Abstract 358: Association of Adiponectin-with Cardio-metabolic Traits
Background and Objectives Current evidence on the association of adiponectin with fatal or non-fatal cardiovascular (CVD) outcomes is inconsistent. In addition association between adiponectin and related metabolic traits has not been systematically evaluated.
Design and Methods A systematic search was performed using MEDLINE and Web of Science databases. Effect estimates and standard errors of associations of adiponectin with metabolic traits including (adiposity, glucose, insulin and cholesterol) and cardiovascular outcomes (coronary heart disease and stroke) were extracted from relevant prospective studies. The effect estimates and standardized correlation coefficients were pooled together using random effects meta-analysis.
Results A total of 18 studies with 32,116 participants and 7,433 cardiovascular events reported on associations for adiponectin. Moderately strong and inverse associations were observed for adiponectin and measures of adiposity, body mass index, r=-0.13 [95% CI -0.29 to -0.02], waist to hip ratio, (r=-0.25 [95% CI -0.31 to -0.21] and waist circumference, r=-0.23 [95% CI -0.29 to -0.16]. Similarly inverse associations were seen with glucose, r=-0.19 [95% CI -0.22 to -0.17], insulin, r=-0.27 [95% CI -0.38 to -0.15] and triglycerides r=-0.31[95% CI -0.36, -0.26] while a positive correlation was observed with HDL-c, r=0.35[95% CI 0.30-0.41]. A pooled adjusted RR[95% CI] of 0.99 (95% CI: 0.86 to 1.14) with CVD for individuals in the top versus bottom third of baseline levels of adiponectin was seen. There was evidence of moderate heterogeneity between the findings of contributing studies (I2 =66%) with little difference explained by several study-level characteristics. Similarly modest associations were observed for both coronary heart disease (CHD), RR[95% CI] 0.89 (0.74 to 1.08) and stroke RR[95% CI] 1.01 (0.83 to 1.22).
Conclusion Results of this systematic analysis give further evidence to the role of adiponectin with metabolic traits. However observational evidence from prospective studies indicates modest association with CHD and stroke outcomes that needs further investigation.
- © 2013 by American Heart Association, Inc.