Abstract 359: Effects of Erythritol on Endothelial Function in People with Type 2 Diabetes Mellitus
Erythritol is a polyol compound used as a low calorie nutritive sweetener. Several animal model studies have shown that erythritol has antioxidant properties and may improve endothelial function. The goal of this pilot study was to obtain evidence for such an effect in patients with type 2 diabetes mellitus (DM). Vascular testing included brachial artery flow-mediated dilation (FMD), reactive hyperemia, digital peripheral arterial tonometry (EndoPAT), carotid-femoral pulse wave velocity (PWV), central pulse pressure, and brachial blood pressure. We also measured blood glucose, insulin, C-peptide, C-reactive protein and urine F2 isoprostanes. Twenty-four participants (age 56±5 yrs, 54% female) consumed erythritol as a flavored beverage (12g x3/day) for 28 days. We assessed the effect of erythritol on vascular function compared to baseline at three time points: Acute (2 hours after erythritol 24 g), chronic (at day 28), and acute-on-chronic (day 28 after erythritol 24g). We did not observe a significant change in brachial artery FMD or reactive hyperemia. Acute consumption of erythritol produced a significant improvement in endothelial function measured by EndoPAT (lnPAT ratio 0.52±0.48 vs. 0.87±0.29, P=0.005). lnPAT ratio was 0.72±0.33 (P=0.19 vs. baseline) after chronic consumption and 0.84±0.34 after acute-on-chronic consumption (P=0.02). Following 28 days of erythritol consumption we observed a favorable effect on markers of aortic compliance: significant reduction in central pulse pressure from 47±13 to 41±9 mmHg (P=0.021) and strong trend for decreased PWV from 9.1±1.4 to 8.6±1.6 cm/sec (P=0.06). Markers of glucose metabolism, oxidative stress and inflammation did not vary throughout the study. We observed a trend for reduced systolic blood pressure after chronic erythritol consumption (131±16 to 128±11 mmHg, P=0.10). A subgroup analysis of 12 patients with systolic blood pressure above 130 mmHg yield a significant reduction in systolic blood pressure from 144±12 to 133±9 mmHg (P=0.01). This pilot study suggests that erythritol may have favorable effects on small vessel endothelial function, blood pressure, and central aortic stiffness in DM patients. Confirmation of these findings will require a placebo-controlled study.
- © 2013 by American Heart Association, Inc.