Abstract 362: Characterization of Triglyceride-Rich Remnant Lipoproteins in the Hypertriglyceridemic Fredrickson-Levy Dyslipidemic Phenotypes without Chylomicrons: The Very Large Database of Lipids (VLDL-6)
Background The major dyslipidemia (DL) classes are relatively rare with limited phenotypic characterization across large populations.
Methods We studied 1,340,614 U.S. adults from the Very Large Database of Lipids. Lipid testing was by ultracentrifugation (VAP, Atherotech, Birmingham, AL). Distributions of total cholesterol (TC), HDL-C, LDL-C and triglycerides (TG) in the database were superimposable with those in the NHANES 2007-2008 survey. We used the following criteria to classify the excess lipoprotein components of DL in subjects with TG >130 mg/dL without chylomicrons (CM): VLDL-C or LDLr-C (directly measured LDL-C - Lp(a)-C -IDL-C) > 90th percentile, Type III DL remnant lipoprotein cholesterol (RLP-C = VLDL3-C + IDL-C) excess by criterion of VLDL-C/TG > 0.3. The remaining subjects (continuum) not classified by DL criteria were further stratified by TG/HDL-C <3 vs. >3, associated with insulin resistance.
Results VLDL3-C/ IDL-C ratio was approximately 1 across DL and the continuum groups. The highest concentration of RLP-C was in Type III DL; lesser RLP-C elevation is present in all DL characterized by VLDL excess. The highest non-HDL-C was present in type IIb with lesser elevations in types III and IV. RLP-C was higher in the TG/HDL-C>3 continuum than TG/HDL-C<3 continuum reference group (Table).
Summary In addition to type III, the major non-CM DL is frequently associated with excess RLP-C. RLP-C tended to be normal in the continuum subjects, trending higher in those with TG/HDL-C>3.
- © 2013 by American Heart Association, Inc.