@atvb.org

Information for:
  • Advertisers
  • Subscribers
  • Subscriber Help
  • Institutions / Librarians
  • Institutional Subscriptions FAQ
  • International Users
American Heart Association Learn and Live
National Center
7272 Greenville Ave.
Dallas, TX 75231

Customer Service

  • 1-800-AHA-USA-1
  • 1-800-242-8721
  • Local Info
  • Contact Us

About Us

Our mission is to build healthier lives, free of cardiovascular diseases and stroke. That single purpose drives all we do. The need for our work is beyond question. Find Out More about the American Heart Association

  • Careers
  • SHOP
  • Latest Heart and Stroke News
  • AHA/ASA Media Newsroom

Our Sites

  • American Heart Association
  • American Stroke Association
  • For Professionals
  • More Sites

Take Action

  • Advocate
  • Donate
  • Planned Giving
  • Volunteer

Online Communities

  • AFib Support
  • Garden Community
  • Patient Support Network
  • Professional Online Network

Follow Us:

  • Follow Circulation on Twitter
  • Visit Circulation on Facebook
  • Follow Circulation on Google Plus
  • Follow Circulation on Instagram
  • Follow Circulation on Pinterest
  • Follow Circulation on YouTube
  • Rss Feeds
  • Privacy Policy
  • Copyright
  • Ethics Policy
  • Conflict of Interest Policy
  • Linking Policy
  • Diversity
  • Careers

©2018 American Heart Association, Inc. All rights reserved. Unauthorized use prohibited. The American Heart Association is a qualified 501(c)(3) tax-exempt organization.
*Red Dress™ DHHS, Go Red™ AHA; National Wear Red Day ® is a registered trademark.

  • PUTTING PATIENTS FIRST National Health Council Standards of Excellence Certification Program
  • BBB Accredited Charity
  • Comodo Secured