Abstract 327: Ankle-Brachial Index is Associated with Subendocardial Viability in Biracial (black-white) Young Adults: The Bogalusa Heart Study.
Ankle-Brachial Index (ABI) has been widely used clinically to define peripheral artery disease (PAD). Previous studies have established the correlation between ABI and coronary artery disease among men and women; however, limited information is available on the association between ABI and subendocardial viability in terms or Subendocardial Viability Ratio (SEVR) -a measure of myocardial perfusion-, among asymptomatic biracial (black-white) young adults.
We assessed the hypothesis that ABI is directly correlated with SEVR in asymptomatic biracial (black-white) young adults.
As a part of The Bogalusa Heart Study, a bi-racial (black/white) community based study, noninvasive assessment of ABI and SEVR was obtained in 610 asymptomatic individuals aged 29-51years (mean 43.4; 68.7% white and 54.6% female), along with evaluation of traditional cardiovascular risk factors. The association of ABI with SEVR was tested through multivariable-adjusted linear regression.
Black and female participants had significantly lower mean levels of SEVR (p<0.001) and ABI (p<0.001), compared to their counterparts. In race-specific stepwise multiple regression analyses, with adjustments for age, body mass index, sex, smoking status and traditional CV risk factors, significant direct associations were observed between ABI and SEVR in both, white (B=0.25, p<0.001) and black participants (B=0.11, p<0.03), with a stronger association in white participants.
The observed association of ABI with SEVR in black-white asymptomatic adults supports the hypothesis that, structural changes in the peripheral vasculature are reflective of changes in the coronary arteries, even at subclinical level, which may aid to enhance early detection of coronary artery disease in asymptomatic individuals.
- © 2013 by American Heart Association, Inc.